Routine laboratory parameters of newly diagnosed pulmonary tuberculosis patients: a single center study in Brazil
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2020 |
| Outros Autores: | , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Research, Society and Development |
| Texto Completo: | https://rsdjournal.org/index.php/rsd/article/view/9873 |
Resumo: | Objective: Evaluate the severity of tuberculosis and its association with laboratory tests before antituberculosis treatment. Methodology: Patients with pulmonary tuberculosis were evaluated for severity using data available in medical records (Clinical; Excretion of mycobacteria; and Diagnostic imaging) and associated with biochemical and hematological parameters requested at the time of diagnosis and before antituberculosis treatment. Results: The evaluation of the severity showed a predominance of smear AFB (+), fever associated with other symptoms and infiltrative tuberculosis. Only a positive correlation between mycobacteria excretion and imaging diagnosis (rho=0.47; p=0.023) was observed. The patients presented hyponatremia (9/21), hypomagnesemia (6/13), and hypercalcemia (1/13), unrelated to the severity. The presence of fever influenced the number of non-segmented neutrophils (p=0.0142) and the total leukocyte count correlated with the increase in total neutrophils (rho=0.9631; p<0.0001). Conclusion: Different severity characteristics of tuberculosis, although they reflect the degree of commitment of the patient, are not always correlated; the evaluation of electrolytes could contribute to clinical behavior; and non-segmented neutrophils are associated with a worse clinical prognosis in patients with tuberculosis. |
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Routine laboratory parameters of newly diagnosed pulmonary tuberculosis patients: a single center study in BrazilParámetros de laboratorio de rutina de pacientes con tuberculosis pulmonar recién diagnosticada: un estudio de un solo centro en BrasilParâmetros laboratoriais de rotina de pacientes recém-diagnosticados com tuberculose pulmonar: um estudo em um único centro no BrasilDiagnóstico por imagemDesequilíbrio hidroeletrolíticoMycobacterium tuberculosisNeutrófiloSinais e sintomas.Diagnóstico por imagenDesequilibrio hidroelectrolíticoMycobacterium tuberculosisNeutrófiloSignos y sintomas.Diagnostic imagingWater-electrolyte imbalanceMycobacterium tuberculosisNeutrophilSigns and symptoms.Objective: Evaluate the severity of tuberculosis and its association with laboratory tests before antituberculosis treatment. Methodology: Patients with pulmonary tuberculosis were evaluated for severity using data available in medical records (Clinical; Excretion of mycobacteria; and Diagnostic imaging) and associated with biochemical and hematological parameters requested at the time of diagnosis and before antituberculosis treatment. Results: The evaluation of the severity showed a predominance of smear AFB (+), fever associated with other symptoms and infiltrative tuberculosis. Only a positive correlation between mycobacteria excretion and imaging diagnosis (rho=0.47; p=0.023) was observed. The patients presented hyponatremia (9/21), hypomagnesemia (6/13), and hypercalcemia (1/13), unrelated to the severity. The presence of fever influenced the number of non-segmented neutrophils (p=0.0142) and the total leukocyte count correlated with the increase in total neutrophils (rho=0.9631; p<0.0001). Conclusion: Different severity characteristics of tuberculosis, although they reflect the degree of commitment of the patient, are not always correlated; the evaluation of electrolytes could contribute to clinical behavior; and non-segmented neutrophils are associated with a worse clinical prognosis in patients with tuberculosis.Objetivo: Evaluar la gravedad de la tuberculosis y su asociación con pruebas de laboratorio antes del tratamiento antituberculoso. Metodología: Se evaluó la gravedad de los pacientes con tuberculosis pulmonar utilizando los datos disponibles en los registros médicos (Clínica; excreción de micobacterias y diagnóstico por imagen) y asociado a parámetros bioquímicos y hematológicos solicitados en el momento del diagnóstico y antes del tratamiento antituberculoso. Resultados: La evaluación de la gravedad mostró un predominio de BAAR frotis (+), fiebre asociada a otros síntomas y tuberculosis infiltrativa. Solo se observó una correlación positiva entre la excreción de micobacterias y el diagnóstico por imágenes (rho = 0,47; p = 0,023). Los pacientes presentaron hiponatremia (9/21), hipomagnesemia (6/13) e hipercalcemia (1/13), sin relación con la gravedad. La presencia de fiebre influyó en el número de neutrófilos no segmentados (p = 0,0142) y el recuento total de leucocitos se correlacionó con el aumento de neutrófilos totales (rho = 0,9631; p <0,0001). Conclusión: Las diferentes características de gravedad de la tuberculosis, aunque reflejan el grado de compromiso del paciente, no siempre están correlacionadas; la evaluación de electrolitos podría contribuir al comportamiento clínico; y los neutrófilos no segmentados se asocian a un peor pronóstico clínico en pacientes con tuberculosis.Objetivo: Avaliar a gravidade da tuberculose e sua associação com testes laboratoriais antes do início do tratamento antituberculose. Metodologia: Pacientes com tuberculose pulmonar foram avaliados quanto à gravidade usando dados disponíveis em prontuários (Clínica; Excreção de micobactéria; Diagnóstico por imagem) e associado a parâmetros bioquímicos e hematológicos solicitados no momento do diagnóstico e antes do tratamento antituberculose. Resultados: A avaliação da gravidade mostrou predomínio de esfregaço de BAAR (+), febre associada a outros sintomas e tuberculose infiltrativa. Observou-se apenas correlação positiva entre excreção de micobactérias e diagnóstico por imagem (rho = 0,47; p = 0,023). Os pacientes apresentavam hiponatremia (9/21), hipomagnesemia (6/13) e hipercalcemia (1/13), sem relação com a gravidade. A presença de febre influenciou o número de neutrófilos não segmentados (p = 0,0142) e a contagem total de leucócitos correlacionou-se com o aumento dos neutrófilos totais (rho = 0,9631; p <0,0001). Conclusão: As diferentes características de gravidade da tuberculose, embora reflitam o grau de comprometimento do paciente, nem sempre estão correlacionadas; a avaliação de eletrólitos pode contribuir para o comportamento clínico; e os neutrófilos não segmentados estão associados a um pior prognóstico clínico em pacientes com tuberculose.Research, Society and Development2020-11-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/987310.33448/rsd-v9i11.9873Research, Society and Development; Vol. 9 No. 11; e2559119873Research, Society and Development; Vol. 9 Núm. 11; e2559119873Research, Society and Development; v. 9 n. 11; e25591198732525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIenghttps://rsdjournal.org/index.php/rsd/article/view/9873/8747Copyright (c) 2020 Ana Paula Biadola; André Aparecido dos Santos Correa; Amanda Aparecida Silva de Aguiar; Ualter Guilherme Cipriano Rosa; Paulo José Mascarenhas Mazaro; Christiane Martinez Húngaro; Marcus Vinícius Pimenta Rodrigues; Eliana Peresi-Lordelohttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessBiadola, Ana Paula Correa, André Aparecido dos Santos Aguiar, Amanda Aparecida Silva de Rosa, Ualter Guilherme Cipriano Mazaro, Paulo José Mascarenhas Húngaro, Christiane Martinez Rodrigues, Marcus Vinícius Pimenta Peresi-Lordelo, Eliana2020-12-10T23:37:57Zoai:ojs.pkp.sfu.ca:article/9873Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:32:03.241442Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false |
| dc.title.none.fl_str_mv |
Routine laboratory parameters of newly diagnosed pulmonary tuberculosis patients: a single center study in Brazil Parámetros de laboratorio de rutina de pacientes con tuberculosis pulmonar recién diagnosticada: un estudio de un solo centro en Brasil Parâmetros laboratoriais de rotina de pacientes recém-diagnosticados com tuberculose pulmonar: um estudo em um único centro no Brasil |
| title |
Routine laboratory parameters of newly diagnosed pulmonary tuberculosis patients: a single center study in Brazil |
| spellingShingle |
Routine laboratory parameters of newly diagnosed pulmonary tuberculosis patients: a single center study in Brazil Biadola, Ana Paula Diagnóstico por imagem Desequilíbrio hidroeletrolítico Mycobacterium tuberculosis Neutrófilo Sinais e sintomas. Diagnóstico por imagen Desequilibrio hidroelectrolítico Mycobacterium tuberculosis Neutrófilo Signos y sintomas. Diagnostic imaging Water-electrolyte imbalance Mycobacterium tuberculosis Neutrophil Signs and symptoms. |
| title_short |
Routine laboratory parameters of newly diagnosed pulmonary tuberculosis patients: a single center study in Brazil |
| title_full |
Routine laboratory parameters of newly diagnosed pulmonary tuberculosis patients: a single center study in Brazil |
| title_fullStr |
Routine laboratory parameters of newly diagnosed pulmonary tuberculosis patients: a single center study in Brazil |
| title_full_unstemmed |
Routine laboratory parameters of newly diagnosed pulmonary tuberculosis patients: a single center study in Brazil |
| title_sort |
Routine laboratory parameters of newly diagnosed pulmonary tuberculosis patients: a single center study in Brazil |
| author |
Biadola, Ana Paula |
| author_facet |
Biadola, Ana Paula Correa, André Aparecido dos Santos Aguiar, Amanda Aparecida Silva de Rosa, Ualter Guilherme Cipriano Mazaro, Paulo José Mascarenhas Húngaro, Christiane Martinez Rodrigues, Marcus Vinícius Pimenta Peresi-Lordelo, Eliana |
| author_role |
author |
| author2 |
Correa, André Aparecido dos Santos Aguiar, Amanda Aparecida Silva de Rosa, Ualter Guilherme Cipriano Mazaro, Paulo José Mascarenhas Húngaro, Christiane Martinez Rodrigues, Marcus Vinícius Pimenta Peresi-Lordelo, Eliana |
| author2_role |
author author author author author author author |
| dc.contributor.author.fl_str_mv |
Biadola, Ana Paula Correa, André Aparecido dos Santos Aguiar, Amanda Aparecida Silva de Rosa, Ualter Guilherme Cipriano Mazaro, Paulo José Mascarenhas Húngaro, Christiane Martinez Rodrigues, Marcus Vinícius Pimenta Peresi-Lordelo, Eliana |
| dc.subject.por.fl_str_mv |
Diagnóstico por imagem Desequilíbrio hidroeletrolítico Mycobacterium tuberculosis Neutrófilo Sinais e sintomas. Diagnóstico por imagen Desequilibrio hidroelectrolítico Mycobacterium tuberculosis Neutrófilo Signos y sintomas. Diagnostic imaging Water-electrolyte imbalance Mycobacterium tuberculosis Neutrophil Signs and symptoms. |
| topic |
Diagnóstico por imagem Desequilíbrio hidroeletrolítico Mycobacterium tuberculosis Neutrófilo Sinais e sintomas. Diagnóstico por imagen Desequilibrio hidroelectrolítico Mycobacterium tuberculosis Neutrófilo Signos y sintomas. Diagnostic imaging Water-electrolyte imbalance Mycobacterium tuberculosis Neutrophil Signs and symptoms. |
| description |
Objective: Evaluate the severity of tuberculosis and its association with laboratory tests before antituberculosis treatment. Methodology: Patients with pulmonary tuberculosis were evaluated for severity using data available in medical records (Clinical; Excretion of mycobacteria; and Diagnostic imaging) and associated with biochemical and hematological parameters requested at the time of diagnosis and before antituberculosis treatment. Results: The evaluation of the severity showed a predominance of smear AFB (+), fever associated with other symptoms and infiltrative tuberculosis. Only a positive correlation between mycobacteria excretion and imaging diagnosis (rho=0.47; p=0.023) was observed. The patients presented hyponatremia (9/21), hypomagnesemia (6/13), and hypercalcemia (1/13), unrelated to the severity. The presence of fever influenced the number of non-segmented neutrophils (p=0.0142) and the total leukocyte count correlated with the increase in total neutrophils (rho=0.9631; p<0.0001). Conclusion: Different severity characteristics of tuberculosis, although they reflect the degree of commitment of the patient, are not always correlated; the evaluation of electrolytes could contribute to clinical behavior; and non-segmented neutrophils are associated with a worse clinical prognosis in patients with tuberculosis. |
| publishDate |
2020 |
| dc.date.none.fl_str_mv |
2020-11-12 |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/9873 10.33448/rsd-v9i11.9873 |
| url |
https://rsdjournal.org/index.php/rsd/article/view/9873 |
| identifier_str_mv |
10.33448/rsd-v9i11.9873 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/9873/8747 |
| dc.rights.driver.fl_str_mv |
https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
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https://creativecommons.org/licenses/by/4.0 |
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openAccess |
| dc.format.none.fl_str_mv |
application/pdf |
| dc.publisher.none.fl_str_mv |
Research, Society and Development |
| publisher.none.fl_str_mv |
Research, Society and Development |
| dc.source.none.fl_str_mv |
Research, Society and Development; Vol. 9 No. 11; e2559119873 Research, Society and Development; Vol. 9 Núm. 11; e2559119873 Research, Society and Development; v. 9 n. 11; e2559119873 2525-3409 reponame:Research, Society and Development instname:Universidade Federal de Itajubá (UNIFEI) instacron:UNIFEI |
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Universidade Federal de Itajubá (UNIFEI) |
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UNIFEI |
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UNIFEI |
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Research, Society and Development |
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Research, Society and Development |
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Research, Society and Development - Universidade Federal de Itajubá (UNIFEI) |
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rsd.articles@gmail.com |
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1797052663448207360 |