Ruta graveolens, Pelargonium graveolens AND Hibiscus cannabinus AS NATURAL INHIBITORS OF GROWTH OF Candida albicans

Detalhes bibliográficos
Autor(a) principal: Reis, Camila Mara dos
Data de Publicação: 2021
Outros Autores: Azevedo, Letícia Maria Soares, Casteluber, Marisa Cristina da Fonseca
Tipo de documento: Artigo
Idioma: por
eng
Título da fonte: Revista Uningá (Online)
Texto Completo: https://revista.uninga.br/uninga/article/view/4124
Resumo: Candidiasis is an infection caused by fungi of the genus Candida, Candida albicans being the species that most causes the disease in Brazil. The Fluconazole is the conventional medicine used as a treatment of these infections; however, it causes many adverse reactions in the patient and its continued use can induce the resistance of the pathogen. The medicinal plants can be very effective as an alternative treatment of diseases and have been used in folk medicine for years. In this study, it was evaluated the antifungal activity of extracts of Ruta graveolens, Pelargonium graveolens and Hibiscus cannabinus against the fungal development of Candida albicans, comparing the efficiency of these extracts to Fluconazole. The extracts were prepared in the concentration of 1g of the plant for each 5 mL of alcohol 70%. The data were obtained using the agar diffusion method. The minimum inhibitory concentration test (MIC) was performed, and showed that R. graveolens was able of inhibiting 100% of the pathogen when using 100 mg.ml-1 concentration. From the results obtained, it was possible to conclude that R. graveolens was the most effective extract when compared to Fluconazole, suggesting that this extract can be used as an alternative to conventional treatment to improve the efficiency of current treatments. The extracts of P. graveolens and H. cannabinus also presented antifungal activity but in smaller proportion than Fluconazole.
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spelling Ruta graveolens, Pelargonium graveolens AND Hibiscus cannabinus AS NATURAL INHIBITORS OF GROWTH OF Candida albicansRuta graveolens, Pelargonium graveolens e Hibiscus cannabinus COMO INIBIDORES FARMACOLÓGICOS NATURAIS DO CRESCIMENTO DE Candida albicansAntifúngicocandidíaseplantas medicinaisresistência fúngicaInibidores de microrganismosAntifungalcandidiasisfungal resistancemedicinal plantsMicrobial inhibitorsCandidiasis is an infection caused by fungi of the genus Candida, Candida albicans being the species that most causes the disease in Brazil. The Fluconazole is the conventional medicine used as a treatment of these infections; however, it causes many adverse reactions in the patient and its continued use can induce the resistance of the pathogen. The medicinal plants can be very effective as an alternative treatment of diseases and have been used in folk medicine for years. In this study, it was evaluated the antifungal activity of extracts of Ruta graveolens, Pelargonium graveolens and Hibiscus cannabinus against the fungal development of Candida albicans, comparing the efficiency of these extracts to Fluconazole. The extracts were prepared in the concentration of 1g of the plant for each 5 mL of alcohol 70%. The data were obtained using the agar diffusion method. The minimum inhibitory concentration test (MIC) was performed, and showed that R. graveolens was able of inhibiting 100% of the pathogen when using 100 mg.ml-1 concentration. From the results obtained, it was possible to conclude that R. graveolens was the most effective extract when compared to Fluconazole, suggesting that this extract can be used as an alternative to conventional treatment to improve the efficiency of current treatments. The extracts of P. graveolens and H. cannabinus also presented antifungal activity but in smaller proportion than Fluconazole.A candidíase é uma infecção causada por fungos do gênero Candida, sendo Candida albicans a espécie que mais causa a doença no Brasil. Fluconazol é um antifúngico utilizado para o tratamento dessas infecções, porém, causa muitas reações adversas no paciente e o uso contínuo pode favorecer a resistência do patógeno. As plantas medicinais podem ser muito eficientes no tratamento alternativo de doenças e têm sido utilizadas na medicina popular há anos. Nesse estudo, foi avaliado in vitro a atividade antifúngica dos extratos de Ruta graveolens, Pelargonium graveolens e Hibiscus cannabinus contra o crescimento de Candida albicans, comparando a eficácia desses extratos vegetais com fluconazol. Os extratos foram preparados na concentração de 1g da planta para cada 5 mL de álcool 70%. Os dados foram obtidos através de difusão em ágar, e posteriormente foi determinada a concentração inibitória mínima (CIM) pela técnica de microdiluição em caldo. Os resultados mostraram que R. graveolens é eficaz na inibição de C. albicans com CIM de 100 mg.mL-1, quando comparado ao tratado com fluconazol. Os extratos de P. graveolens e H. cannabinus foram capazes de inibir a propagação fúngica de C. albicans, porém de forma menos eficiente quando comparados aos medicamentos comumente usados no tratamento. Desse modo, os resultados sugerem que o extrato de R. graveolens possa ser testado em futuros estudos in vivo, a fim de propor sua utilização em tratamento alternativo ou simultâneo com fármacos já utilizados.Editora Uningá2021-12-17info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionTextoinfo:eu-repo/semantics/otherapplication/pdfapplication/pdfhttps://revista.uninga.br/uninga/article/view/412410.46311/2318-0579.58.eUJ4124Revista Uningá; Vol. 58 (2021); eUJ4124Revista Uningá; v. 58 (2021); eUJ41242318-057910.46311/ru.v58i0reponame:Revista Uningá (Online)instname:Centro Universitário Uningáinstacron:UNINGAporenghttps://revista.uninga.br/uninga/article/view/4124/2443https://revista.uninga.br/uninga/article/view/4124/244410.46311/ru.v58i0.4124.g244310.46311/ru.v58i0.4124.g2444Copyright (c) 2021 UNINGÁ JOURNALhttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessReis, Camila Mara dosAzevedo, Letícia Maria SoaresCasteluber, Marisa Cristina da Fonseca2023-10-20T18:43:58Zoai:ojs.revista.uninga.br:article/4124Revistahttps://revista.uninga.br/uninga/indexPUBhttps://revista.uninga.br/uninga/oairevistauninga@uninga.edu.br2318-05792318-0579opendoar:2023-10-20T18:43:58Revista Uningá (Online) - Centro Universitário Uningáfalse
dc.title.none.fl_str_mv Ruta graveolens, Pelargonium graveolens AND Hibiscus cannabinus AS NATURAL INHIBITORS OF GROWTH OF Candida albicans
Ruta graveolens, Pelargonium graveolens e Hibiscus cannabinus COMO INIBIDORES FARMACOLÓGICOS NATURAIS DO CRESCIMENTO DE Candida albicans
title Ruta graveolens, Pelargonium graveolens AND Hibiscus cannabinus AS NATURAL INHIBITORS OF GROWTH OF Candida albicans
spellingShingle Ruta graveolens, Pelargonium graveolens AND Hibiscus cannabinus AS NATURAL INHIBITORS OF GROWTH OF Candida albicans
Reis, Camila Mara dos
Antifúngico
candidíase
plantas medicinais
resistência fúngica
Inibidores de microrganismos
Antifungal
candidiasis
fungal resistance
medicinal plants
Microbial inhibitors
title_short Ruta graveolens, Pelargonium graveolens AND Hibiscus cannabinus AS NATURAL INHIBITORS OF GROWTH OF Candida albicans
title_full Ruta graveolens, Pelargonium graveolens AND Hibiscus cannabinus AS NATURAL INHIBITORS OF GROWTH OF Candida albicans
title_fullStr Ruta graveolens, Pelargonium graveolens AND Hibiscus cannabinus AS NATURAL INHIBITORS OF GROWTH OF Candida albicans
title_full_unstemmed Ruta graveolens, Pelargonium graveolens AND Hibiscus cannabinus AS NATURAL INHIBITORS OF GROWTH OF Candida albicans
title_sort Ruta graveolens, Pelargonium graveolens AND Hibiscus cannabinus AS NATURAL INHIBITORS OF GROWTH OF Candida albicans
author Reis, Camila Mara dos
author_facet Reis, Camila Mara dos
Azevedo, Letícia Maria Soares
Casteluber, Marisa Cristina da Fonseca
author_role author
author2 Azevedo, Letícia Maria Soares
Casteluber, Marisa Cristina da Fonseca
author2_role author
author
dc.contributor.author.fl_str_mv Reis, Camila Mara dos
Azevedo, Letícia Maria Soares
Casteluber, Marisa Cristina da Fonseca
dc.subject.por.fl_str_mv Antifúngico
candidíase
plantas medicinais
resistência fúngica
Inibidores de microrganismos
Antifungal
candidiasis
fungal resistance
medicinal plants
Microbial inhibitors
topic Antifúngico
candidíase
plantas medicinais
resistência fúngica
Inibidores de microrganismos
Antifungal
candidiasis
fungal resistance
medicinal plants
Microbial inhibitors
description Candidiasis is an infection caused by fungi of the genus Candida, Candida albicans being the species that most causes the disease in Brazil. The Fluconazole is the conventional medicine used as a treatment of these infections; however, it causes many adverse reactions in the patient and its continued use can induce the resistance of the pathogen. The medicinal plants can be very effective as an alternative treatment of diseases and have been used in folk medicine for years. In this study, it was evaluated the antifungal activity of extracts of Ruta graveolens, Pelargonium graveolens and Hibiscus cannabinus against the fungal development of Candida albicans, comparing the efficiency of these extracts to Fluconazole. The extracts were prepared in the concentration of 1g of the plant for each 5 mL of alcohol 70%. The data were obtained using the agar diffusion method. The minimum inhibitory concentration test (MIC) was performed, and showed that R. graveolens was able of inhibiting 100% of the pathogen when using 100 mg.ml-1 concentration. From the results obtained, it was possible to conclude that R. graveolens was the most effective extract when compared to Fluconazole, suggesting that this extract can be used as an alternative to conventional treatment to improve the efficiency of current treatments. The extracts of P. graveolens and H. cannabinus also presented antifungal activity but in smaller proportion than Fluconazole.
publishDate 2021
dc.date.none.fl_str_mv 2021-12-17
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Texto
info:eu-repo/semantics/other
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://revista.uninga.br/uninga/article/view/4124
10.46311/2318-0579.58.eUJ4124
url https://revista.uninga.br/uninga/article/view/4124
identifier_str_mv 10.46311/2318-0579.58.eUJ4124
dc.language.iso.fl_str_mv por
eng
language por
eng
dc.relation.none.fl_str_mv https://revista.uninga.br/uninga/article/view/4124/2443
https://revista.uninga.br/uninga/article/view/4124/2444
10.46311/ru.v58i0.4124.g2443
10.46311/ru.v58i0.4124.g2444
dc.rights.driver.fl_str_mv Copyright (c) 2021 UNINGÁ JOURNAL
https://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2021 UNINGÁ JOURNAL
https://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Editora Uningá
publisher.none.fl_str_mv Editora Uningá
dc.source.none.fl_str_mv Revista Uningá; Vol. 58 (2021); eUJ4124
Revista Uningá; v. 58 (2021); eUJ4124
2318-0579
10.46311/ru.v58i0
reponame:Revista Uningá (Online)
instname:Centro Universitário Uningá
instacron:UNINGA
instname_str Centro Universitário Uningá
instacron_str UNINGA
institution UNINGA
reponame_str Revista Uningá (Online)
collection Revista Uningá (Online)
repository.name.fl_str_mv Revista Uningá (Online) - Centro Universitário Uningá
repository.mail.fl_str_mv revistauninga@uninga.edu.br
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