Deciduous teeth stem cells, promising source of stem cells: narrative literature review

Detalhes bibliográficos
Autor(a) principal: Couto, Ana Luiza Maria Rodrigues
Data de Publicação: 2022
Outros Autores: Freire, Mirna de Souza
Tipo de documento: Artigo
Idioma: por
eng
Título da fonte: Revista Uningá (Online)
Texto Completo: https://revista.uninga.br/uninga/article/view/4056
Resumo: Among the most progressive types of medical-scientific research, the study with stem cells stands out. Stem cell therapy has emerged as an innovative model in the treatment of diseases and injuries, presenting numerous advantages, which guarantee it will reach the population in the future. The pulp of deciduous teeth, because it is a tissue rich in stem cells, is capable of producing different cell types and offers an easy and minimally invasive way to obtain stem cells. These cells can be isolated, cultured, and expanded in vitro, differentiated in vitro and in vivo into odontoblasts, chondrocytes, adipocytes, endothelial cells, and neural cells. In addition, they have low reactions or rejection after transplantation and may remain undifferentiated and stable after long-term cryopreservation. This study aimed to review the literature on stem cells from human exfoliated deciduous teeth (SHED) and their possible applications in clinical practice. A bibliographic survey was carried out considering full texts published between 2000 and 2021 in the PUBMED database. In this review, current knowledge about stem cells obtained from human exfoliated deciduous teeth, tissue engineering approaches that use SHED, and possible applications in clinical practice were addressed. When comparing SHED with stem cells from other sources, such as stem cells from permanent teeth (DPSC), bone marrow stem cells, and stem cells from the umbilical cord, it is concluded that SHED has a higher rate of proliferation and multiplication, without ethical or legal implications, representing a new approach in regenerative therapy, being a promising alternative treatment.
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spelling Deciduous teeth stem cells, promising source of stem cells: narrative literature reviewCélulas-tronco de dentes decíduos, fonte promissora de células-tronco: revisão de literatura narrativaCélulas-troncocélula-tronco mesenquimaldente decíduopolpa dentária.Deciduous toothdental pulpmesenchymal stem cellsstem cells. Among the most progressive types of medical-scientific research, the study with stem cells stands out. Stem cell therapy has emerged as an innovative model in the treatment of diseases and injuries, presenting numerous advantages, which guarantee it will reach the population in the future. The pulp of deciduous teeth, because it is a tissue rich in stem cells, is capable of producing different cell types and offers an easy and minimally invasive way to obtain stem cells. These cells can be isolated, cultured, and expanded in vitro, differentiated in vitro and in vivo into odontoblasts, chondrocytes, adipocytes, endothelial cells, and neural cells. In addition, they have low reactions or rejection after transplantation and may remain undifferentiated and stable after long-term cryopreservation. This study aimed to review the literature on stem cells from human exfoliated deciduous teeth (SHED) and their possible applications in clinical practice. A bibliographic survey was carried out considering full texts published between 2000 and 2021 in the PUBMED database. In this review, current knowledge about stem cells obtained from human exfoliated deciduous teeth, tissue engineering approaches that use SHED, and possible applications in clinical practice were addressed. When comparing SHED with stem cells from other sources, such as stem cells from permanent teeth (DPSC), bone marrow stem cells, and stem cells from the umbilical cord, it is concluded that SHED has a higher rate of proliferation and multiplication, without ethical or legal implications, representing a new approach in regenerative therapy, being a promising alternative treatment.Entre os tipos mais progressistas de pesquisa médico-científica destaca-se o estudo com células-tronco. A terapia com células-tronco emergiu como um modelo inovador no tratamento para doenças   e lesões, apresentando inúmeras vantagens, o qual garante ter alcance futuramente sobre a população. A polpa de dentes decíduos, por se tratar de um tecido rico em células-tronco, é capaz de produzir diferentes tipos celulares e oferecer uma forma fácil e minimamente invasiva de obter células-tronco. Essas células podem ser isoladas, cultivadas e expandidas in vitro, diferenciadas in vitro e in vivo em odontoblastos, condrócitos, adipócitos, células endoteliais e células neurais. Além disso, apresentam baixas reações ou rejeição após transplante, podendo permanecer indiferenciadas e estáveis após a criopreservação a longo prazo. O objetivo deste estudo foi fazer uma revisão de literatura das células-tronco de dentes decíduos esfoliados humanos (SHED), e suas possíveis aplicações nas práticas clínicas. Realizou-se um levantamento bibliográfico considerando textos completos publicados entre 2000 e 2021 no banco de dados PUBMED. Nesta revisão, foi abordado o conhecimento atual sobre células-tronco obtidas de dentes decíduos esfoliados humanos, as abordagens de engenharia de tecidos   que usam SHED e possíveis aplicações nas práticas clínicas. Ao se comparar SHED com células-tronco provenientes de outras fontes, tais como: células-tronco de dentes permanentes (DPSC), células-tronco da medula óssea e células-tronco do cordão umbilical, conclui-se que SHED possui uma maior taxa de proliferação e multiplicação, sem implicações éticas ou legais, representando uma nova abordagem em terapia regenerativa, sendo uma alternativa promissora de tratamento.Editora Uningá2022-05-17info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionTextoinfo:eu-repo/semantics/otherapplication/pdfapplication/pdfhttps://revista.uninga.br/uninga/article/view/405610.46311/2318-0579.59.eUJ4056Revista Uningá; Vol. 59 (2022); eUJ4056Revista Uningá; v. 59 (2022); eUJ40562318-057910.46311/ru.v59ireponame:Revista Uningá (Online)instname:Centro Universitário Uningáinstacron:UNINGAporenghttps://revista.uninga.br/uninga/article/view/4056/2610https://revista.uninga.br/uninga/article/view/4056/2611Copyright (c) 2022 Revista Uningáhttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessCouto, Ana Luiza Maria RodriguesFreire, Mirna de Souza2023-10-20T12:55:19Zoai:ojs.revista.uninga.br:article/4056Revistahttps://revista.uninga.br/uninga/indexPUBhttps://revista.uninga.br/uninga/oairevistauninga@uninga.edu.br2318-05792318-0579opendoar:2023-10-20T12:55:19Revista Uningá (Online) - Centro Universitário Uningáfalse
dc.title.none.fl_str_mv Deciduous teeth stem cells, promising source of stem cells: narrative literature review
Células-tronco de dentes decíduos, fonte promissora de células-tronco: revisão de literatura narrativa
title Deciduous teeth stem cells, promising source of stem cells: narrative literature review
spellingShingle Deciduous teeth stem cells, promising source of stem cells: narrative literature review
Couto, Ana Luiza Maria Rodrigues
Células-tronco
célula-tronco mesenquimal
dente decíduo
polpa dentária.
Deciduous tooth
dental pulp
mesenchymal stem cells
stem cells.
title_short Deciduous teeth stem cells, promising source of stem cells: narrative literature review
title_full Deciduous teeth stem cells, promising source of stem cells: narrative literature review
title_fullStr Deciduous teeth stem cells, promising source of stem cells: narrative literature review
title_full_unstemmed Deciduous teeth stem cells, promising source of stem cells: narrative literature review
title_sort Deciduous teeth stem cells, promising source of stem cells: narrative literature review
author Couto, Ana Luiza Maria Rodrigues
author_facet Couto, Ana Luiza Maria Rodrigues
Freire, Mirna de Souza
author_role author
author2 Freire, Mirna de Souza
author2_role author
dc.contributor.author.fl_str_mv Couto, Ana Luiza Maria Rodrigues
Freire, Mirna de Souza
dc.subject.por.fl_str_mv Células-tronco
célula-tronco mesenquimal
dente decíduo
polpa dentária.
Deciduous tooth
dental pulp
mesenchymal stem cells
stem cells.
topic Células-tronco
célula-tronco mesenquimal
dente decíduo
polpa dentária.
Deciduous tooth
dental pulp
mesenchymal stem cells
stem cells.
description Among the most progressive types of medical-scientific research, the study with stem cells stands out. Stem cell therapy has emerged as an innovative model in the treatment of diseases and injuries, presenting numerous advantages, which guarantee it will reach the population in the future. The pulp of deciduous teeth, because it is a tissue rich in stem cells, is capable of producing different cell types and offers an easy and minimally invasive way to obtain stem cells. These cells can be isolated, cultured, and expanded in vitro, differentiated in vitro and in vivo into odontoblasts, chondrocytes, adipocytes, endothelial cells, and neural cells. In addition, they have low reactions or rejection after transplantation and may remain undifferentiated and stable after long-term cryopreservation. This study aimed to review the literature on stem cells from human exfoliated deciduous teeth (SHED) and their possible applications in clinical practice. A bibliographic survey was carried out considering full texts published between 2000 and 2021 in the PUBMED database. In this review, current knowledge about stem cells obtained from human exfoliated deciduous teeth, tissue engineering approaches that use SHED, and possible applications in clinical practice were addressed. When comparing SHED with stem cells from other sources, such as stem cells from permanent teeth (DPSC), bone marrow stem cells, and stem cells from the umbilical cord, it is concluded that SHED has a higher rate of proliferation and multiplication, without ethical or legal implications, representing a new approach in regenerative therapy, being a promising alternative treatment.
publishDate 2022
dc.date.none.fl_str_mv 2022-05-17
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Texto
info:eu-repo/semantics/other
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://revista.uninga.br/uninga/article/view/4056
10.46311/2318-0579.59.eUJ4056
url https://revista.uninga.br/uninga/article/view/4056
identifier_str_mv 10.46311/2318-0579.59.eUJ4056
dc.language.iso.fl_str_mv por
eng
language por
eng
dc.relation.none.fl_str_mv https://revista.uninga.br/uninga/article/view/4056/2610
https://revista.uninga.br/uninga/article/view/4056/2611
dc.rights.driver.fl_str_mv Copyright (c) 2022 Revista Uningá
https://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2022 Revista Uningá
https://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Editora Uningá
publisher.none.fl_str_mv Editora Uningá
dc.source.none.fl_str_mv Revista Uningá; Vol. 59 (2022); eUJ4056
Revista Uningá; v. 59 (2022); eUJ4056
2318-0579
10.46311/ru.v59i
reponame:Revista Uningá (Online)
instname:Centro Universitário Uningá
instacron:UNINGA
instname_str Centro Universitário Uningá
instacron_str UNINGA
institution UNINGA
reponame_str Revista Uningá (Online)
collection Revista Uningá (Online)
repository.name.fl_str_mv Revista Uningá (Online) - Centro Universitário Uningá
repository.mail.fl_str_mv revistauninga@uninga.edu.br
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