Deciduous teeth stem cells, promising source of stem cells: narrative literature review
Autor(a) principal: | |
---|---|
Data de Publicação: | 2022 |
Outros Autores: | |
Tipo de documento: | Artigo |
Idioma: | por eng |
Título da fonte: | Revista Uningá (Online) |
Texto Completo: | https://revista.uninga.br/uninga/article/view/4056 |
Resumo: | Among the most progressive types of medical-scientific research, the study with stem cells stands out. Stem cell therapy has emerged as an innovative model in the treatment of diseases and injuries, presenting numerous advantages, which guarantee it will reach the population in the future. The pulp of deciduous teeth, because it is a tissue rich in stem cells, is capable of producing different cell types and offers an easy and minimally invasive way to obtain stem cells. These cells can be isolated, cultured, and expanded in vitro, differentiated in vitro and in vivo into odontoblasts, chondrocytes, adipocytes, endothelial cells, and neural cells. In addition, they have low reactions or rejection after transplantation and may remain undifferentiated and stable after long-term cryopreservation. This study aimed to review the literature on stem cells from human exfoliated deciduous teeth (SHED) and their possible applications in clinical practice. A bibliographic survey was carried out considering full texts published between 2000 and 2021 in the PUBMED database. In this review, current knowledge about stem cells obtained from human exfoliated deciduous teeth, tissue engineering approaches that use SHED, and possible applications in clinical practice were addressed. When comparing SHED with stem cells from other sources, such as stem cells from permanent teeth (DPSC), bone marrow stem cells, and stem cells from the umbilical cord, it is concluded that SHED has a higher rate of proliferation and multiplication, without ethical or legal implications, representing a new approach in regenerative therapy, being a promising alternative treatment. |
id |
UNINGA-1_d123a28fd68358abe2937c63baed67dd |
---|---|
oai_identifier_str |
oai:ojs.revista.uninga.br:article/4056 |
network_acronym_str |
UNINGA-1 |
network_name_str |
Revista Uningá (Online) |
repository_id_str |
|
spelling |
Deciduous teeth stem cells, promising source of stem cells: narrative literature reviewCélulas-tronco de dentes decíduos, fonte promissora de células-tronco: revisão de literatura narrativaCélulas-troncocélula-tronco mesenquimaldente decíduopolpa dentária.Deciduous toothdental pulpmesenchymal stem cellsstem cells. Among the most progressive types of medical-scientific research, the study with stem cells stands out. Stem cell therapy has emerged as an innovative model in the treatment of diseases and injuries, presenting numerous advantages, which guarantee it will reach the population in the future. The pulp of deciduous teeth, because it is a tissue rich in stem cells, is capable of producing different cell types and offers an easy and minimally invasive way to obtain stem cells. These cells can be isolated, cultured, and expanded in vitro, differentiated in vitro and in vivo into odontoblasts, chondrocytes, adipocytes, endothelial cells, and neural cells. In addition, they have low reactions or rejection after transplantation and may remain undifferentiated and stable after long-term cryopreservation. This study aimed to review the literature on stem cells from human exfoliated deciduous teeth (SHED) and their possible applications in clinical practice. A bibliographic survey was carried out considering full texts published between 2000 and 2021 in the PUBMED database. In this review, current knowledge about stem cells obtained from human exfoliated deciduous teeth, tissue engineering approaches that use SHED, and possible applications in clinical practice were addressed. When comparing SHED with stem cells from other sources, such as stem cells from permanent teeth (DPSC), bone marrow stem cells, and stem cells from the umbilical cord, it is concluded that SHED has a higher rate of proliferation and multiplication, without ethical or legal implications, representing a new approach in regenerative therapy, being a promising alternative treatment.Entre os tipos mais progressistas de pesquisa médico-científica destaca-se o estudo com células-tronco. A terapia com células-tronco emergiu como um modelo inovador no tratamento para doenças e lesões, apresentando inúmeras vantagens, o qual garante ter alcance futuramente sobre a população. A polpa de dentes decíduos, por se tratar de um tecido rico em células-tronco, é capaz de produzir diferentes tipos celulares e oferecer uma forma fácil e minimamente invasiva de obter células-tronco. Essas células podem ser isoladas, cultivadas e expandidas in vitro, diferenciadas in vitro e in vivo em odontoblastos, condrócitos, adipócitos, células endoteliais e células neurais. Além disso, apresentam baixas reações ou rejeição após transplante, podendo permanecer indiferenciadas e estáveis após a criopreservação a longo prazo. O objetivo deste estudo foi fazer uma revisão de literatura das células-tronco de dentes decíduos esfoliados humanos (SHED), e suas possíveis aplicações nas práticas clínicas. Realizou-se um levantamento bibliográfico considerando textos completos publicados entre 2000 e 2021 no banco de dados PUBMED. Nesta revisão, foi abordado o conhecimento atual sobre células-tronco obtidas de dentes decíduos esfoliados humanos, as abordagens de engenharia de tecidos que usam SHED e possíveis aplicações nas práticas clínicas. Ao se comparar SHED com células-tronco provenientes de outras fontes, tais como: células-tronco de dentes permanentes (DPSC), células-tronco da medula óssea e células-tronco do cordão umbilical, conclui-se que SHED possui uma maior taxa de proliferação e multiplicação, sem implicações éticas ou legais, representando uma nova abordagem em terapia regenerativa, sendo uma alternativa promissora de tratamento.Editora Uningá2022-05-17info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionTextoinfo:eu-repo/semantics/otherapplication/pdfapplication/pdfhttps://revista.uninga.br/uninga/article/view/405610.46311/2318-0579.59.eUJ4056Revista Uningá; Vol. 59 (2022); eUJ4056Revista Uningá; v. 59 (2022); eUJ40562318-057910.46311/ru.v59ireponame:Revista Uningá (Online)instname:Centro Universitário Uningáinstacron:UNINGAporenghttps://revista.uninga.br/uninga/article/view/4056/2610https://revista.uninga.br/uninga/article/view/4056/2611Copyright (c) 2022 Revista Uningáhttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessCouto, Ana Luiza Maria RodriguesFreire, Mirna de Souza2023-10-20T12:55:19Zoai:ojs.revista.uninga.br:article/4056Revistahttps://revista.uninga.br/uninga/indexPUBhttps://revista.uninga.br/uninga/oairevistauninga@uninga.edu.br2318-05792318-0579opendoar:2023-10-20T12:55:19Revista Uningá (Online) - Centro Universitário Uningáfalse |
dc.title.none.fl_str_mv |
Deciduous teeth stem cells, promising source of stem cells: narrative literature review Células-tronco de dentes decíduos, fonte promissora de células-tronco: revisão de literatura narrativa |
title |
Deciduous teeth stem cells, promising source of stem cells: narrative literature review |
spellingShingle |
Deciduous teeth stem cells, promising source of stem cells: narrative literature review Couto, Ana Luiza Maria Rodrigues Células-tronco célula-tronco mesenquimal dente decíduo polpa dentária. Deciduous tooth dental pulp mesenchymal stem cells stem cells. |
title_short |
Deciduous teeth stem cells, promising source of stem cells: narrative literature review |
title_full |
Deciduous teeth stem cells, promising source of stem cells: narrative literature review |
title_fullStr |
Deciduous teeth stem cells, promising source of stem cells: narrative literature review |
title_full_unstemmed |
Deciduous teeth stem cells, promising source of stem cells: narrative literature review |
title_sort |
Deciduous teeth stem cells, promising source of stem cells: narrative literature review |
author |
Couto, Ana Luiza Maria Rodrigues |
author_facet |
Couto, Ana Luiza Maria Rodrigues Freire, Mirna de Souza |
author_role |
author |
author2 |
Freire, Mirna de Souza |
author2_role |
author |
dc.contributor.author.fl_str_mv |
Couto, Ana Luiza Maria Rodrigues Freire, Mirna de Souza |
dc.subject.por.fl_str_mv |
Células-tronco célula-tronco mesenquimal dente decíduo polpa dentária. Deciduous tooth dental pulp mesenchymal stem cells stem cells. |
topic |
Células-tronco célula-tronco mesenquimal dente decíduo polpa dentária. Deciduous tooth dental pulp mesenchymal stem cells stem cells. |
description |
Among the most progressive types of medical-scientific research, the study with stem cells stands out. Stem cell therapy has emerged as an innovative model in the treatment of diseases and injuries, presenting numerous advantages, which guarantee it will reach the population in the future. The pulp of deciduous teeth, because it is a tissue rich in stem cells, is capable of producing different cell types and offers an easy and minimally invasive way to obtain stem cells. These cells can be isolated, cultured, and expanded in vitro, differentiated in vitro and in vivo into odontoblasts, chondrocytes, adipocytes, endothelial cells, and neural cells. In addition, they have low reactions or rejection after transplantation and may remain undifferentiated and stable after long-term cryopreservation. This study aimed to review the literature on stem cells from human exfoliated deciduous teeth (SHED) and their possible applications in clinical practice. A bibliographic survey was carried out considering full texts published between 2000 and 2021 in the PUBMED database. In this review, current knowledge about stem cells obtained from human exfoliated deciduous teeth, tissue engineering approaches that use SHED, and possible applications in clinical practice were addressed. When comparing SHED with stem cells from other sources, such as stem cells from permanent teeth (DPSC), bone marrow stem cells, and stem cells from the umbilical cord, it is concluded that SHED has a higher rate of proliferation and multiplication, without ethical or legal implications, representing a new approach in regenerative therapy, being a promising alternative treatment. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-05-17 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Texto info:eu-repo/semantics/other |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://revista.uninga.br/uninga/article/view/4056 10.46311/2318-0579.59.eUJ4056 |
url |
https://revista.uninga.br/uninga/article/view/4056 |
identifier_str_mv |
10.46311/2318-0579.59.eUJ4056 |
dc.language.iso.fl_str_mv |
por eng |
language |
por eng |
dc.relation.none.fl_str_mv |
https://revista.uninga.br/uninga/article/view/4056/2610 https://revista.uninga.br/uninga/article/view/4056/2611 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2022 Revista Uningá https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2022 Revista Uningá https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Editora Uningá |
publisher.none.fl_str_mv |
Editora Uningá |
dc.source.none.fl_str_mv |
Revista Uningá; Vol. 59 (2022); eUJ4056 Revista Uningá; v. 59 (2022); eUJ4056 2318-0579 10.46311/ru.v59i reponame:Revista Uningá (Online) instname:Centro Universitário Uningá instacron:UNINGA |
instname_str |
Centro Universitário Uningá |
instacron_str |
UNINGA |
institution |
UNINGA |
reponame_str |
Revista Uningá (Online) |
collection |
Revista Uningá (Online) |
repository.name.fl_str_mv |
Revista Uningá (Online) - Centro Universitário Uningá |
repository.mail.fl_str_mv |
revistauninga@uninga.edu.br |
_version_ |
1797042158835859456 |