PROBIÓTICOS NA TERAPIA NUTRICIONAL DA DOENÇA DE CROHN: PROBIOTICS IN CROHN'S DISEASE NUTRITIONAL THERAPY

Detalhes bibliográficos
Autor(a) principal: SANTOS, GLEYSON MOURA DOS
Data de Publicação: 2018
Outros Autores: FARIAS, VANESSA GERMANA CAMPELO, BARBOSA, GLIANE SILVA, NEIVA, RENATA CARVALHO, ANDRADE, MARIA CLARA PINTO, DUARTE, ENNYA CRISTINA PEREIRA DOS SANTOS
Tipo de documento: Artigo
Idioma: por
Título da fonte: UNINGÁ Review
Texto Completo: https://revista.uninga.br/uningareviews/article/view/183
Resumo: Crohn's disease (CD) is a chronic inflammatory segmental and transmural dysfunction that can affect any portion of the gastrointestinal tract, ranging from the mouth to the anus, especially in the region of the terminal ileum. The exact mechanism by which microbial contamination contributes to Crohn's disease is not fully explained. Although several processes have been hinted as adjuncts. Thus, probiotic supplementation has been widely studied since they can demonstrate relevant functions under conditions of oxidative and inflammatory stress, from the reduction of the inflammatory mediators production because they are responsible for acting in cell signaling pathways and have the capacity to alter the pattern of expression of some genes. In this context, it is known that the intestinal microbiota is a potential therapeutic target for inflammatory diseases, among them CD, this study aimed to evaluate the effects of probiotics in the treatment of Crohn's disease through a literature review. The bibliographic research was carried out in 02 databases. The researched articles comprised 05 publications between the years 2010 and 2017. The studies demonstrate new possibilities of nutritional intervention that seek to decrease the inflammatory activity of CD with the use of probiotics in which they produce short chain fatty acids, alleviate lactose intolerance, control acute diarrhea, modulate the intestinal flora, immunity and improve the clinical activity of the disease and prevent recurrences of the disease.
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spelling PROBIÓTICOS NA TERAPIA NUTRICIONAL DA DOENÇA DE CROHN: PROBIOTICS IN CROHN'S DISEASE NUTRITIONAL THERAPYProbióticosDoenças inflamatórias intestinaisDoença de CrohnProbioticsInflammatory bowel diseasesCrohn's diseaseCrohn's disease (CD) is a chronic inflammatory segmental and transmural dysfunction that can affect any portion of the gastrointestinal tract, ranging from the mouth to the anus, especially in the region of the terminal ileum. The exact mechanism by which microbial contamination contributes to Crohn's disease is not fully explained. Although several processes have been hinted as adjuncts. Thus, probiotic supplementation has been widely studied since they can demonstrate relevant functions under conditions of oxidative and inflammatory stress, from the reduction of the inflammatory mediators production because they are responsible for acting in cell signaling pathways and have the capacity to alter the pattern of expression of some genes. In this context, it is known that the intestinal microbiota is a potential therapeutic target for inflammatory diseases, among them CD, this study aimed to evaluate the effects of probiotics in the treatment of Crohn's disease through a literature review. The bibliographic research was carried out in 02 databases. The researched articles comprised 05 publications between the years 2010 and 2017. The studies demonstrate new possibilities of nutritional intervention that seek to decrease the inflammatory activity of CD with the use of probiotics in which they produce short chain fatty acids, alleviate lactose intolerance, control acute diarrhea, modulate the intestinal flora, immunity and improve the clinical activity of the disease and prevent recurrences of the disease.A doença de Crohn é uma disfunção inflamatória crônica segmentar e transmural podendo afetar qualquer porção do trato gastrointestinal, variando da boca até o ânus, estabelecendo-se especialmente na região do íleo terminal. O mecanismo exato por meio do qual a contaminação microbiana contribui para a doença de Crohn não está completamente explicado embora vários processos tenham sido insinuados como coadjuvantes. Assim a suplementação com probióticos tem sido largamente estudada, já que eles podem demonstrar funções relevantes em condições de estresse oxidativo e inflamatório, a partir da redução da produção de mediadores inflamatórios por serem responsáveis por atuar em vias de sinalização celular e terem a capacidade de alterar o padrão de expressão de alguns genes. Nesse contexto, sabendo-se que a microbiota intestinal é um potencial alvo terapêutico para doenças inflamatórias, dentre estas a DC, este estudo objetivou avaliar os efeitos de probióticos no tratamento da DC por meio de uma revisão de literatura. A pesquisa bibliográfica foi realizada em 2 bases de dados. Os artigos pesquisados compreenderam 05 publicações entre os anos de 2010 e 2017. Os estudos demonstram novas possibilidades de intervenção nutricional que buscam a diminuição da atividade inflamatória da DC com a utilização dos probióticos nos quais produzem ácidos graxos de cadeia curta, amenizam a intolerância à lactose, controlam a diarreia aguda, modulam a flora intestinal, a imunidade e melhoram a atividade clínica da doença e previnem as recidivas da DC.Editora Uningá2018-06-14info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://revista.uninga.br/uningareviews/article/view/183Uningá Review ; Vol. 33 No. 1 (2018): REVISTA UNINGÁ REVIEW; 111 - 120Uningá Review Journal; v. 33 n. 1 (2018): REVISTA UNINGÁ REVIEW; 111 - 1202178-2571reponame:UNINGÁ Reviewinstname:Centro Universitário Uningáinstacron:UNINGAporhttps://revista.uninga.br/uningareviews/article/view/183/1674Copyright (c) 2018 REVISTA UNINGÁ REVIEWinfo:eu-repo/semantics/openAccessSANTOS, GLEYSON MOURA DOSFARIAS, VANESSA GERMANA CAMPELOBARBOSA, GLIANE SILVANEIVA, RENATA CARVALHOANDRADE, MARIA CLARA PINTODUARTE, ENNYA CRISTINA PEREIRA DOS SANTOS2019-10-28T17:54:36Zoai:ojs.revista.uninga.br:article/183Revistahttps://revista.uninga.br/uningareviews/indexPUBhttps://revista.uninga.br/uningareviews/oairevistauningareview@uninga.edu.br || sec.revistas@uninga.edu.br2178-25712178-2571opendoar:2019-10-28T17:54:36UNINGÁ Review - Centro Universitário Uningáfalse
dc.title.none.fl_str_mv PROBIÓTICOS NA TERAPIA NUTRICIONAL DA DOENÇA DE CROHN: PROBIOTICS IN CROHN'S DISEASE NUTRITIONAL THERAPY
title PROBIÓTICOS NA TERAPIA NUTRICIONAL DA DOENÇA DE CROHN: PROBIOTICS IN CROHN'S DISEASE NUTRITIONAL THERAPY
spellingShingle PROBIÓTICOS NA TERAPIA NUTRICIONAL DA DOENÇA DE CROHN: PROBIOTICS IN CROHN'S DISEASE NUTRITIONAL THERAPY
SANTOS, GLEYSON MOURA DOS
Probióticos
Doenças inflamatórias intestinais
Doença de Crohn
Probiotics
Inflammatory bowel diseases
Crohn's disease
title_short PROBIÓTICOS NA TERAPIA NUTRICIONAL DA DOENÇA DE CROHN: PROBIOTICS IN CROHN'S DISEASE NUTRITIONAL THERAPY
title_full PROBIÓTICOS NA TERAPIA NUTRICIONAL DA DOENÇA DE CROHN: PROBIOTICS IN CROHN'S DISEASE NUTRITIONAL THERAPY
title_fullStr PROBIÓTICOS NA TERAPIA NUTRICIONAL DA DOENÇA DE CROHN: PROBIOTICS IN CROHN'S DISEASE NUTRITIONAL THERAPY
title_full_unstemmed PROBIÓTICOS NA TERAPIA NUTRICIONAL DA DOENÇA DE CROHN: PROBIOTICS IN CROHN'S DISEASE NUTRITIONAL THERAPY
title_sort PROBIÓTICOS NA TERAPIA NUTRICIONAL DA DOENÇA DE CROHN: PROBIOTICS IN CROHN'S DISEASE NUTRITIONAL THERAPY
author SANTOS, GLEYSON MOURA DOS
author_facet SANTOS, GLEYSON MOURA DOS
FARIAS, VANESSA GERMANA CAMPELO
BARBOSA, GLIANE SILVA
NEIVA, RENATA CARVALHO
ANDRADE, MARIA CLARA PINTO
DUARTE, ENNYA CRISTINA PEREIRA DOS SANTOS
author_role author
author2 FARIAS, VANESSA GERMANA CAMPELO
BARBOSA, GLIANE SILVA
NEIVA, RENATA CARVALHO
ANDRADE, MARIA CLARA PINTO
DUARTE, ENNYA CRISTINA PEREIRA DOS SANTOS
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv SANTOS, GLEYSON MOURA DOS
FARIAS, VANESSA GERMANA CAMPELO
BARBOSA, GLIANE SILVA
NEIVA, RENATA CARVALHO
ANDRADE, MARIA CLARA PINTO
DUARTE, ENNYA CRISTINA PEREIRA DOS SANTOS
dc.subject.por.fl_str_mv Probióticos
Doenças inflamatórias intestinais
Doença de Crohn
Probiotics
Inflammatory bowel diseases
Crohn's disease
topic Probióticos
Doenças inflamatórias intestinais
Doença de Crohn
Probiotics
Inflammatory bowel diseases
Crohn's disease
description Crohn's disease (CD) is a chronic inflammatory segmental and transmural dysfunction that can affect any portion of the gastrointestinal tract, ranging from the mouth to the anus, especially in the region of the terminal ileum. The exact mechanism by which microbial contamination contributes to Crohn's disease is not fully explained. Although several processes have been hinted as adjuncts. Thus, probiotic supplementation has been widely studied since they can demonstrate relevant functions under conditions of oxidative and inflammatory stress, from the reduction of the inflammatory mediators production because they are responsible for acting in cell signaling pathways and have the capacity to alter the pattern of expression of some genes. In this context, it is known that the intestinal microbiota is a potential therapeutic target for inflammatory diseases, among them CD, this study aimed to evaluate the effects of probiotics in the treatment of Crohn's disease through a literature review. The bibliographic research was carried out in 02 databases. The researched articles comprised 05 publications between the years 2010 and 2017. The studies demonstrate new possibilities of nutritional intervention that seek to decrease the inflammatory activity of CD with the use of probiotics in which they produce short chain fatty acids, alleviate lactose intolerance, control acute diarrhea, modulate the intestinal flora, immunity and improve the clinical activity of the disease and prevent recurrences of the disease.
publishDate 2018
dc.date.none.fl_str_mv 2018-06-14
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://revista.uninga.br/uningareviews/article/view/183
url https://revista.uninga.br/uningareviews/article/view/183
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://revista.uninga.br/uningareviews/article/view/183/1674
dc.rights.driver.fl_str_mv Copyright (c) 2018 REVISTA UNINGÁ REVIEW
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2018 REVISTA UNINGÁ REVIEW
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Editora Uningá
publisher.none.fl_str_mv Editora Uningá
dc.source.none.fl_str_mv Uningá Review ; Vol. 33 No. 1 (2018): REVISTA UNINGÁ REVIEW; 111 - 120
Uningá Review Journal; v. 33 n. 1 (2018): REVISTA UNINGÁ REVIEW; 111 - 120
2178-2571
reponame:UNINGÁ Review
instname:Centro Universitário Uningá
instacron:UNINGA
instname_str Centro Universitário Uningá
instacron_str UNINGA
institution UNINGA
reponame_str UNINGÁ Review
collection UNINGÁ Review
repository.name.fl_str_mv UNINGÁ Review - Centro Universitário Uningá
repository.mail.fl_str_mv revistauningareview@uninga.edu.br || sec.revistas@uninga.edu.br
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