PROBIÓTICOS NA TERAPIA NUTRICIONAL DA DOENÇA DE CROHN: PROBIOTICS IN CROHN'S DISEASE NUTRITIONAL THERAPY
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | UNINGÁ Review |
Texto Completo: | https://revista.uninga.br/uningareviews/article/view/183 |
Resumo: | Crohn's disease (CD) is a chronic inflammatory segmental and transmural dysfunction that can affect any portion of the gastrointestinal tract, ranging from the mouth to the anus, especially in the region of the terminal ileum. The exact mechanism by which microbial contamination contributes to Crohn's disease is not fully explained. Although several processes have been hinted as adjuncts. Thus, probiotic supplementation has been widely studied since they can demonstrate relevant functions under conditions of oxidative and inflammatory stress, from the reduction of the inflammatory mediators production because they are responsible for acting in cell signaling pathways and have the capacity to alter the pattern of expression of some genes. In this context, it is known that the intestinal microbiota is a potential therapeutic target for inflammatory diseases, among them CD, this study aimed to evaluate the effects of probiotics in the treatment of Crohn's disease through a literature review. The bibliographic research was carried out in 02 databases. The researched articles comprised 05 publications between the years 2010 and 2017. The studies demonstrate new possibilities of nutritional intervention that seek to decrease the inflammatory activity of CD with the use of probiotics in which they produce short chain fatty acids, alleviate lactose intolerance, control acute diarrhea, modulate the intestinal flora, immunity and improve the clinical activity of the disease and prevent recurrences of the disease. |
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PROBIÓTICOS NA TERAPIA NUTRICIONAL DA DOENÇA DE CROHN: PROBIOTICS IN CROHN'S DISEASE NUTRITIONAL THERAPYProbióticosDoenças inflamatórias intestinaisDoença de CrohnProbioticsInflammatory bowel diseasesCrohn's diseaseCrohn's disease (CD) is a chronic inflammatory segmental and transmural dysfunction that can affect any portion of the gastrointestinal tract, ranging from the mouth to the anus, especially in the region of the terminal ileum. The exact mechanism by which microbial contamination contributes to Crohn's disease is not fully explained. Although several processes have been hinted as adjuncts. Thus, probiotic supplementation has been widely studied since they can demonstrate relevant functions under conditions of oxidative and inflammatory stress, from the reduction of the inflammatory mediators production because they are responsible for acting in cell signaling pathways and have the capacity to alter the pattern of expression of some genes. In this context, it is known that the intestinal microbiota is a potential therapeutic target for inflammatory diseases, among them CD, this study aimed to evaluate the effects of probiotics in the treatment of Crohn's disease through a literature review. The bibliographic research was carried out in 02 databases. The researched articles comprised 05 publications between the years 2010 and 2017. The studies demonstrate new possibilities of nutritional intervention that seek to decrease the inflammatory activity of CD with the use of probiotics in which they produce short chain fatty acids, alleviate lactose intolerance, control acute diarrhea, modulate the intestinal flora, immunity and improve the clinical activity of the disease and prevent recurrences of the disease.A doença de Crohn é uma disfunção inflamatória crônica segmentar e transmural podendo afetar qualquer porção do trato gastrointestinal, variando da boca até o ânus, estabelecendo-se especialmente na região do íleo terminal. O mecanismo exato por meio do qual a contaminação microbiana contribui para a doença de Crohn não está completamente explicado embora vários processos tenham sido insinuados como coadjuvantes. Assim a suplementação com probióticos tem sido largamente estudada, já que eles podem demonstrar funções relevantes em condições de estresse oxidativo e inflamatório, a partir da redução da produção de mediadores inflamatórios por serem responsáveis por atuar em vias de sinalização celular e terem a capacidade de alterar o padrão de expressão de alguns genes. Nesse contexto, sabendo-se que a microbiota intestinal é um potencial alvo terapêutico para doenças inflamatórias, dentre estas a DC, este estudo objetivou avaliar os efeitos de probióticos no tratamento da DC por meio de uma revisão de literatura. A pesquisa bibliográfica foi realizada em 2 bases de dados. Os artigos pesquisados compreenderam 05 publicações entre os anos de 2010 e 2017. Os estudos demonstram novas possibilidades de intervenção nutricional que buscam a diminuição da atividade inflamatória da DC com a utilização dos probióticos nos quais produzem ácidos graxos de cadeia curta, amenizam a intolerância à lactose, controlam a diarreia aguda, modulam a flora intestinal, a imunidade e melhoram a atividade clínica da doença e previnem as recidivas da DC.Editora Uningá2018-06-14info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://revista.uninga.br/uningareviews/article/view/183Uningá Review ; Vol. 33 No. 1 (2018): REVISTA UNINGÁ REVIEW; 111 - 120Uningá Review Journal; v. 33 n. 1 (2018): REVISTA UNINGÁ REVIEW; 111 - 1202178-2571reponame:UNINGÁ Reviewinstname:Centro Universitário Uningáinstacron:UNINGAporhttps://revista.uninga.br/uningareviews/article/view/183/1674Copyright (c) 2018 REVISTA UNINGÁ REVIEWinfo:eu-repo/semantics/openAccessSANTOS, GLEYSON MOURA DOSFARIAS, VANESSA GERMANA CAMPELOBARBOSA, GLIANE SILVANEIVA, RENATA CARVALHOANDRADE, MARIA CLARA PINTODUARTE, ENNYA CRISTINA PEREIRA DOS SANTOS2019-10-28T17:54:36Zoai:ojs.revista.uninga.br:article/183Revistahttps://revista.uninga.br/uningareviews/indexPUBhttps://revista.uninga.br/uningareviews/oairevistauningareview@uninga.edu.br || sec.revistas@uninga.edu.br2178-25712178-2571opendoar:2019-10-28T17:54:36UNINGÁ Review - Centro Universitário Uningáfalse |
dc.title.none.fl_str_mv |
PROBIÓTICOS NA TERAPIA NUTRICIONAL DA DOENÇA DE CROHN: PROBIOTICS IN CROHN'S DISEASE NUTRITIONAL THERAPY |
title |
PROBIÓTICOS NA TERAPIA NUTRICIONAL DA DOENÇA DE CROHN: PROBIOTICS IN CROHN'S DISEASE NUTRITIONAL THERAPY |
spellingShingle |
PROBIÓTICOS NA TERAPIA NUTRICIONAL DA DOENÇA DE CROHN: PROBIOTICS IN CROHN'S DISEASE NUTRITIONAL THERAPY SANTOS, GLEYSON MOURA DOS Probióticos Doenças inflamatórias intestinais Doença de Crohn Probiotics Inflammatory bowel diseases Crohn's disease |
title_short |
PROBIÓTICOS NA TERAPIA NUTRICIONAL DA DOENÇA DE CROHN: PROBIOTICS IN CROHN'S DISEASE NUTRITIONAL THERAPY |
title_full |
PROBIÓTICOS NA TERAPIA NUTRICIONAL DA DOENÇA DE CROHN: PROBIOTICS IN CROHN'S DISEASE NUTRITIONAL THERAPY |
title_fullStr |
PROBIÓTICOS NA TERAPIA NUTRICIONAL DA DOENÇA DE CROHN: PROBIOTICS IN CROHN'S DISEASE NUTRITIONAL THERAPY |
title_full_unstemmed |
PROBIÓTICOS NA TERAPIA NUTRICIONAL DA DOENÇA DE CROHN: PROBIOTICS IN CROHN'S DISEASE NUTRITIONAL THERAPY |
title_sort |
PROBIÓTICOS NA TERAPIA NUTRICIONAL DA DOENÇA DE CROHN: PROBIOTICS IN CROHN'S DISEASE NUTRITIONAL THERAPY |
author |
SANTOS, GLEYSON MOURA DOS |
author_facet |
SANTOS, GLEYSON MOURA DOS FARIAS, VANESSA GERMANA CAMPELO BARBOSA, GLIANE SILVA NEIVA, RENATA CARVALHO ANDRADE, MARIA CLARA PINTO DUARTE, ENNYA CRISTINA PEREIRA DOS SANTOS |
author_role |
author |
author2 |
FARIAS, VANESSA GERMANA CAMPELO BARBOSA, GLIANE SILVA NEIVA, RENATA CARVALHO ANDRADE, MARIA CLARA PINTO DUARTE, ENNYA CRISTINA PEREIRA DOS SANTOS |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
SANTOS, GLEYSON MOURA DOS FARIAS, VANESSA GERMANA CAMPELO BARBOSA, GLIANE SILVA NEIVA, RENATA CARVALHO ANDRADE, MARIA CLARA PINTO DUARTE, ENNYA CRISTINA PEREIRA DOS SANTOS |
dc.subject.por.fl_str_mv |
Probióticos Doenças inflamatórias intestinais Doença de Crohn Probiotics Inflammatory bowel diseases Crohn's disease |
topic |
Probióticos Doenças inflamatórias intestinais Doença de Crohn Probiotics Inflammatory bowel diseases Crohn's disease |
description |
Crohn's disease (CD) is a chronic inflammatory segmental and transmural dysfunction that can affect any portion of the gastrointestinal tract, ranging from the mouth to the anus, especially in the region of the terminal ileum. The exact mechanism by which microbial contamination contributes to Crohn's disease is not fully explained. Although several processes have been hinted as adjuncts. Thus, probiotic supplementation has been widely studied since they can demonstrate relevant functions under conditions of oxidative and inflammatory stress, from the reduction of the inflammatory mediators production because they are responsible for acting in cell signaling pathways and have the capacity to alter the pattern of expression of some genes. In this context, it is known that the intestinal microbiota is a potential therapeutic target for inflammatory diseases, among them CD, this study aimed to evaluate the effects of probiotics in the treatment of Crohn's disease through a literature review. The bibliographic research was carried out in 02 databases. The researched articles comprised 05 publications between the years 2010 and 2017. The studies demonstrate new possibilities of nutritional intervention that seek to decrease the inflammatory activity of CD with the use of probiotics in which they produce short chain fatty acids, alleviate lactose intolerance, control acute diarrhea, modulate the intestinal flora, immunity and improve the clinical activity of the disease and prevent recurrences of the disease. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-06-14 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://revista.uninga.br/uningareviews/article/view/183 |
url |
https://revista.uninga.br/uningareviews/article/view/183 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://revista.uninga.br/uningareviews/article/view/183/1674 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2018 REVISTA UNINGÁ REVIEW info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2018 REVISTA UNINGÁ REVIEW |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Editora Uningá |
publisher.none.fl_str_mv |
Editora Uningá |
dc.source.none.fl_str_mv |
Uningá Review ; Vol. 33 No. 1 (2018): REVISTA UNINGÁ REVIEW; 111 - 120 Uningá Review Journal; v. 33 n. 1 (2018): REVISTA UNINGÁ REVIEW; 111 - 120 2178-2571 reponame:UNINGÁ Review instname:Centro Universitário Uningá instacron:UNINGA |
instname_str |
Centro Universitário Uningá |
instacron_str |
UNINGA |
institution |
UNINGA |
reponame_str |
UNINGÁ Review |
collection |
UNINGÁ Review |
repository.name.fl_str_mv |
UNINGÁ Review - Centro Universitário Uningá |
repository.mail.fl_str_mv |
revistauningareview@uninga.edu.br || sec.revistas@uninga.edu.br |
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