Hyperalgesic effect of subarachnoid administration of phentolamine in mice
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Repositório Institucional da UNITAU |
Texto Completo: | http://repositorio.unitau.br/jspui/handle/20.500.11874/2634 |
Resumo: | Background and objectives: Painful phenomenon is one of the most important and complex experiences. Phentolamine is a non-selective alpha-adrenergic antagonist. The objective of this study was to compare the effect of increasing doses of phentolamine into subarachnoid space in rats in the modulation of painful phenomenon. Methods: 84 male Wistar rats were divided into formalin and plantar incision groups, subdivided into six subgroups (n = 7). Control group (CG) received only saline (10 mu L); active subgroups received phentolamine 10 mu mg (GF10), 20 mg (GF20), 30 mg (GF30), 40 mg (GF40), and 50g (GF50). In formalin group, pain was induced by injection of 50 mu L of 2% formalin in dorsal region of right posterior paw. In plantar incision group, pain was induced by plantar incision and evaluated using Von Frey filaments. Induction and maintenance of anesthesia were performed with 3% halothane for catheter placement into subarachnoid space and plantar incision. Statistical analysis was performed using the JMP program from SAS with 5% significance level. Results: Phentolamine at doses of 20 and 30 g increased the algesic response in the intermediate phase of the formalin test. In plantar incision test, it had hyperalgic effect on first, third, fifth, and seventh days at a dose of 10 g and on first, third, and fifth days at a dose of 20g and on fifth day at a dose of 30g. Conclusion: Subarachnoid administration of phentotamine showed hyperalgesic effect, possibly due to the involvement of different subclasses of alpha-adrenergic receptors in modulating pain pathways. (C) 2014 Sociedade Brasileira de Anestesiologia. Published by Elsevier Editora Ltda. All rights reserved. |
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Callegari, Desire CarlosCorrea, Joao AntonioPires, Oscar CésarCorrea Braga, Renan BatistaMarques Gimbo, Ana Flaviade Souza, Adriana AparecidaRovani Pires, Marta HelenaConstantino, EltonPosso, Irimar de Paula2019-09-12T16:53:34Z2019-09-12T16:53:34Z201565211111610.1016/j.bjan.2013.09.0120034-70941806-907Xhttp://repositorio.unitau.br/jspui/handle/20.500.11874/2634WOS:000352509700005Background and objectives: Painful phenomenon is one of the most important and complex experiences. Phentolamine is a non-selective alpha-adrenergic antagonist. The objective of this study was to compare the effect of increasing doses of phentolamine into subarachnoid space in rats in the modulation of painful phenomenon. Methods: 84 male Wistar rats were divided into formalin and plantar incision groups, subdivided into six subgroups (n = 7). Control group (CG) received only saline (10 mu L); active subgroups received phentolamine 10 mu mg (GF10), 20 mg (GF20), 30 mg (GF30), 40 mg (GF40), and 50g (GF50). In formalin group, pain was induced by injection of 50 mu L of 2% formalin in dorsal region of right posterior paw. In plantar incision group, pain was induced by plantar incision and evaluated using Von Frey filaments. Induction and maintenance of anesthesia were performed with 3% halothane for catheter placement into subarachnoid space and plantar incision. Statistical analysis was performed using the JMP program from SAS with 5% significance level. Results: Phentolamine at doses of 20 and 30 g increased the algesic response in the intermediate phase of the formalin test. In plantar incision test, it had hyperalgic effect on first, third, fifth, and seventh days at a dose of 10 g and on first, third, and fifth days at a dose of 20g and on fifth day at a dose of 30g. Conclusion: Subarachnoid administration of phentotamine showed hyperalgesic effect, possibly due to the involvement of different subclasses of alpha-adrenergic receptors in modulating pain pathways. (C) 2014 Sociedade Brasileira de Anestesiologia. Published by Elsevier Editora Ltda. All rights reserved.Made available in DSpace on 2019-09-12T16:53:34Z (GMT). No. of bitstreams: 0 Previous issue date: 2015[Callegari, Desire Carlos; Correa, Joao Antonio] Fac Med ABC FMABC, Santo Andre, SP, Brazil[Pires, Oscar Cesar; Constantino, Elton; Posso, Irimar de Paula] Universidade de Taubaté (Unitau) Unitau[Correa Braga, Renan Batista] Universidade de Taubaté (Unitau) Unitau, Curso Med[Marques Gimbo, Ana Flavia] Universidade de Taubaté (Unitau) Unitau, Curso Enfermagem[de Souza, Adriana Aparecida] Universidade de Taubaté (Unitau) Unitau, Curso Biol[Rovani Pires, Marta Helena] Fac Med Petropolis, Curso Med, Petropolis, RJ, BrazilElsevier Science IncEstados UnidosRevista Brasileira de AnestesiologiaEm verificaçãoinfo:eu-repo/semantics/openAccessWeb of Sciencereponame:Repositório Institucional da UNITAUinstname:Universidade de Taubaté (UNITAU)instacron:UNITAUMicePhentolaminePainFormalin TestVon FreyPain5-HydroxytryptamineBehaviorAnesthesiologyAnesthesiologyHyperalgesic effect of subarachnoid administration of phentolamine in miceinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlepor20.500.11874/26342020-09-17 08:52:58.789oai:repositorio.unitau.br:20.500.11874/2634Repositório InstitucionalPUBhttp://repositorio.unitau.br/oai/requestopendoar:2020-09-17T11:52:58Repositório Institucional da UNITAU - Universidade de Taubaté (UNITAU)false |
dc.title.en.fl_str_mv |
Hyperalgesic effect of subarachnoid administration of phentolamine in mice |
title |
Hyperalgesic effect of subarachnoid administration of phentolamine in mice |
spellingShingle |
Hyperalgesic effect of subarachnoid administration of phentolamine in mice Callegari, Desire Carlos Mice Phentolamine Pain Formalin Test Von Frey Pain 5-Hydroxytryptamine Behavior Anesthesiology Anesthesiology |
title_short |
Hyperalgesic effect of subarachnoid administration of phentolamine in mice |
title_full |
Hyperalgesic effect of subarachnoid administration of phentolamine in mice |
title_fullStr |
Hyperalgesic effect of subarachnoid administration of phentolamine in mice |
title_full_unstemmed |
Hyperalgesic effect of subarachnoid administration of phentolamine in mice |
title_sort |
Hyperalgesic effect of subarachnoid administration of phentolamine in mice |
author |
Callegari, Desire Carlos |
author_facet |
Callegari, Desire Carlos Correa, Joao Antonio Pires, Oscar César Correa Braga, Renan Batista Marques Gimbo, Ana Flavia de Souza, Adriana Aparecida Rovani Pires, Marta Helena Constantino, Elton Posso, Irimar de Paula |
author_role |
author |
author2 |
Correa, Joao Antonio Pires, Oscar César Correa Braga, Renan Batista Marques Gimbo, Ana Flavia de Souza, Adriana Aparecida Rovani Pires, Marta Helena Constantino, Elton Posso, Irimar de Paula |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Callegari, Desire Carlos Correa, Joao Antonio Pires, Oscar César Correa Braga, Renan Batista Marques Gimbo, Ana Flavia de Souza, Adriana Aparecida Rovani Pires, Marta Helena Constantino, Elton Posso, Irimar de Paula |
dc.subject.other.en.fl_str_mv |
Mice Phentolamine Pain Formalin Test Von Frey Pain 5-Hydroxytryptamine Behavior |
topic |
Mice Phentolamine Pain Formalin Test Von Frey Pain 5-Hydroxytryptamine Behavior Anesthesiology Anesthesiology |
dc.subject.wosarea.en.fl_str_mv |
Anesthesiology |
dc.subject.researcharea.en.fl_str_mv |
Anesthesiology |
description |
Background and objectives: Painful phenomenon is one of the most important and complex experiences. Phentolamine is a non-selective alpha-adrenergic antagonist. The objective of this study was to compare the effect of increasing doses of phentolamine into subarachnoid space in rats in the modulation of painful phenomenon. Methods: 84 male Wistar rats were divided into formalin and plantar incision groups, subdivided into six subgroups (n = 7). Control group (CG) received only saline (10 mu L); active subgroups received phentolamine 10 mu mg (GF10), 20 mg (GF20), 30 mg (GF30), 40 mg (GF40), and 50g (GF50). In formalin group, pain was induced by injection of 50 mu L of 2% formalin in dorsal region of right posterior paw. In plantar incision group, pain was induced by plantar incision and evaluated using Von Frey filaments. Induction and maintenance of anesthesia were performed with 3% halothane for catheter placement into subarachnoid space and plantar incision. Statistical analysis was performed using the JMP program from SAS with 5% significance level. Results: Phentolamine at doses of 20 and 30 g increased the algesic response in the intermediate phase of the formalin test. In plantar incision test, it had hyperalgic effect on first, third, fifth, and seventh days at a dose of 10 g and on first, third, and fifth days at a dose of 20g and on fifth day at a dose of 30g. Conclusion: Subarachnoid administration of phentotamine showed hyperalgesic effect, possibly due to the involvement of different subclasses of alpha-adrenergic receptors in modulating pain pathways. (C) 2014 Sociedade Brasileira de Anestesiologia. Published by Elsevier Editora Ltda. All rights reserved. |
publishDate |
2015 |
dc.date.issued.fl_str_mv |
2015 |
dc.date.accessioned.fl_str_mv |
2019-09-12T16:53:34Z |
dc.date.available.fl_str_mv |
2019-09-12T16:53:34Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://repositorio.unitau.br/jspui/handle/20.500.11874/2634 |
dc.identifier.doi.pt_BR.fl_str_mv |
10.1016/j.bjan.2013.09.012 |
dc.identifier.issn.none.fl_str_mv |
0034-7094 1806-907X |
dc.identifier.wos.none.fl_str_mv |
WOS:000352509700005 |
identifier_str_mv |
10.1016/j.bjan.2013.09.012 0034-7094 1806-907X WOS:000352509700005 |
url |
http://repositorio.unitau.br/jspui/handle/20.500.11874/2634 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.ispartof.none.fl_str_mv |
Revista Brasileira de Anestesiologia |
dc.rights.driver.fl_str_mv |
Em verificação info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Em verificação |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Elsevier Science Inc |
dc.publisher.country.fl_str_mv |
Estados Unidos |
publisher.none.fl_str_mv |
Elsevier Science Inc |
dc.source.pt_BR.fl_str_mv |
Web of Science |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNITAU instname:Universidade de Taubaté (UNITAU) instacron:UNITAU |
instname_str |
Universidade de Taubaté (UNITAU) |
instacron_str |
UNITAU |
institution |
UNITAU |
reponame_str |
Repositório Institucional da UNITAU |
collection |
Repositório Institucional da UNITAU |
repository.name.fl_str_mv |
Repositório Institucional da UNITAU - Universidade de Taubaté (UNITAU) |
repository.mail.fl_str_mv |
|
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1797157772734758912 |