[DUPLICADO] Metopic suture craniosynostosis: sodium valproate teratogenic effect. Case report

Detalhes bibliográficos
Autor(a) principal: Assencio-Ferreira, Vicente José
Data de Publicação: 2001
Outros Autores: Abraham, Ronaldo, Veiga, José Carlos Esteves, Santos, Kécia Cristina dos
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Institucional da UNITAU
Texto Completo: http://repositorio.unitau.br/jspui/handle/20.500.11874/2933
Resumo: Objective: the aim of this report is to warn that sodium valproate used during pregnancy can produce craniosynostosis in the newborn, particularly trigonocephaly. Method: we describe a case of trigonocephaly in a six month-old girl, daughter of a young non-smoker couple, whose mother had used phenobarbital 100 mg daily and sodium valproate 500 mg twice daily during the whole pregnancy. We also review current literature about this topic. Result: bone sclerosis over the metopic suture was confirmed during surgery. Bibliographical review yields previous reports on valproate teratogenicity, mainly determining metopic suture craniosynostosis. Conclusion: sodium valproate used during pregnancy can produce craniosynostosis by teratogenic effect, specially trigonocephaly (premature fusion of metopic suture).
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spelling Assencio-Ferreira, Vicente JoséAbraham, RonaldoVeiga, José Carlos EstevesSantos, Kécia Cristina dos2019-09-12T16:56:54Z2019-09-12T16:56:54Z2001592B41742010.1590/S0004-282X20010003000200004-282Xhttp://repositorio.unitau.br/jspui/handle/20.500.11874/2933WOS:000169779700020Objective: the aim of this report is to warn that sodium valproate used during pregnancy can produce craniosynostosis in the newborn, particularly trigonocephaly. Method: we describe a case of trigonocephaly in a six month-old girl, daughter of a young non-smoker couple, whose mother had used phenobarbital 100 mg daily and sodium valproate 500 mg twice daily during the whole pregnancy. We also review current literature about this topic. Result: bone sclerosis over the metopic suture was confirmed during surgery. Bibliographical review yields previous reports on valproate teratogenicity, mainly determining metopic suture craniosynostosis. Conclusion: sodium valproate used during pregnancy can produce craniosynostosis by teratogenic effect, specially trigonocephaly (premature fusion of metopic suture).Made available in DSpace on 2019-09-12T16:56:54Z (GMT). No. of bitstreams: 0 Previous issue date: 2001, Fac Med; Univ Sao Paulo, Area Concentracao Neurol, BR-05508 Sao Paulo, Brazil; Hosp Santa Isabel ClinAssoc Arquivos De Neuro- PsiquiatriaBrasilArquivos de Neuro-PsiquiatriaEm verificaçãoinfo:eu-repo/semantics/openAccessWeb of Sciencereponame:Repositório Institucional da UNITAUinstname:Universidade de Taubaté (UNITAU)instacron:UNITAUValproic AcidTeratogenic EffectCraniosynostosesMetopic SutureIntracranial-PressureAntiepileptic DrugsRiskChildrenVolumeSeriesAcidNeurosciencesPsychiatryNeurosciences & NeurologyPsychiatry[DUPLICADO] Metopic suture craniosynostosis: sodium valproate teratogenic effect. Case reportinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlepor20.500.11874/29332020-08-25 11:07:52.487oai:repositorio.unitau.br:20.500.11874/2933Repositório InstitucionalPUBhttp://repositorio.unitau.br/oai/requestopendoar:2020-08-25T14:07:52Repositório Institucional da UNITAU - Universidade de Taubaté (UNITAU)false
dc.title.en.fl_str_mv [DUPLICADO] Metopic suture craniosynostosis: sodium valproate teratogenic effect. Case report
title [DUPLICADO] Metopic suture craniosynostosis: sodium valproate teratogenic effect. Case report
spellingShingle [DUPLICADO] Metopic suture craniosynostosis: sodium valproate teratogenic effect. Case report
Assencio-Ferreira, Vicente José
Valproic Acid
Teratogenic Effect
Craniosynostoses
Metopic Suture
Intracranial-Pressure
Antiepileptic Drugs
Risk
Children
Volume
Series
Acid
Neurosciences
Psychiatry
Neurosciences & Neurology
Psychiatry
title_short [DUPLICADO] Metopic suture craniosynostosis: sodium valproate teratogenic effect. Case report
title_full [DUPLICADO] Metopic suture craniosynostosis: sodium valproate teratogenic effect. Case report
title_fullStr [DUPLICADO] Metopic suture craniosynostosis: sodium valproate teratogenic effect. Case report
title_full_unstemmed [DUPLICADO] Metopic suture craniosynostosis: sodium valproate teratogenic effect. Case report
title_sort [DUPLICADO] Metopic suture craniosynostosis: sodium valproate teratogenic effect. Case report
author Assencio-Ferreira, Vicente José
author_facet Assencio-Ferreira, Vicente José
Abraham, Ronaldo
Veiga, José Carlos Esteves
Santos, Kécia Cristina dos
author_role author
author2 Abraham, Ronaldo
Veiga, José Carlos Esteves
Santos, Kécia Cristina dos
author2_role author
author
author
dc.contributor.author.fl_str_mv Assencio-Ferreira, Vicente José
Abraham, Ronaldo
Veiga, José Carlos Esteves
Santos, Kécia Cristina dos
dc.subject.other.en.fl_str_mv Valproic Acid
Teratogenic Effect
Craniosynostoses
Metopic Suture
Intracranial-Pressure
Antiepileptic Drugs
Risk
Children
Volume
Series
Acid
topic Valproic Acid
Teratogenic Effect
Craniosynostoses
Metopic Suture
Intracranial-Pressure
Antiepileptic Drugs
Risk
Children
Volume
Series
Acid
Neurosciences
Psychiatry
Neurosciences & Neurology
Psychiatry
dc.subject.wosarea.en.fl_str_mv Neurosciences
Psychiatry
dc.subject.researcharea.en.fl_str_mv Neurosciences & Neurology
Psychiatry
description Objective: the aim of this report is to warn that sodium valproate used during pregnancy can produce craniosynostosis in the newborn, particularly trigonocephaly. Method: we describe a case of trigonocephaly in a six month-old girl, daughter of a young non-smoker couple, whose mother had used phenobarbital 100 mg daily and sodium valproate 500 mg twice daily during the whole pregnancy. We also review current literature about this topic. Result: bone sclerosis over the metopic suture was confirmed during surgery. Bibliographical review yields previous reports on valproate teratogenicity, mainly determining metopic suture craniosynostosis. Conclusion: sodium valproate used during pregnancy can produce craniosynostosis by teratogenic effect, specially trigonocephaly (premature fusion of metopic suture).
publishDate 2001
dc.date.issued.fl_str_mv 2001
dc.date.accessioned.fl_str_mv 2019-09-12T16:56:54Z
dc.date.available.fl_str_mv 2019-09-12T16:56:54Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://repositorio.unitau.br/jspui/handle/20.500.11874/2933
dc.identifier.doi.pt_BR.fl_str_mv 10.1590/S0004-282X2001000300020
dc.identifier.issn.none.fl_str_mv 0004-282X
dc.identifier.wos.none.fl_str_mv WOS:000169779700020
identifier_str_mv 10.1590/S0004-282X2001000300020
0004-282X
WOS:000169779700020
url http://repositorio.unitau.br/jspui/handle/20.500.11874/2933
dc.language.iso.fl_str_mv por
language por
dc.relation.ispartof.none.fl_str_mv Arquivos de Neuro-Psiquiatria
dc.rights.driver.fl_str_mv Em verificação
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Em verificação
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Assoc Arquivos De Neuro- Psiquiatria
dc.publisher.country.fl_str_mv Brasil
publisher.none.fl_str_mv Assoc Arquivos De Neuro- Psiquiatria
dc.source.pt_BR.fl_str_mv Web of Science
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNITAU
instname:Universidade de Taubaté (UNITAU)
instacron:UNITAU
instname_str Universidade de Taubaté (UNITAU)
instacron_str UNITAU
institution UNITAU
reponame_str Repositório Institucional da UNITAU
collection Repositório Institucional da UNITAU
repository.name.fl_str_mv Repositório Institucional da UNITAU - Universidade de Taubaté (UNITAU)
repository.mail.fl_str_mv
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