[DUPLICADO] Metopic suture craniosynostosis: sodium valproate teratogenic effect. Case report

• Autor(a) principal: Assencio-Ferreira, Vicente José
• Data de Publicação: 2001
• Outros Autores: Abraham, Ronaldo, Veiga, José Carlos Esteves, Santos, Kécia Cristina dos
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Repositório Institucional da UNITAU
• DOI: 10.1590/S0004-282X2001000300020
• Texto Completo: http://repositorio.unitau.br/jspui/handle/20.500.11874/2933
• topic: Valproic Acid; Teratogenic Effect; Craniosynostoses; Metopic Suture; Intracranial-Pressure; Antiepileptic Drugs; Risk; Children; Volume; Series; Acid; Neurosciences; Psychiatry; Neurosciences & Neurology; Psychiatry

Objective: the aim of this report is to warn that sodium valproate used during pregnancy can produce craniosynostosis in the newborn, particularly trigonocephaly. Method: we describe a case of trigonocephaly in a six month-old girl, daughter of a young non-smoker couple, whose mother had used phenobarbital 100 mg daily and sodium valproate 500 mg twice daily during the whole pregnancy. We also review current literature about this topic. Result: bone sclerosis over the metopic suture was confirmed during surgery. Bibliographical review yields previous reports on valproate teratogenicity, mainly determining metopic suture craniosynostosis. Conclusion: sodium valproate used during pregnancy can produce craniosynostosis by teratogenic effect, specially trigonocephaly (premature fusion of metopic suture).