Cigarette smoking impairs the diaphragm muscle structure of patients without respiratory pathologies: An autopsy study

Detalhes bibliográficos
Autor(a) principal: Nucci, Ricardo Aparecido Baptista
Data de Publicação: 2019
Outros Autores: De Souza, Romeu Rodrigues, Suemoto, Claudia Kimie, Bussea, Alexandre Leopold, Maifrino, Laura Beatriz Mesiano, Pasqualucci, Carlos Augusto, Anaruma, Carlos Alberto [UNESP], Jacob-Filho, Wilson
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.33594/000000163
http://hdl.handle.net/11449/231436
Resumo: Background/Aims: Smoking is a major risk factor for several cardiovascular and pulmonary diseases, and it has also been associated with the loss of skeletal muscle mass and strength leading to sarcopenia. The aim of this is study is to analyze the effects of cigarette smoking on the diaphragm muscle histopathology of postmortem samples from patients without respiratory diseases. Methods: Diaphragm samples were stained with hematoxylin and eosin for histopathological analysis. Picrosirius stain was used to highlight the collagen fibers. Results: Cigarette smokers had an increase of histopathological alterations as abnormal cytoplasm, abnormal fiber size and shape, and central nucleus. Additionally, smokers had an increase of collagen fibers on diaphragm muscle. Conclusion: Smoking may influence in a negatively fashion the diaphragm musculature.
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spelling Cigarette smoking impairs the diaphragm muscle structure of patients without respiratory pathologies: An autopsy studyAutopsy studyCigarette smokeDiaphragm muscleHistopathological analysisBackground/Aims: Smoking is a major risk factor for several cardiovascular and pulmonary diseases, and it has also been associated with the loss of skeletal muscle mass and strength leading to sarcopenia. The aim of this is study is to analyze the effects of cigarette smoking on the diaphragm muscle histopathology of postmortem samples from patients without respiratory diseases. Methods: Diaphragm samples were stained with hematoxylin and eosin for histopathological analysis. Picrosirius stain was used to highlight the collagen fibers. Results: Cigarette smokers had an increase of histopathological alterations as abnormal cytoplasm, abnormal fiber size and shape, and central nucleus. Additionally, smokers had an increase of collagen fibers on diaphragm muscle. Conclusion: Smoking may influence in a negatively fashion the diaphragm musculature.Universidade de São PauloDepartment of Anatomy Institute of Biomedical Sciences of the University of São PauloDivision of Geriatrics University of São Paulo Medical SchoolLaboratory of Morphological and Immunohistochemical Studies Department of Physical Education São Judas Tadeu UniversityLaboratory of Morphology and Physical Activity Department of Physical Education São Paulo State University “Júlio de Mesquita Filho”Laboratory of Medical Research in Aging (LIM-66) Division of Geriatrics University of São Paulo Medical SchoolDepartment of Pathology University of São Paulo Medical School, Doctor Arnaldo Avenue, 455Laboratory of Morphology and Physical Activity Department of Physical Education São Paulo State University “Júlio de Mesquita Filho”Universidade de São Paulo (USP)São Judas Tadeu UniversityUniversidade Estadual Paulista (UNESP)Nucci, Ricardo Aparecido BaptistaDe Souza, Romeu RodriguesSuemoto, Claudia KimieBussea, Alexandre LeopoldMaifrino, Laura Beatriz MesianoPasqualucci, Carlos AugustoAnaruma, Carlos Alberto [UNESP]Jacob-Filho, Wilson2022-04-29T08:45:26Z2022-04-29T08:45:26Z2019-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article648-655http://dx.doi.org/10.33594/000000163Cellular Physiology and Biochemistry, v. 53, n. 4, p. 648-655, 2019.1421-97781015-8987http://hdl.handle.net/11449/23143610.33594/0000001632-s2.0-85072675328Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengCellular Physiology and Biochemistryinfo:eu-repo/semantics/openAccess2024-09-03T13:18:13Zoai:repositorio.unesp.br:11449/231436Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestrepositoriounesp@unesp.bropendoar:29462024-09-03T13:18:13Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Cigarette smoking impairs the diaphragm muscle structure of patients without respiratory pathologies: An autopsy study
title Cigarette smoking impairs the diaphragm muscle structure of patients without respiratory pathologies: An autopsy study
spellingShingle Cigarette smoking impairs the diaphragm muscle structure of patients without respiratory pathologies: An autopsy study
Nucci, Ricardo Aparecido Baptista
Autopsy study
Cigarette smoke
Diaphragm muscle
Histopathological analysis
title_short Cigarette smoking impairs the diaphragm muscle structure of patients without respiratory pathologies: An autopsy study
title_full Cigarette smoking impairs the diaphragm muscle structure of patients without respiratory pathologies: An autopsy study
title_fullStr Cigarette smoking impairs the diaphragm muscle structure of patients without respiratory pathologies: An autopsy study
title_full_unstemmed Cigarette smoking impairs the diaphragm muscle structure of patients without respiratory pathologies: An autopsy study
title_sort Cigarette smoking impairs the diaphragm muscle structure of patients without respiratory pathologies: An autopsy study
author Nucci, Ricardo Aparecido Baptista
author_facet Nucci, Ricardo Aparecido Baptista
De Souza, Romeu Rodrigues
Suemoto, Claudia Kimie
Bussea, Alexandre Leopold
Maifrino, Laura Beatriz Mesiano
Pasqualucci, Carlos Augusto
Anaruma, Carlos Alberto [UNESP]
Jacob-Filho, Wilson
author_role author
author2 De Souza, Romeu Rodrigues
Suemoto, Claudia Kimie
Bussea, Alexandre Leopold
Maifrino, Laura Beatriz Mesiano
Pasqualucci, Carlos Augusto
Anaruma, Carlos Alberto [UNESP]
Jacob-Filho, Wilson
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade de São Paulo (USP)
São Judas Tadeu University
Universidade Estadual Paulista (UNESP)
dc.contributor.author.fl_str_mv Nucci, Ricardo Aparecido Baptista
De Souza, Romeu Rodrigues
Suemoto, Claudia Kimie
Bussea, Alexandre Leopold
Maifrino, Laura Beatriz Mesiano
Pasqualucci, Carlos Augusto
Anaruma, Carlos Alberto [UNESP]
Jacob-Filho, Wilson
dc.subject.por.fl_str_mv Autopsy study
Cigarette smoke
Diaphragm muscle
Histopathological analysis
topic Autopsy study
Cigarette smoke
Diaphragm muscle
Histopathological analysis
description Background/Aims: Smoking is a major risk factor for several cardiovascular and pulmonary diseases, and it has also been associated with the loss of skeletal muscle mass and strength leading to sarcopenia. The aim of this is study is to analyze the effects of cigarette smoking on the diaphragm muscle histopathology of postmortem samples from patients without respiratory diseases. Methods: Diaphragm samples were stained with hematoxylin and eosin for histopathological analysis. Picrosirius stain was used to highlight the collagen fibers. Results: Cigarette smokers had an increase of histopathological alterations as abnormal cytoplasm, abnormal fiber size and shape, and central nucleus. Additionally, smokers had an increase of collagen fibers on diaphragm muscle. Conclusion: Smoking may influence in a negatively fashion the diaphragm musculature.
publishDate 2019
dc.date.none.fl_str_mv 2019-01-01
2022-04-29T08:45:26Z
2022-04-29T08:45:26Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.33594/000000163
Cellular Physiology and Biochemistry, v. 53, n. 4, p. 648-655, 2019.
1421-9778
1015-8987
http://hdl.handle.net/11449/231436
10.33594/000000163
2-s2.0-85072675328
url http://dx.doi.org/10.33594/000000163
http://hdl.handle.net/11449/231436
identifier_str_mv Cellular Physiology and Biochemistry, v. 53, n. 4, p. 648-655, 2019.
1421-9778
1015-8987
10.33594/000000163
2-s2.0-85072675328
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Cellular Physiology and Biochemistry
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 648-655
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv repositoriounesp@unesp.br
_version_ 1810021404878307328

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