Smoking Intensity Increases Diaphragm Muscle Injury: A Clinicopathologic Study

• Autor(a) principal: Nucci, Ricardo Aparecido Baptista
• Data de Publicação: 2023
• Outros Autores: Busse, Alexandre Leopold, de Souza, Romeu Rodrigues, Maifrino, Laura Beatriz Mesiano, Pasqualucci, Carlos Augusto, Anaruma, Carlos Alberto [UNESP], Leite, Renata Elaine Paraizo, Rodriguez, Roberta Diehl, Suemoto, Claudia Kimie, Jacob-Filho, Wilson
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UNESP
• Texto Completo: http://dx.doi.org/10.3390/jcm12113823; http://hdl.handle.net/11449/250050
• topic: autopsy; cigarette; diaphragm; histopathology

Background: Studying the effects of smoking intensity is important to evaluate the risk of tobacco use on a range of illnesses, such as as sarcopenia among the elderly. Thus, this study aimed to analyze the effects of pack-years of cigarette smoking on the diaphragm muscle (DIAm) histopathology of postmortem samples. Methods: Subjects were divided into three groups: never-smoker (n = 46); less than 30 pack-years of smoking (n = 12); and more than 30 pack-years of smoking (n = 30). Diaphragm samples were stained with Picrosirius red and hematoxylin and eosin stain for general structure. Results: Participants with more than 30 pack-years of cigarette smoking had a significant increase in adipocytes, blood vessels and collagen deposit, as well as an increase in histopathological alterations. Conclusions: Pack-years of smoking was associated with DIAm injury. However, further clinicopathological studies are needed to confirm our findings.