Clinical presentation of tuberculoid leprosy in an epidermodysplasia verruciformis patient
Autor(a) principal: | |
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Data de Publicação: | 2012 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.3855/jidc.2269 http://hdl.handle.net/11449/226856 |
Resumo: | Epidermodysplasia verruciformis (EV) is triggered by a variety of mechanisms that at least partly include genetic background. We present a Brazilian man with a 30-year history of flat, wart-like lesions with clinical, histopathological, and evolutive aspects consistent with papillomavirus (HPV)-associated EV. Histological analysis of the wart lesions showed epidermis with hyperkeratosis, regular acanthosis, hypergranulosis, and cells with abundant basophilic cytoplasm. Moreover, a perivascular lymphocytic infiltrate was found in the superficial dermis, consistent with a viral wart. Type-2-HPV DNA was detected in various fragments of skin-wart lesions using the polymerase chain reaction (PCR). Two years after the EV diagnosis, the patient presented with an anesthetic well-demarcated, erythematous and mildly scaly plaque on his right forearm. A histopathological analysis of this lesion demonstrated the presence of a compact tuberculoid granuloma. Ziehl-Neelsen staining demonstrated the presence of rare acid-fast bacilli and confirmed the tuberculoid leprosy diagnosis. The patient's Mitsuda Intradermal Reaction was positive. To elucidate the possible mechanism involved in this case of EV, we genotyped the HLA genes of this patient. DQB genotyping showed the polymorphic HLA alleles DQB1*0301 and 0501. The patient was treated with a paucibacillary multi-drug therapy scheme, and the disease was cured in six months. This report describes an EV patient with an M. leprae infection, confirming that tuberculoid leprosy patients possess a relatively specific and efficient cell-mediated immunity against the bacillus and, therefore, localized forms of the disease. Moreover, we show the possible involvement of the polymorphic HLA alleles DQB1*0301 and 0501 in EV induction mechanisms. © 2012 Prestes-Carneiro et al. |
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Clinical presentation of tuberculoid leprosy in an epidermodysplasia verruciformis patientDQB1*0301/ 0501HLA allelesEpidermodysplasia verruciformisMycobacterium lepraePapillomavirusEpidermodysplasia verruciformis (EV) is triggered by a variety of mechanisms that at least partly include genetic background. We present a Brazilian man with a 30-year history of flat, wart-like lesions with clinical, histopathological, and evolutive aspects consistent with papillomavirus (HPV)-associated EV. Histological analysis of the wart lesions showed epidermis with hyperkeratosis, regular acanthosis, hypergranulosis, and cells with abundant basophilic cytoplasm. Moreover, a perivascular lymphocytic infiltrate was found in the superficial dermis, consistent with a viral wart. Type-2-HPV DNA was detected in various fragments of skin-wart lesions using the polymerase chain reaction (PCR). Two years after the EV diagnosis, the patient presented with an anesthetic well-demarcated, erythematous and mildly scaly plaque on his right forearm. A histopathological analysis of this lesion demonstrated the presence of a compact tuberculoid granuloma. Ziehl-Neelsen staining demonstrated the presence of rare acid-fast bacilli and confirmed the tuberculoid leprosy diagnosis. The patient's Mitsuda Intradermal Reaction was positive. To elucidate the possible mechanism involved in this case of EV, we genotyped the HLA genes of this patient. DQB genotyping showed the polymorphic HLA alleles DQB1*0301 and 0501. The patient was treated with a paucibacillary multi-drug therapy scheme, and the disease was cured in six months. This report describes an EV patient with an M. leprae infection, confirming that tuberculoid leprosy patients possess a relatively specific and efficient cell-mediated immunity against the bacillus and, therefore, localized forms of the disease. Moreover, we show the possible involvement of the polymorphic HLA alleles DQB1*0301 and 0501 in EV induction mechanisms. © 2012 Prestes-Carneiro et al.Departamento de Imunologia Departamento de Dermatologia Universidade do Oeste Paulista, São PauloDepartamento de Patologia Faculdade de Medicina da UNESP, BotucatuLaboratório de Biologia Molecular Instituto Adolfo LutzDepartamento de Análises Clínicas e Imunogenética Universidade Estadual de Maringá, MaringáDepartamento de Patologia Faculdade de Medicina da UNESP, BotucatuUniversidade do Oeste PaulistaUniversidade Estadual Paulista (UNESP)Instituto Adolfo LutzUniversidade Estadual de Maringá (UEM)Prestes-Carneiro, Luiz EuribelNai, Gisele AlborghettiSilva, Márcia G. [UNESP]Cristofano, CarlosCrivelin, Luciana LeiteCalabreta, Carmela Beatriz RamosMoliterno, Ricardo Albertode Abreu, Marilda Aparecida Milanez Morgado2022-04-29T02:57:49Z2022-04-29T02:57:49Z2012-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article526-530http://dx.doi.org/10.3855/jidc.2269Journal of Infection in Developing Countries, v. 6, n. 6, p. 526-530, 2012.1972-26802036-6590http://hdl.handle.net/11449/22685610.3855/jidc.22692-s2.0-84862701222Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal of Infection in Developing Countriesinfo:eu-repo/semantics/openAccess2024-09-03T13:15:27Zoai:repositorio.unesp.br:11449/226856Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestrepositoriounesp@unesp.bropendoar:29462024-09-03T13:15:27Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Clinical presentation of tuberculoid leprosy in an epidermodysplasia verruciformis patient |
title |
Clinical presentation of tuberculoid leprosy in an epidermodysplasia verruciformis patient |
spellingShingle |
Clinical presentation of tuberculoid leprosy in an epidermodysplasia verruciformis patient Prestes-Carneiro, Luiz Euribel DQB1*0301/ 0501HLA alleles Epidermodysplasia verruciformis Mycobacterium leprae Papillomavirus |
title_short |
Clinical presentation of tuberculoid leprosy in an epidermodysplasia verruciformis patient |
title_full |
Clinical presentation of tuberculoid leprosy in an epidermodysplasia verruciformis patient |
title_fullStr |
Clinical presentation of tuberculoid leprosy in an epidermodysplasia verruciformis patient |
title_full_unstemmed |
Clinical presentation of tuberculoid leprosy in an epidermodysplasia verruciformis patient |
title_sort |
Clinical presentation of tuberculoid leprosy in an epidermodysplasia verruciformis patient |
author |
Prestes-Carneiro, Luiz Euribel |
author_facet |
Prestes-Carneiro, Luiz Euribel Nai, Gisele Alborghetti Silva, Márcia G. [UNESP] Cristofano, Carlos Crivelin, Luciana Leite Calabreta, Carmela Beatriz Ramos Moliterno, Ricardo Alberto de Abreu, Marilda Aparecida Milanez Morgado |
author_role |
author |
author2 |
Nai, Gisele Alborghetti Silva, Márcia G. [UNESP] Cristofano, Carlos Crivelin, Luciana Leite Calabreta, Carmela Beatriz Ramos Moliterno, Ricardo Alberto de Abreu, Marilda Aparecida Milanez Morgado |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade do Oeste Paulista Universidade Estadual Paulista (UNESP) Instituto Adolfo Lutz Universidade Estadual de Maringá (UEM) |
dc.contributor.author.fl_str_mv |
Prestes-Carneiro, Luiz Euribel Nai, Gisele Alborghetti Silva, Márcia G. [UNESP] Cristofano, Carlos Crivelin, Luciana Leite Calabreta, Carmela Beatriz Ramos Moliterno, Ricardo Alberto de Abreu, Marilda Aparecida Milanez Morgado |
dc.subject.por.fl_str_mv |
DQB1*0301/ 0501HLA alleles Epidermodysplasia verruciformis Mycobacterium leprae Papillomavirus |
topic |
DQB1*0301/ 0501HLA alleles Epidermodysplasia verruciformis Mycobacterium leprae Papillomavirus |
description |
Epidermodysplasia verruciformis (EV) is triggered by a variety of mechanisms that at least partly include genetic background. We present a Brazilian man with a 30-year history of flat, wart-like lesions with clinical, histopathological, and evolutive aspects consistent with papillomavirus (HPV)-associated EV. Histological analysis of the wart lesions showed epidermis with hyperkeratosis, regular acanthosis, hypergranulosis, and cells with abundant basophilic cytoplasm. Moreover, a perivascular lymphocytic infiltrate was found in the superficial dermis, consistent with a viral wart. Type-2-HPV DNA was detected in various fragments of skin-wart lesions using the polymerase chain reaction (PCR). Two years after the EV diagnosis, the patient presented with an anesthetic well-demarcated, erythematous and mildly scaly plaque on his right forearm. A histopathological analysis of this lesion demonstrated the presence of a compact tuberculoid granuloma. Ziehl-Neelsen staining demonstrated the presence of rare acid-fast bacilli and confirmed the tuberculoid leprosy diagnosis. The patient's Mitsuda Intradermal Reaction was positive. To elucidate the possible mechanism involved in this case of EV, we genotyped the HLA genes of this patient. DQB genotyping showed the polymorphic HLA alleles DQB1*0301 and 0501. The patient was treated with a paucibacillary multi-drug therapy scheme, and the disease was cured in six months. This report describes an EV patient with an M. leprae infection, confirming that tuberculoid leprosy patients possess a relatively specific and efficient cell-mediated immunity against the bacillus and, therefore, localized forms of the disease. Moreover, we show the possible involvement of the polymorphic HLA alleles DQB1*0301 and 0501 in EV induction mechanisms. © 2012 Prestes-Carneiro et al. |
publishDate |
2012 |
dc.date.none.fl_str_mv |
2012-01-01 2022-04-29T02:57:49Z 2022-04-29T02:57:49Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.3855/jidc.2269 Journal of Infection in Developing Countries, v. 6, n. 6, p. 526-530, 2012. 1972-2680 2036-6590 http://hdl.handle.net/11449/226856 10.3855/jidc.2269 2-s2.0-84862701222 |
url |
http://dx.doi.org/10.3855/jidc.2269 http://hdl.handle.net/11449/226856 |
identifier_str_mv |
Journal of Infection in Developing Countries, v. 6, n. 6, p. 526-530, 2012. 1972-2680 2036-6590 10.3855/jidc.2269 2-s2.0-84862701222 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Journal of Infection in Developing Countries |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
526-530 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
repositoriounesp@unesp.br |
_version_ |
1810021390984675328 |