Clinical presentation of tuberculoid leprosy in an epidermodysplasia verruciformis patient

Detalhes bibliográficos
Autor(a) principal: Prestes-Carneiro, Luiz Euribel
Data de Publicação: 2012
Outros Autores: Nai, Gisele Alborghetti, Silva, Marcia Guimarães da [UNESP], Cristofano, Carlos, Crivelin, Luciana Leite, Ramos Calabreta, Carmela Beatriz, Moliterno, Ricardo Alberto, Milanez Morgado de Abreu, Marilda Aparecida
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://www.jidc.org/index.php/journal/article/view/22711134
http://hdl.handle.net/11449/13005
Resumo: Epidermodysplasia verruciformis (EV) is triggered by a variety of mechanisms that at least partly include genetic background. We present a Brazilian man with a 30-year history of flat, wart-like lesions with clinical, histopathological, and evolutive aspects consistent with papillomavirus (HPV)-associated EV. Histological analysis of the wart lesions showed epidermis with hyperkeratosis, regular acanthosis, hypergranulosis, and cells with abundant basophilic cytoplasm. Moreover, a perivascular lymphocytic infiltrate was found in the superficial dermis, consistent with a viral wart. Type-2-HPV DNA was detected in various fragments of skin-wart lesions using the polymerase chain reaction (PCR). Two years after the EV diagnosis, the patient presented with an anesthetic well-demarcated, erythematous and mildly scaly plaque on his right forearm. A histopathological analysis of this lesion demonstrated the presence of a compact tuberculoid granuloma. Ziehl-Neelsen staining demonstrated the presence of rare acid-fast bacilli and confirmed the tuberculoid leprosy diagnosis. The patient's Mitsuda Intradermal Reaction was positive. To elucidate the possible mechanism involved in this case of EV, we genotyped the HLA genes of this patient. DQB genotyping showed the polymorphic HLA alleles DQB1*0301 and 0501. The patient was treated with a paucibacillary multidrug therapy scheme, and the disease was cured in six months. This report describes an EV patient with an M. leprae infection, confirming that tuberculoid leprosy patients possess a relatively specific and efficient cell-mediated immunity against the bacillus and, therefore, localized forms of the disease. Moreover, we show the possible involvement of the polymorphic HLA alleles DQB1*0301 and 0501 in EV induction mechanisms.
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spelling Clinical presentation of tuberculoid leprosy in an epidermodysplasia verruciformis patientEpidermodysplasia verruciformispapillomavirusMycobacterium lepraeDQB1*0301/0501HLA allelesEpidermodysplasia verruciformis (EV) is triggered by a variety of mechanisms that at least partly include genetic background. We present a Brazilian man with a 30-year history of flat, wart-like lesions with clinical, histopathological, and evolutive aspects consistent with papillomavirus (HPV)-associated EV. Histological analysis of the wart lesions showed epidermis with hyperkeratosis, regular acanthosis, hypergranulosis, and cells with abundant basophilic cytoplasm. Moreover, a perivascular lymphocytic infiltrate was found in the superficial dermis, consistent with a viral wart. Type-2-HPV DNA was detected in various fragments of skin-wart lesions using the polymerase chain reaction (PCR). Two years after the EV diagnosis, the patient presented with an anesthetic well-demarcated, erythematous and mildly scaly plaque on his right forearm. A histopathological analysis of this lesion demonstrated the presence of a compact tuberculoid granuloma. Ziehl-Neelsen staining demonstrated the presence of rare acid-fast bacilli and confirmed the tuberculoid leprosy diagnosis. The patient's Mitsuda Intradermal Reaction was positive. To elucidate the possible mechanism involved in this case of EV, we genotyped the HLA genes of this patient. DQB genotyping showed the polymorphic HLA alleles DQB1*0301 and 0501. The patient was treated with a paucibacillary multidrug therapy scheme, and the disease was cured in six months. This report describes an EV patient with an M. leprae infection, confirming that tuberculoid leprosy patients possess a relatively specific and efficient cell-mediated immunity against the bacillus and, therefore, localized forms of the disease. Moreover, we show the possible involvement of the polymorphic HLA alleles DQB1*0301 and 0501 in EV induction mechanisms.Univ Oeste Paulista, Dept Imunol, BR-19050680 São Paulo, BrazilUniv Oeste Paulista, Dept Dermatol, BR-19050680 São Paulo, BrazilUNESP, Fac Med, Dept Patol, Botucatu, SP, BrazilAdolfo Lutz Inst, Lab Biol Mol, Presidente Prudente, BrazilUniversidade Estadual de Maringá (UEM), Dept Anal Clin & Imunogenet, Maringa, Parana, BrazilUNESP, Fac Med, Dept Patol, Botucatu, SP, BrazilJ Infection Developing CountriesUniversidade do Oeste Paulista (UNOESTE)Universidade Estadual Paulista (Unesp)Instituto Adolfo Lutz (IAL)Universidade Estadual de Maringá (UEM)Prestes-Carneiro, Luiz EuribelNai, Gisele AlborghettiSilva, Marcia Guimarães da [UNESP]Cristofano, CarlosCrivelin, Luciana LeiteRamos Calabreta, Carmela BeatrizMoliterno, Ricardo AlbertoMilanez Morgado de Abreu, Marilda Aparecida2014-05-20T13:37:32Z2014-05-20T13:37:32Z2012-06-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article526-530application/pdfhttp://www.jidc.org/index.php/journal/article/view/22711134Journal of Infection In Developing Countries. Tramaniglio: J Infection Developing Countries, v. 6, n. 6, p. 526-530, 2012.1972-2680http://hdl.handle.net/11449/13005WOS:000305912100011WOS000305912100011.pdf4940791909535775Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal of Infection In Developing Countries1.3300,704info:eu-repo/semantics/openAccess2024-09-03T13:17:55Zoai:repositorio.unesp.br:11449/13005Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestrepositoriounesp@unesp.bropendoar:29462024-09-03T13:17:55Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Clinical presentation of tuberculoid leprosy in an epidermodysplasia verruciformis patient
title Clinical presentation of tuberculoid leprosy in an epidermodysplasia verruciformis patient
spellingShingle Clinical presentation of tuberculoid leprosy in an epidermodysplasia verruciformis patient
Prestes-Carneiro, Luiz Euribel
Epidermodysplasia verruciformis
papillomavirus
Mycobacterium leprae
DQB1*0301/0501HLA alleles
title_short Clinical presentation of tuberculoid leprosy in an epidermodysplasia verruciformis patient
title_full Clinical presentation of tuberculoid leprosy in an epidermodysplasia verruciformis patient
title_fullStr Clinical presentation of tuberculoid leprosy in an epidermodysplasia verruciformis patient
title_full_unstemmed Clinical presentation of tuberculoid leprosy in an epidermodysplasia verruciformis patient
title_sort Clinical presentation of tuberculoid leprosy in an epidermodysplasia verruciformis patient
author Prestes-Carneiro, Luiz Euribel
author_facet Prestes-Carneiro, Luiz Euribel
Nai, Gisele Alborghetti
Silva, Marcia Guimarães da [UNESP]
Cristofano, Carlos
Crivelin, Luciana Leite
Ramos Calabreta, Carmela Beatriz
Moliterno, Ricardo Alberto
Milanez Morgado de Abreu, Marilda Aparecida
author_role author
author2 Nai, Gisele Alborghetti
Silva, Marcia Guimarães da [UNESP]
Cristofano, Carlos
Crivelin, Luciana Leite
Ramos Calabreta, Carmela Beatriz
Moliterno, Ricardo Alberto
Milanez Morgado de Abreu, Marilda Aparecida
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Oeste Paulista (UNOESTE)
Universidade Estadual Paulista (Unesp)
Instituto Adolfo Lutz (IAL)
Universidade Estadual de Maringá (UEM)
dc.contributor.author.fl_str_mv Prestes-Carneiro, Luiz Euribel
Nai, Gisele Alborghetti
Silva, Marcia Guimarães da [UNESP]
Cristofano, Carlos
Crivelin, Luciana Leite
Ramos Calabreta, Carmela Beatriz
Moliterno, Ricardo Alberto
Milanez Morgado de Abreu, Marilda Aparecida
dc.subject.por.fl_str_mv Epidermodysplasia verruciformis
papillomavirus
Mycobacterium leprae
DQB1*0301/0501HLA alleles
topic Epidermodysplasia verruciformis
papillomavirus
Mycobacterium leprae
DQB1*0301/0501HLA alleles
description Epidermodysplasia verruciformis (EV) is triggered by a variety of mechanisms that at least partly include genetic background. We present a Brazilian man with a 30-year history of flat, wart-like lesions with clinical, histopathological, and evolutive aspects consistent with papillomavirus (HPV)-associated EV. Histological analysis of the wart lesions showed epidermis with hyperkeratosis, regular acanthosis, hypergranulosis, and cells with abundant basophilic cytoplasm. Moreover, a perivascular lymphocytic infiltrate was found in the superficial dermis, consistent with a viral wart. Type-2-HPV DNA was detected in various fragments of skin-wart lesions using the polymerase chain reaction (PCR). Two years after the EV diagnosis, the patient presented with an anesthetic well-demarcated, erythematous and mildly scaly plaque on his right forearm. A histopathological analysis of this lesion demonstrated the presence of a compact tuberculoid granuloma. Ziehl-Neelsen staining demonstrated the presence of rare acid-fast bacilli and confirmed the tuberculoid leprosy diagnosis. The patient's Mitsuda Intradermal Reaction was positive. To elucidate the possible mechanism involved in this case of EV, we genotyped the HLA genes of this patient. DQB genotyping showed the polymorphic HLA alleles DQB1*0301 and 0501. The patient was treated with a paucibacillary multidrug therapy scheme, and the disease was cured in six months. This report describes an EV patient with an M. leprae infection, confirming that tuberculoid leprosy patients possess a relatively specific and efficient cell-mediated immunity against the bacillus and, therefore, localized forms of the disease. Moreover, we show the possible involvement of the polymorphic HLA alleles DQB1*0301 and 0501 in EV induction mechanisms.
publishDate 2012
dc.date.none.fl_str_mv 2012-06-01
2014-05-20T13:37:32Z
2014-05-20T13:37:32Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.jidc.org/index.php/journal/article/view/22711134
Journal of Infection In Developing Countries. Tramaniglio: J Infection Developing Countries, v. 6, n. 6, p. 526-530, 2012.
1972-2680
http://hdl.handle.net/11449/13005
WOS:000305912100011
WOS000305912100011.pdf
4940791909535775
url http://www.jidc.org/index.php/journal/article/view/22711134
http://hdl.handle.net/11449/13005
identifier_str_mv Journal of Infection In Developing Countries. Tramaniglio: J Infection Developing Countries, v. 6, n. 6, p. 526-530, 2012.
1972-2680
WOS:000305912100011
WOS000305912100011.pdf
4940791909535775
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Journal of Infection In Developing Countries
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dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 526-530
application/pdf
dc.publisher.none.fl_str_mv J Infection Developing Countries
publisher.none.fl_str_mv J Infection Developing Countries
dc.source.none.fl_str_mv Web of Science
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv repositoriounesp@unesp.br
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