Clinical presentation of tuberculoid leprosy in an epidermodysplasia verruciformis patient
Autor(a) principal: | |
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Data de Publicação: | 2012 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://www.jidc.org/index.php/journal/article/view/22711134 http://hdl.handle.net/11449/13005 |
Resumo: | Epidermodysplasia verruciformis (EV) is triggered by a variety of mechanisms that at least partly include genetic background. We present a Brazilian man with a 30-year history of flat, wart-like lesions with clinical, histopathological, and evolutive aspects consistent with papillomavirus (HPV)-associated EV. Histological analysis of the wart lesions showed epidermis with hyperkeratosis, regular acanthosis, hypergranulosis, and cells with abundant basophilic cytoplasm. Moreover, a perivascular lymphocytic infiltrate was found in the superficial dermis, consistent with a viral wart. Type-2-HPV DNA was detected in various fragments of skin-wart lesions using the polymerase chain reaction (PCR). Two years after the EV diagnosis, the patient presented with an anesthetic well-demarcated, erythematous and mildly scaly plaque on his right forearm. A histopathological analysis of this lesion demonstrated the presence of a compact tuberculoid granuloma. Ziehl-Neelsen staining demonstrated the presence of rare acid-fast bacilli and confirmed the tuberculoid leprosy diagnosis. The patient's Mitsuda Intradermal Reaction was positive. To elucidate the possible mechanism involved in this case of EV, we genotyped the HLA genes of this patient. DQB genotyping showed the polymorphic HLA alleles DQB1*0301 and 0501. The patient was treated with a paucibacillary multidrug therapy scheme, and the disease was cured in six months. This report describes an EV patient with an M. leprae infection, confirming that tuberculoid leprosy patients possess a relatively specific and efficient cell-mediated immunity against the bacillus and, therefore, localized forms of the disease. Moreover, we show the possible involvement of the polymorphic HLA alleles DQB1*0301 and 0501 in EV induction mechanisms. |
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Clinical presentation of tuberculoid leprosy in an epidermodysplasia verruciformis patientEpidermodysplasia verruciformispapillomavirusMycobacterium lepraeDQB1*0301/0501HLA allelesEpidermodysplasia verruciformis (EV) is triggered by a variety of mechanisms that at least partly include genetic background. We present a Brazilian man with a 30-year history of flat, wart-like lesions with clinical, histopathological, and evolutive aspects consistent with papillomavirus (HPV)-associated EV. Histological analysis of the wart lesions showed epidermis with hyperkeratosis, regular acanthosis, hypergranulosis, and cells with abundant basophilic cytoplasm. Moreover, a perivascular lymphocytic infiltrate was found in the superficial dermis, consistent with a viral wart. Type-2-HPV DNA was detected in various fragments of skin-wart lesions using the polymerase chain reaction (PCR). Two years after the EV diagnosis, the patient presented with an anesthetic well-demarcated, erythematous and mildly scaly plaque on his right forearm. A histopathological analysis of this lesion demonstrated the presence of a compact tuberculoid granuloma. Ziehl-Neelsen staining demonstrated the presence of rare acid-fast bacilli and confirmed the tuberculoid leprosy diagnosis. The patient's Mitsuda Intradermal Reaction was positive. To elucidate the possible mechanism involved in this case of EV, we genotyped the HLA genes of this patient. DQB genotyping showed the polymorphic HLA alleles DQB1*0301 and 0501. The patient was treated with a paucibacillary multidrug therapy scheme, and the disease was cured in six months. This report describes an EV patient with an M. leprae infection, confirming that tuberculoid leprosy patients possess a relatively specific and efficient cell-mediated immunity against the bacillus and, therefore, localized forms of the disease. Moreover, we show the possible involvement of the polymorphic HLA alleles DQB1*0301 and 0501 in EV induction mechanisms.Univ Oeste Paulista, Dept Imunol, BR-19050680 São Paulo, BrazilUniv Oeste Paulista, Dept Dermatol, BR-19050680 São Paulo, BrazilUNESP, Fac Med, Dept Patol, Botucatu, SP, BrazilAdolfo Lutz Inst, Lab Biol Mol, Presidente Prudente, BrazilUniversidade Estadual de Maringá (UEM), Dept Anal Clin & Imunogenet, Maringa, Parana, BrazilUNESP, Fac Med, Dept Patol, Botucatu, SP, BrazilJ Infection Developing CountriesUniversidade do Oeste Paulista (UNOESTE)Universidade Estadual Paulista (Unesp)Instituto Adolfo Lutz (IAL)Universidade Estadual de Maringá (UEM)Prestes-Carneiro, Luiz EuribelNai, Gisele AlborghettiSilva, Marcia Guimarães da [UNESP]Cristofano, CarlosCrivelin, Luciana LeiteRamos Calabreta, Carmela BeatrizMoliterno, Ricardo AlbertoMilanez Morgado de Abreu, Marilda Aparecida2014-05-20T13:37:32Z2014-05-20T13:37:32Z2012-06-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article526-530application/pdfhttp://www.jidc.org/index.php/journal/article/view/22711134Journal of Infection In Developing Countries. Tramaniglio: J Infection Developing Countries, v. 6, n. 6, p. 526-530, 2012.1972-2680http://hdl.handle.net/11449/13005WOS:000305912100011WOS000305912100011.pdf4940791909535775Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal of Infection In Developing Countries1.3300,704info:eu-repo/semantics/openAccess2024-09-03T13:17:55Zoai:repositorio.unesp.br:11449/13005Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestrepositoriounesp@unesp.bropendoar:29462024-09-03T13:17:55Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Clinical presentation of tuberculoid leprosy in an epidermodysplasia verruciformis patient |
title |
Clinical presentation of tuberculoid leprosy in an epidermodysplasia verruciformis patient |
spellingShingle |
Clinical presentation of tuberculoid leprosy in an epidermodysplasia verruciformis patient Prestes-Carneiro, Luiz Euribel Epidermodysplasia verruciformis papillomavirus Mycobacterium leprae DQB1*0301/0501HLA alleles |
title_short |
Clinical presentation of tuberculoid leprosy in an epidermodysplasia verruciformis patient |
title_full |
Clinical presentation of tuberculoid leprosy in an epidermodysplasia verruciformis patient |
title_fullStr |
Clinical presentation of tuberculoid leprosy in an epidermodysplasia verruciformis patient |
title_full_unstemmed |
Clinical presentation of tuberculoid leprosy in an epidermodysplasia verruciformis patient |
title_sort |
Clinical presentation of tuberculoid leprosy in an epidermodysplasia verruciformis patient |
author |
Prestes-Carneiro, Luiz Euribel |
author_facet |
Prestes-Carneiro, Luiz Euribel Nai, Gisele Alborghetti Silva, Marcia Guimarães da [UNESP] Cristofano, Carlos Crivelin, Luciana Leite Ramos Calabreta, Carmela Beatriz Moliterno, Ricardo Alberto Milanez Morgado de Abreu, Marilda Aparecida |
author_role |
author |
author2 |
Nai, Gisele Alborghetti Silva, Marcia Guimarães da [UNESP] Cristofano, Carlos Crivelin, Luciana Leite Ramos Calabreta, Carmela Beatriz Moliterno, Ricardo Alberto Milanez Morgado de Abreu, Marilda Aparecida |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade do Oeste Paulista (UNOESTE) Universidade Estadual Paulista (Unesp) Instituto Adolfo Lutz (IAL) Universidade Estadual de Maringá (UEM) |
dc.contributor.author.fl_str_mv |
Prestes-Carneiro, Luiz Euribel Nai, Gisele Alborghetti Silva, Marcia Guimarães da [UNESP] Cristofano, Carlos Crivelin, Luciana Leite Ramos Calabreta, Carmela Beatriz Moliterno, Ricardo Alberto Milanez Morgado de Abreu, Marilda Aparecida |
dc.subject.por.fl_str_mv |
Epidermodysplasia verruciformis papillomavirus Mycobacterium leprae DQB1*0301/0501HLA alleles |
topic |
Epidermodysplasia verruciformis papillomavirus Mycobacterium leprae DQB1*0301/0501HLA alleles |
description |
Epidermodysplasia verruciformis (EV) is triggered by a variety of mechanisms that at least partly include genetic background. We present a Brazilian man with a 30-year history of flat, wart-like lesions with clinical, histopathological, and evolutive aspects consistent with papillomavirus (HPV)-associated EV. Histological analysis of the wart lesions showed epidermis with hyperkeratosis, regular acanthosis, hypergranulosis, and cells with abundant basophilic cytoplasm. Moreover, a perivascular lymphocytic infiltrate was found in the superficial dermis, consistent with a viral wart. Type-2-HPV DNA was detected in various fragments of skin-wart lesions using the polymerase chain reaction (PCR). Two years after the EV diagnosis, the patient presented with an anesthetic well-demarcated, erythematous and mildly scaly plaque on his right forearm. A histopathological analysis of this lesion demonstrated the presence of a compact tuberculoid granuloma. Ziehl-Neelsen staining demonstrated the presence of rare acid-fast bacilli and confirmed the tuberculoid leprosy diagnosis. The patient's Mitsuda Intradermal Reaction was positive. To elucidate the possible mechanism involved in this case of EV, we genotyped the HLA genes of this patient. DQB genotyping showed the polymorphic HLA alleles DQB1*0301 and 0501. The patient was treated with a paucibacillary multidrug therapy scheme, and the disease was cured in six months. This report describes an EV patient with an M. leprae infection, confirming that tuberculoid leprosy patients possess a relatively specific and efficient cell-mediated immunity against the bacillus and, therefore, localized forms of the disease. Moreover, we show the possible involvement of the polymorphic HLA alleles DQB1*0301 and 0501 in EV induction mechanisms. |
publishDate |
2012 |
dc.date.none.fl_str_mv |
2012-06-01 2014-05-20T13:37:32Z 2014-05-20T13:37:32Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://www.jidc.org/index.php/journal/article/view/22711134 Journal of Infection In Developing Countries. Tramaniglio: J Infection Developing Countries, v. 6, n. 6, p. 526-530, 2012. 1972-2680 http://hdl.handle.net/11449/13005 WOS:000305912100011 WOS000305912100011.pdf 4940791909535775 |
url |
http://www.jidc.org/index.php/journal/article/view/22711134 http://hdl.handle.net/11449/13005 |
identifier_str_mv |
Journal of Infection In Developing Countries. Tramaniglio: J Infection Developing Countries, v. 6, n. 6, p. 526-530, 2012. 1972-2680 WOS:000305912100011 WOS000305912100011.pdf 4940791909535775 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Journal of Infection In Developing Countries 1.330 0,704 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
526-530 application/pdf |
dc.publisher.none.fl_str_mv |
J Infection Developing Countries |
publisher.none.fl_str_mv |
J Infection Developing Countries |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
repositoriounesp@unesp.br |
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1810021399716167680 |