Modular 3D-printed fluorometer/photometer for determination of iron(ii), caffeine, and ciprofloxacin in pharmaceutical samples
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1039/d3ra01281f http://hdl.handle.net/11449/248789 |
Resumo: | The demand for the development of portable and low-cost analytical devices has encouraged studies employing additive manufacturing techniques, such as 3D-printing. This method can be used to produce components such as printed electrodes, photometers, and fluorometers for low-cost systems that provide advantages including low sample volume, reduced chemical waste, and easy coupling with LED-based optics and other instrumental devices. In the present work, a modular 3D-printed fluorometer/photometer was designed and applied for the determination of caffeine (CAF), ciprofloxacin (CIP), and Fe(ii) in pharmaceutical samples. All the plastic parts were printed separately by a 3D printer, using Tritan as the plastic material (black color). The final size of the modular 3D-printed device was 12 × 8 cm. The radiation sources were light-emitting diodes (LEDs), while a light dependent resistor (LDR) was used as a photodetector. The analytical curves obtained for the device were: y = 3.00 × 10−4 [CAF] + 1.00 and R2 = 0.987 for caffeine; y = 6.90 × 10−3 [CIP] − 3.39 × 10−2 and R2 = 0.991 for ciprofloxacin; and y = 1.12 × 10−1 [Fe(ii)] + 1.26 × 10−2 and R2 = 0.998 for iron(ii). The results obtained using the developed device were compared with reference methods, with no statistically significant differences observed. The 3D-printed device was composed of moveable parts, providing flexibility for adaptation and application as a photometer or fluorometer, by only switching the photodetector position. The LED could also be easily switched, permitting application of the device for different purposes. The cost of the device, including the printing and electronic components, was lower than US$10. The use of 3D-printing enables the development of portable instruments for use in remote locations with a lack of research resources. |
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spelling |
Modular 3D-printed fluorometer/photometer for determination of iron(ii), caffeine, and ciprofloxacin in pharmaceutical samplesThe demand for the development of portable and low-cost analytical devices has encouraged studies employing additive manufacturing techniques, such as 3D-printing. This method can be used to produce components such as printed electrodes, photometers, and fluorometers for low-cost systems that provide advantages including low sample volume, reduced chemical waste, and easy coupling with LED-based optics and other instrumental devices. In the present work, a modular 3D-printed fluorometer/photometer was designed and applied for the determination of caffeine (CAF), ciprofloxacin (CIP), and Fe(ii) in pharmaceutical samples. All the plastic parts were printed separately by a 3D printer, using Tritan as the plastic material (black color). The final size of the modular 3D-printed device was 12 × 8 cm. The radiation sources were light-emitting diodes (LEDs), while a light dependent resistor (LDR) was used as a photodetector. The analytical curves obtained for the device were: y = 3.00 × 10−4 [CAF] + 1.00 and R2 = 0.987 for caffeine; y = 6.90 × 10−3 [CIP] − 3.39 × 10−2 and R2 = 0.991 for ciprofloxacin; and y = 1.12 × 10−1 [Fe(ii)] + 1.26 × 10−2 and R2 = 0.998 for iron(ii). The results obtained using the developed device were compared with reference methods, with no statistically significant differences observed. The 3D-printed device was composed of moveable parts, providing flexibility for adaptation and application as a photometer or fluorometer, by only switching the photodetector position. The LED could also be easily switched, permitting application of the device for different purposes. The cost of the device, including the printing and electronic components, was lower than US$10. The use of 3D-printing enables the development of portable instruments for use in remote locations with a lack of research resources.Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Fundação de Amparo à Pesquisa do Estado de GoiásFundação de Amparo à Pesquisa do Estado do PiauíFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Department of Analytical Chemistry Physical Chemistry and Inorganic Chemistry National Institute for Alternative Technologies of Detection Toxicological Evaluation and Removal of Micropollutants and Radioactives (INCT-DATREM) Institute of Chemistry São Paulo State University (UNESP), São PauloDepartment of Analytical Chemistry Physical Chemistry and Inorganic Chemistry National Institute for Alternative Technologies of Detection Toxicological Evaluation and Removal of Micropollutants and Radioactives (INCT-DATREM) Institute of Chemistry São Paulo State University (UNESP), São PauloUniversidade Estadual Paulista (UNESP)Lamarca, Rafaela Silva [UNESP]Silva, João Pedro [UNESP]Varoni dos Santos, João Paulo [UNESP]Ayala-Durán, Saidy Cristina [UNESP]Lima Gomes, Paulo Clairmont Feitosa de [UNESP]2023-07-29T13:53:49Z2023-07-29T13:53:49Z2023-04-17info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article12050-12058http://dx.doi.org/10.1039/d3ra01281fRSC Advances, v. 13, n. 18, p. 12050-12058, 2023.2046-2069http://hdl.handle.net/11449/24878910.1039/d3ra01281f2-s2.0-85158057993Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengRSC Advancesinfo:eu-repo/semantics/openAccess2023-07-29T13:53:49Zoai:repositorio.unesp.br:11449/248789Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T20:47:05.532731Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Modular 3D-printed fluorometer/photometer for determination of iron(ii), caffeine, and ciprofloxacin in pharmaceutical samples |
title |
Modular 3D-printed fluorometer/photometer for determination of iron(ii), caffeine, and ciprofloxacin in pharmaceutical samples |
spellingShingle |
Modular 3D-printed fluorometer/photometer for determination of iron(ii), caffeine, and ciprofloxacin in pharmaceutical samples Lamarca, Rafaela Silva [UNESP] |
title_short |
Modular 3D-printed fluorometer/photometer for determination of iron(ii), caffeine, and ciprofloxacin in pharmaceutical samples |
title_full |
Modular 3D-printed fluorometer/photometer for determination of iron(ii), caffeine, and ciprofloxacin in pharmaceutical samples |
title_fullStr |
Modular 3D-printed fluorometer/photometer for determination of iron(ii), caffeine, and ciprofloxacin in pharmaceutical samples |
title_full_unstemmed |
Modular 3D-printed fluorometer/photometer for determination of iron(ii), caffeine, and ciprofloxacin in pharmaceutical samples |
title_sort |
Modular 3D-printed fluorometer/photometer for determination of iron(ii), caffeine, and ciprofloxacin in pharmaceutical samples |
author |
Lamarca, Rafaela Silva [UNESP] |
author_facet |
Lamarca, Rafaela Silva [UNESP] Silva, João Pedro [UNESP] Varoni dos Santos, João Paulo [UNESP] Ayala-Durán, Saidy Cristina [UNESP] Lima Gomes, Paulo Clairmont Feitosa de [UNESP] |
author_role |
author |
author2 |
Silva, João Pedro [UNESP] Varoni dos Santos, João Paulo [UNESP] Ayala-Durán, Saidy Cristina [UNESP] Lima Gomes, Paulo Clairmont Feitosa de [UNESP] |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (UNESP) |
dc.contributor.author.fl_str_mv |
Lamarca, Rafaela Silva [UNESP] Silva, João Pedro [UNESP] Varoni dos Santos, João Paulo [UNESP] Ayala-Durán, Saidy Cristina [UNESP] Lima Gomes, Paulo Clairmont Feitosa de [UNESP] |
description |
The demand for the development of portable and low-cost analytical devices has encouraged studies employing additive manufacturing techniques, such as 3D-printing. This method can be used to produce components such as printed electrodes, photometers, and fluorometers for low-cost systems that provide advantages including low sample volume, reduced chemical waste, and easy coupling with LED-based optics and other instrumental devices. In the present work, a modular 3D-printed fluorometer/photometer was designed and applied for the determination of caffeine (CAF), ciprofloxacin (CIP), and Fe(ii) in pharmaceutical samples. All the plastic parts were printed separately by a 3D printer, using Tritan as the plastic material (black color). The final size of the modular 3D-printed device was 12 × 8 cm. The radiation sources were light-emitting diodes (LEDs), while a light dependent resistor (LDR) was used as a photodetector. The analytical curves obtained for the device were: y = 3.00 × 10−4 [CAF] + 1.00 and R2 = 0.987 for caffeine; y = 6.90 × 10−3 [CIP] − 3.39 × 10−2 and R2 = 0.991 for ciprofloxacin; and y = 1.12 × 10−1 [Fe(ii)] + 1.26 × 10−2 and R2 = 0.998 for iron(ii). The results obtained using the developed device were compared with reference methods, with no statistically significant differences observed. The 3D-printed device was composed of moveable parts, providing flexibility for adaptation and application as a photometer or fluorometer, by only switching the photodetector position. The LED could also be easily switched, permitting application of the device for different purposes. The cost of the device, including the printing and electronic components, was lower than US$10. The use of 3D-printing enables the development of portable instruments for use in remote locations with a lack of research resources. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-07-29T13:53:49Z 2023-07-29T13:53:49Z 2023-04-17 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1039/d3ra01281f RSC Advances, v. 13, n. 18, p. 12050-12058, 2023. 2046-2069 http://hdl.handle.net/11449/248789 10.1039/d3ra01281f 2-s2.0-85158057993 |
url |
http://dx.doi.org/10.1039/d3ra01281f http://hdl.handle.net/11449/248789 |
identifier_str_mv |
RSC Advances, v. 13, n. 18, p. 12050-12058, 2023. 2046-2069 10.1039/d3ra01281f 2-s2.0-85158057993 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
RSC Advances |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
12050-12058 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
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1808129248251084800 |