Disfunção miocárdica e alterações no trânsito de cálcio intracelular em ratos obesos
Autor(a) principal: | |
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Data de Publicação: | 2011 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://www.scielo.br/scielo.php?pid=S0066-782X2011005000061&script=sci_arttext http://hdl.handle.net/11449/136828 |
Resumo: | Abstract Background: Several mechanisms have been proposed to contribute to cardiac dysfunction in obesity models, such as alterations in calcium (Ca2+) handling proteins and β-adrenergic receptors. Nevertheless, the role of these factors in the development of myocardial dysfunction induced by obesity is still not clear. Objective: The purpose of this study was to investigate whether obesity induced by hypercaloric diets results in cardiac dysfunction. Furthermore, it was evaluated whether this functional abnormality in obese rats is related to abnormal Ca2+ handling and the β-adrenoceptor system. Methods: Male 30-day-old Wistar rats were fed with standard food (C) and a cycle of five hypercaloric diets (Ob) for 15 weeks. Obesity was defined as increases in body fat percentage in rats. Cardiac function was evaluated by isolated analysis of the left ventricle papillary muscle under basal conditions and after inotropic and lusitropic maneuvers. Results: Compared with the control group, the obese rats had increased body fat and glucose intolerance. The muscles of obese rats developed similar baseline data, but the myocardial responsiveness to post-rest contraction stimulus and increased extracellular Ca2+ were compromised. There were no changes in cardiac function between groups after β-adrenergic stimulation. Conclusion: Obesity promotes cardiac dysfunction related to changes in intracellular Ca2+ handling. This functional damage is probably caused by reduced cardiac sarcoplasmic reticulum Ca2+ ATPase (SERCA2) activation via Ca2+ calmodulin kinase. (Arq Bras Cardiol 2011; 97(3) : 232-240). |
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Disfunção miocárdica e alterações no trânsito de cálcio intracelular em ratos obesosMyocardial dysfunction and abnormalities in intracellular calcium handling in obese ratsMyocardial dysfunctionRatsObesityCalcium elevationReceptorsAdrenergicBetaDisfunção ventricularRatosObesidadeHipercalcemiaReceptores beta-adrenérgicosAbstract Background: Several mechanisms have been proposed to contribute to cardiac dysfunction in obesity models, such as alterations in calcium (Ca2+) handling proteins and β-adrenergic receptors. Nevertheless, the role of these factors in the development of myocardial dysfunction induced by obesity is still not clear. Objective: The purpose of this study was to investigate whether obesity induced by hypercaloric diets results in cardiac dysfunction. Furthermore, it was evaluated whether this functional abnormality in obese rats is related to abnormal Ca2+ handling and the β-adrenoceptor system. Methods: Male 30-day-old Wistar rats were fed with standard food (C) and a cycle of five hypercaloric diets (Ob) for 15 weeks. Obesity was defined as increases in body fat percentage in rats. Cardiac function was evaluated by isolated analysis of the left ventricle papillary muscle under basal conditions and after inotropic and lusitropic maneuvers. Results: Compared with the control group, the obese rats had increased body fat and glucose intolerance. The muscles of obese rats developed similar baseline data, but the myocardial responsiveness to post-rest contraction stimulus and increased extracellular Ca2+ were compromised. There were no changes in cardiac function between groups after β-adrenergic stimulation. Conclusion: Obesity promotes cardiac dysfunction related to changes in intracellular Ca2+ handling. This functional damage is probably caused by reduced cardiac sarcoplasmic reticulum Ca2+ ATPase (SERCA2) activation via Ca2+ calmodulin kinase. (Arq Bras Cardiol 2011; 97(3) : 232-240).Departamento de Desportos, Centro de Educação Física e Desportos, UFES - Universidade Federal do Espírito SantoInstituto de Ciências da Saúde, UFMT - Universidade Federal de Mato GrossoUniversidade Estadual Paulista Júlio de Mesquita Filho, Departamento de Clínica Médica, Faculdade de Medicina de Botucatu, Botucatu, Distrito de Rubião Júnior, s/nº, CEP 18600-000, SP, BrasilUniversidade Federal do Espírito Santo (UFES)Universidade Estadual Paulista (Unesp)Universidade Federal do Mato Grosso (UFMT)Leopoldo, Ana Paula LimaAndré S. Leopoldo [UNESP]Sugizaki, Mario MateusBruno, AlessandroNascimento, André Ferreira doLuvizotto, R A MOliveira Júnior, A SCastardeli, EdsonPadovani, Carlos RobertoCicogna, Antonio Carlos [UNESP]2016-04-01T18:42:48Z2016-04-01T18:42:48Z2011info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article232-240application/pdfhttp://www.scielo.br/scielo.php?pid=S0066-782X2011005000061&script=sci_arttextArquivos Brasileiros de Cardiologia, v. 13, n. x, p. x-xx, 2011.0066-782Xhttp://hdl.handle.net/11449/136828ISSN0066-782X-2011-13-232-240.pdf9418970103564137Currículo Lattesreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPporArquivos Brasileiros de Cardiologia1.318info:eu-repo/semantics/openAccess2024-08-14T17:36:03Zoai:repositorio.unesp.br:11449/136828Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-14T17:36:03Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Disfunção miocárdica e alterações no trânsito de cálcio intracelular em ratos obesos Myocardial dysfunction and abnormalities in intracellular calcium handling in obese rats |
title |
Disfunção miocárdica e alterações no trânsito de cálcio intracelular em ratos obesos |
spellingShingle |
Disfunção miocárdica e alterações no trânsito de cálcio intracelular em ratos obesos Leopoldo, Ana Paula Lima Myocardial dysfunction Rats Obesity Calcium elevation Receptors Adrenergic Beta Disfunção ventricular Ratos Obesidade Hipercalcemia Receptores beta-adrenérgicos |
title_short |
Disfunção miocárdica e alterações no trânsito de cálcio intracelular em ratos obesos |
title_full |
Disfunção miocárdica e alterações no trânsito de cálcio intracelular em ratos obesos |
title_fullStr |
Disfunção miocárdica e alterações no trânsito de cálcio intracelular em ratos obesos |
title_full_unstemmed |
Disfunção miocárdica e alterações no trânsito de cálcio intracelular em ratos obesos |
title_sort |
Disfunção miocárdica e alterações no trânsito de cálcio intracelular em ratos obesos |
author |
Leopoldo, Ana Paula Lima |
author_facet |
Leopoldo, Ana Paula Lima André S. Leopoldo [UNESP] Sugizaki, Mario Mateus Bruno, Alessandro Nascimento, André Ferreira do Luvizotto, R A M Oliveira Júnior, A S Castardeli, Edson Padovani, Carlos Roberto Cicogna, Antonio Carlos [UNESP] |
author_role |
author |
author2 |
André S. Leopoldo [UNESP] Sugizaki, Mario Mateus Bruno, Alessandro Nascimento, André Ferreira do Luvizotto, R A M Oliveira Júnior, A S Castardeli, Edson Padovani, Carlos Roberto Cicogna, Antonio Carlos [UNESP] |
author2_role |
author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Federal do Espírito Santo (UFES) Universidade Estadual Paulista (Unesp) Universidade Federal do Mato Grosso (UFMT) |
dc.contributor.author.fl_str_mv |
Leopoldo, Ana Paula Lima André S. Leopoldo [UNESP] Sugizaki, Mario Mateus Bruno, Alessandro Nascimento, André Ferreira do Luvizotto, R A M Oliveira Júnior, A S Castardeli, Edson Padovani, Carlos Roberto Cicogna, Antonio Carlos [UNESP] |
dc.subject.por.fl_str_mv |
Myocardial dysfunction Rats Obesity Calcium elevation Receptors Adrenergic Beta Disfunção ventricular Ratos Obesidade Hipercalcemia Receptores beta-adrenérgicos |
topic |
Myocardial dysfunction Rats Obesity Calcium elevation Receptors Adrenergic Beta Disfunção ventricular Ratos Obesidade Hipercalcemia Receptores beta-adrenérgicos |
description |
Abstract Background: Several mechanisms have been proposed to contribute to cardiac dysfunction in obesity models, such as alterations in calcium (Ca2+) handling proteins and β-adrenergic receptors. Nevertheless, the role of these factors in the development of myocardial dysfunction induced by obesity is still not clear. Objective: The purpose of this study was to investigate whether obesity induced by hypercaloric diets results in cardiac dysfunction. Furthermore, it was evaluated whether this functional abnormality in obese rats is related to abnormal Ca2+ handling and the β-adrenoceptor system. Methods: Male 30-day-old Wistar rats were fed with standard food (C) and a cycle of five hypercaloric diets (Ob) for 15 weeks. Obesity was defined as increases in body fat percentage in rats. Cardiac function was evaluated by isolated analysis of the left ventricle papillary muscle under basal conditions and after inotropic and lusitropic maneuvers. Results: Compared with the control group, the obese rats had increased body fat and glucose intolerance. The muscles of obese rats developed similar baseline data, but the myocardial responsiveness to post-rest contraction stimulus and increased extracellular Ca2+ were compromised. There were no changes in cardiac function between groups after β-adrenergic stimulation. Conclusion: Obesity promotes cardiac dysfunction related to changes in intracellular Ca2+ handling. This functional damage is probably caused by reduced cardiac sarcoplasmic reticulum Ca2+ ATPase (SERCA2) activation via Ca2+ calmodulin kinase. (Arq Bras Cardiol 2011; 97(3) : 232-240). |
publishDate |
2011 |
dc.date.none.fl_str_mv |
2011 2016-04-01T18:42:48Z 2016-04-01T18:42:48Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://www.scielo.br/scielo.php?pid=S0066-782X2011005000061&script=sci_arttext Arquivos Brasileiros de Cardiologia, v. 13, n. x, p. x-xx, 2011. 0066-782X http://hdl.handle.net/11449/136828 ISSN0066-782X-2011-13-232-240.pdf 9418970103564137 |
url |
http://www.scielo.br/scielo.php?pid=S0066-782X2011005000061&script=sci_arttext http://hdl.handle.net/11449/136828 |
identifier_str_mv |
Arquivos Brasileiros de Cardiologia, v. 13, n. x, p. x-xx, 2011. 0066-782X ISSN0066-782X-2011-13-232-240.pdf 9418970103564137 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
Arquivos Brasileiros de Cardiologia 1.318 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
232-240 application/pdf |
dc.source.none.fl_str_mv |
Currículo Lattes reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
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1808128180034207744 |