Disfunção miocárdica e alterações no trânsito de cálcio intracelular em ratos obesos

Detalhes bibliográficos
Autor(a) principal: Leopoldo, Ana Paula Lima
Data de Publicação: 2011
Outros Autores: André S. Leopoldo [UNESP], Sugizaki, Mario Mateus, Bruno, Alessandro, Nascimento, André Ferreira do, Luvizotto, R A M, Oliveira Júnior, A S, Castardeli, Edson, Padovani, Carlos Roberto, Cicogna, Antonio Carlos [UNESP]
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://www.scielo.br/scielo.php?pid=S0066-782X2011005000061&script=sci_arttext
http://hdl.handle.net/11449/136828
Resumo: Abstract Background: Several mechanisms have been proposed to contribute to cardiac dysfunction in obesity models, such as alterations in calcium (Ca2+) handling proteins and β-adrenergic receptors. Nevertheless, the role of these factors in the development of myocardial dysfunction induced by obesity is still not clear. Objective: The purpose of this study was to investigate whether obesity induced by hypercaloric diets results in cardiac dysfunction. Furthermore, it was evaluated whether this functional abnormality in obese rats is related to abnormal Ca2+ handling and the β-adrenoceptor system. Methods: Male 30-day-old Wistar rats were fed with standard food (C) and a cycle of five hypercaloric diets (Ob) for 15 weeks. Obesity was defined as increases in body fat percentage in rats. Cardiac function was evaluated by isolated analysis of the left ventricle papillary muscle under basal conditions and after inotropic and lusitropic maneuvers. Results: Compared with the control group, the obese rats had increased body fat and glucose intolerance. The muscles of obese rats developed similar baseline data, but the myocardial responsiveness to post-rest contraction stimulus and increased extracellular Ca2+ were compromised. There were no changes in cardiac function between groups after β-adrenergic stimulation. Conclusion: Obesity promotes cardiac dysfunction related to changes in intracellular Ca2+ handling. This functional damage is probably caused by reduced cardiac sarcoplasmic reticulum Ca2+ ATPase (SERCA2) activation via Ca2+ calmodulin kinase. (Arq Bras Cardiol 2011; 97(3) : 232-240).
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spelling Disfunção miocárdica e alterações no trânsito de cálcio intracelular em ratos obesosMyocardial dysfunction and abnormalities in intracellular calcium handling in obese ratsMyocardial dysfunctionRatsObesityCalcium elevationReceptorsAdrenergicBetaDisfunção ventricularRatosObesidadeHipercalcemiaReceptores beta-adrenérgicosAbstract Background: Several mechanisms have been proposed to contribute to cardiac dysfunction in obesity models, such as alterations in calcium (Ca2+) handling proteins and β-adrenergic receptors. Nevertheless, the role of these factors in the development of myocardial dysfunction induced by obesity is still not clear. Objective: The purpose of this study was to investigate whether obesity induced by hypercaloric diets results in cardiac dysfunction. Furthermore, it was evaluated whether this functional abnormality in obese rats is related to abnormal Ca2+ handling and the β-adrenoceptor system. Methods: Male 30-day-old Wistar rats were fed with standard food (C) and a cycle of five hypercaloric diets (Ob) for 15 weeks. Obesity was defined as increases in body fat percentage in rats. Cardiac function was evaluated by isolated analysis of the left ventricle papillary muscle under basal conditions and after inotropic and lusitropic maneuvers. Results: Compared with the control group, the obese rats had increased body fat and glucose intolerance. The muscles of obese rats developed similar baseline data, but the myocardial responsiveness to post-rest contraction stimulus and increased extracellular Ca2+ were compromised. There were no changes in cardiac function between groups after β-adrenergic stimulation. Conclusion: Obesity promotes cardiac dysfunction related to changes in intracellular Ca2+ handling. This functional damage is probably caused by reduced cardiac sarcoplasmic reticulum Ca2+ ATPase (SERCA2) activation via Ca2+ calmodulin kinase. (Arq Bras Cardiol 2011; 97(3) : 232-240).Departamento de Desportos, Centro de Educação Física e Desportos, UFES - Universidade Federal do Espírito SantoInstituto de Ciências da Saúde, UFMT - Universidade Federal de Mato GrossoUniversidade Estadual Paulista Júlio de Mesquita Filho, Departamento de Clínica Médica, Faculdade de Medicina de Botucatu, Botucatu, Distrito de Rubião Júnior, s/nº, CEP 18600-000, SP, BrasilUniversidade Federal do Espírito Santo (UFES)Universidade Estadual Paulista (Unesp)Universidade Federal do Mato Grosso (UFMT)Leopoldo, Ana Paula LimaAndré S. Leopoldo [UNESP]Sugizaki, Mario MateusBruno, AlessandroNascimento, André Ferreira doLuvizotto, R A MOliveira Júnior, A SCastardeli, EdsonPadovani, Carlos RobertoCicogna, Antonio Carlos [UNESP]2016-04-01T18:42:48Z2016-04-01T18:42:48Z2011info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article232-240application/pdfhttp://www.scielo.br/scielo.php?pid=S0066-782X2011005000061&script=sci_arttextArquivos Brasileiros de Cardiologia, v. 13, n. x, p. x-xx, 2011.0066-782Xhttp://hdl.handle.net/11449/136828ISSN0066-782X-2011-13-232-240.pdf9418970103564137Currículo Lattesreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPporArquivos Brasileiros de Cardiologia1.318info:eu-repo/semantics/openAccess2024-08-14T17:36:03Zoai:repositorio.unesp.br:11449/136828Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-14T17:36:03Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Disfunção miocárdica e alterações no trânsito de cálcio intracelular em ratos obesos
Myocardial dysfunction and abnormalities in intracellular calcium handling in obese rats
title Disfunção miocárdica e alterações no trânsito de cálcio intracelular em ratos obesos
spellingShingle Disfunção miocárdica e alterações no trânsito de cálcio intracelular em ratos obesos
Leopoldo, Ana Paula Lima
Myocardial dysfunction
Rats
Obesity
Calcium elevation
Receptors
Adrenergic
Beta
Disfunção ventricular
Ratos
Obesidade
Hipercalcemia
Receptores beta-adrenérgicos
title_short Disfunção miocárdica e alterações no trânsito de cálcio intracelular em ratos obesos
title_full Disfunção miocárdica e alterações no trânsito de cálcio intracelular em ratos obesos
title_fullStr Disfunção miocárdica e alterações no trânsito de cálcio intracelular em ratos obesos
title_full_unstemmed Disfunção miocárdica e alterações no trânsito de cálcio intracelular em ratos obesos
title_sort Disfunção miocárdica e alterações no trânsito de cálcio intracelular em ratos obesos
author Leopoldo, Ana Paula Lima
author_facet Leopoldo, Ana Paula Lima
André S. Leopoldo [UNESP]
Sugizaki, Mario Mateus
Bruno, Alessandro
Nascimento, André Ferreira do
Luvizotto, R A M
Oliveira Júnior, A S
Castardeli, Edson
Padovani, Carlos Roberto
Cicogna, Antonio Carlos [UNESP]
author_role author
author2 André S. Leopoldo [UNESP]
Sugizaki, Mario Mateus
Bruno, Alessandro
Nascimento, André Ferreira do
Luvizotto, R A M
Oliveira Júnior, A S
Castardeli, Edson
Padovani, Carlos Roberto
Cicogna, Antonio Carlos [UNESP]
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Federal do Espírito Santo (UFES)
Universidade Estadual Paulista (Unesp)
Universidade Federal do Mato Grosso (UFMT)
dc.contributor.author.fl_str_mv Leopoldo, Ana Paula Lima
André S. Leopoldo [UNESP]
Sugizaki, Mario Mateus
Bruno, Alessandro
Nascimento, André Ferreira do
Luvizotto, R A M
Oliveira Júnior, A S
Castardeli, Edson
Padovani, Carlos Roberto
Cicogna, Antonio Carlos [UNESP]
dc.subject.por.fl_str_mv Myocardial dysfunction
Rats
Obesity
Calcium elevation
Receptors
Adrenergic
Beta
Disfunção ventricular
Ratos
Obesidade
Hipercalcemia
Receptores beta-adrenérgicos
topic Myocardial dysfunction
Rats
Obesity
Calcium elevation
Receptors
Adrenergic
Beta
Disfunção ventricular
Ratos
Obesidade
Hipercalcemia
Receptores beta-adrenérgicos
description Abstract Background: Several mechanisms have been proposed to contribute to cardiac dysfunction in obesity models, such as alterations in calcium (Ca2+) handling proteins and β-adrenergic receptors. Nevertheless, the role of these factors in the development of myocardial dysfunction induced by obesity is still not clear. Objective: The purpose of this study was to investigate whether obesity induced by hypercaloric diets results in cardiac dysfunction. Furthermore, it was evaluated whether this functional abnormality in obese rats is related to abnormal Ca2+ handling and the β-adrenoceptor system. Methods: Male 30-day-old Wistar rats were fed with standard food (C) and a cycle of five hypercaloric diets (Ob) for 15 weeks. Obesity was defined as increases in body fat percentage in rats. Cardiac function was evaluated by isolated analysis of the left ventricle papillary muscle under basal conditions and after inotropic and lusitropic maneuvers. Results: Compared with the control group, the obese rats had increased body fat and glucose intolerance. The muscles of obese rats developed similar baseline data, but the myocardial responsiveness to post-rest contraction stimulus and increased extracellular Ca2+ were compromised. There were no changes in cardiac function between groups after β-adrenergic stimulation. Conclusion: Obesity promotes cardiac dysfunction related to changes in intracellular Ca2+ handling. This functional damage is probably caused by reduced cardiac sarcoplasmic reticulum Ca2+ ATPase (SERCA2) activation via Ca2+ calmodulin kinase. (Arq Bras Cardiol 2011; 97(3) : 232-240).
publishDate 2011
dc.date.none.fl_str_mv 2011
2016-04-01T18:42:48Z
2016-04-01T18:42:48Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.scielo.br/scielo.php?pid=S0066-782X2011005000061&script=sci_arttext
Arquivos Brasileiros de Cardiologia, v. 13, n. x, p. x-xx, 2011.
0066-782X
http://hdl.handle.net/11449/136828
ISSN0066-782X-2011-13-232-240.pdf
9418970103564137
url http://www.scielo.br/scielo.php?pid=S0066-782X2011005000061&script=sci_arttext
http://hdl.handle.net/11449/136828
identifier_str_mv Arquivos Brasileiros de Cardiologia, v. 13, n. x, p. x-xx, 2011.
0066-782X
ISSN0066-782X-2011-13-232-240.pdf
9418970103564137
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv Arquivos Brasileiros de Cardiologia
1.318
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 232-240
application/pdf
dc.source.none.fl_str_mv Currículo Lattes
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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