Optimal control theory applied to the anti-viral treatment of AIDS
Autor(a) principal: | |
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Data de Publicação: | 2000 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1109/CDC.2001.914696 http://hdl.handle.net/11449/224177 |
Resumo: | This work concerns a particular application of the Optimal Control Theory to a model related to HIV infection dynamics. The mathematical model adopted in this work was proposed by Nowak et al., 1996 and describes the dynamics of viral concentration in terms of interaction with CD4 cells and the cytotoxic T lymphocytes, which are responsible for the immune defense of the organism. The control variable is the drug dose, which, in turn, affects the rate of infection of CD4 cells by HIV virus. The cost function to be minimized is a weighted sum of the final viral load and the accumulated side effects. Simulation results show that the optimal control scheme can achieve improved quality of the treatment in terms of reduction in the viral load and quantity of administered drugs, but has the inconvenience related to the necessity of frequent and periodic laboratory analysis to provide feedback information to adjust the doses. |
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Repositório Institucional da UNESP |
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Optimal control theory applied to the anti-viral treatment of AIDSThis work concerns a particular application of the Optimal Control Theory to a model related to HIV infection dynamics. The mathematical model adopted in this work was proposed by Nowak et al., 1996 and describes the dynamics of viral concentration in terms of interaction with CD4 cells and the cytotoxic T lymphocytes, which are responsible for the immune defense of the organism. The control variable is the drug dose, which, in turn, affects the rate of infection of CD4 cells by HIV virus. The cost function to be minimized is a weighted sum of the final viral load and the accumulated side effects. Simulation results show that the optimal control scheme can achieve improved quality of the treatment in terms of reduction in the viral load and quantity of administered drugs, but has the inconvenience related to the necessity of frequent and periodic laboratory analysis to provide feedback information to adjust the doses.Departament of Electromechanical Engineering Universidade da Beira Interior, 6201-001 - CovilhãDepartment of Statistical Computational and Applied Mathematics Universidade Estadual Paulista, Rio Claro - SPDepartment of Eletronics Engineering Instituto Tecnológico de Aerondutica, São José dos Campos - SPDepartment of Statistical Computational and Applied Mathematics Universidade Estadual Paulista, Rio Claro - SPUniversidade da Beira InteriorUniversidade Estadual Paulista (UNESP)Instituto Tecnológico de AeronduticaFelippe De Souza, J. A.M.Caetano, Marco Antonio Leone1 [UNESP]Yoneyama, Takashi2022-04-28T19:55:02Z2022-04-28T19:55:02Z2000-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article4839-4844http://dx.doi.org/10.1109/CDC.2001.914696Proceedings of the IEEE Conference on Decision and Control, v. 5, p. 4839-4844.0191-2216http://hdl.handle.net/11449/22417710.1109/CDC.2001.9146962-s2.0-0034445348Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengProceedings of the IEEE Conference on Decision and Controlinfo:eu-repo/semantics/openAccess2022-04-28T19:55:02Zoai:repositorio.unesp.br:11449/224177Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462022-04-28T19:55:02Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Optimal control theory applied to the anti-viral treatment of AIDS |
title |
Optimal control theory applied to the anti-viral treatment of AIDS |
spellingShingle |
Optimal control theory applied to the anti-viral treatment of AIDS Felippe De Souza, J. A.M. |
title_short |
Optimal control theory applied to the anti-viral treatment of AIDS |
title_full |
Optimal control theory applied to the anti-viral treatment of AIDS |
title_fullStr |
Optimal control theory applied to the anti-viral treatment of AIDS |
title_full_unstemmed |
Optimal control theory applied to the anti-viral treatment of AIDS |
title_sort |
Optimal control theory applied to the anti-viral treatment of AIDS |
author |
Felippe De Souza, J. A.M. |
author_facet |
Felippe De Souza, J. A.M. Caetano, Marco Antonio Leone1 [UNESP] Yoneyama, Takashi |
author_role |
author |
author2 |
Caetano, Marco Antonio Leone1 [UNESP] Yoneyama, Takashi |
author2_role |
author author |
dc.contributor.none.fl_str_mv |
Universidade da Beira Interior Universidade Estadual Paulista (UNESP) Instituto Tecnológico de Aerondutica |
dc.contributor.author.fl_str_mv |
Felippe De Souza, J. A.M. Caetano, Marco Antonio Leone1 [UNESP] Yoneyama, Takashi |
description |
This work concerns a particular application of the Optimal Control Theory to a model related to HIV infection dynamics. The mathematical model adopted in this work was proposed by Nowak et al., 1996 and describes the dynamics of viral concentration in terms of interaction with CD4 cells and the cytotoxic T lymphocytes, which are responsible for the immune defense of the organism. The control variable is the drug dose, which, in turn, affects the rate of infection of CD4 cells by HIV virus. The cost function to be minimized is a weighted sum of the final viral load and the accumulated side effects. Simulation results show that the optimal control scheme can achieve improved quality of the treatment in terms of reduction in the viral load and quantity of administered drugs, but has the inconvenience related to the necessity of frequent and periodic laboratory analysis to provide feedback information to adjust the doses. |
publishDate |
2000 |
dc.date.none.fl_str_mv |
2000-01-01 2022-04-28T19:55:02Z 2022-04-28T19:55:02Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1109/CDC.2001.914696 Proceedings of the IEEE Conference on Decision and Control, v. 5, p. 4839-4844. 0191-2216 http://hdl.handle.net/11449/224177 10.1109/CDC.2001.914696 2-s2.0-0034445348 |
url |
http://dx.doi.org/10.1109/CDC.2001.914696 http://hdl.handle.net/11449/224177 |
identifier_str_mv |
Proceedings of the IEEE Conference on Decision and Control, v. 5, p. 4839-4844. 0191-2216 10.1109/CDC.2001.914696 2-s2.0-0034445348 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Proceedings of the IEEE Conference on Decision and Control |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
4839-4844 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1799965044693270528 |