Comparison of droperidol and ondansetron prophylactic effect on subarachnoid morphine-induced pruritus
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.bjane.2013.11.005 http://hdl.handle.net/11449/169601 |
Resumo: | BACKGROUND AND OBJECTIVES: The prophylactic effect of ondansetron on subarachnoid morphine-induced pruritus is controversial, while evidence suggests that droperidol prevents pruritus. The aim of this study is to compare the effects of droperidol and ondansetron on subarachnoid morphine-induced pruritus. METHODS: 180 ASA I or II patients scheduled to undergo cesarean sections under subarachnoid anesthesia combined with morphine 0.2mg were randomized to receive, after the child's birth, metoclopramide 10mg (Group I - control), droperidol 2.5mg (Group II) or ondansetron 8mg (Group III). Postoperatively, the patients were assessed for pruritus (absent, mild, moderate or severe) or other side effects by blinded investigators. Patients were also blinded to their group allocation. The tendency to present more severe forms of pruritus was compared between groups. NNT was also determined. RESULTS: Patients assigned to receive droperidol [Proportional odds ratio: 0.45 (95% confidence interval 0.23-0.88)] reported less pruritus than those who received metoclopramide. Ondansetron effect was similar to metoclopramide [Proportional odds ratio: 0.95 (95% confidence interval 0.49-1.83)]. The NNT for droperidol and ondansetron was 4.0 and 14.7, respectively. CONCLUSIONS: Ondansetron does not inhibit subarachnoid morphine-induced pruritus. |
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Repositório Institucional da UNESP |
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2946 |
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Comparison of droperidol and ondansetron prophylactic effect on subarachnoid morphine-induced pruritusDroperidolInjeção subaracnoideaMorfinaMorphineOndansetronPruridoPruritusSubarachnoid injectionBACKGROUND AND OBJECTIVES: The prophylactic effect of ondansetron on subarachnoid morphine-induced pruritus is controversial, while evidence suggests that droperidol prevents pruritus. The aim of this study is to compare the effects of droperidol and ondansetron on subarachnoid morphine-induced pruritus. METHODS: 180 ASA I or II patients scheduled to undergo cesarean sections under subarachnoid anesthesia combined with morphine 0.2mg were randomized to receive, after the child's birth, metoclopramide 10mg (Group I - control), droperidol 2.5mg (Group II) or ondansetron 8mg (Group III). Postoperatively, the patients were assessed for pruritus (absent, mild, moderate or severe) or other side effects by blinded investigators. Patients were also blinded to their group allocation. The tendency to present more severe forms of pruritus was compared between groups. NNT was also determined. RESULTS: Patients assigned to receive droperidol [Proportional odds ratio: 0.45 (95% confidence interval 0.23-0.88)] reported less pruritus than those who received metoclopramide. Ondansetron effect was similar to metoclopramide [Proportional odds ratio: 0.95 (95% confidence interval 0.49-1.83)]. The NNT for droperidol and ondansetron was 4.0 and 14.7, respectively. CONCLUSIONS: Ondansetron does not inhibit subarachnoid morphine-induced pruritus.Anesthesiology, Universidade Católica de Pelotas (UCPel), Pelotas, RS, Brazil. Electronic address: marciolealhorta@gmail.comAnesthesiology, Universidade Católica de Pelotas (UCPel), Pelotas, RS, BrazilEpidemiology, Universidade Federal de Pelotas (UFPel), Pelotas, RS, BrazilUniversidade Estadual Paulista, Faculdade de Medicina de Botucatu (UNESP), Pelotas, RS, BrazilUniversidade Católica de Pelotas (UCPel), Pelotas, RS, BrazilUniversidade Federal de Pernambuco (UFPE)Universidade Estadual Paulista (Unesp)Brião, Fabio Ferreira da CunhaHorta, Marcio LealHorta, Bernardo Lessade Barros, Guilherme Antônio MoreiraBehrensdorf, Ana PaulaSevero, IngridNunes, Mariana AntunesBoabaid, RobertaReal, André2018-12-11T16:46:47Z2018-12-11T16:46:47Z2015-07-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article244-248application/pdfhttp://dx.doi.org/10.1016/j.bjane.2013.11.005Brazilian journal of anesthesiology (Elsevier), v. 65, n. 4, p. 244-248, 2015.0104-0014http://hdl.handle.net/11449/16960110.1016/j.bjane.2013.11.0052-s2.0-850169244192-s2.0-85016924419.pdfScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengBrazilian journal of anesthesiology (Elsevier)0,288info:eu-repo/semantics/openAccess2024-01-24T06:36:18Zoai:repositorio.unesp.br:11449/169601Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T23:52:36.465824Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Comparison of droperidol and ondansetron prophylactic effect on subarachnoid morphine-induced pruritus |
title |
Comparison of droperidol and ondansetron prophylactic effect on subarachnoid morphine-induced pruritus |
spellingShingle |
Comparison of droperidol and ondansetron prophylactic effect on subarachnoid morphine-induced pruritus Brião, Fabio Ferreira da Cunha Droperidol Injeção subaracnoidea Morfina Morphine Ondansetron Prurido Pruritus Subarachnoid injection |
title_short |
Comparison of droperidol and ondansetron prophylactic effect on subarachnoid morphine-induced pruritus |
title_full |
Comparison of droperidol and ondansetron prophylactic effect on subarachnoid morphine-induced pruritus |
title_fullStr |
Comparison of droperidol and ondansetron prophylactic effect on subarachnoid morphine-induced pruritus |
title_full_unstemmed |
Comparison of droperidol and ondansetron prophylactic effect on subarachnoid morphine-induced pruritus |
title_sort |
Comparison of droperidol and ondansetron prophylactic effect on subarachnoid morphine-induced pruritus |
author |
Brião, Fabio Ferreira da Cunha |
author_facet |
Brião, Fabio Ferreira da Cunha Horta, Marcio Leal Horta, Bernardo Lessa de Barros, Guilherme Antônio Moreira Behrensdorf, Ana Paula Severo, Ingrid Nunes, Mariana Antunes Boabaid, Roberta Real, André |
author_role |
author |
author2 |
Horta, Marcio Leal Horta, Bernardo Lessa de Barros, Guilherme Antônio Moreira Behrensdorf, Ana Paula Severo, Ingrid Nunes, Mariana Antunes Boabaid, Roberta Real, André |
author2_role |
author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Federal de Pernambuco (UFPE) Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Brião, Fabio Ferreira da Cunha Horta, Marcio Leal Horta, Bernardo Lessa de Barros, Guilherme Antônio Moreira Behrensdorf, Ana Paula Severo, Ingrid Nunes, Mariana Antunes Boabaid, Roberta Real, André |
dc.subject.por.fl_str_mv |
Droperidol Injeção subaracnoidea Morfina Morphine Ondansetron Prurido Pruritus Subarachnoid injection |
topic |
Droperidol Injeção subaracnoidea Morfina Morphine Ondansetron Prurido Pruritus Subarachnoid injection |
description |
BACKGROUND AND OBJECTIVES: The prophylactic effect of ondansetron on subarachnoid morphine-induced pruritus is controversial, while evidence suggests that droperidol prevents pruritus. The aim of this study is to compare the effects of droperidol and ondansetron on subarachnoid morphine-induced pruritus. METHODS: 180 ASA I or II patients scheduled to undergo cesarean sections under subarachnoid anesthesia combined with morphine 0.2mg were randomized to receive, after the child's birth, metoclopramide 10mg (Group I - control), droperidol 2.5mg (Group II) or ondansetron 8mg (Group III). Postoperatively, the patients were assessed for pruritus (absent, mild, moderate or severe) or other side effects by blinded investigators. Patients were also blinded to their group allocation. The tendency to present more severe forms of pruritus was compared between groups. NNT was also determined. RESULTS: Patients assigned to receive droperidol [Proportional odds ratio: 0.45 (95% confidence interval 0.23-0.88)] reported less pruritus than those who received metoclopramide. Ondansetron effect was similar to metoclopramide [Proportional odds ratio: 0.95 (95% confidence interval 0.49-1.83)]. The NNT for droperidol and ondansetron was 4.0 and 14.7, respectively. CONCLUSIONS: Ondansetron does not inhibit subarachnoid morphine-induced pruritus. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-07-01 2018-12-11T16:46:47Z 2018-12-11T16:46:47Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.bjane.2013.11.005 Brazilian journal of anesthesiology (Elsevier), v. 65, n. 4, p. 244-248, 2015. 0104-0014 http://hdl.handle.net/11449/169601 10.1016/j.bjane.2013.11.005 2-s2.0-85016924419 2-s2.0-85016924419.pdf |
url |
http://dx.doi.org/10.1016/j.bjane.2013.11.005 http://hdl.handle.net/11449/169601 |
identifier_str_mv |
Brazilian journal of anesthesiology (Elsevier), v. 65, n. 4, p. 244-248, 2015. 0104-0014 10.1016/j.bjane.2013.11.005 2-s2.0-85016924419 2-s2.0-85016924419.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Brazilian journal of anesthesiology (Elsevier) 0,288 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
244-248 application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808129560910233600 |