Polymeric micelles-mediated photodynamic therapy

Detalhes bibliográficos
Autor(a) principal: de Santana, Willian Max O.S. [UNESP]
Data de Publicação: 2023
Outros Autores: Pochapski, Daniel José [UNESP], Pulcinelli, Sandra H. [UNESP], Fontana, Carla Raquel [UNESP], Santilli, Celso V. [UNESP]
Tipo de documento: Capítulo de livro
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1016/B978-0-323-85595-2.00003-7
http://hdl.handle.net/11449/249767
Resumo: Polymeric micelles (PM) have been demonstrating high potential as multifunctional therapeutic nanoplatforms for anticancer photodynamic therapy (PDT). PM increase photosensitizer (PS) accumulation in tumor tissues, thus improving its antitumor effect. The development of PM responsive to endogenous (e.g., pH, reducing agents, and hypoxia) or exogenous (e.g., light) stimuli makes these polymeric structures even more versatile, since the delivery of PS to the target tissue occurs with good spatio-temporal control. This chapter covers the application of PM in PDT, focusing on targeting and stimulus-responsiveness release strategies. Our discussion will be based on the physical-chemical properties of the PM and the interaction of these carriers with biological systems.
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spelling Polymeric micelles-mediated photodynamic therapycancer therapynanocarriersorganic nanoparticlesPhotodynamic therapypolymeric micellespolymeric nanoparticlesstimuli-responsive nanoparticlesPolymeric micelles (PM) have been demonstrating high potential as multifunctional therapeutic nanoplatforms for anticancer photodynamic therapy (PDT). PM increase photosensitizer (PS) accumulation in tumor tissues, thus improving its antitumor effect. The development of PM responsive to endogenous (e.g., pH, reducing agents, and hypoxia) or exogenous (e.g., light) stimuli makes these polymeric structures even more versatile, since the delivery of PS to the target tissue occurs with good spatio-temporal control. This chapter covers the application of PM in PDT, focusing on targeting and stimulus-responsiveness release strategies. Our discussion will be based on the physical-chemical properties of the PM and the interaction of these carriers with biological systems.Institute of Chemistry São Paulo State University (UNESP), SPSchool of Pharmaceutical Sciences São Paulo State University (UNESP), SPInstitute of Chemistry São Paulo State University (UNESP), SPSchool of Pharmaceutical Sciences São Paulo State University (UNESP), SPUniversidade Estadual Paulista (UNESP)de Santana, Willian Max O.S. [UNESP]Pochapski, Daniel José [UNESP]Pulcinelli, Sandra H. [UNESP]Fontana, Carla Raquel [UNESP]Santilli, Celso V. [UNESP]2023-07-29T16:08:39Z2023-07-29T16:08:39Z2023-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/bookPart105-139http://dx.doi.org/10.1016/B978-0-323-85595-2.00003-7Nanomaterials for Photodynamic Therapy, p. 105-139.http://hdl.handle.net/11449/24976710.1016/B978-0-323-85595-2.00003-72-s2.0-85150125570Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengNanomaterials for Photodynamic Therapyinfo:eu-repo/semantics/openAccess2023-07-29T16:08:39Zoai:repositorio.unesp.br:11449/249767Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T16:58:57.655518Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Polymeric micelles-mediated photodynamic therapy
title Polymeric micelles-mediated photodynamic therapy
spellingShingle Polymeric micelles-mediated photodynamic therapy
de Santana, Willian Max O.S. [UNESP]
cancer therapy
nanocarriers
organic nanoparticles
Photodynamic therapy
polymeric micelles
polymeric nanoparticles
stimuli-responsive nanoparticles
title_short Polymeric micelles-mediated photodynamic therapy
title_full Polymeric micelles-mediated photodynamic therapy
title_fullStr Polymeric micelles-mediated photodynamic therapy
title_full_unstemmed Polymeric micelles-mediated photodynamic therapy
title_sort Polymeric micelles-mediated photodynamic therapy
author de Santana, Willian Max O.S. [UNESP]
author_facet de Santana, Willian Max O.S. [UNESP]
Pochapski, Daniel José [UNESP]
Pulcinelli, Sandra H. [UNESP]
Fontana, Carla Raquel [UNESP]
Santilli, Celso V. [UNESP]
author_role author
author2 Pochapski, Daniel José [UNESP]
Pulcinelli, Sandra H. [UNESP]
Fontana, Carla Raquel [UNESP]
Santilli, Celso V. [UNESP]
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (UNESP)
dc.contributor.author.fl_str_mv de Santana, Willian Max O.S. [UNESP]
Pochapski, Daniel José [UNESP]
Pulcinelli, Sandra H. [UNESP]
Fontana, Carla Raquel [UNESP]
Santilli, Celso V. [UNESP]
dc.subject.por.fl_str_mv cancer therapy
nanocarriers
organic nanoparticles
Photodynamic therapy
polymeric micelles
polymeric nanoparticles
stimuli-responsive nanoparticles
topic cancer therapy
nanocarriers
organic nanoparticles
Photodynamic therapy
polymeric micelles
polymeric nanoparticles
stimuli-responsive nanoparticles
description Polymeric micelles (PM) have been demonstrating high potential as multifunctional therapeutic nanoplatforms for anticancer photodynamic therapy (PDT). PM increase photosensitizer (PS) accumulation in tumor tissues, thus improving its antitumor effect. The development of PM responsive to endogenous (e.g., pH, reducing agents, and hypoxia) or exogenous (e.g., light) stimuli makes these polymeric structures even more versatile, since the delivery of PS to the target tissue occurs with good spatio-temporal control. This chapter covers the application of PM in PDT, focusing on targeting and stimulus-responsiveness release strategies. Our discussion will be based on the physical-chemical properties of the PM and the interaction of these carriers with biological systems.
publishDate 2023
dc.date.none.fl_str_mv 2023-07-29T16:08:39Z
2023-07-29T16:08:39Z
2023-01-01
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/bookPart
format bookPart
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1016/B978-0-323-85595-2.00003-7
Nanomaterials for Photodynamic Therapy, p. 105-139.
http://hdl.handle.net/11449/249767
10.1016/B978-0-323-85595-2.00003-7
2-s2.0-85150125570
url http://dx.doi.org/10.1016/B978-0-323-85595-2.00003-7
http://hdl.handle.net/11449/249767
identifier_str_mv Nanomaterials for Photodynamic Therapy, p. 105-139.
10.1016/B978-0-323-85595-2.00003-7
2-s2.0-85150125570
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Nanomaterials for Photodynamic Therapy
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 105-139
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
_version_ 1808128729388417024

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