Relationship between chronological and bone ages and pubertal stage of breasts with bone biomarkers and bone mineral density in adolescents
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.jped.2014.04.008 http://hdl.handle.net/11449/114485 |
Resumo: | OBJECTIVE:To study bone mineral density (BMD) in adolescent females according to five groups of chronological age (CA), bone age (BA), and breast development stage (B), and to correlate these parameters with plasma bone biomarkers (BB).METHODS:This was a cross-sectional study performed in 101 healthy adolescent females between 10 and 20 years old. The study variables were: weight, height, body mass index (BMI), CA, B, BA, calcium intake, BMD, and BB. Osteocalcin (OC), bone alkaline phosphatase (BAP), and C-terminal telopeptide (S-CTx) were evaluated for BB. BMD was measured using dual energy X-ray absorptiometry (DXA).RESULTS:BMD in lumbar spine, proximal femur, and total body increased with age, and the respective observed averages were: in CA1 (10 years old), 0.631, 0.692, 0.798 g/cm2; in CA2 (11 to 12 years old), 0.698, 0.763, 0.840 g/cm2; in CA3 (13 to 14 years old), 0.865, 0.889, 0.972 g/cm2; in CA4 (15 to 16 years old), 0.902, 0.922, 1.013 g/cm2; and in CA5 (17 to 19 years old), 0.944, 0.929, 1.35 g/cm2. These results showed significant differences between 13 and 14 years of age (CA3) or when girls reached the B3 stage (0.709, 0.832, 0.867 g/cm2). The highest median concentrations of BB were between 10 and 12 years of age when adolescents were in the B2-B3 (p < 0.001). Median BB concentrations decreased in advanced BA and B.CONCLUSIONS:BB concentrations were positively correlated with the peak height velocity and negatively correlated with BMD in the study sites. Increased BMD and BB concentrations were observed in B3. |
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Relationship between chronological and bone ages and pubertal stage of breasts with bone biomarkers and bone mineral density in adolescentsRelação entre as idades cronológica e óssea e o estágio puberal das mamas com os biomarcadores ósseos e a densidade mineral óssea em adolescentesAdolescentsBone mineral densityBone mineralizationBone remodelingBone reabsorptionOsteocalcinOsteoporosisGrowthBone healthAdolescentesDensidade mineral ósseaMineralização ósseaRemodelação ósseaReabsorção ósseaOsteocalcinaOsteoporoseCrescimentoSaúde ósseaOBJECTIVE:To study bone mineral density (BMD) in adolescent females according to five groups of chronological age (CA), bone age (BA), and breast development stage (B), and to correlate these parameters with plasma bone biomarkers (BB).METHODS:This was a cross-sectional study performed in 101 healthy adolescent females between 10 and 20 years old. The study variables were: weight, height, body mass index (BMI), CA, B, BA, calcium intake, BMD, and BB. Osteocalcin (OC), bone alkaline phosphatase (BAP), and C-terminal telopeptide (S-CTx) were evaluated for BB. BMD was measured using dual energy X-ray absorptiometry (DXA).RESULTS:BMD in lumbar spine, proximal femur, and total body increased with age, and the respective observed averages were: in CA1 (10 years old), 0.631, 0.692, 0.798 g/cm2; in CA2 (11 to 12 years old), 0.698, 0.763, 0.840 g/cm2; in CA3 (13 to 14 years old), 0.865, 0.889, 0.972 g/cm2; in CA4 (15 to 16 years old), 0.902, 0.922, 1.013 g/cm2; and in CA5 (17 to 19 years old), 0.944, 0.929, 1.35 g/cm2. These results showed significant differences between 13 and 14 years of age (CA3) or when girls reached the B3 stage (0.709, 0.832, 0.867 g/cm2). The highest median concentrations of BB were between 10 and 12 years of age when adolescents were in the B2-B3 (p < 0.001). Median BB concentrations decreased in advanced BA and B.CONCLUSIONS:BB concentrations were positively correlated with the peak height velocity and negatively correlated with BMD in the study sites. Increased BMD and BB concentrations were observed in B3.Objetivo Avaliar a densidade mineral óssea (DMO) em adolescentes do sexo feminino de acordo com a idade cronológica (IC), idade óssea (IO) e desenvolvimento das mamas (M) e suas correlações com biomarcadores de remodelação óssea em plasma (BO). Métodos Este foi um estudo transversal prospectivo feito em 101 adolescentes saudáveis do sexo feminino com idade entre 10 e 20 anos. As variáveis estudadas foram: peso, altura, índice de massa corpórea (IMC), IC, IO, M, ingestão de cálcio, DMO e BO. A osteocalcina (OC), fosfatase alcalina óssea (BAP) e o telopeptídeo C terminal (S-CTx) foram os biomarcadores de remodelação óssea avaliados. A DMO foi obtida por absorciometria de raios-X de dupla energia (DXA). Resultados A DMO de coluna lombar, fêmur proximal e corpo total aumentou com a idade, e as respectivas médias observadas foram: IC1 = 0,631, 0.692, 0,798 g/cm2; IC2, 0,698, 0,763, 0,840 g/cm2; IC3, 0,865, 0,889, 0,972 g/cm2; IC4, 0,902, 0,922, 1,013 g/cm2; e IC5, 0,944, 0,929, 1,35 g/cm2. Observou-se diferença significativa entre 13 e 14 anos (IC3) ou quando as meninas estavam em M3 (0,709, 0,832, 0,867 g/cm2). Os valores dos BO apresentaram elevação entre 10 e 12 anos e quando as adolescentes estavam em M2–M3 (p < 0,001). Os valores das medianas dos BO diminuíram com o avançar da IO e M. Conclusões Os BOs mostraram paralelismo com o pico de velocidade de crescimento e demonstraram correlação negativa com a DMO no sítios avaliados. O aumento da DMO e dos BOs foi observado em M3.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Universidade Estadual Paulista Botucatu Medical School Department of PediatricsUniversidade Estadual Paulista Botucatu Medical School Graduate Program in Gynecology, Obstetrics, and MastologyUniversidade Estadual do Norte do Paraná Department of Physical EducationUniversidade Estadual Paulista Botucatu Medical School Tropical Diseases and Image Diagnosis DepartmentUniversidade Estadual Paulista Botucatu Medical SchoolUniversidade Estadual Paulista Botucatu Medical School Department of PediatricsUniversidade Estadual Paulista Botucatu Medical School Graduate Program in Gynecology, Obstetrics, and MastologyUniversidade Estadual Paulista Botucatu Medical School Tropical Diseases and Image Diagnosis DepartmentUniversidade Estadual Paulista Botucatu Medical SchoolSociedade Brasileira de PediatriaUniversidade Estadual Paulista (Unesp)Universidade Estadual do Norte do Paraná (UENP)Fortes, Cristina Maria TeixeiraGoldberg, Tamara Beres Lederer [UNESP]Kurokawa, Cilmery Suemi [UNESP]Silva, Carla CristianiMoretto, Maria ReginaBiason, Talita PoliTeixeira, Altamir Santos [UNESP]Nunes, Hélio Rubens De Carvalho2015-02-02T12:39:35Z2015-02-02T12:39:35Z2014-12-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article624-631application/pdfhttp://dx.doi.org/10.1016/j.jped.2014.04.008Jornal de Pediatria. Sociedade Brasileira de Pediatria, v. 90, n. 6, p. 624-631, 2014.0021-7557http://hdl.handle.net/11449/11448510.1016/j.jped.2014.04.008S0021-75572014000600624S0021-75572014000600624.pdf721483485926039785104232695404650000-0001-7017-766X0000-0003-1380-7527SciELOreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJornal de Pediatria1.6900,704info:eu-repo/semantics/openAccess2024-09-03T13:47:03Zoai:repositorio.unesp.br:11449/114485Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestrepositoriounesp@unesp.bropendoar:29462024-09-03T13:47:03Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Relationship between chronological and bone ages and pubertal stage of breasts with bone biomarkers and bone mineral density in adolescents Relação entre as idades cronológica e óssea e o estágio puberal das mamas com os biomarcadores ósseos e a densidade mineral óssea em adolescentes |
title |
Relationship between chronological and bone ages and pubertal stage of breasts with bone biomarkers and bone mineral density in adolescents |
spellingShingle |
Relationship between chronological and bone ages and pubertal stage of breasts with bone biomarkers and bone mineral density in adolescents Fortes, Cristina Maria Teixeira Adolescents Bone mineral density Bone mineralization Bone remodeling Bone reabsorption Osteocalcin Osteoporosis Growth Bone health Adolescentes Densidade mineral óssea Mineralização óssea Remodelação óssea Reabsorção óssea Osteocalcina Osteoporose Crescimento Saúde óssea |
title_short |
Relationship between chronological and bone ages and pubertal stage of breasts with bone biomarkers and bone mineral density in adolescents |
title_full |
Relationship between chronological and bone ages and pubertal stage of breasts with bone biomarkers and bone mineral density in adolescents |
title_fullStr |
Relationship between chronological and bone ages and pubertal stage of breasts with bone biomarkers and bone mineral density in adolescents |
title_full_unstemmed |
Relationship between chronological and bone ages and pubertal stage of breasts with bone biomarkers and bone mineral density in adolescents |
title_sort |
Relationship between chronological and bone ages and pubertal stage of breasts with bone biomarkers and bone mineral density in adolescents |
author |
Fortes, Cristina Maria Teixeira |
author_facet |
Fortes, Cristina Maria Teixeira Goldberg, Tamara Beres Lederer [UNESP] Kurokawa, Cilmery Suemi [UNESP] Silva, Carla Cristiani Moretto, Maria Regina Biason, Talita Poli Teixeira, Altamir Santos [UNESP] Nunes, Hélio Rubens De Carvalho |
author_role |
author |
author2 |
Goldberg, Tamara Beres Lederer [UNESP] Kurokawa, Cilmery Suemi [UNESP] Silva, Carla Cristiani Moretto, Maria Regina Biason, Talita Poli Teixeira, Altamir Santos [UNESP] Nunes, Hélio Rubens De Carvalho |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Universidade Estadual do Norte do Paraná (UENP) |
dc.contributor.author.fl_str_mv |
Fortes, Cristina Maria Teixeira Goldberg, Tamara Beres Lederer [UNESP] Kurokawa, Cilmery Suemi [UNESP] Silva, Carla Cristiani Moretto, Maria Regina Biason, Talita Poli Teixeira, Altamir Santos [UNESP] Nunes, Hélio Rubens De Carvalho |
dc.subject.por.fl_str_mv |
Adolescents Bone mineral density Bone mineralization Bone remodeling Bone reabsorption Osteocalcin Osteoporosis Growth Bone health Adolescentes Densidade mineral óssea Mineralização óssea Remodelação óssea Reabsorção óssea Osteocalcina Osteoporose Crescimento Saúde óssea |
topic |
Adolescents Bone mineral density Bone mineralization Bone remodeling Bone reabsorption Osteocalcin Osteoporosis Growth Bone health Adolescentes Densidade mineral óssea Mineralização óssea Remodelação óssea Reabsorção óssea Osteocalcina Osteoporose Crescimento Saúde óssea |
description |
OBJECTIVE:To study bone mineral density (BMD) in adolescent females according to five groups of chronological age (CA), bone age (BA), and breast development stage (B), and to correlate these parameters with plasma bone biomarkers (BB).METHODS:This was a cross-sectional study performed in 101 healthy adolescent females between 10 and 20 years old. The study variables were: weight, height, body mass index (BMI), CA, B, BA, calcium intake, BMD, and BB. Osteocalcin (OC), bone alkaline phosphatase (BAP), and C-terminal telopeptide (S-CTx) were evaluated for BB. BMD was measured using dual energy X-ray absorptiometry (DXA).RESULTS:BMD in lumbar spine, proximal femur, and total body increased with age, and the respective observed averages were: in CA1 (10 years old), 0.631, 0.692, 0.798 g/cm2; in CA2 (11 to 12 years old), 0.698, 0.763, 0.840 g/cm2; in CA3 (13 to 14 years old), 0.865, 0.889, 0.972 g/cm2; in CA4 (15 to 16 years old), 0.902, 0.922, 1.013 g/cm2; and in CA5 (17 to 19 years old), 0.944, 0.929, 1.35 g/cm2. These results showed significant differences between 13 and 14 years of age (CA3) or when girls reached the B3 stage (0.709, 0.832, 0.867 g/cm2). The highest median concentrations of BB were between 10 and 12 years of age when adolescents were in the B2-B3 (p < 0.001). Median BB concentrations decreased in advanced BA and B.CONCLUSIONS:BB concentrations were positively correlated with the peak height velocity and negatively correlated with BMD in the study sites. Increased BMD and BB concentrations were observed in B3. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014-12-01 2015-02-02T12:39:35Z 2015-02-02T12:39:35Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.jped.2014.04.008 Jornal de Pediatria. Sociedade Brasileira de Pediatria, v. 90, n. 6, p. 624-631, 2014. 0021-7557 http://hdl.handle.net/11449/114485 10.1016/j.jped.2014.04.008 S0021-75572014000600624 S0021-75572014000600624.pdf 7214834859260397 8510423269540465 0000-0001-7017-766X 0000-0003-1380-7527 |
url |
http://dx.doi.org/10.1016/j.jped.2014.04.008 http://hdl.handle.net/11449/114485 |
identifier_str_mv |
Jornal de Pediatria. Sociedade Brasileira de Pediatria, v. 90, n. 6, p. 624-631, 2014. 0021-7557 10.1016/j.jped.2014.04.008 S0021-75572014000600624 S0021-75572014000600624.pdf 7214834859260397 8510423269540465 0000-0001-7017-766X 0000-0003-1380-7527 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Jornal de Pediatria 1.690 0,704 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
624-631 application/pdf |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Pediatria |
publisher.none.fl_str_mv |
Sociedade Brasileira de Pediatria |
dc.source.none.fl_str_mv |
SciELO reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
repositoriounesp@unesp.br |
_version_ |
1810021413391695872 |