Exposição de fibroblastos provenientes de pterígios recidivados e da cápsula de Tenon normal ao tacrolimus (FK-506)

Detalhes bibliográficos
Autor(a) principal: de Carvalho, Clodomir S.C. [UNESP]
Data de Publicação: 2007
Outros Autores: Viveiros, Magda Massae Hata [UNESP], Schellini, Silvana Artioli [UNESP], Candeias, João Manoel Grisi [UNESP], Padovani, Carlos Roberto [UNESP]
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://hdl.handle.net/11449/224916
Resumo: Purpose: To evaluate fibroblast proliferation activity of normal Tenon's capsule and of recurrent pterygia exposed in vitro to tacrolimus (FK506). Methods: A randomized prospective study was performed with 8 samples of recurrent pterygia and 6 samples of normal Tenon's capsule from the same patient with pterygium at the Faculdade de Medicina de Botucatu - UNESP. The samples were cultivated and exposed once to 1M tacrolimus (FK 506) and the proliferation rate was evaluated 1, 5, 12 and 19 days after the exposure. The data were statistically analyzed. Results: The fibroblasts from pterygia exposed in vitro to tacrolimus had a significantly lower proliferation rate than controls after one day of exposure (p<0.05). Nineteen days after exposure to tacrolimus, exposed cells proliferated more than the non-exposed. Conclusion: Tacrolimus is effective to inhibit proliferation of Tenon's capsule fibroblasts from pterygia one day after exposure. Further studies are needed to define the role of tacrolimus in pterygium treatment.
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spelling Exposição de fibroblastos provenientes de pterígios recidivados e da cápsula de Tenon normal ao tacrolimus (FK-506)Fibroblasts from recurrent pterygium and normal Tenon's capsule exposed to tacrolimus (FK-506)Cell culture techniquesCell proliferationFibroblasts/pathologyPterygium/pathologyRecurrenceTacrolimus/therapeutic usePurpose: To evaluate fibroblast proliferation activity of normal Tenon's capsule and of recurrent pterygia exposed in vitro to tacrolimus (FK506). Methods: A randomized prospective study was performed with 8 samples of recurrent pterygia and 6 samples of normal Tenon's capsule from the same patient with pterygium at the Faculdade de Medicina de Botucatu - UNESP. The samples were cultivated and exposed once to 1M tacrolimus (FK 506) and the proliferation rate was evaluated 1, 5, 12 and 19 days after the exposure. The data were statistically analyzed. Results: The fibroblasts from pterygia exposed in vitro to tacrolimus had a significantly lower proliferation rate than controls after one day of exposure (p<0.05). Nineteen days after exposure to tacrolimus, exposed cells proliferated more than the non-exposed. Conclusion: Tacrolimus is effective to inhibit proliferation of Tenon's capsule fibroblasts from pterygia one day after exposure. Further studies are needed to define the role of tacrolimus in pterygium treatment.Depto. de Oftalmologia Otorrinolargingologia e Cirurgia de Cabeça e Pescoço Faculdade de Medicina UNESP, Botucatu, SP 18618-970UNESP, Botucatu, SP 18618-970Departamento de Imunologia Faculdade de Medicina UNESP, Botucatu, SP 18618-970Departamento de Bioestatística Instituto de Biociências UNESP, Botucatu, SP 18618-970Depto. de Oftalmologia Otorrinolargingologia e Cirurgia de Cabeça e Pescoço Faculdade de Medicina UNESP, Botucatu, SP 18618-970UNESP, Botucatu, SP 18618-970Departamento de Imunologia Faculdade de Medicina UNESP, Botucatu, SP 18618-970Departamento de Bioestatística Instituto de Biociências UNESP, Botucatu, SP 18618-970Universidade Estadual Paulista (UNESP)de Carvalho, Clodomir S.C. [UNESP]Viveiros, Magda Massae Hata [UNESP]Schellini, Silvana Artioli [UNESP]Candeias, João Manoel Grisi [UNESP]Padovani, Carlos Roberto [UNESP]2022-04-28T20:17:21Z2022-04-28T20:17:21Z2007-03-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article235-238Arquivos Brasileiros de Oftalmologia, v. 70, n. 2, p. 235-238, 2007.0004-27491678-2925http://hdl.handle.net/11449/2249162-s2.0-34249942082Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPporArquivos Brasileiros de Oftalmologiainfo:eu-repo/semantics/openAccess2024-08-16T18:44:31Zoai:repositorio.unesp.br:11449/224916Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-16T18:44:31Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Exposição de fibroblastos provenientes de pterígios recidivados e da cápsula de Tenon normal ao tacrolimus (FK-506)
Fibroblasts from recurrent pterygium and normal Tenon's capsule exposed to tacrolimus (FK-506)
title Exposição de fibroblastos provenientes de pterígios recidivados e da cápsula de Tenon normal ao tacrolimus (FK-506)
spellingShingle Exposição de fibroblastos provenientes de pterígios recidivados e da cápsula de Tenon normal ao tacrolimus (FK-506)
de Carvalho, Clodomir S.C. [UNESP]
Cell culture techniques
Cell proliferation
Fibroblasts/pathology
Pterygium/pathology
Recurrence
Tacrolimus/therapeutic use
title_short Exposição de fibroblastos provenientes de pterígios recidivados e da cápsula de Tenon normal ao tacrolimus (FK-506)
title_full Exposição de fibroblastos provenientes de pterígios recidivados e da cápsula de Tenon normal ao tacrolimus (FK-506)
title_fullStr Exposição de fibroblastos provenientes de pterígios recidivados e da cápsula de Tenon normal ao tacrolimus (FK-506)
title_full_unstemmed Exposição de fibroblastos provenientes de pterígios recidivados e da cápsula de Tenon normal ao tacrolimus (FK-506)
title_sort Exposição de fibroblastos provenientes de pterígios recidivados e da cápsula de Tenon normal ao tacrolimus (FK-506)
author de Carvalho, Clodomir S.C. [UNESP]
author_facet de Carvalho, Clodomir S.C. [UNESP]
Viveiros, Magda Massae Hata [UNESP]
Schellini, Silvana Artioli [UNESP]
Candeias, João Manoel Grisi [UNESP]
Padovani, Carlos Roberto [UNESP]
author_role author
author2 Viveiros, Magda Massae Hata [UNESP]
Schellini, Silvana Artioli [UNESP]
Candeias, João Manoel Grisi [UNESP]
Padovani, Carlos Roberto [UNESP]
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (UNESP)
dc.contributor.author.fl_str_mv de Carvalho, Clodomir S.C. [UNESP]
Viveiros, Magda Massae Hata [UNESP]
Schellini, Silvana Artioli [UNESP]
Candeias, João Manoel Grisi [UNESP]
Padovani, Carlos Roberto [UNESP]
dc.subject.por.fl_str_mv Cell culture techniques
Cell proliferation
Fibroblasts/pathology
Pterygium/pathology
Recurrence
Tacrolimus/therapeutic use
topic Cell culture techniques
Cell proliferation
Fibroblasts/pathology
Pterygium/pathology
Recurrence
Tacrolimus/therapeutic use
description Purpose: To evaluate fibroblast proliferation activity of normal Tenon's capsule and of recurrent pterygia exposed in vitro to tacrolimus (FK506). Methods: A randomized prospective study was performed with 8 samples of recurrent pterygia and 6 samples of normal Tenon's capsule from the same patient with pterygium at the Faculdade de Medicina de Botucatu - UNESP. The samples were cultivated and exposed once to 1M tacrolimus (FK 506) and the proliferation rate was evaluated 1, 5, 12 and 19 days after the exposure. The data were statistically analyzed. Results: The fibroblasts from pterygia exposed in vitro to tacrolimus had a significantly lower proliferation rate than controls after one day of exposure (p<0.05). Nineteen days after exposure to tacrolimus, exposed cells proliferated more than the non-exposed. Conclusion: Tacrolimus is effective to inhibit proliferation of Tenon's capsule fibroblasts from pterygia one day after exposure. Further studies are needed to define the role of tacrolimus in pterygium treatment.
publishDate 2007
dc.date.none.fl_str_mv 2007-03-01
2022-04-28T20:17:21Z
2022-04-28T20:17:21Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv Arquivos Brasileiros de Oftalmologia, v. 70, n. 2, p. 235-238, 2007.
0004-2749
1678-2925
http://hdl.handle.net/11449/224916
2-s2.0-34249942082
identifier_str_mv Arquivos Brasileiros de Oftalmologia, v. 70, n. 2, p. 235-238, 2007.
0004-2749
1678-2925
2-s2.0-34249942082
url http://hdl.handle.net/11449/224916
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv Arquivos Brasileiros de Oftalmologia
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 235-238
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
_version_ 1808128192460881920

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