Assessment of the potential clastogenic/aneugenic risk of Casearia sylvestris extract using in vivo assays

Detalhes bibliográficos
Autor(a) principal: Maistro, Edson Luis [UNESP]
Data de Publicação: 2007
Outros Autores: De Andrade, Sergio Faloni, Puras, Marilane Aparecida [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1508/cytologia.72.401
http://hdl.handle.net/11449/70044
Resumo: Casearia sylvestris (Flacourtiaceae) is a plant which grows in wild and has been widely used in folk medicine. In this study, clastogenic/aneugenic properties of Casearia sylvestris crude ethanolic extract were evaluated using in vivo chromosomal aberrations (CAs) and micronucleus (MN) assays in rodents. The animals were treated by gavage with 3 concentrations of the extract: 150, 300 and 500 mg/kg body weight. Bone marrow cells from Wistar rats were collected 24 h after having been submitted to the MN and CAs test. Peripheral blood cells from Swiss mice were collected 48 and 72 h after having been submitted to the MN test. The results show that C. sylvestris extract does not induce a significant increase in mean values for micronucleated polychromatic erythrocytes (MNPCE) in Swiss mice and Wistar rats, or CAs in rat bone marrow cells, at the 3 tested doses, indicating that the extract showed no clastogenic/aneugenic effects on chromosomes of the rodent cells tested. © 2007 The Japan Mendel Society.
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spelling Assessment of the potential clastogenic/aneugenic risk of Casearia sylvestris extract using in vivo assaysCasearia sylvestrisChromosome aberrationIn vivoMicronucleus testAnimaliaCaseariaFlacourtiaceaeMusRattusRattus norvegicusRodentiaCasearia sylvestris (Flacourtiaceae) is a plant which grows in wild and has been widely used in folk medicine. In this study, clastogenic/aneugenic properties of Casearia sylvestris crude ethanolic extract were evaluated using in vivo chromosomal aberrations (CAs) and micronucleus (MN) assays in rodents. The animals were treated by gavage with 3 concentrations of the extract: 150, 300 and 500 mg/kg body weight. Bone marrow cells from Wistar rats were collected 24 h after having been submitted to the MN and CAs test. Peripheral blood cells from Swiss mice were collected 48 and 72 h after having been submitted to the MN test. The results show that C. sylvestris extract does not induce a significant increase in mean values for micronucleated polychromatic erythrocytes (MNPCE) in Swiss mice and Wistar rats, or CAs in rat bone marrow cells, at the 3 tested doses, indicating that the extract showed no clastogenic/aneugenic effects on chromosomes of the rodent cells tested. © 2007 The Japan Mendel Society.Universidade Estadual Paulista UNESP Departamento de Fonoaudiologia, Marilia, SP 17525-900Núcleo de Investigações Químico- Farmacêuticas (NIQFAR) Universidade do Vale do Itajaí-UNIVALI, Itajaí, Santa CatarinaUniversidade Estadual Paulista UNESP Departamento de Fonoaudiologia, Marilia, SP 17525-900Universidade Estadual Paulista (Unesp)Universidade do Vale do Itajaí-UNIVALIMaistro, Edson Luis [UNESP]De Andrade, Sergio FaloniPuras, Marilane Aparecida [UNESP]2014-05-27T11:22:40Z2014-05-27T11:22:40Z2007-12-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article401-407application/pdfhttp://dx.doi.org/10.1508/cytologia.72.401Cytologia, v. 72, n. 4, p. 401-407, 2007.0011-4545http://hdl.handle.net/11449/7004410.1508/cytologia.72.4012-s2.0-393491070502-s2.0-39349107050.pdf47875216130383150000-0003-0757-7876Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengCytologia0.4810,233info:eu-repo/semantics/openAccess2024-08-09T17:39:29Zoai:repositorio.unesp.br:11449/70044Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestrepositoriounesp@unesp.bropendoar:29462024-08-09T17:39:29Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Assessment of the potential clastogenic/aneugenic risk of Casearia sylvestris extract using in vivo assays
title Assessment of the potential clastogenic/aneugenic risk of Casearia sylvestris extract using in vivo assays
spellingShingle Assessment of the potential clastogenic/aneugenic risk of Casearia sylvestris extract using in vivo assays
Maistro, Edson Luis [UNESP]
Casearia sylvestris
Chromosome aberration
In vivo
Micronucleus test
Animalia
Casearia
Flacourtiaceae
Mus
Rattus
Rattus norvegicus
Rodentia
title_short Assessment of the potential clastogenic/aneugenic risk of Casearia sylvestris extract using in vivo assays
title_full Assessment of the potential clastogenic/aneugenic risk of Casearia sylvestris extract using in vivo assays
title_fullStr Assessment of the potential clastogenic/aneugenic risk of Casearia sylvestris extract using in vivo assays
title_full_unstemmed Assessment of the potential clastogenic/aneugenic risk of Casearia sylvestris extract using in vivo assays
title_sort Assessment of the potential clastogenic/aneugenic risk of Casearia sylvestris extract using in vivo assays
author Maistro, Edson Luis [UNESP]
author_facet Maistro, Edson Luis [UNESP]
De Andrade, Sergio Faloni
Puras, Marilane Aparecida [UNESP]
author_role author
author2 De Andrade, Sergio Faloni
Puras, Marilane Aparecida [UNESP]
author2_role author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
Universidade do Vale do Itajaí-UNIVALI
dc.contributor.author.fl_str_mv Maistro, Edson Luis [UNESP]
De Andrade, Sergio Faloni
Puras, Marilane Aparecida [UNESP]
dc.subject.por.fl_str_mv Casearia sylvestris
Chromosome aberration
In vivo
Micronucleus test
Animalia
Casearia
Flacourtiaceae
Mus
Rattus
Rattus norvegicus
Rodentia
topic Casearia sylvestris
Chromosome aberration
In vivo
Micronucleus test
Animalia
Casearia
Flacourtiaceae
Mus
Rattus
Rattus norvegicus
Rodentia
description Casearia sylvestris (Flacourtiaceae) is a plant which grows in wild and has been widely used in folk medicine. In this study, clastogenic/aneugenic properties of Casearia sylvestris crude ethanolic extract were evaluated using in vivo chromosomal aberrations (CAs) and micronucleus (MN) assays in rodents. The animals were treated by gavage with 3 concentrations of the extract: 150, 300 and 500 mg/kg body weight. Bone marrow cells from Wistar rats were collected 24 h after having been submitted to the MN and CAs test. Peripheral blood cells from Swiss mice were collected 48 and 72 h after having been submitted to the MN test. The results show that C. sylvestris extract does not induce a significant increase in mean values for micronucleated polychromatic erythrocytes (MNPCE) in Swiss mice and Wistar rats, or CAs in rat bone marrow cells, at the 3 tested doses, indicating that the extract showed no clastogenic/aneugenic effects on chromosomes of the rodent cells tested. © 2007 The Japan Mendel Society.
publishDate 2007
dc.date.none.fl_str_mv 2007-12-01
2014-05-27T11:22:40Z
2014-05-27T11:22:40Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1508/cytologia.72.401
Cytologia, v. 72, n. 4, p. 401-407, 2007.
0011-4545
http://hdl.handle.net/11449/70044
10.1508/cytologia.72.401
2-s2.0-39349107050
2-s2.0-39349107050.pdf
4787521613038315
0000-0003-0757-7876
url http://dx.doi.org/10.1508/cytologia.72.401
http://hdl.handle.net/11449/70044
identifier_str_mv Cytologia, v. 72, n. 4, p. 401-407, 2007.
0011-4545
10.1508/cytologia.72.401
2-s2.0-39349107050
2-s2.0-39349107050.pdf
4787521613038315
0000-0003-0757-7876
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Cytologia
0.481
0,233
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 401-407
application/pdf
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv repositoriounesp@unesp.br
_version_ 1826304080705748992

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