An immunogenetic view of COVID-19
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1590/1678-4685-GMB-2021-0036 http://hdl.handle.net/11449/229487 |
Resumo: | Meeting the challenges brought by the COVID-19 pandemic requires an interdisciplinary approach. In this context, integrating knowledge of immune function with an understanding of how genetic variation influences the nature of immunity is a key challenge. Immunogenetics can help explain the heterogeneity of susceptibility and protection to the viral infection and disease progression. Here, we review the knowledge developed so far, discussing fundamental genes for triggering the innate and adaptive immune responses associated with a viral infection, especially with the SARS-CoV-2 mechanisms. We emphasize the role of the HLA and KIR genes, discussing what has been uncovered about their role in COVID-19 and addressing methodological challenges of studying these genes. Finally, we comment on questions that arise when studying admixed populations, highlighting the case of Brazil. We argue that the interplay between immunology and an understanding of genetic associations can provide an important contribution to our knowledge of COVID-19. |
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Repositório Institucional da UNESP |
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An immunogenetic view of COVID-19COVID-19HLAImmunogeneticsKIRSARS-CoV-2Meeting the challenges brought by the COVID-19 pandemic requires an interdisciplinary approach. In this context, integrating knowledge of immune function with an understanding of how genetic variation influences the nature of immunity is a key challenge. Immunogenetics can help explain the heterogeneity of susceptibility and protection to the viral infection and disease progression. Here, we review the knowledge developed so far, discussing fundamental genes for triggering the innate and adaptive immune responses associated with a viral infection, especially with the SARS-CoV-2 mechanisms. We emphasize the role of the HLA and KIR genes, discussing what has been uncovered about their role in COVID-19 and addressing methodological challenges of studying these genes. Finally, we comment on questions that arise when studying admixed populations, highlighting the case of Brazil. We argue that the interplay between immunology and an understanding of genetic associations can provide an important contribution to our knowledge of COVID-19.National Institutes of HealthConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Universidade de São Paulo Departamento de Genética e Biologia EvolutivaUniversity of California UCSF Weill Institute for Neurosciences Department of NeurologyUniversidade Federal do Paraná Departamento de GenéticaUniversidade Estadual Paulista Faculdade de Medicina de Botucatu Departamento de PatologiaUniversidade Estadual Paulista Faculdade de Medicina de Botucatu Departamento de PatologiaNational Institutes of Health: 1R01NS102153CNPq: 308783/2019-0National Institutes of Health: R01 GM075091Universidade de São Paulo (USP)UCSF Weill Institute for NeurosciencesUniversidade Federal do Paraná (UFPR)Universidade Estadual Paulista (UNESP)Aguiar, Vitor R. C.Augusto, Danillo G.Castelli, Erick C. [UNESP]Hollenbach, Jill A.Meyer, DiogoNunes, KellyPetzl-Erler, Maria Luiza2022-04-29T08:32:46Z2022-04-29T08:32:46Z2021-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1590/1678-4685-GMB-2021-0036Genetics and Molecular Biology, v. 44, n. 1, 2021.1678-46851415-4757http://hdl.handle.net/11449/22948710.1590/1678-4685-GMB-2021-00362-s2.0-85114511018Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengGenetics and Molecular Biologyinfo:eu-repo/semantics/openAccess2024-09-03T13:14:31Zoai:repositorio.unesp.br:11449/229487Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestrepositoriounesp@unesp.bropendoar:29462024-09-03T13:14:31Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
An immunogenetic view of COVID-19 |
title |
An immunogenetic view of COVID-19 |
spellingShingle |
An immunogenetic view of COVID-19 Aguiar, Vitor R. C. COVID-19 HLA Immunogenetics KIR SARS-CoV-2 |
title_short |
An immunogenetic view of COVID-19 |
title_full |
An immunogenetic view of COVID-19 |
title_fullStr |
An immunogenetic view of COVID-19 |
title_full_unstemmed |
An immunogenetic view of COVID-19 |
title_sort |
An immunogenetic view of COVID-19 |
author |
Aguiar, Vitor R. C. |
author_facet |
Aguiar, Vitor R. C. Augusto, Danillo G. Castelli, Erick C. [UNESP] Hollenbach, Jill A. Meyer, Diogo Nunes, Kelly Petzl-Erler, Maria Luiza |
author_role |
author |
author2 |
Augusto, Danillo G. Castelli, Erick C. [UNESP] Hollenbach, Jill A. Meyer, Diogo Nunes, Kelly Petzl-Erler, Maria Luiza |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade de São Paulo (USP) UCSF Weill Institute for Neurosciences Universidade Federal do Paraná (UFPR) Universidade Estadual Paulista (UNESP) |
dc.contributor.author.fl_str_mv |
Aguiar, Vitor R. C. Augusto, Danillo G. Castelli, Erick C. [UNESP] Hollenbach, Jill A. Meyer, Diogo Nunes, Kelly Petzl-Erler, Maria Luiza |
dc.subject.por.fl_str_mv |
COVID-19 HLA Immunogenetics KIR SARS-CoV-2 |
topic |
COVID-19 HLA Immunogenetics KIR SARS-CoV-2 |
description |
Meeting the challenges brought by the COVID-19 pandemic requires an interdisciplinary approach. In this context, integrating knowledge of immune function with an understanding of how genetic variation influences the nature of immunity is a key challenge. Immunogenetics can help explain the heterogeneity of susceptibility and protection to the viral infection and disease progression. Here, we review the knowledge developed so far, discussing fundamental genes for triggering the innate and adaptive immune responses associated with a viral infection, especially with the SARS-CoV-2 mechanisms. We emphasize the role of the HLA and KIR genes, discussing what has been uncovered about their role in COVID-19 and addressing methodological challenges of studying these genes. Finally, we comment on questions that arise when studying admixed populations, highlighting the case of Brazil. We argue that the interplay between immunology and an understanding of genetic associations can provide an important contribution to our knowledge of COVID-19. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-01-01 2022-04-29T08:32:46Z 2022-04-29T08:32:46Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/1678-4685-GMB-2021-0036 Genetics and Molecular Biology, v. 44, n. 1, 2021. 1678-4685 1415-4757 http://hdl.handle.net/11449/229487 10.1590/1678-4685-GMB-2021-0036 2-s2.0-85114511018 |
url |
http://dx.doi.org/10.1590/1678-4685-GMB-2021-0036 http://hdl.handle.net/11449/229487 |
identifier_str_mv |
Genetics and Molecular Biology, v. 44, n. 1, 2021. 1678-4685 1415-4757 10.1590/1678-4685-GMB-2021-0036 2-s2.0-85114511018 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Genetics and Molecular Biology |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
repositoriounesp@unesp.br |
_version_ |
1810021363642007552 |