Classic and molecular cytogenetic analyses reveal chromosomal gains and losses correlated with survival in head and neck cancer patients
Autor(a) principal: | |
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Data de Publicação: | 2005 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://hdl.handle.net/11449/224481 |
Resumo: | Purpose: Genetic biomarkers of head and neck tumors could be useful for distinguishing among patients with similar clinical and histopathologic characteristics but having differential probabilities of survival. The purpose of this study was to investigate chromosomal alterations in head and neck carcinomas and to correlate the results with clinical and epidemiologic variables. Experimental Design: Cytogenetic analysis of short-term cultures from 64 primary untreated head and neck squamous cell carcinomas was used to determine the overall pattern of chromosome aberrations. A representative subset of tumors was analyzed in detail by spectral karyotyping and/or confirmatory fluorescence in situ hybridization analysis. Results: Recurrent losses of chromosomes Y (26 cases) and 19 (14 cases), and gains of chromosomes 22 (23 cases), 8 and 20 (11 cases each) were observed. The most frequent structural aberration was del(22)(q13.1) followed by rearrangements involving 6q and 12p. The presence of specific cytogenetic aberrations was found to correlate significantly with an unfavorable outcome. There was a significant association between survival and gains in chromosomes 10 (P = 0.008) and 20 (P = 0.002) and losses of chromosomes 15 (P = 0.005) and 22 (P = 0.021). Univariate analysis indicated that acquisition of monosomy 17 was a significant (P = 9.0012) factor for patients with a previous family history of cancer. Conclusions: The significant associations found in this study emphasize that alterations of distinct regions of the genome may be genetic biomarkers for a poor prognosis. Losses of chromosomes 17 and 22 can be associated with a family history of cancer. |
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Classic and molecular cytogenetic analyses reveal chromosomal gains and losses correlated with survival in head and neck cancer patientsPurpose: Genetic biomarkers of head and neck tumors could be useful for distinguishing among patients with similar clinical and histopathologic characteristics but having differential probabilities of survival. The purpose of this study was to investigate chromosomal alterations in head and neck carcinomas and to correlate the results with clinical and epidemiologic variables. Experimental Design: Cytogenetic analysis of short-term cultures from 64 primary untreated head and neck squamous cell carcinomas was used to determine the overall pattern of chromosome aberrations. A representative subset of tumors was analyzed in detail by spectral karyotyping and/or confirmatory fluorescence in situ hybridization analysis. Results: Recurrent losses of chromosomes Y (26 cases) and 19 (14 cases), and gains of chromosomes 22 (23 cases), 8 and 20 (11 cases each) were observed. The most frequent structural aberration was del(22)(q13.1) followed by rearrangements involving 6q and 12p. The presence of specific cytogenetic aberrations was found to correlate significantly with an unfavorable outcome. There was a significant association between survival and gains in chromosomes 10 (P = 0.008) and 20 (P = 0.002) and losses of chromosomes 15 (P = 0.005) and 22 (P = 0.021). Univariate analysis indicated that acquisition of monosomy 17 was a significant (P = 9.0012) factor for patients with a previous family history of cancer. Conclusions: The significant associations found in this study emphasize that alterations of distinct regions of the genome may be genetic biomarkers for a poor prognosis. Losses of chromosomes 17 and 22 can be associated with a family history of cancer.Department of Genetics Institute of Biosciences São Paulo State University, São PauloDepartment of Urology Faculty of Medicine São Paulo State University, São PauloDept. of Head/Neck Surg./Otorinol. AC Camargo Hospital, São PauloDept. of Cell. and Molecular Biology Princess Margaret Hospital University of Toronto, Toronto, Ont.Department of Urology Faculty of Medicine São Paulo State University, CEP 18618-000, Botucatu, Sao PauloDepartment of Genetics Institute of Biosciences São Paulo State University, São PauloDepartment of Urology Faculty of Medicine São Paulo State University, São PauloDepartment of Urology Faculty of Medicine São Paulo State University, CEP 18618-000, Botucatu, Sao PauloUniversidade Estadual Paulista (UNESP)AC Camargo HospitalUniversity of TorontoBérgamo, Nádia Aparecida [UNESP]Da Silva Veiga, Luciana Caricati [UNESP]Dos Reis, Patricia PintorNishimoto, Inês NobukoMagrin, JoséKowalski, Luiz PauloSquire, Jeremy A.Rogatto, Sílvia Regina [UNESP]2022-04-28T19:56:41Z2022-04-28T19:56:41Z2005-01-15info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article621-631Clinical Cancer Research, v. 11, n. 2 I, p. 621-631, 2005.1078-0432http://hdl.handle.net/11449/2244812-s2.0-12244289921Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengClinical Cancer Researchinfo:eu-repo/semantics/openAccess2024-09-03T14:29:55Zoai:repositorio.unesp.br:11449/224481Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestrepositoriounesp@unesp.bropendoar:29462024-09-03T14:29:55Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Classic and molecular cytogenetic analyses reveal chromosomal gains and losses correlated with survival in head and neck cancer patients |
title |
Classic and molecular cytogenetic analyses reveal chromosomal gains and losses correlated with survival in head and neck cancer patients |
spellingShingle |
Classic and molecular cytogenetic analyses reveal chromosomal gains and losses correlated with survival in head and neck cancer patients Bérgamo, Nádia Aparecida [UNESP] |
title_short |
Classic and molecular cytogenetic analyses reveal chromosomal gains and losses correlated with survival in head and neck cancer patients |
title_full |
Classic and molecular cytogenetic analyses reveal chromosomal gains and losses correlated with survival in head and neck cancer patients |
title_fullStr |
Classic and molecular cytogenetic analyses reveal chromosomal gains and losses correlated with survival in head and neck cancer patients |
title_full_unstemmed |
Classic and molecular cytogenetic analyses reveal chromosomal gains and losses correlated with survival in head and neck cancer patients |
title_sort |
Classic and molecular cytogenetic analyses reveal chromosomal gains and losses correlated with survival in head and neck cancer patients |
author |
Bérgamo, Nádia Aparecida [UNESP] |
author_facet |
Bérgamo, Nádia Aparecida [UNESP] Da Silva Veiga, Luciana Caricati [UNESP] Dos Reis, Patricia Pintor Nishimoto, Inês Nobuko Magrin, José Kowalski, Luiz Paulo Squire, Jeremy A. Rogatto, Sílvia Regina [UNESP] |
author_role |
author |
author2 |
Da Silva Veiga, Luciana Caricati [UNESP] Dos Reis, Patricia Pintor Nishimoto, Inês Nobuko Magrin, José Kowalski, Luiz Paulo Squire, Jeremy A. Rogatto, Sílvia Regina [UNESP] |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (UNESP) AC Camargo Hospital University of Toronto |
dc.contributor.author.fl_str_mv |
Bérgamo, Nádia Aparecida [UNESP] Da Silva Veiga, Luciana Caricati [UNESP] Dos Reis, Patricia Pintor Nishimoto, Inês Nobuko Magrin, José Kowalski, Luiz Paulo Squire, Jeremy A. Rogatto, Sílvia Regina [UNESP] |
description |
Purpose: Genetic biomarkers of head and neck tumors could be useful for distinguishing among patients with similar clinical and histopathologic characteristics but having differential probabilities of survival. The purpose of this study was to investigate chromosomal alterations in head and neck carcinomas and to correlate the results with clinical and epidemiologic variables. Experimental Design: Cytogenetic analysis of short-term cultures from 64 primary untreated head and neck squamous cell carcinomas was used to determine the overall pattern of chromosome aberrations. A representative subset of tumors was analyzed in detail by spectral karyotyping and/or confirmatory fluorescence in situ hybridization analysis. Results: Recurrent losses of chromosomes Y (26 cases) and 19 (14 cases), and gains of chromosomes 22 (23 cases), 8 and 20 (11 cases each) were observed. The most frequent structural aberration was del(22)(q13.1) followed by rearrangements involving 6q and 12p. The presence of specific cytogenetic aberrations was found to correlate significantly with an unfavorable outcome. There was a significant association between survival and gains in chromosomes 10 (P = 0.008) and 20 (P = 0.002) and losses of chromosomes 15 (P = 0.005) and 22 (P = 0.021). Univariate analysis indicated that acquisition of monosomy 17 was a significant (P = 9.0012) factor for patients with a previous family history of cancer. Conclusions: The significant associations found in this study emphasize that alterations of distinct regions of the genome may be genetic biomarkers for a poor prognosis. Losses of chromosomes 17 and 22 can be associated with a family history of cancer. |
publishDate |
2005 |
dc.date.none.fl_str_mv |
2005-01-15 2022-04-28T19:56:41Z 2022-04-28T19:56:41Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
Clinical Cancer Research, v. 11, n. 2 I, p. 621-631, 2005. 1078-0432 http://hdl.handle.net/11449/224481 2-s2.0-12244289921 |
identifier_str_mv |
Clinical Cancer Research, v. 11, n. 2 I, p. 621-631, 2005. 1078-0432 2-s2.0-12244289921 |
url |
http://hdl.handle.net/11449/224481 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Clinical Cancer Research |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
621-631 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
repositoriounesp@unesp.br |
_version_ |
1810021357427097600 |