Effect of continuous and pulsed therapeutic ultrasound in the appearance of local recurrence of mammary cancer in rats

Detalhes bibliográficos
Autor(a) principal: De Rezende, Laura Ferreira
Data de Publicação: 2012
Outros Autores: Da Costa, E.C. Silva, Schenka, N. Guimarães Moraes, Schenka, A. Almeida, Uemura, G. [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://hdl.handle.net/11449/227004
Resumo: Purpose: Ultrasound (US) therapy is an electrothermotherapeutic modality that uses US energy to provoke physical and chemical alterations. US therapy has been widely used in physical therapy. However, in clinical practice, it is contra-indicated in cancer patients due to the possibility of exacerbating tumor growth. Methods: Sixty-eight female Sprague-Dawley rats bred in UNIFAE vivarium were studied. At 50 days of age, 7,12-dimetylbenz(a)anthracene (7,12-DMBA) was administered to 35 rats by gastric gavage to induce mammary cancer. After 90 days the mammary glands of the rats belonging to the group with mammary cancer induction and stimulated by US were removed. Animals received either continuous or pulsed US. US waves were generated at a frequency of 1 MHz during 10 days, with an intensity dose of 0.5 W in the continuous group, and 0.9 W (duty cycle: 20%) in the pulsed group. Results: Among the rats treated with continuous US, 44.4% developed local recurrence, while among the rats treated with pulsed US, 22.2% had local tumor recurrence (p<0.05). No evidence of distant metastases was shown in any of the rats studied. Conclusion: The use of continuous and pulsed therapeutic US promoted the development of local recurrence of mammary cancer in female Sprague-Dawley rats in the postoperative period. © 2012 Zerbinis Medical Publications.
id UNSP_07b9a65f935c064596ad1c0b2a638a04
oai_identifier_str oai:repositorio.unesp.br:11449/227004
network_acronym_str UNSP
network_name_str Repositório Institucional da UNESP
repository_id_str 2946
spelling Effect of continuous and pulsed therapeutic ultrasound in the appearance of local recurrence of mammary cancer in ratsBreast cancerBreast cancer recurrencePhysical therapyTherapeutic ultrasoundPurpose: Ultrasound (US) therapy is an electrothermotherapeutic modality that uses US energy to provoke physical and chemical alterations. US therapy has been widely used in physical therapy. However, in clinical practice, it is contra-indicated in cancer patients due to the possibility of exacerbating tumor growth. Methods: Sixty-eight female Sprague-Dawley rats bred in UNIFAE vivarium were studied. At 50 days of age, 7,12-dimetylbenz(a)anthracene (7,12-DMBA) was administered to 35 rats by gastric gavage to induce mammary cancer. After 90 days the mammary glands of the rats belonging to the group with mammary cancer induction and stimulated by US were removed. Animals received either continuous or pulsed US. US waves were generated at a frequency of 1 MHz during 10 days, with an intensity dose of 0.5 W in the continuous group, and 0.9 W (duty cycle: 20%) in the pulsed group. Results: Among the rats treated with continuous US, 44.4% developed local recurrence, while among the rats treated with pulsed US, 22.2% had local tumor recurrence (p<0.05). No evidence of distant metastases was shown in any of the rats studied. Conclusion: The use of continuous and pulsed therapeutic US promoted the development of local recurrence of mammary cancer in female Sprague-Dawley rats in the postoperative period. © 2012 Zerbinis Medical Publications.Physical Therapy Department Centro Universitário das Faculdades Associadas de Ensino - FAE, São João da Boa Vista, São PauloPharmacology Department Universidade Estadual de Campinas - UNICAMP, Campinas, São PauloObstetrics, Gynecology and Mastology Department Universidade Estadual Paulista - UNESP, Botucatu, São PauloObstetrics, Gynecology and Mastology Department Universidade Estadual Paulista - UNESP, Botucatu, São PauloCentro Universitário das Faculdades Associadas de Ensino - FAEUniversidade Estadual de Campinas (UNICAMP)Universidade Estadual Paulista (UNESP)De Rezende, Laura FerreiraDa Costa, E.C. SilvaSchenka, N. Guimarães MoraesSchenka, A. AlmeidaUemura, G. [UNESP]2022-04-29T05:36:43Z2022-04-29T05:36:43Z2012-07-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article581-584Journal of B.U.ON., v. 17, n. 3, p. 581-584, 2012.1107-0625http://hdl.handle.net/11449/2270042-s2.0-84867549448Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal of B.U.ON.info:eu-repo/semantics/openAccess2024-08-16T14:06:54Zoai:repositorio.unesp.br:11449/227004Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-16T14:06:54Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Effect of continuous and pulsed therapeutic ultrasound in the appearance of local recurrence of mammary cancer in rats
title Effect of continuous and pulsed therapeutic ultrasound in the appearance of local recurrence of mammary cancer in rats
spellingShingle Effect of continuous and pulsed therapeutic ultrasound in the appearance of local recurrence of mammary cancer in rats
De Rezende, Laura Ferreira
Breast cancer
Breast cancer recurrence
Physical therapy
Therapeutic ultrasound
title_short Effect of continuous and pulsed therapeutic ultrasound in the appearance of local recurrence of mammary cancer in rats
title_full Effect of continuous and pulsed therapeutic ultrasound in the appearance of local recurrence of mammary cancer in rats
title_fullStr Effect of continuous and pulsed therapeutic ultrasound in the appearance of local recurrence of mammary cancer in rats
title_full_unstemmed Effect of continuous and pulsed therapeutic ultrasound in the appearance of local recurrence of mammary cancer in rats
title_sort Effect of continuous and pulsed therapeutic ultrasound in the appearance of local recurrence of mammary cancer in rats
author De Rezende, Laura Ferreira
author_facet De Rezende, Laura Ferreira
Da Costa, E.C. Silva
Schenka, N. Guimarães Moraes
Schenka, A. Almeida
Uemura, G. [UNESP]
author_role author
author2 Da Costa, E.C. Silva
Schenka, N. Guimarães Moraes
Schenka, A. Almeida
Uemura, G. [UNESP]
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Centro Universitário das Faculdades Associadas de Ensino - FAE
Universidade Estadual de Campinas (UNICAMP)
Universidade Estadual Paulista (UNESP)
dc.contributor.author.fl_str_mv De Rezende, Laura Ferreira
Da Costa, E.C. Silva
Schenka, N. Guimarães Moraes
Schenka, A. Almeida
Uemura, G. [UNESP]
dc.subject.por.fl_str_mv Breast cancer
Breast cancer recurrence
Physical therapy
Therapeutic ultrasound
topic Breast cancer
Breast cancer recurrence
Physical therapy
Therapeutic ultrasound
description Purpose: Ultrasound (US) therapy is an electrothermotherapeutic modality that uses US energy to provoke physical and chemical alterations. US therapy has been widely used in physical therapy. However, in clinical practice, it is contra-indicated in cancer patients due to the possibility of exacerbating tumor growth. Methods: Sixty-eight female Sprague-Dawley rats bred in UNIFAE vivarium were studied. At 50 days of age, 7,12-dimetylbenz(a)anthracene (7,12-DMBA) was administered to 35 rats by gastric gavage to induce mammary cancer. After 90 days the mammary glands of the rats belonging to the group with mammary cancer induction and stimulated by US were removed. Animals received either continuous or pulsed US. US waves were generated at a frequency of 1 MHz during 10 days, with an intensity dose of 0.5 W in the continuous group, and 0.9 W (duty cycle: 20%) in the pulsed group. Results: Among the rats treated with continuous US, 44.4% developed local recurrence, while among the rats treated with pulsed US, 22.2% had local tumor recurrence (p<0.05). No evidence of distant metastases was shown in any of the rats studied. Conclusion: The use of continuous and pulsed therapeutic US promoted the development of local recurrence of mammary cancer in female Sprague-Dawley rats in the postoperative period. © 2012 Zerbinis Medical Publications.
publishDate 2012
dc.date.none.fl_str_mv 2012-07-01
2022-04-29T05:36:43Z
2022-04-29T05:36:43Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv Journal of B.U.ON., v. 17, n. 3, p. 581-584, 2012.
1107-0625
http://hdl.handle.net/11449/227004
2-s2.0-84867549448
identifier_str_mv Journal of B.U.ON., v. 17, n. 3, p. 581-584, 2012.
1107-0625
2-s2.0-84867549448
url http://hdl.handle.net/11449/227004
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Journal of B.U.ON.
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 581-584
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
_version_ 1808128138569318400

Registros relacionados