Effect of continuous and pulsed therapeutic ultrasound in the appearance of local recurrence of mammary cancer in rats

Detalhes bibliográficos
Autor(a) principal: de Rezende, L. Ferreira
Data de Publicação: 2012
Outros Autores: Silva da Costa, E. C., Guimaraes Moraes Schenka, N., Almeida Schenka, A., Uemura, Gilberto [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://www.ncbi.nlm.nih.gov/pubmed/23033303
http://hdl.handle.net/11449/40550
Resumo: Purpose: Ultrasound (US) therapy is an elect rot hermotherapeutic modality that uses US energy to provoke physical and chemical alterations. US therapy has been widely used in physical therapy. However in clinical practice, it is contra-indicated in cancer patients due to the possibility of exacerbating tumor growth.Methods: Sixty-eight female Sprague-Dawley rats bred in UNIFAE vivarium were studied. At 50 days of age, 7, 12-dimetylbenz(a)anthracene (7, 12-DMBA) was administered to 35 rats by gastric gavage to induce mammary cancer After 90 days the mammary glands of the rats belonging to the group with mammary cancer induction and stimulated by US were removed. Animals received either continuous or pulsed US. US waves were generated at a frequency of 1 MHz during 10 days, with an intensity dose of 0.5 W in the continuous group, and 0.9 W (duty cycle: 20%) in the pulsed group.Results: Among the rats treated with continuous US, 44.4% developed local recurrence, while among the rats treated with pulsed US, 22.2% had local tumor recurrence (p < 0.05). No evidence of distant metastases was shown in any of the rats studied.Conclusion: The use ofcontinuous and pulsed therapeutic US promoted the development of local recurrence of mammary cancer in female Sprague-Dawley rats in the postoperative period.
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spelling Effect of continuous and pulsed therapeutic ultrasound in the appearance of local recurrence of mammary cancer in ratsbreast cancerbreast cancer recurrencetherapeutic ultrasoundphysical therapyPurpose: Ultrasound (US) therapy is an elect rot hermotherapeutic modality that uses US energy to provoke physical and chemical alterations. US therapy has been widely used in physical therapy. However in clinical practice, it is contra-indicated in cancer patients due to the possibility of exacerbating tumor growth.Methods: Sixty-eight female Sprague-Dawley rats bred in UNIFAE vivarium were studied. At 50 days of age, 7, 12-dimetylbenz(a)anthracene (7, 12-DMBA) was administered to 35 rats by gastric gavage to induce mammary cancer After 90 days the mammary glands of the rats belonging to the group with mammary cancer induction and stimulated by US were removed. Animals received either continuous or pulsed US. US waves were generated at a frequency of 1 MHz during 10 days, with an intensity dose of 0.5 W in the continuous group, and 0.9 W (duty cycle: 20%) in the pulsed group.Results: Among the rats treated with continuous US, 44.4% developed local recurrence, while among the rats treated with pulsed US, 22.2% had local tumor recurrence (p < 0.05). No evidence of distant metastases was shown in any of the rats studied.Conclusion: The use ofcontinuous and pulsed therapeutic US promoted the development of local recurrence of mammary cancer in female Sprague-Dawley rats in the postoperative period.PAPEC - Centro Universitario das Faculdades Associadas de Ensino - FAE, Sao Joao da Boa Vista, São Paulo, BrazilCtr Univ Fac Associadas Ensino FAE, Phys Therapy Dept, São Paulo, BrazilUniv Estadual Campinas UNICAMP, Dept Pharmacol, São Paulo, BrazilUniv Estadual Paulista UNESP, Obstet Gynecol & Mastol Dept, São Paulo, BrazilUniv Estadual Paulista UNESP, Obstet Gynecol & Mastol Dept, São Paulo, BrazilZerbinis Medical PublCtr Univ Fac Associadas Ensino FAEUniversidade Estadual de Campinas (UNICAMP)Universidade Estadual Paulista (Unesp)de Rezende, L. FerreiraSilva da Costa, E. C.Guimaraes Moraes Schenka, N.Almeida Schenka, A.Uemura, Gilberto [UNESP]2014-05-20T15:31:24Z2014-05-20T15:31:24Z2012-07-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article581-584http://www.ncbi.nlm.nih.gov/pubmed/23033303Journal of Buon. Athens: Zerbinis Medical Publ, v. 17, n. 3, p. 581-584, 2012.1107-0625http://hdl.handle.net/11449/40550WOS:0003097930000299878648143577124Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal of Buon1.7660,420info:eu-repo/semantics/openAccess2024-08-16T14:07:23Zoai:repositorio.unesp.br:11449/40550Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-16T14:07:23Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Effect of continuous and pulsed therapeutic ultrasound in the appearance of local recurrence of mammary cancer in rats
title Effect of continuous and pulsed therapeutic ultrasound in the appearance of local recurrence of mammary cancer in rats
spellingShingle Effect of continuous and pulsed therapeutic ultrasound in the appearance of local recurrence of mammary cancer in rats
de Rezende, L. Ferreira
breast cancer
breast cancer recurrence
therapeutic ultrasound
physical therapy
title_short Effect of continuous and pulsed therapeutic ultrasound in the appearance of local recurrence of mammary cancer in rats
title_full Effect of continuous and pulsed therapeutic ultrasound in the appearance of local recurrence of mammary cancer in rats
title_fullStr Effect of continuous and pulsed therapeutic ultrasound in the appearance of local recurrence of mammary cancer in rats
title_full_unstemmed Effect of continuous and pulsed therapeutic ultrasound in the appearance of local recurrence of mammary cancer in rats
title_sort Effect of continuous and pulsed therapeutic ultrasound in the appearance of local recurrence of mammary cancer in rats
author de Rezende, L. Ferreira
author_facet de Rezende, L. Ferreira
Silva da Costa, E. C.
Guimaraes Moraes Schenka, N.
Almeida Schenka, A.
Uemura, Gilberto [UNESP]
author_role author
author2 Silva da Costa, E. C.
Guimaraes Moraes Schenka, N.
Almeida Schenka, A.
Uemura, Gilberto [UNESP]
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Ctr Univ Fac Associadas Ensino FAE
Universidade Estadual de Campinas (UNICAMP)
Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv de Rezende, L. Ferreira
Silva da Costa, E. C.
Guimaraes Moraes Schenka, N.
Almeida Schenka, A.
Uemura, Gilberto [UNESP]
dc.subject.por.fl_str_mv breast cancer
breast cancer recurrence
therapeutic ultrasound
physical therapy
topic breast cancer
breast cancer recurrence
therapeutic ultrasound
physical therapy
description Purpose: Ultrasound (US) therapy is an elect rot hermotherapeutic modality that uses US energy to provoke physical and chemical alterations. US therapy has been widely used in physical therapy. However in clinical practice, it is contra-indicated in cancer patients due to the possibility of exacerbating tumor growth.Methods: Sixty-eight female Sprague-Dawley rats bred in UNIFAE vivarium were studied. At 50 days of age, 7, 12-dimetylbenz(a)anthracene (7, 12-DMBA) was administered to 35 rats by gastric gavage to induce mammary cancer After 90 days the mammary glands of the rats belonging to the group with mammary cancer induction and stimulated by US were removed. Animals received either continuous or pulsed US. US waves were generated at a frequency of 1 MHz during 10 days, with an intensity dose of 0.5 W in the continuous group, and 0.9 W (duty cycle: 20%) in the pulsed group.Results: Among the rats treated with continuous US, 44.4% developed local recurrence, while among the rats treated with pulsed US, 22.2% had local tumor recurrence (p < 0.05). No evidence of distant metastases was shown in any of the rats studied.Conclusion: The use ofcontinuous and pulsed therapeutic US promoted the development of local recurrence of mammary cancer in female Sprague-Dawley rats in the postoperative period.
publishDate 2012
dc.date.none.fl_str_mv 2012-07-01
2014-05-20T15:31:24Z
2014-05-20T15:31:24Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.ncbi.nlm.nih.gov/pubmed/23033303
Journal of Buon. Athens: Zerbinis Medical Publ, v. 17, n. 3, p. 581-584, 2012.
1107-0625
http://hdl.handle.net/11449/40550
WOS:000309793000029
9878648143577124
url http://www.ncbi.nlm.nih.gov/pubmed/23033303
http://hdl.handle.net/11449/40550
identifier_str_mv Journal of Buon. Athens: Zerbinis Medical Publ, v. 17, n. 3, p. 581-584, 2012.
1107-0625
WOS:000309793000029
9878648143577124
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Journal of Buon
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0,420
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 581-584
dc.publisher.none.fl_str_mv Zerbinis Medical Publ
publisher.none.fl_str_mv Zerbinis Medical Publ
dc.source.none.fl_str_mv Web of Science
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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