Ausência de arteriosclerose na porção intramiocárdica das artérias coronárias: Um mistério a ser resolvido?

Detalhes bibliográficos
Autor(a) principal: Ramalli Jr, Edvaldo Luiz
Data de Publicação: 2011
Outros Autores: Braga, Leonardo Henrique, Evora, Patricia Martinez [UNESP], Albuquerque, Agnes Afrodite Sumarelli, Celotto, Andrea Carla, Mota, André Lupp, Evora, Paulo Roberto Barbosa
Tipo de documento: Artigo
Idioma: eng
por
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.5935/1678-9741.20110020
http://hdl.handle.net/11449/72538
Resumo: Several studies show that portions of intramyocardial coronary arteries are spared of arteriosclerosis, involving morphological, embryological, biochemical and pathophysiological aspects. Endothelial function is significantly affected in the segment of transition, as estimated by the vasoactive response to Ach. These findings suggest that myocardial bridge can provide protection against arteriosclerosis by counteracting the negative effects of endothelial dysfunction. The intramyocardial portion's protection phenomenon deserves further scientific research on all research fronts. Improved morphological, biomechanical and especially physiological and embryological knowledge may be the key to a future window of opportunity for chronic arterial disease therapy and prevention. In addition, this review discusses possible therapeutic approaches for symptomatic coronary ischemia caused by myocardial bridges.
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spelling Ausência de arteriosclerose na porção intramiocárdica das artérias coronárias: Um mistério a ser resolvido?Absence of arteriosclerosis in intramyocardial coronary arteries: A mystery to be solved?Coronary circulationEndotheliumMyocardial bridgingACE protein, humandipeptidyl carboxypeptidaseendothelin 1adipose tissuecoronary artery blood flowcoronary artery diseasecoronary blood vesselhistologyhumanmetabolismmyocardial bridgingparacrine signalingpathologypathophysiologyphysiologyprenatal developmentreviewvascular endotheliumAdipose TissueCoronary Artery DiseaseCoronary CirculationCoronary VesselsEndothelin-1Endothelium, VascularHumansMyocardial BridgingParacrine CommunicationPeptidyl-Dipeptidase ASeveral studies show that portions of intramyocardial coronary arteries are spared of arteriosclerosis, involving morphological, embryological, biochemical and pathophysiological aspects. Endothelial function is significantly affected in the segment of transition, as estimated by the vasoactive response to Ach. These findings suggest that myocardial bridge can provide protection against arteriosclerosis by counteracting the negative effects of endothelial dysfunction. The intramyocardial portion's protection phenomenon deserves further scientific research on all research fronts. Improved morphological, biomechanical and especially physiological and embryological knowledge may be the key to a future window of opportunity for chronic arterial disease therapy and prevention. In addition, this review discusses possible therapeutic approaches for symptomatic coronary ischemia caused by myocardial bridges.Monitor, Surgery and Anatomy Department Faculdade de Medicina de Ribeirão Preto Universidade de São Paulo, Ribeirão Preto, SPGraduate School of Veterinary Sciences of Jaboticabal UNESP, Jaboticabal, SPLaboratory of Vascular Reactivity and Endothelial Function, Ribeirão Preto, SPLaboratory of Biomedical Vascular Reactivity and Endothelial Function, Ribeirão Preto, SPResident of Surgery and Anatomy Department Faculdade de Medicina de Ribeirão Preto Universidade de São, Paulo, Ribeirão Preto, SPDepartment Chief of Faculdade de Medicina de Ribeirão Preto Universidade de São Paulo, Ribeirão Preto, SPGraduate School of Veterinary Sciences of Jaboticabal UNESP, Jaboticabal, SPUniversidade de São Paulo (USP)Universidade Estadual Paulista (Unesp)Laboratory of Vascular Reactivity and Endothelial FunctionLaboratory of Biomedical Vascular Reactivity and Endothelial FunctionUniversidade de SãoRamalli Jr, Edvaldo LuizBraga, Leonardo HenriqueEvora, Patricia Martinez [UNESP]Albuquerque, Agnes Afrodite SumarelliCelotto, Andrea CarlaMota, André LuppEvora, Paulo Roberto Barbosa2014-05-27T11:25:56Z2014-05-27T11:25:56Z2011-07-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article440-446application/pdfhttp://dx.doi.org/10.5935/1678-9741.20110020Brazilian Journal of Cardiovascular Surgery, v. 26, n. 3, p. 440-446, 2011.0102-76381678-9741http://hdl.handle.net/11449/7253810.5935/1678-9741.201100202-s2.0-813551333362-s2.0-81355133336.pdfScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengporBrazilian Journal of Cardiovascular Surgery0.8050,231info:eu-repo/semantics/openAccess2023-11-03T06:06:23Zoai:repositorio.unesp.br:11449/72538Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T16:46:02.309304Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Ausência de arteriosclerose na porção intramiocárdica das artérias coronárias: Um mistério a ser resolvido?
Absence of arteriosclerosis in intramyocardial coronary arteries: A mystery to be solved?
title Ausência de arteriosclerose na porção intramiocárdica das artérias coronárias: Um mistério a ser resolvido?
spellingShingle Ausência de arteriosclerose na porção intramiocárdica das artérias coronárias: Um mistério a ser resolvido?
Ramalli Jr, Edvaldo Luiz
Coronary circulation
Endothelium
Myocardial bridging
ACE protein, human
dipeptidyl carboxypeptidase
endothelin 1
adipose tissue
coronary artery blood flow
coronary artery disease
coronary blood vessel
histology
human
metabolism
myocardial bridging
paracrine signaling
pathology
pathophysiology
physiology
prenatal development
review
vascular endothelium
Adipose Tissue
Coronary Artery Disease
Coronary Circulation
Coronary Vessels
Endothelin-1
Endothelium, Vascular
Humans
Myocardial Bridging
Paracrine Communication
Peptidyl-Dipeptidase A
title_short Ausência de arteriosclerose na porção intramiocárdica das artérias coronárias: Um mistério a ser resolvido?
title_full Ausência de arteriosclerose na porção intramiocárdica das artérias coronárias: Um mistério a ser resolvido?
title_fullStr Ausência de arteriosclerose na porção intramiocárdica das artérias coronárias: Um mistério a ser resolvido?
title_full_unstemmed Ausência de arteriosclerose na porção intramiocárdica das artérias coronárias: Um mistério a ser resolvido?
title_sort Ausência de arteriosclerose na porção intramiocárdica das artérias coronárias: Um mistério a ser resolvido?
author Ramalli Jr, Edvaldo Luiz
author_facet Ramalli Jr, Edvaldo Luiz
Braga, Leonardo Henrique
Evora, Patricia Martinez [UNESP]
Albuquerque, Agnes Afrodite Sumarelli
Celotto, Andrea Carla
Mota, André Lupp
Evora, Paulo Roberto Barbosa
author_role author
author2 Braga, Leonardo Henrique
Evora, Patricia Martinez [UNESP]
Albuquerque, Agnes Afrodite Sumarelli
Celotto, Andrea Carla
Mota, André Lupp
Evora, Paulo Roberto Barbosa
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade de São Paulo (USP)
Universidade Estadual Paulista (Unesp)
Laboratory of Vascular Reactivity and Endothelial Function
Laboratory of Biomedical Vascular Reactivity and Endothelial Function
Universidade de São
dc.contributor.author.fl_str_mv Ramalli Jr, Edvaldo Luiz
Braga, Leonardo Henrique
Evora, Patricia Martinez [UNESP]
Albuquerque, Agnes Afrodite Sumarelli
Celotto, Andrea Carla
Mota, André Lupp
Evora, Paulo Roberto Barbosa
dc.subject.por.fl_str_mv Coronary circulation
Endothelium
Myocardial bridging
ACE protein, human
dipeptidyl carboxypeptidase
endothelin 1
adipose tissue
coronary artery blood flow
coronary artery disease
coronary blood vessel
histology
human
metabolism
myocardial bridging
paracrine signaling
pathology
pathophysiology
physiology
prenatal development
review
vascular endothelium
Adipose Tissue
Coronary Artery Disease
Coronary Circulation
Coronary Vessels
Endothelin-1
Endothelium, Vascular
Humans
Myocardial Bridging
Paracrine Communication
Peptidyl-Dipeptidase A
topic Coronary circulation
Endothelium
Myocardial bridging
ACE protein, human
dipeptidyl carboxypeptidase
endothelin 1
adipose tissue
coronary artery blood flow
coronary artery disease
coronary blood vessel
histology
human
metabolism
myocardial bridging
paracrine signaling
pathology
pathophysiology
physiology
prenatal development
review
vascular endothelium
Adipose Tissue
Coronary Artery Disease
Coronary Circulation
Coronary Vessels
Endothelin-1
Endothelium, Vascular
Humans
Myocardial Bridging
Paracrine Communication
Peptidyl-Dipeptidase A
description Several studies show that portions of intramyocardial coronary arteries are spared of arteriosclerosis, involving morphological, embryological, biochemical and pathophysiological aspects. Endothelial function is significantly affected in the segment of transition, as estimated by the vasoactive response to Ach. These findings suggest that myocardial bridge can provide protection against arteriosclerosis by counteracting the negative effects of endothelial dysfunction. The intramyocardial portion's protection phenomenon deserves further scientific research on all research fronts. Improved morphological, biomechanical and especially physiological and embryological knowledge may be the key to a future window of opportunity for chronic arterial disease therapy and prevention. In addition, this review discusses possible therapeutic approaches for symptomatic coronary ischemia caused by myocardial bridges.
publishDate 2011
dc.date.none.fl_str_mv 2011-07-01
2014-05-27T11:25:56Z
2014-05-27T11:25:56Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.5935/1678-9741.20110020
Brazilian Journal of Cardiovascular Surgery, v. 26, n. 3, p. 440-446, 2011.
0102-7638
1678-9741
http://hdl.handle.net/11449/72538
10.5935/1678-9741.20110020
2-s2.0-81355133336
2-s2.0-81355133336.pdf
url http://dx.doi.org/10.5935/1678-9741.20110020
http://hdl.handle.net/11449/72538
identifier_str_mv Brazilian Journal of Cardiovascular Surgery, v. 26, n. 3, p. 440-446, 2011.
0102-7638
1678-9741
10.5935/1678-9741.20110020
2-s2.0-81355133336
2-s2.0-81355133336.pdf
dc.language.iso.fl_str_mv eng
por
language eng
por
dc.relation.none.fl_str_mv Brazilian Journal of Cardiovascular Surgery
0.805
0,231
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 440-446
application/pdf
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
_version_ 1808128698364198912

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