Development and characterization of biocompatible isotropic and anisotropic oil-in-water colloidal dispersions as a new delivery system for methyl dihydrojasmonate antitumor drug
Autor(a) principal: | |
---|---|
Data de Publicação: | 2014 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.2147/IJN.S46055 http://hdl.handle.net/11449/113464 |
Resumo: | Microemulsions (MEs) are colloidal systems that can be used for drug-delivery and drug-targeting purposes. These systems are able to incorporate drugs modifying bioavailability and stability and reducing toxic effects. The jasmonate compounds belong to a group of plant stress hormones, and the jasmonic acid and its methyl ester derivative have been described as having anticancer activity. However, these compounds are very poorly water-soluble, not allowing administration by an intravenous route without an efficient nanostructured carrier system. In this work, biocompatible MEs of appropriate diameter size for intravenous route administration, loaded and unloaded with methyl dihydrojasmonate (MJ), were developed and described in a pseudo-ternary phase diagram. The compositions of the MEs were carefully selected from their own regions in the pseudo-ternary phase diagram. The formulations were analyzed by light scattering, polarized light microscopy, and X-ray diffraction. Also, a study on rheological profile was performed. The results showed that the droplet size decreased with both MJ incorporation and oil phase/surfactant ratio. All compositions of the studied MEs showed rheological behavior of pseudoplastic fluid and amorphous structures. In the absence of MJ, most of the studied MEs had thixotropic characteristics, which became antithixotropic in the presence of the drug. Almost all MJ-unloaded MEs presented anisotropic characteristics, but some formulations became isotropic, especially in the presence of MJ. The results of this study support the conclusion that the studied system represents a promising vehicle for in vivo administration of the MJ antitumor drug. |
id |
UNSP_0a890cda5b86b033c8e1a76b9a9627fd |
---|---|
oai_identifier_str |
oai:repositorio.unesp.br:11449/113464 |
network_acronym_str |
UNSP |
network_name_str |
Repositório Institucional da UNESP |
repository_id_str |
2946 |
spelling |
Development and characterization of biocompatible isotropic and anisotropic oil-in-water colloidal dispersions as a new delivery system for methyl dihydrojasmonate antitumor drugmethyl dihydrojasmonateanticancer drugbiocompatible microemulsionspseudo-ternary phase diagrammicroemulsion characterizationMicroemulsions (MEs) are colloidal systems that can be used for drug-delivery and drug-targeting purposes. These systems are able to incorporate drugs modifying bioavailability and stability and reducing toxic effects. The jasmonate compounds belong to a group of plant stress hormones, and the jasmonic acid and its methyl ester derivative have been described as having anticancer activity. However, these compounds are very poorly water-soluble, not allowing administration by an intravenous route without an efficient nanostructured carrier system. In this work, biocompatible MEs of appropriate diameter size for intravenous route administration, loaded and unloaded with methyl dihydrojasmonate (MJ), were developed and described in a pseudo-ternary phase diagram. The compositions of the MEs were carefully selected from their own regions in the pseudo-ternary phase diagram. The formulations were analyzed by light scattering, polarized light microscopy, and X-ray diffraction. Also, a study on rheological profile was performed. The results showed that the droplet size decreased with both MJ incorporation and oil phase/surfactant ratio. All compositions of the studied MEs showed rheological behavior of pseudoplastic fluid and amorphous structures. In the absence of MJ, most of the studied MEs had thixotropic characteristics, which became antithixotropic in the presence of the drug. Almost all MJ-unloaded MEs presented anisotropic characteristics, but some formulations became isotropic, especially in the presence of MJ. The results of this study support the conclusion that the studied system represents a promising vehicle for in vivo administration of the MJ antitumor drug.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Univ Estadual Paulista, UNESP, Dept Farmacos & Medicamentos, BR-14801902 Araraquara, SP, BrazilUniv Fed Rio Grande do Norte UFRN, Lab Sistemas Dispersos, Natal, RN, BrazilUniv Estadual Paulista, UNESP, Dept Farmacos & Medicamentos, BR-14801902 Araraquara, SP, BrazilDove Medical Press LtdUniversidade Estadual Paulista (Unesp)Universidade Federal do Rio Grande do Norte (UFRN)Rolfsen Ferreira da Silva, Gisela Bevilacqua [UNESP]Scarpa, Maria Virginia [UNESP]Rossanezi, Gustavo [UNESP]Tabosa do Egito, Eryvaldo SocratesOliveira, Anselmo Gomes de [UNESP]2014-12-03T13:11:43Z2014-12-03T13:11:43Z2014-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article867-876application/pdfhttp://dx.doi.org/10.2147/IJN.S46055International Journal Of Nanomedicine. Albany: Dove Medical Press Ltd, v. 9, p. 867-876, 2014.1178-2013http://hdl.handle.net/11449/11346410.2147/IJN.S46055WOS:000331040500001WOS000331040500001.pdf9114495952533044Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengInternational Journal of Nanomedicine4.3701,225info:eu-repo/semantics/openAccess2024-06-24T13:44:53Zoai:repositorio.unesp.br:11449/113464Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T13:57:55.294590Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Development and characterization of biocompatible isotropic and anisotropic oil-in-water colloidal dispersions as a new delivery system for methyl dihydrojasmonate antitumor drug |
title |
Development and characterization of biocompatible isotropic and anisotropic oil-in-water colloidal dispersions as a new delivery system for methyl dihydrojasmonate antitumor drug |
spellingShingle |
Development and characterization of biocompatible isotropic and anisotropic oil-in-water colloidal dispersions as a new delivery system for methyl dihydrojasmonate antitumor drug Rolfsen Ferreira da Silva, Gisela Bevilacqua [UNESP] methyl dihydrojasmonate anticancer drug biocompatible microemulsions pseudo-ternary phase diagram microemulsion characterization |
title_short |
Development and characterization of biocompatible isotropic and anisotropic oil-in-water colloidal dispersions as a new delivery system for methyl dihydrojasmonate antitumor drug |
title_full |
Development and characterization of biocompatible isotropic and anisotropic oil-in-water colloidal dispersions as a new delivery system for methyl dihydrojasmonate antitumor drug |
title_fullStr |
Development and characterization of biocompatible isotropic and anisotropic oil-in-water colloidal dispersions as a new delivery system for methyl dihydrojasmonate antitumor drug |
title_full_unstemmed |
Development and characterization of biocompatible isotropic and anisotropic oil-in-water colloidal dispersions as a new delivery system for methyl dihydrojasmonate antitumor drug |
title_sort |
Development and characterization of biocompatible isotropic and anisotropic oil-in-water colloidal dispersions as a new delivery system for methyl dihydrojasmonate antitumor drug |
author |
Rolfsen Ferreira da Silva, Gisela Bevilacqua [UNESP] |
author_facet |
Rolfsen Ferreira da Silva, Gisela Bevilacqua [UNESP] Scarpa, Maria Virginia [UNESP] Rossanezi, Gustavo [UNESP] Tabosa do Egito, Eryvaldo Socrates Oliveira, Anselmo Gomes de [UNESP] |
author_role |
author |
author2 |
Scarpa, Maria Virginia [UNESP] Rossanezi, Gustavo [UNESP] Tabosa do Egito, Eryvaldo Socrates Oliveira, Anselmo Gomes de [UNESP] |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Universidade Federal do Rio Grande do Norte (UFRN) |
dc.contributor.author.fl_str_mv |
Rolfsen Ferreira da Silva, Gisela Bevilacqua [UNESP] Scarpa, Maria Virginia [UNESP] Rossanezi, Gustavo [UNESP] Tabosa do Egito, Eryvaldo Socrates Oliveira, Anselmo Gomes de [UNESP] |
dc.subject.por.fl_str_mv |
methyl dihydrojasmonate anticancer drug biocompatible microemulsions pseudo-ternary phase diagram microemulsion characterization |
topic |
methyl dihydrojasmonate anticancer drug biocompatible microemulsions pseudo-ternary phase diagram microemulsion characterization |
description |
Microemulsions (MEs) are colloidal systems that can be used for drug-delivery and drug-targeting purposes. These systems are able to incorporate drugs modifying bioavailability and stability and reducing toxic effects. The jasmonate compounds belong to a group of plant stress hormones, and the jasmonic acid and its methyl ester derivative have been described as having anticancer activity. However, these compounds are very poorly water-soluble, not allowing administration by an intravenous route without an efficient nanostructured carrier system. In this work, biocompatible MEs of appropriate diameter size for intravenous route administration, loaded and unloaded with methyl dihydrojasmonate (MJ), were developed and described in a pseudo-ternary phase diagram. The compositions of the MEs were carefully selected from their own regions in the pseudo-ternary phase diagram. The formulations were analyzed by light scattering, polarized light microscopy, and X-ray diffraction. Also, a study on rheological profile was performed. The results showed that the droplet size decreased with both MJ incorporation and oil phase/surfactant ratio. All compositions of the studied MEs showed rheological behavior of pseudoplastic fluid and amorphous structures. In the absence of MJ, most of the studied MEs had thixotropic characteristics, which became antithixotropic in the presence of the drug. Almost all MJ-unloaded MEs presented anisotropic characteristics, but some formulations became isotropic, especially in the presence of MJ. The results of this study support the conclusion that the studied system represents a promising vehicle for in vivo administration of the MJ antitumor drug. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014-12-03T13:11:43Z 2014-12-03T13:11:43Z 2014-01-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.2147/IJN.S46055 International Journal Of Nanomedicine. Albany: Dove Medical Press Ltd, v. 9, p. 867-876, 2014. 1178-2013 http://hdl.handle.net/11449/113464 10.2147/IJN.S46055 WOS:000331040500001 WOS000331040500001.pdf 9114495952533044 |
url |
http://dx.doi.org/10.2147/IJN.S46055 http://hdl.handle.net/11449/113464 |
identifier_str_mv |
International Journal Of Nanomedicine. Albany: Dove Medical Press Ltd, v. 9, p. 867-876, 2014. 1178-2013 10.2147/IJN.S46055 WOS:000331040500001 WOS000331040500001.pdf 9114495952533044 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
International Journal of Nanomedicine 4.370 1,225 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
867-876 application/pdf |
dc.publisher.none.fl_str_mv |
Dove Medical Press Ltd |
publisher.none.fl_str_mv |
Dove Medical Press Ltd |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808128296480669696 |