Development and characterization of biocompatible isotropic and anisotropic oil-in-water colloidal dispersions as a new delivery system for methyl dihydrojasmonate antitumor drug

Detalhes bibliográficos
Autor(a) principal: Rolfsen Ferreira da Silva, Gisela Bevilacqua [UNESP]
Data de Publicação: 2014
Outros Autores: Scarpa, Maria Virginia [UNESP], Rossanezi, Gustavo [UNESP], Tabosa do Egito, Eryvaldo Socrates, Oliveira, Anselmo Gomes de [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.2147/IJN.S46055
http://hdl.handle.net/11449/113464
Resumo: Microemulsions (MEs) are colloidal systems that can be used for drug-delivery and drug-targeting purposes. These systems are able to incorporate drugs modifying bioavailability and stability and reducing toxic effects. The jasmonate compounds belong to a group of plant stress hormones, and the jasmonic acid and its methyl ester derivative have been described as having anticancer activity. However, these compounds are very poorly water-soluble, not allowing administration by an intravenous route without an efficient nanostructured carrier system. In this work, biocompatible MEs of appropriate diameter size for intravenous route administration, loaded and unloaded with methyl dihydrojasmonate (MJ), were developed and described in a pseudo-ternary phase diagram. The compositions of the MEs were carefully selected from their own regions in the pseudo-ternary phase diagram. The formulations were analyzed by light scattering, polarized light microscopy, and X-ray diffraction. Also, a study on rheological profile was performed. The results showed that the droplet size decreased with both MJ incorporation and oil phase/surfactant ratio. All compositions of the studied MEs showed rheological behavior of pseudoplastic fluid and amorphous structures. In the absence of MJ, most of the studied MEs had thixotropic characteristics, which became antithixotropic in the presence of the drug. Almost all MJ-unloaded MEs presented anisotropic characteristics, but some formulations became isotropic, especially in the presence of MJ. The results of this study support the conclusion that the studied system represents a promising vehicle for in vivo administration of the MJ antitumor drug.
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spelling Development and characterization of biocompatible isotropic and anisotropic oil-in-water colloidal dispersions as a new delivery system for methyl dihydrojasmonate antitumor drugmethyl dihydrojasmonateanticancer drugbiocompatible microemulsionspseudo-ternary phase diagrammicroemulsion characterizationMicroemulsions (MEs) are colloidal systems that can be used for drug-delivery and drug-targeting purposes. These systems are able to incorporate drugs modifying bioavailability and stability and reducing toxic effects. The jasmonate compounds belong to a group of plant stress hormones, and the jasmonic acid and its methyl ester derivative have been described as having anticancer activity. However, these compounds are very poorly water-soluble, not allowing administration by an intravenous route without an efficient nanostructured carrier system. In this work, biocompatible MEs of appropriate diameter size for intravenous route administration, loaded and unloaded with methyl dihydrojasmonate (MJ), were developed and described in a pseudo-ternary phase diagram. The compositions of the MEs were carefully selected from their own regions in the pseudo-ternary phase diagram. The formulations were analyzed by light scattering, polarized light microscopy, and X-ray diffraction. Also, a study on rheological profile was performed. The results showed that the droplet size decreased with both MJ incorporation and oil phase/surfactant ratio. All compositions of the studied MEs showed rheological behavior of pseudoplastic fluid and amorphous structures. In the absence of MJ, most of the studied MEs had thixotropic characteristics, which became antithixotropic in the presence of the drug. Almost all MJ-unloaded MEs presented anisotropic characteristics, but some formulations became isotropic, especially in the presence of MJ. The results of this study support the conclusion that the studied system represents a promising vehicle for in vivo administration of the MJ antitumor drug.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Univ Estadual Paulista, UNESP, Dept Farmacos & Medicamentos, BR-14801902 Araraquara, SP, BrazilUniv Fed Rio Grande do Norte UFRN, Lab Sistemas Dispersos, Natal, RN, BrazilUniv Estadual Paulista, UNESP, Dept Farmacos & Medicamentos, BR-14801902 Araraquara, SP, BrazilDove Medical Press LtdUniversidade Estadual Paulista (Unesp)Universidade Federal do Rio Grande do Norte (UFRN)Rolfsen Ferreira da Silva, Gisela Bevilacqua [UNESP]Scarpa, Maria Virginia [UNESP]Rossanezi, Gustavo [UNESP]Tabosa do Egito, Eryvaldo SocratesOliveira, Anselmo Gomes de [UNESP]2014-12-03T13:11:43Z2014-12-03T13:11:43Z2014-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article867-876application/pdfhttp://dx.doi.org/10.2147/IJN.S46055International Journal Of Nanomedicine. Albany: Dove Medical Press Ltd, v. 9, p. 867-876, 2014.1178-2013http://hdl.handle.net/11449/11346410.2147/IJN.S46055WOS:000331040500001WOS000331040500001.pdf9114495952533044Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengInternational Journal of Nanomedicine4.3701,225info:eu-repo/semantics/openAccess2024-06-24T13:44:53Zoai:repositorio.unesp.br:11449/113464Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T13:57:55.294590Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Development and characterization of biocompatible isotropic and anisotropic oil-in-water colloidal dispersions as a new delivery system for methyl dihydrojasmonate antitumor drug
title Development and characterization of biocompatible isotropic and anisotropic oil-in-water colloidal dispersions as a new delivery system for methyl dihydrojasmonate antitumor drug
spellingShingle Development and characterization of biocompatible isotropic and anisotropic oil-in-water colloidal dispersions as a new delivery system for methyl dihydrojasmonate antitumor drug
Rolfsen Ferreira da Silva, Gisela Bevilacqua [UNESP]
methyl dihydrojasmonate
anticancer drug
biocompatible microemulsions
pseudo-ternary phase diagram
microemulsion characterization
title_short Development and characterization of biocompatible isotropic and anisotropic oil-in-water colloidal dispersions as a new delivery system for methyl dihydrojasmonate antitumor drug
title_full Development and characterization of biocompatible isotropic and anisotropic oil-in-water colloidal dispersions as a new delivery system for methyl dihydrojasmonate antitumor drug
title_fullStr Development and characterization of biocompatible isotropic and anisotropic oil-in-water colloidal dispersions as a new delivery system for methyl dihydrojasmonate antitumor drug
title_full_unstemmed Development and characterization of biocompatible isotropic and anisotropic oil-in-water colloidal dispersions as a new delivery system for methyl dihydrojasmonate antitumor drug
title_sort Development and characterization of biocompatible isotropic and anisotropic oil-in-water colloidal dispersions as a new delivery system for methyl dihydrojasmonate antitumor drug
author Rolfsen Ferreira da Silva, Gisela Bevilacqua [UNESP]
author_facet Rolfsen Ferreira da Silva, Gisela Bevilacqua [UNESP]
Scarpa, Maria Virginia [UNESP]
Rossanezi, Gustavo [UNESP]
Tabosa do Egito, Eryvaldo Socrates
Oliveira, Anselmo Gomes de [UNESP]
author_role author
author2 Scarpa, Maria Virginia [UNESP]
Rossanezi, Gustavo [UNESP]
Tabosa do Egito, Eryvaldo Socrates
Oliveira, Anselmo Gomes de [UNESP]
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
Universidade Federal do Rio Grande do Norte (UFRN)
dc.contributor.author.fl_str_mv Rolfsen Ferreira da Silva, Gisela Bevilacqua [UNESP]
Scarpa, Maria Virginia [UNESP]
Rossanezi, Gustavo [UNESP]
Tabosa do Egito, Eryvaldo Socrates
Oliveira, Anselmo Gomes de [UNESP]
dc.subject.por.fl_str_mv methyl dihydrojasmonate
anticancer drug
biocompatible microemulsions
pseudo-ternary phase diagram
microemulsion characterization
topic methyl dihydrojasmonate
anticancer drug
biocompatible microemulsions
pseudo-ternary phase diagram
microemulsion characterization
description Microemulsions (MEs) are colloidal systems that can be used for drug-delivery and drug-targeting purposes. These systems are able to incorporate drugs modifying bioavailability and stability and reducing toxic effects. The jasmonate compounds belong to a group of plant stress hormones, and the jasmonic acid and its methyl ester derivative have been described as having anticancer activity. However, these compounds are very poorly water-soluble, not allowing administration by an intravenous route without an efficient nanostructured carrier system. In this work, biocompatible MEs of appropriate diameter size for intravenous route administration, loaded and unloaded with methyl dihydrojasmonate (MJ), were developed and described in a pseudo-ternary phase diagram. The compositions of the MEs were carefully selected from their own regions in the pseudo-ternary phase diagram. The formulations were analyzed by light scattering, polarized light microscopy, and X-ray diffraction. Also, a study on rheological profile was performed. The results showed that the droplet size decreased with both MJ incorporation and oil phase/surfactant ratio. All compositions of the studied MEs showed rheological behavior of pseudoplastic fluid and amorphous structures. In the absence of MJ, most of the studied MEs had thixotropic characteristics, which became antithixotropic in the presence of the drug. Almost all MJ-unloaded MEs presented anisotropic characteristics, but some formulations became isotropic, especially in the presence of MJ. The results of this study support the conclusion that the studied system represents a promising vehicle for in vivo administration of the MJ antitumor drug.
publishDate 2014
dc.date.none.fl_str_mv 2014-12-03T13:11:43Z
2014-12-03T13:11:43Z
2014-01-01
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.2147/IJN.S46055
International Journal Of Nanomedicine. Albany: Dove Medical Press Ltd, v. 9, p. 867-876, 2014.
1178-2013
http://hdl.handle.net/11449/113464
10.2147/IJN.S46055
WOS:000331040500001
WOS000331040500001.pdf
9114495952533044
url http://dx.doi.org/10.2147/IJN.S46055
http://hdl.handle.net/11449/113464
identifier_str_mv International Journal Of Nanomedicine. Albany: Dove Medical Press Ltd, v. 9, p. 867-876, 2014.
1178-2013
10.2147/IJN.S46055
WOS:000331040500001
WOS000331040500001.pdf
9114495952533044
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv International Journal of Nanomedicine
4.370
1,225
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 867-876
application/pdf
dc.publisher.none.fl_str_mv Dove Medical Press Ltd
publisher.none.fl_str_mv Dove Medical Press Ltd
dc.source.none.fl_str_mv Web of Science
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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