An analytical GC-MS method to quantify methyl dihydrojasmonate in biocompatible oil-in-water microemulsions: physicochemical characterization and in vitro release studies
Autor(a) principal: | |
---|---|
Data de Publicação: | 2018 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1080/10837450.2017.1337792 http://hdl.handle.net/11449/174791 |
Resumo: | Microemulsions (MEs) loaded with methyl dihydrojasmonate (MJ) were developed to improve the aqueous solubility of this drug. The composition of the formulations ranged according to the oil/surfactant ratio (O/S). The MEs were characterized according to diameter of droplets, X-ray diffraction and polarized light microscopy. The MJ identification and quantification was performed by gas chromatography-mass spectrometry (GC-MS). The MJ showed a retention time of ∼16.7 min for all samples. The obtained correlation coefficient from the calibration graph was 0.991. The developed analytical method was effective enough to quantify low and high concentrations of MJ. The increase of the O/S ME ratio led to a reduction of the droplet diameter. All formulations showed an amorphous structure and the behavior varied between isotropic and anisotropic systems. A decrease in the release of MJ with the increase of the O/S ratio in the formulations was observed. The analytical method developed for the quantitative determination of MJ is suitable to detect and quantify the drug compound from different compositions of MEs in the in vitro release test, and by analogy in other prolonged effects related to the drug reservoir effect of these systems was observed, revealing that ME can be a promising nanocarrier for MJ delivery to tumor cells. |
id |
UNSP_f67b096b8bd8936169b41210b505dced |
---|---|
oai_identifier_str |
oai:repositorio.unesp.br:11449/174791 |
network_acronym_str |
UNSP |
network_name_str |
Repositório Institucional da UNESP |
repository_id_str |
2946 |
spelling |
An analytical GC-MS method to quantify methyl dihydrojasmonate in biocompatible oil-in-water microemulsions: physicochemical characterization and in vitro release studiesanalytical GC-MS methodantitumor drugbiocompatible microemulsionsin vitro releaseMethyl dihydrojasmonateMicroemulsions (MEs) loaded with methyl dihydrojasmonate (MJ) were developed to improve the aqueous solubility of this drug. The composition of the formulations ranged according to the oil/surfactant ratio (O/S). The MEs were characterized according to diameter of droplets, X-ray diffraction and polarized light microscopy. The MJ identification and quantification was performed by gas chromatography-mass spectrometry (GC-MS). The MJ showed a retention time of ∼16.7 min for all samples. The obtained correlation coefficient from the calibration graph was 0.991. The developed analytical method was effective enough to quantify low and high concentrations of MJ. The increase of the O/S ME ratio led to a reduction of the droplet diameter. All formulations showed an amorphous structure and the behavior varied between isotropic and anisotropic systems. A decrease in the release of MJ with the increase of the O/S ratio in the formulations was observed. The analytical method developed for the quantitative determination of MJ is suitable to detect and quantify the drug compound from different compositions of MEs in the in vitro release test, and by analogy in other prolonged effects related to the drug reservoir effect of these systems was observed, revealing that ME can be a promising nanocarrier for MJ delivery to tumor cells.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Faculdade de Ciências Farmacêuticas Departamento de Fármacos e Medicamentos PPG em Ciências Farmacêuticas Unesp-Universidade Estadual PaulistaInstituto de Quimica Centro de Monitoramento e Pesquisa da Qualidade de Combustíveis (CEMPEQC) Unesp-Universidade Estadual PaulistaCentro de Ciências da Saúde Departamento de Farmácia Universidade Federal do Rio Grande do NorteFaculdade de Ciências Farmacêuticas Departamento de Fármacos e Medicamentos PPG em Ciências Farmacêuticas Unesp-Universidade Estadual PaulistaInstituto de Quimica Centro de Monitoramento e Pesquisa da Qualidade de Combustíveis (CEMPEQC) Unesp-Universidade Estadual PaulistaUniversidade Estadual Paulista (Unesp)Universidade Federal do Rio Grande do Norteda Silva, Gisela Bevilacqua Rolfsen Ferreira [UNESP]Alécio, Alberto Camilo [UNESP]Scarpa, Maria Virginia Costa [UNESP]do Egito, Eryvaldo Socrates TabosaSequinel, Rodrigo [UNESP]Hatanaka, Rafael Rodrigues [UNESP]Oliveira, José Eduardo [UNESP]Oliveira, Anselmo Gomes de [UNESP]2018-12-11T17:12:53Z2018-12-11T17:12:53Z2018-02-07info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article151-157http://dx.doi.org/10.1080/10837450.2017.1337792Pharmaceutical Development and Technology, v. 23, n. 2, p. 151-157, 2018.1097-98671083-7450http://hdl.handle.net/11449/17479110.1080/10837450.2017.13377922-s2.0-850211612242-s2.0-85021161224.pdf4930795298045665Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengPharmaceutical Development and Technology0,4790,479info:eu-repo/semantics/openAccess2024-06-24T13:45:30Zoai:repositorio.unesp.br:11449/174791Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T16:58:00.180176Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
An analytical GC-MS method to quantify methyl dihydrojasmonate in biocompatible oil-in-water microemulsions: physicochemical characterization and in vitro release studies |
title |
An analytical GC-MS method to quantify methyl dihydrojasmonate in biocompatible oil-in-water microemulsions: physicochemical characterization and in vitro release studies |
spellingShingle |
An analytical GC-MS method to quantify methyl dihydrojasmonate in biocompatible oil-in-water microemulsions: physicochemical characterization and in vitro release studies da Silva, Gisela Bevilacqua Rolfsen Ferreira [UNESP] analytical GC-MS method antitumor drug biocompatible microemulsions in vitro release Methyl dihydrojasmonate |
title_short |
An analytical GC-MS method to quantify methyl dihydrojasmonate in biocompatible oil-in-water microemulsions: physicochemical characterization and in vitro release studies |
title_full |
An analytical GC-MS method to quantify methyl dihydrojasmonate in biocompatible oil-in-water microemulsions: physicochemical characterization and in vitro release studies |
title_fullStr |
An analytical GC-MS method to quantify methyl dihydrojasmonate in biocompatible oil-in-water microemulsions: physicochemical characterization and in vitro release studies |
title_full_unstemmed |
An analytical GC-MS method to quantify methyl dihydrojasmonate in biocompatible oil-in-water microemulsions: physicochemical characterization and in vitro release studies |
title_sort |
An analytical GC-MS method to quantify methyl dihydrojasmonate in biocompatible oil-in-water microemulsions: physicochemical characterization and in vitro release studies |
author |
da Silva, Gisela Bevilacqua Rolfsen Ferreira [UNESP] |
author_facet |
da Silva, Gisela Bevilacqua Rolfsen Ferreira [UNESP] Alécio, Alberto Camilo [UNESP] Scarpa, Maria Virginia Costa [UNESP] do Egito, Eryvaldo Socrates Tabosa Sequinel, Rodrigo [UNESP] Hatanaka, Rafael Rodrigues [UNESP] Oliveira, José Eduardo [UNESP] Oliveira, Anselmo Gomes de [UNESP] |
author_role |
author |
author2 |
Alécio, Alberto Camilo [UNESP] Scarpa, Maria Virginia Costa [UNESP] do Egito, Eryvaldo Socrates Tabosa Sequinel, Rodrigo [UNESP] Hatanaka, Rafael Rodrigues [UNESP] Oliveira, José Eduardo [UNESP] Oliveira, Anselmo Gomes de [UNESP] |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Universidade Federal do Rio Grande do Norte |
dc.contributor.author.fl_str_mv |
da Silva, Gisela Bevilacqua Rolfsen Ferreira [UNESP] Alécio, Alberto Camilo [UNESP] Scarpa, Maria Virginia Costa [UNESP] do Egito, Eryvaldo Socrates Tabosa Sequinel, Rodrigo [UNESP] Hatanaka, Rafael Rodrigues [UNESP] Oliveira, José Eduardo [UNESP] Oliveira, Anselmo Gomes de [UNESP] |
dc.subject.por.fl_str_mv |
analytical GC-MS method antitumor drug biocompatible microemulsions in vitro release Methyl dihydrojasmonate |
topic |
analytical GC-MS method antitumor drug biocompatible microemulsions in vitro release Methyl dihydrojasmonate |
description |
Microemulsions (MEs) loaded with methyl dihydrojasmonate (MJ) were developed to improve the aqueous solubility of this drug. The composition of the formulations ranged according to the oil/surfactant ratio (O/S). The MEs were characterized according to diameter of droplets, X-ray diffraction and polarized light microscopy. The MJ identification and quantification was performed by gas chromatography-mass spectrometry (GC-MS). The MJ showed a retention time of ∼16.7 min for all samples. The obtained correlation coefficient from the calibration graph was 0.991. The developed analytical method was effective enough to quantify low and high concentrations of MJ. The increase of the O/S ME ratio led to a reduction of the droplet diameter. All formulations showed an amorphous structure and the behavior varied between isotropic and anisotropic systems. A decrease in the release of MJ with the increase of the O/S ratio in the formulations was observed. The analytical method developed for the quantitative determination of MJ is suitable to detect and quantify the drug compound from different compositions of MEs in the in vitro release test, and by analogy in other prolonged effects related to the drug reservoir effect of these systems was observed, revealing that ME can be a promising nanocarrier for MJ delivery to tumor cells. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-12-11T17:12:53Z 2018-12-11T17:12:53Z 2018-02-07 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1080/10837450.2017.1337792 Pharmaceutical Development and Technology, v. 23, n. 2, p. 151-157, 2018. 1097-9867 1083-7450 http://hdl.handle.net/11449/174791 10.1080/10837450.2017.1337792 2-s2.0-85021161224 2-s2.0-85021161224.pdf 4930795298045665 |
url |
http://dx.doi.org/10.1080/10837450.2017.1337792 http://hdl.handle.net/11449/174791 |
identifier_str_mv |
Pharmaceutical Development and Technology, v. 23, n. 2, p. 151-157, 2018. 1097-9867 1083-7450 10.1080/10837450.2017.1337792 2-s2.0-85021161224 2-s2.0-85021161224.pdf 4930795298045665 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Pharmaceutical Development and Technology 0,479 0,479 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
151-157 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808128726818357248 |