An analytical GC-MS method to quantify methyl dihydrojasmonate in biocompatible oil-in-water microemulsions: physicochemical characterization and in vitro release studies

Detalhes bibliográficos
Autor(a) principal: da Silva, Gisela Bevilacqua Rolfsen Ferreira [UNESP]
Data de Publicação: 2018
Outros Autores: Alécio, Alberto Camilo [UNESP], Scarpa, Maria Virginia Costa [UNESP], do Egito, Eryvaldo Socrates Tabosa, Sequinel, Rodrigo [UNESP], Hatanaka, Rafael Rodrigues [UNESP], Oliveira, José Eduardo [UNESP], Oliveira, Anselmo Gomes de [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1080/10837450.2017.1337792
http://hdl.handle.net/11449/174791
Resumo: Microemulsions (MEs) loaded with methyl dihydrojasmonate (MJ) were developed to improve the aqueous solubility of this drug. The composition of the formulations ranged according to the oil/surfactant ratio (O/S). The MEs were characterized according to diameter of droplets, X-ray diffraction and polarized light microscopy. The MJ identification and quantification was performed by gas chromatography-mass spectrometry (GC-MS). The MJ showed a retention time of ∼16.7 min for all samples. The obtained correlation coefficient from the calibration graph was 0.991. The developed analytical method was effective enough to quantify low and high concentrations of MJ. The increase of the O/S ME ratio led to a reduction of the droplet diameter. All formulations showed an amorphous structure and the behavior varied between isotropic and anisotropic systems. A decrease in the release of MJ with the increase of the O/S ratio in the formulations was observed. The analytical method developed for the quantitative determination of MJ is suitable to detect and quantify the drug compound from different compositions of MEs in the in vitro release test, and by analogy in other prolonged effects related to the drug reservoir effect of these systems was observed, revealing that ME can be a promising nanocarrier for MJ delivery to tumor cells.
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spelling An analytical GC-MS method to quantify methyl dihydrojasmonate in biocompatible oil-in-water microemulsions: physicochemical characterization and in vitro release studiesanalytical GC-MS methodantitumor drugbiocompatible microemulsionsin vitro releaseMethyl dihydrojasmonateMicroemulsions (MEs) loaded with methyl dihydrojasmonate (MJ) were developed to improve the aqueous solubility of this drug. The composition of the formulations ranged according to the oil/surfactant ratio (O/S). The MEs were characterized according to diameter of droplets, X-ray diffraction and polarized light microscopy. The MJ identification and quantification was performed by gas chromatography-mass spectrometry (GC-MS). The MJ showed a retention time of ∼16.7 min for all samples. The obtained correlation coefficient from the calibration graph was 0.991. The developed analytical method was effective enough to quantify low and high concentrations of MJ. The increase of the O/S ME ratio led to a reduction of the droplet diameter. All formulations showed an amorphous structure and the behavior varied between isotropic and anisotropic systems. A decrease in the release of MJ with the increase of the O/S ratio in the formulations was observed. The analytical method developed for the quantitative determination of MJ is suitable to detect and quantify the drug compound from different compositions of MEs in the in vitro release test, and by analogy in other prolonged effects related to the drug reservoir effect of these systems was observed, revealing that ME can be a promising nanocarrier for MJ delivery to tumor cells.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Faculdade de Ciências Farmacêuticas Departamento de Fármacos e Medicamentos PPG em Ciências Farmacêuticas Unesp-Universidade Estadual PaulistaInstituto de Quimica Centro de Monitoramento e Pesquisa da Qualidade de Combustíveis (CEMPEQC) Unesp-Universidade Estadual PaulistaCentro de Ciências da Saúde Departamento de Farmácia Universidade Federal do Rio Grande do NorteFaculdade de Ciências Farmacêuticas Departamento de Fármacos e Medicamentos PPG em Ciências Farmacêuticas Unesp-Universidade Estadual PaulistaInstituto de Quimica Centro de Monitoramento e Pesquisa da Qualidade de Combustíveis (CEMPEQC) Unesp-Universidade Estadual PaulistaUniversidade Estadual Paulista (Unesp)Universidade Federal do Rio Grande do Norteda Silva, Gisela Bevilacqua Rolfsen Ferreira [UNESP]Alécio, Alberto Camilo [UNESP]Scarpa, Maria Virginia Costa [UNESP]do Egito, Eryvaldo Socrates TabosaSequinel, Rodrigo [UNESP]Hatanaka, Rafael Rodrigues [UNESP]Oliveira, José Eduardo [UNESP]Oliveira, Anselmo Gomes de [UNESP]2018-12-11T17:12:53Z2018-12-11T17:12:53Z2018-02-07info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article151-157http://dx.doi.org/10.1080/10837450.2017.1337792Pharmaceutical Development and Technology, v. 23, n. 2, p. 151-157, 2018.1097-98671083-7450http://hdl.handle.net/11449/17479110.1080/10837450.2017.13377922-s2.0-850211612242-s2.0-85021161224.pdf4930795298045665Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengPharmaceutical Development and Technology0,4790,479info:eu-repo/semantics/openAccess2024-06-24T13:45:30Zoai:repositorio.unesp.br:11449/174791Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T16:58:00.180176Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv An analytical GC-MS method to quantify methyl dihydrojasmonate in biocompatible oil-in-water microemulsions: physicochemical characterization and in vitro release studies
title An analytical GC-MS method to quantify methyl dihydrojasmonate in biocompatible oil-in-water microemulsions: physicochemical characterization and in vitro release studies
spellingShingle An analytical GC-MS method to quantify methyl dihydrojasmonate in biocompatible oil-in-water microemulsions: physicochemical characterization and in vitro release studies
da Silva, Gisela Bevilacqua Rolfsen Ferreira [UNESP]
analytical GC-MS method
antitumor drug
biocompatible microemulsions
in vitro release
Methyl dihydrojasmonate
title_short An analytical GC-MS method to quantify methyl dihydrojasmonate in biocompatible oil-in-water microemulsions: physicochemical characterization and in vitro release studies
title_full An analytical GC-MS method to quantify methyl dihydrojasmonate in biocompatible oil-in-water microemulsions: physicochemical characterization and in vitro release studies
title_fullStr An analytical GC-MS method to quantify methyl dihydrojasmonate in biocompatible oil-in-water microemulsions: physicochemical characterization and in vitro release studies
title_full_unstemmed An analytical GC-MS method to quantify methyl dihydrojasmonate in biocompatible oil-in-water microemulsions: physicochemical characterization and in vitro release studies
title_sort An analytical GC-MS method to quantify methyl dihydrojasmonate in biocompatible oil-in-water microemulsions: physicochemical characterization and in vitro release studies
author da Silva, Gisela Bevilacqua Rolfsen Ferreira [UNESP]
author_facet da Silva, Gisela Bevilacqua Rolfsen Ferreira [UNESP]
Alécio, Alberto Camilo [UNESP]
Scarpa, Maria Virginia Costa [UNESP]
do Egito, Eryvaldo Socrates Tabosa
Sequinel, Rodrigo [UNESP]
Hatanaka, Rafael Rodrigues [UNESP]
Oliveira, José Eduardo [UNESP]
Oliveira, Anselmo Gomes de [UNESP]
author_role author
author2 Alécio, Alberto Camilo [UNESP]
Scarpa, Maria Virginia Costa [UNESP]
do Egito, Eryvaldo Socrates Tabosa
Sequinel, Rodrigo [UNESP]
Hatanaka, Rafael Rodrigues [UNESP]
Oliveira, José Eduardo [UNESP]
Oliveira, Anselmo Gomes de [UNESP]
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
Universidade Federal do Rio Grande do Norte
dc.contributor.author.fl_str_mv da Silva, Gisela Bevilacqua Rolfsen Ferreira [UNESP]
Alécio, Alberto Camilo [UNESP]
Scarpa, Maria Virginia Costa [UNESP]
do Egito, Eryvaldo Socrates Tabosa
Sequinel, Rodrigo [UNESP]
Hatanaka, Rafael Rodrigues [UNESP]
Oliveira, José Eduardo [UNESP]
Oliveira, Anselmo Gomes de [UNESP]
dc.subject.por.fl_str_mv analytical GC-MS method
antitumor drug
biocompatible microemulsions
in vitro release
Methyl dihydrojasmonate
topic analytical GC-MS method
antitumor drug
biocompatible microemulsions
in vitro release
Methyl dihydrojasmonate
description Microemulsions (MEs) loaded with methyl dihydrojasmonate (MJ) were developed to improve the aqueous solubility of this drug. The composition of the formulations ranged according to the oil/surfactant ratio (O/S). The MEs were characterized according to diameter of droplets, X-ray diffraction and polarized light microscopy. The MJ identification and quantification was performed by gas chromatography-mass spectrometry (GC-MS). The MJ showed a retention time of ∼16.7 min for all samples. The obtained correlation coefficient from the calibration graph was 0.991. The developed analytical method was effective enough to quantify low and high concentrations of MJ. The increase of the O/S ME ratio led to a reduction of the droplet diameter. All formulations showed an amorphous structure and the behavior varied between isotropic and anisotropic systems. A decrease in the release of MJ with the increase of the O/S ratio in the formulations was observed. The analytical method developed for the quantitative determination of MJ is suitable to detect and quantify the drug compound from different compositions of MEs in the in vitro release test, and by analogy in other prolonged effects related to the drug reservoir effect of these systems was observed, revealing that ME can be a promising nanocarrier for MJ delivery to tumor cells.
publishDate 2018
dc.date.none.fl_str_mv 2018-12-11T17:12:53Z
2018-12-11T17:12:53Z
2018-02-07
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1080/10837450.2017.1337792
Pharmaceutical Development and Technology, v. 23, n. 2, p. 151-157, 2018.
1097-9867
1083-7450
http://hdl.handle.net/11449/174791
10.1080/10837450.2017.1337792
2-s2.0-85021161224
2-s2.0-85021161224.pdf
4930795298045665
url http://dx.doi.org/10.1080/10837450.2017.1337792
http://hdl.handle.net/11449/174791
identifier_str_mv Pharmaceutical Development and Technology, v. 23, n. 2, p. 151-157, 2018.
1097-9867
1083-7450
10.1080/10837450.2017.1337792
2-s2.0-85021161224
2-s2.0-85021161224.pdf
4930795298045665
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Pharmaceutical Development and Technology
0,479
0,479
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 151-157
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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