Relaxin-2 during pregnancy according to glycemia, continence status, and pelvic floor muscle function

Detalhes bibliográficos
Autor(a) principal: Prudencio, Caroline Baldini [UNESP]
Data de Publicação: 2022
Outros Autores: Nunes, Sthefanie Kenickel [UNESP], Pinheiro, Fabiane Affonso [UNESP], Filho, Carlos Isaias Sartorão [UNESP], Antônio, Flávia Ignácio, de Aquino Nava, Guilherme Thomaz [UNESP], Rudge, Marilza Vieira Cunha [UNESP], Barbosa, Angélica Mércia Pascon [UNESP], Calderon, I. M.P., Souza, F. P., Berghmans, B., de Bie, R., Thabane, L., Junginger, B., Graeff, C. F.O., Magalhães, C. G., Costa, R. A., Lima, S. A.M., Kron-Rodrigues, M. R., Felisbino, S., Barbosa, W., Campos, F. J., Bossolan, G., Corrente, J. E., Nunes, H. R.C., Abbade, J., Rossignoli, P. S., Pedroni, C. R., Atallah, A. N., Di Bella, Z. I.K.J., Uchoa, S. M.M., Hungaro, M. A., Mareco, E. A., Sakalem, M. E., Martinho, N., Hallur, L. S.R., Reyes, D. R.A., Alves, F. C.B., Marcondes, J. P.C., Quiroz, S. B.C.V., Pascon, T., Catinelli, B. B., Reis, F. V.D.S., Oliveira, R. G., Barneze, S., Enriquez, E. M.A., Takano, L., Carr, A. M., Magyori, A. B.M., Iamundo, L. F., Carvalho, C. N.F., Jacomin, M., Avramidis, R. E., Silva, A. J.B., Orlandi, M. I.G., Dangió, T. D., Bassin, H. C.M., Melo, J. V.F., Takemoto, M. L.S., Menezes, M. D., Caldeirão, T. D., Santos, N. J., Lourenço, I. O., de Sá Marostica, J., Caruso, I. P., Rasmussen, L. T., Garcia, G. A., Pascon, C., Bussaneli, D. G., Nogueira, V. K.C., Rudge, C. V.C., Piculo, F., Prata, G. M., Barbosa, V. P.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1007/s00192-022-05245-y
http://hdl.handle.net/11449/241312
Resumo: Introduction and hypothesis: To investigate relaxin-2 concentration comparing gestational diabetes mellitus (GDM) and non-GDM patients during pregnancy according to urinary incontinence (UI) and pelvic function status. Methods: This is a cross-sectional study evaluating 282 pregnant women from 24 weeks of gestation. The participants were divided into two groups, non-GDM and GDM, according to American Diabetes Association’s diabetes mellitus gestational threshold. In addition, according to subanalysis, both groups were subdivided according to the presence of pregnancy-specific urinary incontinence: non-GDM continent, non-GDM incontinent, GDM continent, and GDM incontinent. All participants filled in questionnaires on clinical, obstetric, and urinary continence status (International Consultation on Incontinence Questionnaire-Short Form, ICIQ-SF, and Incontinence Severity Index, ISI), followed by pelvic floor muscle evaluation by the PERFECT scheme in which strength, endurance, and speed of contractions were evaluated. Results: Serum relaxin-2 concentrations were significantly lower in pregnant women with pregnancy-specific urinary incontinence in both non-GDM and GDM patients, but GDM showed the lowest concentration. In addition, the stratification of the groups according to pelvic floor muscle strength showed that pregnant patients with GDM and modified Oxford scale 0–2 had significantly lower levels than those who were non-GDM and GDM with Modified Oxford Scale 3–5. Relaxin-2 level was much lower in GDM incontinent pregnant women with MOS 0–2 compared to the other three groups. Conclusions: Lower relaxin-2 concentration was associated with the presence of pregnancy-specific urinary incontinence, but the combination of GDM, pregnancy-specific urinary incontinence, and lower levels of pelvic floor strength led to lower levels of relaxin-2 compared to the other three groups.
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spelling Relaxin-2 during pregnancy according to glycemia, continence status, and pelvic floor muscle functionGestational diabetesObstetricsPelvic floorPregnancyRelaxin-2Introduction and hypothesis: To investigate relaxin-2 concentration comparing gestational diabetes mellitus (GDM) and non-GDM patients during pregnancy according to urinary incontinence (UI) and pelvic function status. Methods: This is a cross-sectional study evaluating 282 pregnant women from 24 weeks of gestation. The participants were divided into two groups, non-GDM and GDM, according to American Diabetes Association’s diabetes mellitus gestational threshold. In addition, according to subanalysis, both groups were subdivided according to the presence of pregnancy-specific urinary incontinence: non-GDM continent, non-GDM incontinent, GDM continent, and GDM incontinent. All participants filled in questionnaires on clinical, obstetric, and urinary continence status (International Consultation on Incontinence Questionnaire-Short Form, ICIQ-SF, and Incontinence Severity Index, ISI), followed by pelvic floor muscle evaluation by the PERFECT scheme in which strength, endurance, and speed of contractions were evaluated. Results: Serum relaxin-2 concentrations were significantly lower in pregnant women with pregnancy-specific urinary incontinence in both non-GDM and GDM patients, but GDM showed the lowest concentration. In addition, the stratification of the groups according to pelvic floor muscle strength showed that pregnant patients with GDM and modified Oxford scale 0–2 had significantly lower levels than those who were non-GDM and GDM with Modified Oxford Scale 3–5. Relaxin-2 level was much lower in GDM incontinent pregnant women with MOS 0–2 compared to the other three groups. Conclusions: Lower relaxin-2 concentration was associated with the presence of pregnancy-specific urinary incontinence, but the combination of GDM, pregnancy-specific urinary incontinence, and lower levels of pelvic floor strength led to lower levels of relaxin-2 compared to the other three groups.Postgraduate Program on Tocogynecology São Paulo State University (UNESP), BotucatuSchool of Rehabilitation Sciences Faculty of Health Sciences University of OttawaDepartment of Physical Education Institute of Biosciences of Rio Claro São Paulo State University (UNESP), Rio ClaroPostgraduate Program on Tocogynecology São Paulo State University (UNESP), BotucatuDepartment of Physical Education Institute of Biosciences of Rio Claro São Paulo State University (UNESP), Rio ClaroUniversidade Estadual Paulista (UNESP)University of OttawaPrudencio, Caroline Baldini [UNESP]Nunes, Sthefanie Kenickel [UNESP]Pinheiro, Fabiane Affonso [UNESP]Filho, Carlos Isaias Sartorão [UNESP]Antônio, Flávia Ignáciode Aquino Nava, Guilherme Thomaz [UNESP]Rudge, Marilza Vieira Cunha [UNESP]Barbosa, Angélica Mércia Pascon [UNESP]Calderon, I. M.P.Souza, F. P.Berghmans, B.de Bie, R.Thabane, L.Junginger, B.Graeff, C. F.O.Magalhães, C. G.Costa, R. A.Lima, S. A.M.Kron-Rodrigues, M. R.Felisbino, S.Barbosa, W.Campos, F. J.Bossolan, G.Corrente, J. E.Nunes, H. R.C.Abbade, J.Rossignoli, P. S.Pedroni, C. R.Atallah, A. N.Di Bella, Z. I.K.J.Uchoa, S. M.M.Hungaro, M. A.Mareco, E. A.Sakalem, M. E.Martinho, N.Hallur, L. S.R.Reyes, D. R.A.Alves, F. C.B.Marcondes, J. P.C.Quiroz, S. B.C.V.Pascon, T.Catinelli, B. B.Reis, F. V.D.S.Oliveira, R. G.Barneze, S.Enriquez, E. M.A.Takano, L.Carr, A. M.Magyori, A. B.M.Iamundo, L. F.Carvalho, C. N.F.Jacomin, M.Avramidis, R. E.Silva, A. J.B.Orlandi, M. I.G.Dangió, T. D.Bassin, H. C.M.Melo, J. V.F.Takemoto, M. L.S.Menezes, M. D.Caldeirão, T. D.Santos, N. J.Lourenço, I. O.de Sá Marostica, J.Caruso, I. P.Rasmussen, L. T.Garcia, G. A.Pascon, C.Bussaneli, D. G.Nogueira, V. K.C.Rudge, C. V.C.Piculo, F.Prata, G. M.Barbosa, V. P.2023-03-01T20:56:21Z2023-03-01T20:56:21Z2022-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1007/s00192-022-05245-yInternational Urogynecology Journal.1433-30230937-3462http://hdl.handle.net/11449/24131210.1007/s00192-022-05245-y2-s2.0-85133849696Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengInternational Urogynecology Journalinfo:eu-repo/semantics/openAccess2024-08-16T14:12:33Zoai:repositorio.unesp.br:11449/241312Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-16T14:12:33Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Relaxin-2 during pregnancy according to glycemia, continence status, and pelvic floor muscle function
title Relaxin-2 during pregnancy according to glycemia, continence status, and pelvic floor muscle function
spellingShingle Relaxin-2 during pregnancy according to glycemia, continence status, and pelvic floor muscle function
Prudencio, Caroline Baldini [UNESP]
Gestational diabetes
Obstetrics
Pelvic floor
Pregnancy
Relaxin-2
title_short Relaxin-2 during pregnancy according to glycemia, continence status, and pelvic floor muscle function
title_full Relaxin-2 during pregnancy according to glycemia, continence status, and pelvic floor muscle function
title_fullStr Relaxin-2 during pregnancy according to glycemia, continence status, and pelvic floor muscle function
title_full_unstemmed Relaxin-2 during pregnancy according to glycemia, continence status, and pelvic floor muscle function
title_sort Relaxin-2 during pregnancy according to glycemia, continence status, and pelvic floor muscle function
author Prudencio, Caroline Baldini [UNESP]
author_facet Prudencio, Caroline Baldini [UNESP]
Nunes, Sthefanie Kenickel [UNESP]
Pinheiro, Fabiane Affonso [UNESP]
Filho, Carlos Isaias Sartorão [UNESP]
Antônio, Flávia Ignácio
de Aquino Nava, Guilherme Thomaz [UNESP]
Rudge, Marilza Vieira Cunha [UNESP]
Barbosa, Angélica Mércia Pascon [UNESP]
Calderon, I. M.P.
Souza, F. P.
Berghmans, B.
de Bie, R.
Thabane, L.
Junginger, B.
Graeff, C. F.O.
Magalhães, C. G.
Costa, R. A.
Lima, S. A.M.
Kron-Rodrigues, M. R.
Felisbino, S.
Barbosa, W.
Campos, F. J.
Bossolan, G.
Corrente, J. E.
Nunes, H. R.C.
Abbade, J.
Rossignoli, P. S.
Pedroni, C. R.
Atallah, A. N.
Di Bella, Z. I.K.J.
Uchoa, S. M.M.
Hungaro, M. A.
Mareco, E. A.
Sakalem, M. E.
Martinho, N.
Hallur, L. S.R.
Reyes, D. R.A.
Alves, F. C.B.
Marcondes, J. P.C.
Quiroz, S. B.C.V.
Pascon, T.
Catinelli, B. B.
Reis, F. V.D.S.
Oliveira, R. G.
Barneze, S.
Enriquez, E. M.A.
Takano, L.
Carr, A. M.
Magyori, A. B.M.
Iamundo, L. F.
Carvalho, C. N.F.
Jacomin, M.
Avramidis, R. E.
Silva, A. J.B.
Orlandi, M. I.G.
Dangió, T. D.
Bassin, H. C.M.
Melo, J. V.F.
Takemoto, M. L.S.
Menezes, M. D.
Caldeirão, T. D.
Santos, N. J.
Lourenço, I. O.
de Sá Marostica, J.
Caruso, I. P.
Rasmussen, L. T.
Garcia, G. A.
Pascon, C.
Bussaneli, D. G.
Nogueira, V. K.C.
Rudge, C. V.C.
Piculo, F.
Prata, G. M.
Barbosa, V. P.
author_role author
author2 Nunes, Sthefanie Kenickel [UNESP]
Pinheiro, Fabiane Affonso [UNESP]
Filho, Carlos Isaias Sartorão [UNESP]
Antônio, Flávia Ignácio
de Aquino Nava, Guilherme Thomaz [UNESP]
Rudge, Marilza Vieira Cunha [UNESP]
Barbosa, Angélica Mércia Pascon [UNESP]
Calderon, I. M.P.
Souza, F. P.
Berghmans, B.
de Bie, R.
Thabane, L.
Junginger, B.
Graeff, C. F.O.
Magalhães, C. G.
Costa, R. A.
Lima, S. A.M.
Kron-Rodrigues, M. R.
Felisbino, S.
Barbosa, W.
Campos, F. J.
Bossolan, G.
Corrente, J. E.
Nunes, H. R.C.
Abbade, J.
Rossignoli, P. S.
Pedroni, C. R.
Atallah, A. N.
Di Bella, Z. I.K.J.
Uchoa, S. M.M.
Hungaro, M. A.
Mareco, E. A.
Sakalem, M. E.
Martinho, N.
Hallur, L. S.R.
Reyes, D. R.A.
Alves, F. C.B.
Marcondes, J. P.C.
Quiroz, S. B.C.V.
Pascon, T.
Catinelli, B. B.
Reis, F. V.D.S.
Oliveira, R. G.
Barneze, S.
Enriquez, E. M.A.
Takano, L.
Carr, A. M.
Magyori, A. B.M.
Iamundo, L. F.
Carvalho, C. N.F.
Jacomin, M.
Avramidis, R. E.
Silva, A. J.B.
Orlandi, M. I.G.
Dangió, T. D.
Bassin, H. C.M.
Melo, J. V.F.
Takemoto, M. L.S.
Menezes, M. D.
Caldeirão, T. D.
Santos, N. J.
Lourenço, I. O.
de Sá Marostica, J.
Caruso, I. P.
Rasmussen, L. T.
Garcia, G. A.
Pascon, C.
Bussaneli, D. G.
Nogueira, V. K.C.
Rudge, C. V.C.
Piculo, F.
Prata, G. M.
Barbosa, V. P.
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dc.contributor.none.fl_str_mv Universidade Estadual Paulista (UNESP)
University of Ottawa
dc.contributor.author.fl_str_mv Prudencio, Caroline Baldini [UNESP]
Nunes, Sthefanie Kenickel [UNESP]
Pinheiro, Fabiane Affonso [UNESP]
Filho, Carlos Isaias Sartorão [UNESP]
Antônio, Flávia Ignácio
de Aquino Nava, Guilherme Thomaz [UNESP]
Rudge, Marilza Vieira Cunha [UNESP]
Barbosa, Angélica Mércia Pascon [UNESP]
Calderon, I. M.P.
Souza, F. P.
Berghmans, B.
de Bie, R.
Thabane, L.
Junginger, B.
Graeff, C. F.O.
Magalhães, C. G.
Costa, R. A.
Lima, S. A.M.
Kron-Rodrigues, M. R.
Felisbino, S.
Barbosa, W.
Campos, F. J.
Bossolan, G.
Corrente, J. E.
Nunes, H. R.C.
Abbade, J.
Rossignoli, P. S.
Pedroni, C. R.
Atallah, A. N.
Di Bella, Z. I.K.J.
Uchoa, S. M.M.
Hungaro, M. A.
Mareco, E. A.
Sakalem, M. E.
Martinho, N.
Hallur, L. S.R.
Reyes, D. R.A.
Alves, F. C.B.
Marcondes, J. P.C.
Quiroz, S. B.C.V.
Pascon, T.
Catinelli, B. B.
Reis, F. V.D.S.
Oliveira, R. G.
Barneze, S.
Enriquez, E. M.A.
Takano, L.
Carr, A. M.
Magyori, A. B.M.
Iamundo, L. F.
Carvalho, C. N.F.
Jacomin, M.
Avramidis, R. E.
Silva, A. J.B.
Orlandi, M. I.G.
Dangió, T. D.
Bassin, H. C.M.
Melo, J. V.F.
Takemoto, M. L.S.
Menezes, M. D.
Caldeirão, T. D.
Santos, N. J.
Lourenço, I. O.
de Sá Marostica, J.
Caruso, I. P.
Rasmussen, L. T.
Garcia, G. A.
Pascon, C.
Bussaneli, D. G.
Nogueira, V. K.C.
Rudge, C. V.C.
Piculo, F.
Prata, G. M.
Barbosa, V. P.
dc.subject.por.fl_str_mv Gestational diabetes
Obstetrics
Pelvic floor
Pregnancy
Relaxin-2
topic Gestational diabetes
Obstetrics
Pelvic floor
Pregnancy
Relaxin-2
description Introduction and hypothesis: To investigate relaxin-2 concentration comparing gestational diabetes mellitus (GDM) and non-GDM patients during pregnancy according to urinary incontinence (UI) and pelvic function status. Methods: This is a cross-sectional study evaluating 282 pregnant women from 24 weeks of gestation. The participants were divided into two groups, non-GDM and GDM, according to American Diabetes Association’s diabetes mellitus gestational threshold. In addition, according to subanalysis, both groups were subdivided according to the presence of pregnancy-specific urinary incontinence: non-GDM continent, non-GDM incontinent, GDM continent, and GDM incontinent. All participants filled in questionnaires on clinical, obstetric, and urinary continence status (International Consultation on Incontinence Questionnaire-Short Form, ICIQ-SF, and Incontinence Severity Index, ISI), followed by pelvic floor muscle evaluation by the PERFECT scheme in which strength, endurance, and speed of contractions were evaluated. Results: Serum relaxin-2 concentrations were significantly lower in pregnant women with pregnancy-specific urinary incontinence in both non-GDM and GDM patients, but GDM showed the lowest concentration. In addition, the stratification of the groups according to pelvic floor muscle strength showed that pregnant patients with GDM and modified Oxford scale 0–2 had significantly lower levels than those who were non-GDM and GDM with Modified Oxford Scale 3–5. Relaxin-2 level was much lower in GDM incontinent pregnant women with MOS 0–2 compared to the other three groups. Conclusions: Lower relaxin-2 concentration was associated with the presence of pregnancy-specific urinary incontinence, but the combination of GDM, pregnancy-specific urinary incontinence, and lower levels of pelvic floor strength led to lower levels of relaxin-2 compared to the other three groups.
publishDate 2022
dc.date.none.fl_str_mv 2022-01-01
2023-03-01T20:56:21Z
2023-03-01T20:56:21Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1007/s00192-022-05245-y
International Urogynecology Journal.
1433-3023
0937-3462
http://hdl.handle.net/11449/241312
10.1007/s00192-022-05245-y
2-s2.0-85133849696
url http://dx.doi.org/10.1007/s00192-022-05245-y
http://hdl.handle.net/11449/241312
identifier_str_mv International Urogynecology Journal.
1433-3023
0937-3462
10.1007/s00192-022-05245-y
2-s2.0-85133849696
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv International Urogynecology Journal
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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