Relaxin-2 during pregnancy according to glycemia, continence status, and pelvic floor muscle function
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1007/s00192-022-05245-y http://hdl.handle.net/11449/241312 |
Resumo: | Introduction and hypothesis: To investigate relaxin-2 concentration comparing gestational diabetes mellitus (GDM) and non-GDM patients during pregnancy according to urinary incontinence (UI) and pelvic function status. Methods: This is a cross-sectional study evaluating 282 pregnant women from 24 weeks of gestation. The participants were divided into two groups, non-GDM and GDM, according to American Diabetes Association’s diabetes mellitus gestational threshold. In addition, according to subanalysis, both groups were subdivided according to the presence of pregnancy-specific urinary incontinence: non-GDM continent, non-GDM incontinent, GDM continent, and GDM incontinent. All participants filled in questionnaires on clinical, obstetric, and urinary continence status (International Consultation on Incontinence Questionnaire-Short Form, ICIQ-SF, and Incontinence Severity Index, ISI), followed by pelvic floor muscle evaluation by the PERFECT scheme in which strength, endurance, and speed of contractions were evaluated. Results: Serum relaxin-2 concentrations were significantly lower in pregnant women with pregnancy-specific urinary incontinence in both non-GDM and GDM patients, but GDM showed the lowest concentration. In addition, the stratification of the groups according to pelvic floor muscle strength showed that pregnant patients with GDM and modified Oxford scale 0–2 had significantly lower levels than those who were non-GDM and GDM with Modified Oxford Scale 3–5. Relaxin-2 level was much lower in GDM incontinent pregnant women with MOS 0–2 compared to the other three groups. Conclusions: Lower relaxin-2 concentration was associated with the presence of pregnancy-specific urinary incontinence, but the combination of GDM, pregnancy-specific urinary incontinence, and lower levels of pelvic floor strength led to lower levels of relaxin-2 compared to the other three groups. |
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Relaxin-2 during pregnancy according to glycemia, continence status, and pelvic floor muscle functionGestational diabetesObstetricsPelvic floorPregnancyRelaxin-2Introduction and hypothesis: To investigate relaxin-2 concentration comparing gestational diabetes mellitus (GDM) and non-GDM patients during pregnancy according to urinary incontinence (UI) and pelvic function status. Methods: This is a cross-sectional study evaluating 282 pregnant women from 24 weeks of gestation. The participants were divided into two groups, non-GDM and GDM, according to American Diabetes Association’s diabetes mellitus gestational threshold. In addition, according to subanalysis, both groups were subdivided according to the presence of pregnancy-specific urinary incontinence: non-GDM continent, non-GDM incontinent, GDM continent, and GDM incontinent. All participants filled in questionnaires on clinical, obstetric, and urinary continence status (International Consultation on Incontinence Questionnaire-Short Form, ICIQ-SF, and Incontinence Severity Index, ISI), followed by pelvic floor muscle evaluation by the PERFECT scheme in which strength, endurance, and speed of contractions were evaluated. Results: Serum relaxin-2 concentrations were significantly lower in pregnant women with pregnancy-specific urinary incontinence in both non-GDM and GDM patients, but GDM showed the lowest concentration. In addition, the stratification of the groups according to pelvic floor muscle strength showed that pregnant patients with GDM and modified Oxford scale 0–2 had significantly lower levels than those who were non-GDM and GDM with Modified Oxford Scale 3–5. Relaxin-2 level was much lower in GDM incontinent pregnant women with MOS 0–2 compared to the other three groups. Conclusions: Lower relaxin-2 concentration was associated with the presence of pregnancy-specific urinary incontinence, but the combination of GDM, pregnancy-specific urinary incontinence, and lower levels of pelvic floor strength led to lower levels of relaxin-2 compared to the other three groups.Postgraduate Program on Tocogynecology São Paulo State University (UNESP), BotucatuSchool of Rehabilitation Sciences Faculty of Health Sciences University of OttawaDepartment of Physical Education Institute of Biosciences of Rio Claro São Paulo State University (UNESP), Rio ClaroPostgraduate Program on Tocogynecology São Paulo State University (UNESP), BotucatuDepartment of Physical Education Institute of Biosciences of Rio Claro São Paulo State University (UNESP), Rio ClaroUniversidade Estadual Paulista (UNESP)University of OttawaPrudencio, Caroline Baldini [UNESP]Nunes, Sthefanie Kenickel [UNESP]Pinheiro, Fabiane Affonso [UNESP]Filho, Carlos Isaias Sartorão [UNESP]Antônio, Flávia Ignáciode Aquino Nava, Guilherme Thomaz [UNESP]Rudge, Marilza Vieira Cunha [UNESP]Barbosa, Angélica Mércia Pascon [UNESP]Calderon, I. M.P.Souza, F. P.Berghmans, B.de Bie, R.Thabane, L.Junginger, B.Graeff, C. F.O.Magalhães, C. G.Costa, R. A.Lima, S. A.M.Kron-Rodrigues, M. R.Felisbino, S.Barbosa, W.Campos, F. J.Bossolan, G.Corrente, J. E.Nunes, H. R.C.Abbade, J.Rossignoli, P. S.Pedroni, C. R.Atallah, A. N.Di Bella, Z. I.K.J.Uchoa, S. M.M.Hungaro, M. A.Mareco, E. A.Sakalem, M. E.Martinho, N.Hallur, L. S.R.Reyes, D. R.A.Alves, F. C.B.Marcondes, J. P.C.Quiroz, S. B.C.V.Pascon, T.Catinelli, B. B.Reis, F. V.D.S.Oliveira, R. G.Barneze, S.Enriquez, E. M.A.Takano, L.Carr, A. M.Magyori, A. B.M.Iamundo, L. F.Carvalho, C. N.F.Jacomin, M.Avramidis, R. E.Silva, A. J.B.Orlandi, M. I.G.Dangió, T. D.Bassin, H. C.M.Melo, J. V.F.Takemoto, M. L.S.Menezes, M. D.Caldeirão, T. D.Santos, N. J.Lourenço, I. O.de Sá Marostica, J.Caruso, I. P.Rasmussen, L. T.Garcia, G. A.Pascon, C.Bussaneli, D. G.Nogueira, V. K.C.Rudge, C. V.C.Piculo, F.Prata, G. M.Barbosa, V. P.2023-03-01T20:56:21Z2023-03-01T20:56:21Z2022-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1007/s00192-022-05245-yInternational Urogynecology Journal.1433-30230937-3462http://hdl.handle.net/11449/24131210.1007/s00192-022-05245-y2-s2.0-85133849696Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengInternational Urogynecology Journalinfo:eu-repo/semantics/openAccess2024-08-16T14:12:33Zoai:repositorio.unesp.br:11449/241312Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-16T14:12:33Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Relaxin-2 during pregnancy according to glycemia, continence status, and pelvic floor muscle function |
title |
Relaxin-2 during pregnancy according to glycemia, continence status, and pelvic floor muscle function |
spellingShingle |
Relaxin-2 during pregnancy according to glycemia, continence status, and pelvic floor muscle function Prudencio, Caroline Baldini [UNESP] Gestational diabetes Obstetrics Pelvic floor Pregnancy Relaxin-2 |
title_short |
Relaxin-2 during pregnancy according to glycemia, continence status, and pelvic floor muscle function |
title_full |
Relaxin-2 during pregnancy according to glycemia, continence status, and pelvic floor muscle function |
title_fullStr |
Relaxin-2 during pregnancy according to glycemia, continence status, and pelvic floor muscle function |
title_full_unstemmed |
Relaxin-2 during pregnancy according to glycemia, continence status, and pelvic floor muscle function |
title_sort |
Relaxin-2 during pregnancy according to glycemia, continence status, and pelvic floor muscle function |
author |
Prudencio, Caroline Baldini [UNESP] |
author_facet |
Prudencio, Caroline Baldini [UNESP] Nunes, Sthefanie Kenickel [UNESP] Pinheiro, Fabiane Affonso [UNESP] Filho, Carlos Isaias Sartorão [UNESP] Antônio, Flávia Ignácio de Aquino Nava, Guilherme Thomaz [UNESP] Rudge, Marilza Vieira Cunha [UNESP] Barbosa, Angélica Mércia Pascon [UNESP] Calderon, I. M.P. Souza, F. P. Berghmans, B. de Bie, R. Thabane, L. Junginger, B. Graeff, C. F.O. Magalhães, C. G. Costa, R. A. Lima, S. A.M. Kron-Rodrigues, M. R. Felisbino, S. Barbosa, W. Campos, F. J. Bossolan, G. Corrente, J. E. Nunes, H. R.C. Abbade, J. Rossignoli, P. S. Pedroni, C. R. Atallah, A. N. Di Bella, Z. I.K.J. Uchoa, S. M.M. Hungaro, M. A. Mareco, E. A. Sakalem, M. E. Martinho, N. Hallur, L. S.R. Reyes, D. R.A. Alves, F. C.B. Marcondes, J. P.C. Quiroz, S. B.C.V. Pascon, T. Catinelli, B. B. Reis, F. V.D.S. Oliveira, R. G. Barneze, S. Enriquez, E. M.A. Takano, L. Carr, A. M. Magyori, A. B.M. Iamundo, L. F. Carvalho, C. N.F. Jacomin, M. Avramidis, R. E. Silva, A. J.B. Orlandi, M. I.G. Dangió, T. D. Bassin, H. C.M. Melo, J. V.F. Takemoto, M. L.S. Menezes, M. D. Caldeirão, T. D. Santos, N. J. Lourenço, I. O. de Sá Marostica, J. Caruso, I. P. Rasmussen, L. T. Garcia, G. A. Pascon, C. Bussaneli, D. G. Nogueira, V. K.C. Rudge, C. V.C. Piculo, F. Prata, G. M. Barbosa, V. P. |
author_role |
author |
author2 |
Nunes, Sthefanie Kenickel [UNESP] Pinheiro, Fabiane Affonso [UNESP] Filho, Carlos Isaias Sartorão [UNESP] Antônio, Flávia Ignácio de Aquino Nava, Guilherme Thomaz [UNESP] Rudge, Marilza Vieira Cunha [UNESP] Barbosa, Angélica Mércia Pascon [UNESP] Calderon, I. M.P. Souza, F. P. Berghmans, B. de Bie, R. Thabane, L. Junginger, B. Graeff, C. F.O. Magalhães, C. G. Costa, R. A. Lima, S. A.M. Kron-Rodrigues, M. R. Felisbino, S. Barbosa, W. Campos, F. J. Bossolan, G. Corrente, J. E. Nunes, H. R.C. Abbade, J. Rossignoli, P. S. Pedroni, C. R. Atallah, A. N. Di Bella, Z. I.K.J. Uchoa, S. M.M. Hungaro, M. A. Mareco, E. A. Sakalem, M. E. Martinho, N. Hallur, L. S.R. Reyes, D. R.A. Alves, F. C.B. Marcondes, J. P.C. Quiroz, S. B.C.V. Pascon, T. Catinelli, B. B. Reis, F. V.D.S. Oliveira, R. G. Barneze, S. Enriquez, E. M.A. Takano, L. Carr, A. M. Magyori, A. B.M. Iamundo, L. F. Carvalho, C. N.F. Jacomin, M. Avramidis, R. E. Silva, A. J.B. Orlandi, M. I.G. Dangió, T. D. Bassin, H. C.M. Melo, J. V.F. Takemoto, M. L.S. Menezes, M. D. Caldeirão, T. D. Santos, N. J. Lourenço, I. O. de Sá Marostica, J. Caruso, I. P. Rasmussen, L. T. Garcia, G. A. Pascon, C. Bussaneli, D. G. Nogueira, V. K.C. Rudge, C. V.C. Piculo, F. Prata, G. M. Barbosa, V. P. |
author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (UNESP) University of Ottawa |
dc.contributor.author.fl_str_mv |
Prudencio, Caroline Baldini [UNESP] Nunes, Sthefanie Kenickel [UNESP] Pinheiro, Fabiane Affonso [UNESP] Filho, Carlos Isaias Sartorão [UNESP] Antônio, Flávia Ignácio de Aquino Nava, Guilherme Thomaz [UNESP] Rudge, Marilza Vieira Cunha [UNESP] Barbosa, Angélica Mércia Pascon [UNESP] Calderon, I. M.P. Souza, F. P. Berghmans, B. de Bie, R. Thabane, L. Junginger, B. Graeff, C. F.O. Magalhães, C. G. Costa, R. A. Lima, S. A.M. Kron-Rodrigues, M. R. Felisbino, S. Barbosa, W. Campos, F. J. Bossolan, G. Corrente, J. E. Nunes, H. R.C. Abbade, J. Rossignoli, P. S. Pedroni, C. R. Atallah, A. N. Di Bella, Z. I.K.J. Uchoa, S. M.M. Hungaro, M. A. Mareco, E. A. Sakalem, M. E. Martinho, N. Hallur, L. S.R. Reyes, D. R.A. Alves, F. C.B. Marcondes, J. P.C. Quiroz, S. B.C.V. Pascon, T. Catinelli, B. B. Reis, F. V.D.S. Oliveira, R. G. Barneze, S. Enriquez, E. M.A. Takano, L. Carr, A. M. Magyori, A. B.M. Iamundo, L. F. Carvalho, C. N.F. Jacomin, M. Avramidis, R. E. Silva, A. J.B. Orlandi, M. I.G. Dangió, T. D. Bassin, H. C.M. Melo, J. V.F. Takemoto, M. L.S. Menezes, M. D. Caldeirão, T. D. Santos, N. J. Lourenço, I. O. de Sá Marostica, J. Caruso, I. P. Rasmussen, L. T. Garcia, G. A. Pascon, C. Bussaneli, D. G. Nogueira, V. K.C. Rudge, C. V.C. Piculo, F. Prata, G. M. Barbosa, V. P. |
dc.subject.por.fl_str_mv |
Gestational diabetes Obstetrics Pelvic floor Pregnancy Relaxin-2 |
topic |
Gestational diabetes Obstetrics Pelvic floor Pregnancy Relaxin-2 |
description |
Introduction and hypothesis: To investigate relaxin-2 concentration comparing gestational diabetes mellitus (GDM) and non-GDM patients during pregnancy according to urinary incontinence (UI) and pelvic function status. Methods: This is a cross-sectional study evaluating 282 pregnant women from 24 weeks of gestation. The participants were divided into two groups, non-GDM and GDM, according to American Diabetes Association’s diabetes mellitus gestational threshold. In addition, according to subanalysis, both groups were subdivided according to the presence of pregnancy-specific urinary incontinence: non-GDM continent, non-GDM incontinent, GDM continent, and GDM incontinent. All participants filled in questionnaires on clinical, obstetric, and urinary continence status (International Consultation on Incontinence Questionnaire-Short Form, ICIQ-SF, and Incontinence Severity Index, ISI), followed by pelvic floor muscle evaluation by the PERFECT scheme in which strength, endurance, and speed of contractions were evaluated. Results: Serum relaxin-2 concentrations were significantly lower in pregnant women with pregnancy-specific urinary incontinence in both non-GDM and GDM patients, but GDM showed the lowest concentration. In addition, the stratification of the groups according to pelvic floor muscle strength showed that pregnant patients with GDM and modified Oxford scale 0–2 had significantly lower levels than those who were non-GDM and GDM with Modified Oxford Scale 3–5. Relaxin-2 level was much lower in GDM incontinent pregnant women with MOS 0–2 compared to the other three groups. Conclusions: Lower relaxin-2 concentration was associated with the presence of pregnancy-specific urinary incontinence, but the combination of GDM, pregnancy-specific urinary incontinence, and lower levels of pelvic floor strength led to lower levels of relaxin-2 compared to the other three groups. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-01-01 2023-03-01T20:56:21Z 2023-03-01T20:56:21Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1007/s00192-022-05245-y International Urogynecology Journal. 1433-3023 0937-3462 http://hdl.handle.net/11449/241312 10.1007/s00192-022-05245-y 2-s2.0-85133849696 |
url |
http://dx.doi.org/10.1007/s00192-022-05245-y http://hdl.handle.net/11449/241312 |
identifier_str_mv |
International Urogynecology Journal. 1433-3023 0937-3462 10.1007/s00192-022-05245-y 2-s2.0-85133849696 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
International Urogynecology Journal |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
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Universidade Estadual Paulista (UNESP) |
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UNESP |
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UNESP |
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Repositório Institucional da UNESP |
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Repositório Institucional da UNESP |
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Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
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1808128178235899904 |