Standardization and Prevalence of the Booster Phenomenon: Evaluation Using a Two-Step Skin Test with 43 kDa Glycoprotein in Individuals from an Endemic Region of Paracoccidioidomycosis

Detalhes bibliográficos
Autor(a) principal: Marques, Ana Paula C.
Data de Publicação: 2017
Outros Autores: Oliveira, Sandra Maria V. L., Rezende, Grazielli R., Melo, Dayane A., Fernandes-Fitts, Sonia M., Pontes, Elenir Rose J. C., Bonecini-Almeida, Maria da Gloria, Camargo, Zoilo P., Mendes, Rinaldo P. [UNESP], Paniago, Anamaria M. M.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1007/s11046-017-0159-z
http://hdl.handle.net/11449/163215
Resumo: We estimated the occurrence rate of the booster phenomenon by using an intradermal test with 43 kDa glycoprotein in an endemic area of paracoccidioidomycosis in the central-west region of Brazil. Individuals who had a negative result on a survey performed by using an intradermal test with 43 kDa glycoprotein in an endemic area of paracoccidioidomycosis underwent a second intradermal test after 10-15 days to determine the presence or absence of the booster phenomenon. Statistical analyses were performed using the Chi-square test, Chi-square for linear trend test, Student's t test, and binomial test; p < 0.05 was considered significant. For the first time, we reported the occurrence of the booster phenomenon to an intradermal reaction caused by 43 kDa glycoprotein at a rate of 5.8-8.4%, depending on the test's cutoff point. This suggests that a cutoff point should be considered for the booster phenomenon in intradermal tests with 43 kDa glycoprotein: a difference of 6-7 mm between readings according to the first and second tests, depending on the purpose of the evaluation. The results indicate that the prevalence of paracoccidioidal infection in endemic areas is underestimated, as the booster phenomenon has not been considered in epidemiological surveys for this infection.
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spelling Standardization and Prevalence of the Booster Phenomenon: Evaluation Using a Two-Step Skin Test with 43 kDa Glycoprotein in Individuals from an Endemic Region of ParacoccidioidomycosisParacoccidioidic infectionBooster phenomenonIntradermal testsParacoccidioides brasiliensisParacoccidioidomycosisgp43We estimated the occurrence rate of the booster phenomenon by using an intradermal test with 43 kDa glycoprotein in an endemic area of paracoccidioidomycosis in the central-west region of Brazil. Individuals who had a negative result on a survey performed by using an intradermal test with 43 kDa glycoprotein in an endemic area of paracoccidioidomycosis underwent a second intradermal test after 10-15 days to determine the presence or absence of the booster phenomenon. Statistical analyses were performed using the Chi-square test, Chi-square for linear trend test, Student's t test, and binomial test; p < 0.05 was considered significant. For the first time, we reported the occurrence of the booster phenomenon to an intradermal reaction caused by 43 kDa glycoprotein at a rate of 5.8-8.4%, depending on the test's cutoff point. This suggests that a cutoff point should be considered for the booster phenomenon in intradermal tests with 43 kDa glycoprotein: a difference of 6-7 mm between readings according to the first and second tests, depending on the purpose of the evaluation. The results indicate that the prevalence of paracoccidioidal infection in endemic areas is underestimated, as the booster phenomenon has not been considered in epidemiological surveys for this infection.Health Department of the Municipality of Jaraguari (Mato Grosso do Sul, Brazil)Post-Graduation Program for Health and Development of the Central-West Region BrazilUniv Fed Mato Grosso do Sul, Fac Med, Cidade Univ S-N, BR-79070900 Campo Grande, BrazilFundacao Oswaldo Cruz, Evandro Chagas Clin Res Inst, Lab Immunol & Immunogenet, BR-21040360 Rio De Janeiro, BrazilUniv Fed Sao Paulo, Fac Med, Clin Hosp, Med Mycol Lab, BR-04023062 Sao Paulo, BrazilUniv Estadual Paulista, Fac Med Botucatu, Dept Trop Dis, Botucatu, SP, BrazilUniv Estadual Paulista, Fac Med Botucatu, Dept Trop Dis, Botucatu, SP, BrazilSpringerUniversidade Federal de Mato Grosso do Sul (UFMS)Fundacao Oswaldo CruzUniversidade Federal de São Paulo (UNIFESP)Universidade Estadual Paulista (Unesp)Marques, Ana Paula C.Oliveira, Sandra Maria V. L.Rezende, Grazielli R.Melo, Dayane A.Fernandes-Fitts, Sonia M.Pontes, Elenir Rose J. C.Bonecini-Almeida, Maria da GloriaCamargo, Zoilo P.Mendes, Rinaldo P. [UNESP]Paniago, Anamaria M. M.2018-11-26T17:40:32Z2018-11-26T17:40:32Z2017-10-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article809-817application/pdfhttp://dx.doi.org/10.1007/s11046-017-0159-zMycopathologia. Dordrecht: Springer, v. 182, n. 9-10, p. 809-817, 2017.0301-486Xhttp://hdl.handle.net/11449/16321510.1007/s11046-017-0159-zWOS:000409494400004WOS000409494400004.pdfWeb of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengMycopathologiainfo:eu-repo/semantics/openAccess2024-08-15T15:23:02Zoai:repositorio.unesp.br:11449/163215Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-15T15:23:02Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Standardization and Prevalence of the Booster Phenomenon: Evaluation Using a Two-Step Skin Test with 43 kDa Glycoprotein in Individuals from an Endemic Region of Paracoccidioidomycosis
title Standardization and Prevalence of the Booster Phenomenon: Evaluation Using a Two-Step Skin Test with 43 kDa Glycoprotein in Individuals from an Endemic Region of Paracoccidioidomycosis
spellingShingle Standardization and Prevalence of the Booster Phenomenon: Evaluation Using a Two-Step Skin Test with 43 kDa Glycoprotein in Individuals from an Endemic Region of Paracoccidioidomycosis
Marques, Ana Paula C.
Paracoccidioidic infection
Booster phenomenon
Intradermal tests
Paracoccidioides brasiliensis
Paracoccidioidomycosis
gp43
title_short Standardization and Prevalence of the Booster Phenomenon: Evaluation Using a Two-Step Skin Test with 43 kDa Glycoprotein in Individuals from an Endemic Region of Paracoccidioidomycosis
title_full Standardization and Prevalence of the Booster Phenomenon: Evaluation Using a Two-Step Skin Test with 43 kDa Glycoprotein in Individuals from an Endemic Region of Paracoccidioidomycosis
title_fullStr Standardization and Prevalence of the Booster Phenomenon: Evaluation Using a Two-Step Skin Test with 43 kDa Glycoprotein in Individuals from an Endemic Region of Paracoccidioidomycosis
title_full_unstemmed Standardization and Prevalence of the Booster Phenomenon: Evaluation Using a Two-Step Skin Test with 43 kDa Glycoprotein in Individuals from an Endemic Region of Paracoccidioidomycosis
title_sort Standardization and Prevalence of the Booster Phenomenon: Evaluation Using a Two-Step Skin Test with 43 kDa Glycoprotein in Individuals from an Endemic Region of Paracoccidioidomycosis
author Marques, Ana Paula C.
author_facet Marques, Ana Paula C.
Oliveira, Sandra Maria V. L.
Rezende, Grazielli R.
Melo, Dayane A.
Fernandes-Fitts, Sonia M.
Pontes, Elenir Rose J. C.
Bonecini-Almeida, Maria da Gloria
Camargo, Zoilo P.
Mendes, Rinaldo P. [UNESP]
Paniago, Anamaria M. M.
author_role author
author2 Oliveira, Sandra Maria V. L.
Rezende, Grazielli R.
Melo, Dayane A.
Fernandes-Fitts, Sonia M.
Pontes, Elenir Rose J. C.
Bonecini-Almeida, Maria da Gloria
Camargo, Zoilo P.
Mendes, Rinaldo P. [UNESP]
Paniago, Anamaria M. M.
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Federal de Mato Grosso do Sul (UFMS)
Fundacao Oswaldo Cruz
Universidade Federal de São Paulo (UNIFESP)
Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv Marques, Ana Paula C.
Oliveira, Sandra Maria V. L.
Rezende, Grazielli R.
Melo, Dayane A.
Fernandes-Fitts, Sonia M.
Pontes, Elenir Rose J. C.
Bonecini-Almeida, Maria da Gloria
Camargo, Zoilo P.
Mendes, Rinaldo P. [UNESP]
Paniago, Anamaria M. M.
dc.subject.por.fl_str_mv Paracoccidioidic infection
Booster phenomenon
Intradermal tests
Paracoccidioides brasiliensis
Paracoccidioidomycosis
gp43
topic Paracoccidioidic infection
Booster phenomenon
Intradermal tests
Paracoccidioides brasiliensis
Paracoccidioidomycosis
gp43
description We estimated the occurrence rate of the booster phenomenon by using an intradermal test with 43 kDa glycoprotein in an endemic area of paracoccidioidomycosis in the central-west region of Brazil. Individuals who had a negative result on a survey performed by using an intradermal test with 43 kDa glycoprotein in an endemic area of paracoccidioidomycosis underwent a second intradermal test after 10-15 days to determine the presence or absence of the booster phenomenon. Statistical analyses were performed using the Chi-square test, Chi-square for linear trend test, Student's t test, and binomial test; p < 0.05 was considered significant. For the first time, we reported the occurrence of the booster phenomenon to an intradermal reaction caused by 43 kDa glycoprotein at a rate of 5.8-8.4%, depending on the test's cutoff point. This suggests that a cutoff point should be considered for the booster phenomenon in intradermal tests with 43 kDa glycoprotein: a difference of 6-7 mm between readings according to the first and second tests, depending on the purpose of the evaluation. The results indicate that the prevalence of paracoccidioidal infection in endemic areas is underestimated, as the booster phenomenon has not been considered in epidemiological surveys for this infection.
publishDate 2017
dc.date.none.fl_str_mv 2017-10-01
2018-11-26T17:40:32Z
2018-11-26T17:40:32Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1007/s11046-017-0159-z
Mycopathologia. Dordrecht: Springer, v. 182, n. 9-10, p. 809-817, 2017.
0301-486X
http://hdl.handle.net/11449/163215
10.1007/s11046-017-0159-z
WOS:000409494400004
WOS000409494400004.pdf
url http://dx.doi.org/10.1007/s11046-017-0159-z
http://hdl.handle.net/11449/163215
identifier_str_mv Mycopathologia. Dordrecht: Springer, v. 182, n. 9-10, p. 809-817, 2017.
0301-486X
10.1007/s11046-017-0159-z
WOS:000409494400004
WOS000409494400004.pdf
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Mycopathologia
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 809-817
application/pdf
dc.publisher.none.fl_str_mv Springer
publisher.none.fl_str_mv Springer
dc.source.none.fl_str_mv Web of Science
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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