Standardization and Prevalence of the Booster Phenomenon: Evaluation Using a Two-Step Skin Test with 43 kDa Glycoprotein in Individuals from an Endemic Region of Paracoccidioidomycosis
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1007/s11046-017-0159-z http://hdl.handle.net/11449/163215 |
Resumo: | We estimated the occurrence rate of the booster phenomenon by using an intradermal test with 43 kDa glycoprotein in an endemic area of paracoccidioidomycosis in the central-west region of Brazil. Individuals who had a negative result on a survey performed by using an intradermal test with 43 kDa glycoprotein in an endemic area of paracoccidioidomycosis underwent a second intradermal test after 10-15 days to determine the presence or absence of the booster phenomenon. Statistical analyses were performed using the Chi-square test, Chi-square for linear trend test, Student's t test, and binomial test; p < 0.05 was considered significant. For the first time, we reported the occurrence of the booster phenomenon to an intradermal reaction caused by 43 kDa glycoprotein at a rate of 5.8-8.4%, depending on the test's cutoff point. This suggests that a cutoff point should be considered for the booster phenomenon in intradermal tests with 43 kDa glycoprotein: a difference of 6-7 mm between readings according to the first and second tests, depending on the purpose of the evaluation. The results indicate that the prevalence of paracoccidioidal infection in endemic areas is underestimated, as the booster phenomenon has not been considered in epidemiological surveys for this infection. |
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Standardization and Prevalence of the Booster Phenomenon: Evaluation Using a Two-Step Skin Test with 43 kDa Glycoprotein in Individuals from an Endemic Region of ParacoccidioidomycosisParacoccidioidic infectionBooster phenomenonIntradermal testsParacoccidioides brasiliensisParacoccidioidomycosisgp43We estimated the occurrence rate of the booster phenomenon by using an intradermal test with 43 kDa glycoprotein in an endemic area of paracoccidioidomycosis in the central-west region of Brazil. Individuals who had a negative result on a survey performed by using an intradermal test with 43 kDa glycoprotein in an endemic area of paracoccidioidomycosis underwent a second intradermal test after 10-15 days to determine the presence or absence of the booster phenomenon. Statistical analyses were performed using the Chi-square test, Chi-square for linear trend test, Student's t test, and binomial test; p < 0.05 was considered significant. For the first time, we reported the occurrence of the booster phenomenon to an intradermal reaction caused by 43 kDa glycoprotein at a rate of 5.8-8.4%, depending on the test's cutoff point. This suggests that a cutoff point should be considered for the booster phenomenon in intradermal tests with 43 kDa glycoprotein: a difference of 6-7 mm between readings according to the first and second tests, depending on the purpose of the evaluation. The results indicate that the prevalence of paracoccidioidal infection in endemic areas is underestimated, as the booster phenomenon has not been considered in epidemiological surveys for this infection.Health Department of the Municipality of Jaraguari (Mato Grosso do Sul, Brazil)Post-Graduation Program for Health and Development of the Central-West Region BrazilUniv Fed Mato Grosso do Sul, Fac Med, Cidade Univ S-N, BR-79070900 Campo Grande, BrazilFundacao Oswaldo Cruz, Evandro Chagas Clin Res Inst, Lab Immunol & Immunogenet, BR-21040360 Rio De Janeiro, BrazilUniv Fed Sao Paulo, Fac Med, Clin Hosp, Med Mycol Lab, BR-04023062 Sao Paulo, BrazilUniv Estadual Paulista, Fac Med Botucatu, Dept Trop Dis, Botucatu, SP, BrazilUniv Estadual Paulista, Fac Med Botucatu, Dept Trop Dis, Botucatu, SP, BrazilSpringerUniversidade Federal de Mato Grosso do Sul (UFMS)Fundacao Oswaldo CruzUniversidade Federal de São Paulo (UNIFESP)Universidade Estadual Paulista (Unesp)Marques, Ana Paula C.Oliveira, Sandra Maria V. L.Rezende, Grazielli R.Melo, Dayane A.Fernandes-Fitts, Sonia M.Pontes, Elenir Rose J. C.Bonecini-Almeida, Maria da GloriaCamargo, Zoilo P.Mendes, Rinaldo P. [UNESP]Paniago, Anamaria M. M.2018-11-26T17:40:32Z2018-11-26T17:40:32Z2017-10-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article809-817application/pdfhttp://dx.doi.org/10.1007/s11046-017-0159-zMycopathologia. Dordrecht: Springer, v. 182, n. 9-10, p. 809-817, 2017.0301-486Xhttp://hdl.handle.net/11449/16321510.1007/s11046-017-0159-zWOS:000409494400004WOS000409494400004.pdfWeb of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengMycopathologiainfo:eu-repo/semantics/openAccess2024-08-15T15:23:02Zoai:repositorio.unesp.br:11449/163215Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-15T15:23:02Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Standardization and Prevalence of the Booster Phenomenon: Evaluation Using a Two-Step Skin Test with 43 kDa Glycoprotein in Individuals from an Endemic Region of Paracoccidioidomycosis |
title |
Standardization and Prevalence of the Booster Phenomenon: Evaluation Using a Two-Step Skin Test with 43 kDa Glycoprotein in Individuals from an Endemic Region of Paracoccidioidomycosis |
spellingShingle |
Standardization and Prevalence of the Booster Phenomenon: Evaluation Using a Two-Step Skin Test with 43 kDa Glycoprotein in Individuals from an Endemic Region of Paracoccidioidomycosis Marques, Ana Paula C. Paracoccidioidic infection Booster phenomenon Intradermal tests Paracoccidioides brasiliensis Paracoccidioidomycosis gp43 |
title_short |
Standardization and Prevalence of the Booster Phenomenon: Evaluation Using a Two-Step Skin Test with 43 kDa Glycoprotein in Individuals from an Endemic Region of Paracoccidioidomycosis |
title_full |
Standardization and Prevalence of the Booster Phenomenon: Evaluation Using a Two-Step Skin Test with 43 kDa Glycoprotein in Individuals from an Endemic Region of Paracoccidioidomycosis |
title_fullStr |
Standardization and Prevalence of the Booster Phenomenon: Evaluation Using a Two-Step Skin Test with 43 kDa Glycoprotein in Individuals from an Endemic Region of Paracoccidioidomycosis |
title_full_unstemmed |
Standardization and Prevalence of the Booster Phenomenon: Evaluation Using a Two-Step Skin Test with 43 kDa Glycoprotein in Individuals from an Endemic Region of Paracoccidioidomycosis |
title_sort |
Standardization and Prevalence of the Booster Phenomenon: Evaluation Using a Two-Step Skin Test with 43 kDa Glycoprotein in Individuals from an Endemic Region of Paracoccidioidomycosis |
author |
Marques, Ana Paula C. |
author_facet |
Marques, Ana Paula C. Oliveira, Sandra Maria V. L. Rezende, Grazielli R. Melo, Dayane A. Fernandes-Fitts, Sonia M. Pontes, Elenir Rose J. C. Bonecini-Almeida, Maria da Gloria Camargo, Zoilo P. Mendes, Rinaldo P. [UNESP] Paniago, Anamaria M. M. |
author_role |
author |
author2 |
Oliveira, Sandra Maria V. L. Rezende, Grazielli R. Melo, Dayane A. Fernandes-Fitts, Sonia M. Pontes, Elenir Rose J. C. Bonecini-Almeida, Maria da Gloria Camargo, Zoilo P. Mendes, Rinaldo P. [UNESP] Paniago, Anamaria M. M. |
author2_role |
author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Federal de Mato Grosso do Sul (UFMS) Fundacao Oswaldo Cruz Universidade Federal de São Paulo (UNIFESP) Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Marques, Ana Paula C. Oliveira, Sandra Maria V. L. Rezende, Grazielli R. Melo, Dayane A. Fernandes-Fitts, Sonia M. Pontes, Elenir Rose J. C. Bonecini-Almeida, Maria da Gloria Camargo, Zoilo P. Mendes, Rinaldo P. [UNESP] Paniago, Anamaria M. M. |
dc.subject.por.fl_str_mv |
Paracoccidioidic infection Booster phenomenon Intradermal tests Paracoccidioides brasiliensis Paracoccidioidomycosis gp43 |
topic |
Paracoccidioidic infection Booster phenomenon Intradermal tests Paracoccidioides brasiliensis Paracoccidioidomycosis gp43 |
description |
We estimated the occurrence rate of the booster phenomenon by using an intradermal test with 43 kDa glycoprotein in an endemic area of paracoccidioidomycosis in the central-west region of Brazil. Individuals who had a negative result on a survey performed by using an intradermal test with 43 kDa glycoprotein in an endemic area of paracoccidioidomycosis underwent a second intradermal test after 10-15 days to determine the presence or absence of the booster phenomenon. Statistical analyses were performed using the Chi-square test, Chi-square for linear trend test, Student's t test, and binomial test; p < 0.05 was considered significant. For the first time, we reported the occurrence of the booster phenomenon to an intradermal reaction caused by 43 kDa glycoprotein at a rate of 5.8-8.4%, depending on the test's cutoff point. This suggests that a cutoff point should be considered for the booster phenomenon in intradermal tests with 43 kDa glycoprotein: a difference of 6-7 mm between readings according to the first and second tests, depending on the purpose of the evaluation. The results indicate that the prevalence of paracoccidioidal infection in endemic areas is underestimated, as the booster phenomenon has not been considered in epidemiological surveys for this infection. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-10-01 2018-11-26T17:40:32Z 2018-11-26T17:40:32Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1007/s11046-017-0159-z Mycopathologia. Dordrecht: Springer, v. 182, n. 9-10, p. 809-817, 2017. 0301-486X http://hdl.handle.net/11449/163215 10.1007/s11046-017-0159-z WOS:000409494400004 WOS000409494400004.pdf |
url |
http://dx.doi.org/10.1007/s11046-017-0159-z http://hdl.handle.net/11449/163215 |
identifier_str_mv |
Mycopathologia. Dordrecht: Springer, v. 182, n. 9-10, p. 809-817, 2017. 0301-486X 10.1007/s11046-017-0159-z WOS:000409494400004 WOS000409494400004.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Mycopathologia |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
809-817 application/pdf |
dc.publisher.none.fl_str_mv |
Springer |
publisher.none.fl_str_mv |
Springer |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808128170489020416 |