Polymorphisms of DNA repair genes XRCC1 and XRCC3, interaction with environmental exposure and risk of chronic gastritis and grastic cancer

Detalhes bibliográficos
Autor(a) principal: Duarte, Márcia Cristina [UNESP]
Data de Publicação: 2005
Outros Autores: Colombo, Jucimara [UNESP], Rossit, Andrea Regina Baptista, Caetano, Alaor, Borim, Aldenis Albaneze, Wornrath, Durval, Silva, Ana Elizabete [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://www.wjgnet.com/1007-9327/abstract_en.asp?f=6593&v=11
http://hdl.handle.net/11449/68491
Resumo: Aim: To evaluate the association between polymorphisms XRCC1 Arg194Trp and Arg399Gln and XRCC3 Thr241Met and the risk for chronic gastritis and gastric cancer, in a Southeastern Brazilian population. Methods: Genotyping by PCR-RFLP was carried out on 202 patients with chronic gastritis (CG) and 160 patients with gastric cancer (GC), matched to 202 (C1) and 150 (C2) controls, respectively. Results: No differences were observed among the studied groups with regard to the genotype distribution of XRCC1 codons 194 and 399 and of XRCC3 codon 241. However, the combined analyses of the three variant alleles (194Trp, 399Gln and 241Met) showed an increased risk for chronic gastritis when compared to the GC group. Moreover, an interaction between the polymorphic alleles and demographic and environmental factors was observed in the CG and GC groups. XRCC1 194Trp was associated with smoking in the CG group, while the variant alleles XRCC1 399Gln and XRCC3 241Met were related with gender, smoking, drinking and H pylori infection in the CG and GC groups. Conclusion: Our results showed no evidence of a rela-tionship between the polymorphisms XRCC1 Arg194Trp and Arg399Gln and XRCC3 Thr241Met and the risk of chronic gastritis and gastric cancer in the Brazilian population, but the combined effect of these variants may interact to increase the risk for chronic gastritis, considered a premalignant lesion. Our data also indicate a gene-environment interaction in the susceptibility to chronic gastritis and gastric cancer. © 2005 The WJG Press and Elsevier Inc. All rights reserved.
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spelling Polymorphisms of DNA repair genes XRCC1 and XRCC3, interaction with environmental exposure and risk of chronic gastritis and grastic cancerEnvironmental exposureGastric cancerGastritisPolymorphismXRCC1XRCC3arginineDNADNA binding proteinglycinemethionineprotein XRCC1protein XRCC3threoninetryptophanunclassified drugadultagedalleleBrazilchronic gastritiscigarette smokingcodoncontrolled studydata analysisdemographydisease predispositionDNA repairdrinking behaviorenvironmental exposureenvironmental factorfemalegendergenetic polymorphismgenetic variabilitygenotypegenotype environment interactionHelicobacter infectionHelicobacter pylorihumanmajor clinical studymalenonhumanpolymerase chain reactionpopulation researchprecancerrestriction fragment length polymorphismrisk assessmentstomach cancerAdultAgedAged, 80 and overCase-Control StudiesChronic DiseaseDNA RepairDNA-Binding ProteinsEnvironmental ExposureFemaleGenetic Predisposition to DiseaseGenotypeHumansMaleMiddle AgedPolymorphism, GeneticPolymorphism, Restriction Fragment LengthRisk FactorsStomach NeoplasmsAim: To evaluate the association between polymorphisms XRCC1 Arg194Trp and Arg399Gln and XRCC3 Thr241Met and the risk for chronic gastritis and gastric cancer, in a Southeastern Brazilian population. Methods: Genotyping by PCR-RFLP was carried out on 202 patients with chronic gastritis (CG) and 160 patients with gastric cancer (GC), matched to 202 (C1) and 150 (C2) controls, respectively. Results: No differences were observed among the studied groups with regard to the genotype distribution of XRCC1 codons 194 and 399 and of XRCC3 codon 241. However, the combined analyses of the three variant alleles (194Trp, 399Gln and 241Met) showed an increased risk for chronic gastritis when compared to the GC group. Moreover, an interaction between the polymorphic alleles and demographic and environmental factors was observed in the CG and GC groups. XRCC1 194Trp was associated with smoking in the CG group, while the variant alleles XRCC1 399Gln and XRCC3 241Met were related with gender, smoking, drinking and H pylori infection in the CG and GC groups. Conclusion: Our results showed no evidence of a rela-tionship between the polymorphisms XRCC1 Arg194Trp and Arg399Gln and XRCC3 Thr241Met and the risk of chronic gastritis and gastric cancer in the Brazilian population, but the combined effect of these variants may interact to increase the risk for chronic gastritis, considered a premalignant lesion. Our data also indicate a gene-environment interaction in the susceptibility to chronic gastritis and gastric cancer. © 2005 The WJG Press and Elsevier Inc. All rights reserved.UNESP São Paulo State University Department of Biology, Rua Crisovao Colombo 2265, 5054-000 Sao Jose do Rio PretoFAMERP São José do Rio Preto School of Medicine Microorganism Investigation Center, Sao Jose do Rio Preto, SPFAMERP São José do Rio Preto School of Medicine Hospital de Base, Sao Jose do Rio Preto, SPPio XII Foundation, Barretos, SPUNESP São Paulo State University Department of Biology, Rua Crisovao Colombo 2265, 5054-000 Sao Jose do Rio PretoUniversidade Estadual Paulista (Unesp)Microorganism Investigation CenterHospital de BasePio XII FoundationDuarte, Márcia Cristina [UNESP]Colombo, Jucimara [UNESP]Rossit, Andrea Regina BaptistaCaetano, AlaorBorim, Aldenis AlbanezeWornrath, DurvalSilva, Ana Elizabete [UNESP]2014-05-27T11:21:40Z2014-05-27T11:21:40Z2005-11-14info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article6593-6600application/pdfhttp://www.wjgnet.com/1007-9327/abstract_en.asp?f=6593&v=11World Journal of Gastroenterology, v. 11, n. 42, p. 6593-6600, 2005.1007-9327http://hdl.handle.net/11449/684912-s2.0-304444347642-s2.0-30444434764.pdfScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengWorld Journal of Gastroenterology3.3001,409info:eu-repo/semantics/openAccess2023-10-20T06:10:15Zoai:repositorio.unesp.br:11449/68491Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T15:29:15.475579Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Polymorphisms of DNA repair genes XRCC1 and XRCC3, interaction with environmental exposure and risk of chronic gastritis and grastic cancer
title Polymorphisms of DNA repair genes XRCC1 and XRCC3, interaction with environmental exposure and risk of chronic gastritis and grastic cancer
spellingShingle Polymorphisms of DNA repair genes XRCC1 and XRCC3, interaction with environmental exposure and risk of chronic gastritis and grastic cancer
Duarte, Márcia Cristina [UNESP]
Environmental exposure
Gastric cancer
Gastritis
Polymorphism
XRCC1
XRCC3
arginine
DNA
DNA binding protein
glycine
methionine
protein XRCC1
protein XRCC3
threonine
tryptophan
unclassified drug
adult
aged
allele
Brazil
chronic gastritis
cigarette smoking
codon
controlled study
data analysis
demography
disease predisposition
DNA repair
drinking behavior
environmental exposure
environmental factor
female
gender
genetic polymorphism
genetic variability
genotype
genotype environment interaction
Helicobacter infection
Helicobacter pylori
human
major clinical study
male
nonhuman
polymerase chain reaction
population research
precancer
restriction fragment length polymorphism
risk assessment
stomach cancer
Adult
Aged
Aged, 80 and over
Case-Control Studies
Chronic Disease
DNA Repair
DNA-Binding Proteins
Environmental Exposure
Female
Genetic Predisposition to Disease
Genotype
Humans
Male
Middle Aged
Polymorphism, Genetic
Polymorphism, Restriction Fragment Length
Risk Factors
Stomach Neoplasms
title_short Polymorphisms of DNA repair genes XRCC1 and XRCC3, interaction with environmental exposure and risk of chronic gastritis and grastic cancer
title_full Polymorphisms of DNA repair genes XRCC1 and XRCC3, interaction with environmental exposure and risk of chronic gastritis and grastic cancer
title_fullStr Polymorphisms of DNA repair genes XRCC1 and XRCC3, interaction with environmental exposure and risk of chronic gastritis and grastic cancer
title_full_unstemmed Polymorphisms of DNA repair genes XRCC1 and XRCC3, interaction with environmental exposure and risk of chronic gastritis and grastic cancer
title_sort Polymorphisms of DNA repair genes XRCC1 and XRCC3, interaction with environmental exposure and risk of chronic gastritis and grastic cancer
author Duarte, Márcia Cristina [UNESP]
author_facet Duarte, Márcia Cristina [UNESP]
Colombo, Jucimara [UNESP]
Rossit, Andrea Regina Baptista
Caetano, Alaor
Borim, Aldenis Albaneze
Wornrath, Durval
Silva, Ana Elizabete [UNESP]
author_role author
author2 Colombo, Jucimara [UNESP]
Rossit, Andrea Regina Baptista
Caetano, Alaor
Borim, Aldenis Albaneze
Wornrath, Durval
Silva, Ana Elizabete [UNESP]
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
Microorganism Investigation Center
Hospital de Base
Pio XII Foundation
dc.contributor.author.fl_str_mv Duarte, Márcia Cristina [UNESP]
Colombo, Jucimara [UNESP]
Rossit, Andrea Regina Baptista
Caetano, Alaor
Borim, Aldenis Albaneze
Wornrath, Durval
Silva, Ana Elizabete [UNESP]
dc.subject.por.fl_str_mv Environmental exposure
Gastric cancer
Gastritis
Polymorphism
XRCC1
XRCC3
arginine
DNA
DNA binding protein
glycine
methionine
protein XRCC1
protein XRCC3
threonine
tryptophan
unclassified drug
adult
aged
allele
Brazil
chronic gastritis
cigarette smoking
codon
controlled study
data analysis
demography
disease predisposition
DNA repair
drinking behavior
environmental exposure
environmental factor
female
gender
genetic polymorphism
genetic variability
genotype
genotype environment interaction
Helicobacter infection
Helicobacter pylori
human
major clinical study
male
nonhuman
polymerase chain reaction
population research
precancer
restriction fragment length polymorphism
risk assessment
stomach cancer
Adult
Aged
Aged, 80 and over
Case-Control Studies
Chronic Disease
DNA Repair
DNA-Binding Proteins
Environmental Exposure
Female
Genetic Predisposition to Disease
Genotype
Humans
Male
Middle Aged
Polymorphism, Genetic
Polymorphism, Restriction Fragment Length
Risk Factors
Stomach Neoplasms
topic Environmental exposure
Gastric cancer
Gastritis
Polymorphism
XRCC1
XRCC3
arginine
DNA
DNA binding protein
glycine
methionine
protein XRCC1
protein XRCC3
threonine
tryptophan
unclassified drug
adult
aged
allele
Brazil
chronic gastritis
cigarette smoking
codon
controlled study
data analysis
demography
disease predisposition
DNA repair
drinking behavior
environmental exposure
environmental factor
female
gender
genetic polymorphism
genetic variability
genotype
genotype environment interaction
Helicobacter infection
Helicobacter pylori
human
major clinical study
male
nonhuman
polymerase chain reaction
population research
precancer
restriction fragment length polymorphism
risk assessment
stomach cancer
Adult
Aged
Aged, 80 and over
Case-Control Studies
Chronic Disease
DNA Repair
DNA-Binding Proteins
Environmental Exposure
Female
Genetic Predisposition to Disease
Genotype
Humans
Male
Middle Aged
Polymorphism, Genetic
Polymorphism, Restriction Fragment Length
Risk Factors
Stomach Neoplasms
description Aim: To evaluate the association between polymorphisms XRCC1 Arg194Trp and Arg399Gln and XRCC3 Thr241Met and the risk for chronic gastritis and gastric cancer, in a Southeastern Brazilian population. Methods: Genotyping by PCR-RFLP was carried out on 202 patients with chronic gastritis (CG) and 160 patients with gastric cancer (GC), matched to 202 (C1) and 150 (C2) controls, respectively. Results: No differences were observed among the studied groups with regard to the genotype distribution of XRCC1 codons 194 and 399 and of XRCC3 codon 241. However, the combined analyses of the three variant alleles (194Trp, 399Gln and 241Met) showed an increased risk for chronic gastritis when compared to the GC group. Moreover, an interaction between the polymorphic alleles and demographic and environmental factors was observed in the CG and GC groups. XRCC1 194Trp was associated with smoking in the CG group, while the variant alleles XRCC1 399Gln and XRCC3 241Met were related with gender, smoking, drinking and H pylori infection in the CG and GC groups. Conclusion: Our results showed no evidence of a rela-tionship between the polymorphisms XRCC1 Arg194Trp and Arg399Gln and XRCC3 Thr241Met and the risk of chronic gastritis and gastric cancer in the Brazilian population, but the combined effect of these variants may interact to increase the risk for chronic gastritis, considered a premalignant lesion. Our data also indicate a gene-environment interaction in the susceptibility to chronic gastritis and gastric cancer. © 2005 The WJG Press and Elsevier Inc. All rights reserved.
publishDate 2005
dc.date.none.fl_str_mv 2005-11-14
2014-05-27T11:21:40Z
2014-05-27T11:21:40Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.wjgnet.com/1007-9327/abstract_en.asp?f=6593&v=11
World Journal of Gastroenterology, v. 11, n. 42, p. 6593-6600, 2005.
1007-9327
http://hdl.handle.net/11449/68491
2-s2.0-30444434764
2-s2.0-30444434764.pdf
url http://www.wjgnet.com/1007-9327/abstract_en.asp?f=6593&v=11
http://hdl.handle.net/11449/68491
identifier_str_mv World Journal of Gastroenterology, v. 11, n. 42, p. 6593-6600, 2005.
1007-9327
2-s2.0-30444434764
2-s2.0-30444434764.pdf
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv World Journal of Gastroenterology
3.300
1,409
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 6593-6600
application/pdf
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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