Lipase-oxovanadium heterogeneous catalysis system: a robust protocol for the dynamic kinetic resolution of sec-alcohols

• Autor(a) principal: De Almeida, Laiza A. [UNESP]
• Data de Publicação: 2020
• Outros Autores: Marcondes, Thayna H. [UNESP], Milagre, Cintia D. F. [UNESP], Milagre, Humberto M. S. [UNESP]
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UNESP
• Texto Completo: http://dx.doi.org/10.1002/cctc.202000292; http://hdl.handle.net/11449/198696
• topic: dynamic kinetic resolution; heterogeneous catalysis; lipase; sec-alcohols; vanadium

Herein, we present a robust and eco-friendly dynamic kinetic resolution (DKR) protocol for secondary alcohols using a combined heterogeneous catalytic CAL−B/VOSO4 system at 50 °C in the relatively green solvent heptane. This catalytic system is active and chemo- and enantioselective for up to 5 cycles. A set of 13 aromatic and heteroaromatic secondary alcohols were evaluated to determine the substrate scope. The performance of the combined CAL−B/VOSO4 system was improved by employing a low-cost, homemade Teflon tube to compartmentalize the catalysts in one-pot conditions, making this system for up to 8 reaction cycles.