Understanding Drug Release Data through Thermodynamic Analysis

Detalhes bibliográficos
Autor(a) principal: Liberato Cavalcanti Freire, Marjorie Caroline
Data de Publicação: 2017
Outros Autores: Alexandrino, Francisco, Marcelino, Henrique Rodrigues, Souza Picciani, Paulo Henrique de, Holanda e Silva, Kattya Gyselle de, Genre, Julieta, Oliveira, Anselmo Gomes de [UNESP], Tabosa do Egito, Eryvaldo Socrates
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.3390/ma10060651
http://hdl.handle.net/11449/162933
Resumo: Understanding the factors that can modify the drug release profile of a drug from a Drug-Delivery-System (DDS) is a mandatory step to determine the effectiveness of new therapies. The aim of this study was to assess the Amphotericin-B (AmB) kinetic release profiles from polymeric systems with different compositions and geometries and to correlate these profiles with the thermodynamic parameters through mathematical modeling. Film casting and electrospinning techniques were used to compare behavior of films and fibers, respectively. Release profiles from the DDSs were performed, and the mathematical modeling of the data was carried out. Activation energy, enthalpy, entropy and Gibbs free energy of the drug release process were determined. AmB release profiles showed that the relationship to overcome the enthalpic barrier was PVA-fiber > PVA-film > PLA-fiber > PLA-film. Drug release kinetics from the fibers and the films were better fitted on the Peppas-Sahlin and Higuchi models, respectively. The thermodynamic parameters corroborate these findings, revealing that the AmB release from the evaluated systems was an endothermic and non-spontaneous process. Thermodynamic parameters can be used to explain the drug kinetic release profiles. Such an approach is of utmost importance for DDS containing insoluble compounds, such as AmB, which is associated with an erratic bioavailability.
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spelling Understanding Drug Release Data through Thermodynamic AnalysisAmphotericin Bdrug releasekinetic profilethermodynamicshydrogelsfilmsnanofibersUnderstanding the factors that can modify the drug release profile of a drug from a Drug-Delivery-System (DDS) is a mandatory step to determine the effectiveness of new therapies. The aim of this study was to assess the Amphotericin-B (AmB) kinetic release profiles from polymeric systems with different compositions and geometries and to correlate these profiles with the thermodynamic parameters through mathematical modeling. Film casting and electrospinning techniques were used to compare behavior of films and fibers, respectively. Release profiles from the DDSs were performed, and the mathematical modeling of the data was carried out. Activation energy, enthalpy, entropy and Gibbs free energy of the drug release process were determined. AmB release profiles showed that the relationship to overcome the enthalpic barrier was PVA-fiber > PVA-film > PLA-fiber > PLA-film. Drug release kinetics from the fibers and the films were better fitted on the Peppas-Sahlin and Higuchi models, respectively. The thermodynamic parameters corroborate these findings, revealing that the AmB release from the evaluated systems was an endothermic and non-spontaneous process. Thermodynamic parameters can be used to explain the drug kinetic release profiles. Such an approach is of utmost importance for DDS containing insoluble compounds, such as AmB, which is associated with an erratic bioavailability.Univ Fed Rio Grande do Norte, Fac Farm, BR-59012570 Natal, RN, BrazilUniv Fed Rio Grande do Norte, Programa Posgrad Nanotecnol Farmaceut, BR-59012570 Natal, RN, BrazilUniv Fed Rio Grande do Norte, Programa Posgrad Ciencias Saude, BR-59012570 Natal, RN, BrazilUniv Fed Rio de Janeiro, Inst Macromol Eloisa Mano, BR-21941598 Rio De Janeiro, RJ, BrazilUniv Fed Rio de Janeiro, Fac Farm, BR-21949900 Rio De Janeiro, RJ, BrazilUniv Estadual Paulista, Dept Farmacos & Med, Fac Ciencias Farmaceut, BR-14800903 Araraquara, SP, BrazilUniv Estadual Paulista, Dept Farmacos & Med, Fac Ciencias Farmaceut, BR-14800903 Araraquara, SP, BrazilMdpi AgUniv Fed Rio Grande do NorteUniversidade Federal do Rio de Janeiro (UFRJ)Universidade Estadual Paulista (Unesp)Liberato Cavalcanti Freire, Marjorie CarolineAlexandrino, FranciscoMarcelino, Henrique RodriguesSouza Picciani, Paulo Henrique deHolanda e Silva, Kattya Gyselle deGenre, JulietaOliveira, Anselmo Gomes de [UNESP]Tabosa do Egito, Eryvaldo Socrates2018-11-26T17:35:00Z2018-11-26T17:35:00Z2017-06-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article18application/pdfhttp://dx.doi.org/10.3390/ma10060651Materials. Basel: Mdpi Ag, v. 10, n. 6, 18 p., 2017.1996-1944http://hdl.handle.net/11449/16293310.3390/ma10060651WOS:000404415000085WOS000404415000085.pdfWeb of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengMaterials0,732info:eu-repo/semantics/openAccess2024-06-24T13:46:00Zoai:repositorio.unesp.br:11449/162933Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T19:36:42.766842Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Understanding Drug Release Data through Thermodynamic Analysis
title Understanding Drug Release Data through Thermodynamic Analysis
spellingShingle Understanding Drug Release Data through Thermodynamic Analysis
Liberato Cavalcanti Freire, Marjorie Caroline
Amphotericin B
drug release
kinetic profile
thermodynamics
hydrogels
films
nanofibers
title_short Understanding Drug Release Data through Thermodynamic Analysis
title_full Understanding Drug Release Data through Thermodynamic Analysis
title_fullStr Understanding Drug Release Data through Thermodynamic Analysis
title_full_unstemmed Understanding Drug Release Data through Thermodynamic Analysis
title_sort Understanding Drug Release Data through Thermodynamic Analysis
author Liberato Cavalcanti Freire, Marjorie Caroline
author_facet Liberato Cavalcanti Freire, Marjorie Caroline
Alexandrino, Francisco
Marcelino, Henrique Rodrigues
Souza Picciani, Paulo Henrique de
Holanda e Silva, Kattya Gyselle de
Genre, Julieta
Oliveira, Anselmo Gomes de [UNESP]
Tabosa do Egito, Eryvaldo Socrates
author_role author
author2 Alexandrino, Francisco
Marcelino, Henrique Rodrigues
Souza Picciani, Paulo Henrique de
Holanda e Silva, Kattya Gyselle de
Genre, Julieta
Oliveira, Anselmo Gomes de [UNESP]
Tabosa do Egito, Eryvaldo Socrates
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Univ Fed Rio Grande do Norte
Universidade Federal do Rio de Janeiro (UFRJ)
Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv Liberato Cavalcanti Freire, Marjorie Caroline
Alexandrino, Francisco
Marcelino, Henrique Rodrigues
Souza Picciani, Paulo Henrique de
Holanda e Silva, Kattya Gyselle de
Genre, Julieta
Oliveira, Anselmo Gomes de [UNESP]
Tabosa do Egito, Eryvaldo Socrates
dc.subject.por.fl_str_mv Amphotericin B
drug release
kinetic profile
thermodynamics
hydrogels
films
nanofibers
topic Amphotericin B
drug release
kinetic profile
thermodynamics
hydrogels
films
nanofibers
description Understanding the factors that can modify the drug release profile of a drug from a Drug-Delivery-System (DDS) is a mandatory step to determine the effectiveness of new therapies. The aim of this study was to assess the Amphotericin-B (AmB) kinetic release profiles from polymeric systems with different compositions and geometries and to correlate these profiles with the thermodynamic parameters through mathematical modeling. Film casting and electrospinning techniques were used to compare behavior of films and fibers, respectively. Release profiles from the DDSs were performed, and the mathematical modeling of the data was carried out. Activation energy, enthalpy, entropy and Gibbs free energy of the drug release process were determined. AmB release profiles showed that the relationship to overcome the enthalpic barrier was PVA-fiber > PVA-film > PLA-fiber > PLA-film. Drug release kinetics from the fibers and the films were better fitted on the Peppas-Sahlin and Higuchi models, respectively. The thermodynamic parameters corroborate these findings, revealing that the AmB release from the evaluated systems was an endothermic and non-spontaneous process. Thermodynamic parameters can be used to explain the drug kinetic release profiles. Such an approach is of utmost importance for DDS containing insoluble compounds, such as AmB, which is associated with an erratic bioavailability.
publishDate 2017
dc.date.none.fl_str_mv 2017-06-01
2018-11-26T17:35:00Z
2018-11-26T17:35:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.3390/ma10060651
Materials. Basel: Mdpi Ag, v. 10, n. 6, 18 p., 2017.
1996-1944
http://hdl.handle.net/11449/162933
10.3390/ma10060651
WOS:000404415000085
WOS000404415000085.pdf
url http://dx.doi.org/10.3390/ma10060651
http://hdl.handle.net/11449/162933
identifier_str_mv Materials. Basel: Mdpi Ag, v. 10, n. 6, 18 p., 2017.
1996-1944
10.3390/ma10060651
WOS:000404415000085
WOS000404415000085.pdf
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Materials
0,732
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 18
application/pdf
dc.publisher.none.fl_str_mv Mdpi Ag
publisher.none.fl_str_mv Mdpi Ag
dc.source.none.fl_str_mv Web of Science
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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