Understanding Drug Release Data through Thermodynamic Analysis
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.3390/ma10060651 http://hdl.handle.net/11449/162933 |
Resumo: | Understanding the factors that can modify the drug release profile of a drug from a Drug-Delivery-System (DDS) is a mandatory step to determine the effectiveness of new therapies. The aim of this study was to assess the Amphotericin-B (AmB) kinetic release profiles from polymeric systems with different compositions and geometries and to correlate these profiles with the thermodynamic parameters through mathematical modeling. Film casting and electrospinning techniques were used to compare behavior of films and fibers, respectively. Release profiles from the DDSs were performed, and the mathematical modeling of the data was carried out. Activation energy, enthalpy, entropy and Gibbs free energy of the drug release process were determined. AmB release profiles showed that the relationship to overcome the enthalpic barrier was PVA-fiber > PVA-film > PLA-fiber > PLA-film. Drug release kinetics from the fibers and the films were better fitted on the Peppas-Sahlin and Higuchi models, respectively. The thermodynamic parameters corroborate these findings, revealing that the AmB release from the evaluated systems was an endothermic and non-spontaneous process. Thermodynamic parameters can be used to explain the drug kinetic release profiles. Such an approach is of utmost importance for DDS containing insoluble compounds, such as AmB, which is associated with an erratic bioavailability. |
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Understanding Drug Release Data through Thermodynamic AnalysisAmphotericin Bdrug releasekinetic profilethermodynamicshydrogelsfilmsnanofibersUnderstanding the factors that can modify the drug release profile of a drug from a Drug-Delivery-System (DDS) is a mandatory step to determine the effectiveness of new therapies. The aim of this study was to assess the Amphotericin-B (AmB) kinetic release profiles from polymeric systems with different compositions and geometries and to correlate these profiles with the thermodynamic parameters through mathematical modeling. Film casting and electrospinning techniques were used to compare behavior of films and fibers, respectively. Release profiles from the DDSs were performed, and the mathematical modeling of the data was carried out. Activation energy, enthalpy, entropy and Gibbs free energy of the drug release process were determined. AmB release profiles showed that the relationship to overcome the enthalpic barrier was PVA-fiber > PVA-film > PLA-fiber > PLA-film. Drug release kinetics from the fibers and the films were better fitted on the Peppas-Sahlin and Higuchi models, respectively. The thermodynamic parameters corroborate these findings, revealing that the AmB release from the evaluated systems was an endothermic and non-spontaneous process. Thermodynamic parameters can be used to explain the drug kinetic release profiles. Such an approach is of utmost importance for DDS containing insoluble compounds, such as AmB, which is associated with an erratic bioavailability.Univ Fed Rio Grande do Norte, Fac Farm, BR-59012570 Natal, RN, BrazilUniv Fed Rio Grande do Norte, Programa Posgrad Nanotecnol Farmaceut, BR-59012570 Natal, RN, BrazilUniv Fed Rio Grande do Norte, Programa Posgrad Ciencias Saude, BR-59012570 Natal, RN, BrazilUniv Fed Rio de Janeiro, Inst Macromol Eloisa Mano, BR-21941598 Rio De Janeiro, RJ, BrazilUniv Fed Rio de Janeiro, Fac Farm, BR-21949900 Rio De Janeiro, RJ, BrazilUniv Estadual Paulista, Dept Farmacos & Med, Fac Ciencias Farmaceut, BR-14800903 Araraquara, SP, BrazilUniv Estadual Paulista, Dept Farmacos & Med, Fac Ciencias Farmaceut, BR-14800903 Araraquara, SP, BrazilMdpi AgUniv Fed Rio Grande do NorteUniversidade Federal do Rio de Janeiro (UFRJ)Universidade Estadual Paulista (Unesp)Liberato Cavalcanti Freire, Marjorie CarolineAlexandrino, FranciscoMarcelino, Henrique RodriguesSouza Picciani, Paulo Henrique deHolanda e Silva, Kattya Gyselle deGenre, JulietaOliveira, Anselmo Gomes de [UNESP]Tabosa do Egito, Eryvaldo Socrates2018-11-26T17:35:00Z2018-11-26T17:35:00Z2017-06-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article18application/pdfhttp://dx.doi.org/10.3390/ma10060651Materials. Basel: Mdpi Ag, v. 10, n. 6, 18 p., 2017.1996-1944http://hdl.handle.net/11449/16293310.3390/ma10060651WOS:000404415000085WOS000404415000085.pdfWeb of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengMaterials0,732info:eu-repo/semantics/openAccess2024-06-24T13:46:00Zoai:repositorio.unesp.br:11449/162933Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T19:36:42.766842Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Understanding Drug Release Data through Thermodynamic Analysis |
title |
Understanding Drug Release Data through Thermodynamic Analysis |
spellingShingle |
Understanding Drug Release Data through Thermodynamic Analysis Liberato Cavalcanti Freire, Marjorie Caroline Amphotericin B drug release kinetic profile thermodynamics hydrogels films nanofibers |
title_short |
Understanding Drug Release Data through Thermodynamic Analysis |
title_full |
Understanding Drug Release Data through Thermodynamic Analysis |
title_fullStr |
Understanding Drug Release Data through Thermodynamic Analysis |
title_full_unstemmed |
Understanding Drug Release Data through Thermodynamic Analysis |
title_sort |
Understanding Drug Release Data through Thermodynamic Analysis |
author |
Liberato Cavalcanti Freire, Marjorie Caroline |
author_facet |
Liberato Cavalcanti Freire, Marjorie Caroline Alexandrino, Francisco Marcelino, Henrique Rodrigues Souza Picciani, Paulo Henrique de Holanda e Silva, Kattya Gyselle de Genre, Julieta Oliveira, Anselmo Gomes de [UNESP] Tabosa do Egito, Eryvaldo Socrates |
author_role |
author |
author2 |
Alexandrino, Francisco Marcelino, Henrique Rodrigues Souza Picciani, Paulo Henrique de Holanda e Silva, Kattya Gyselle de Genre, Julieta Oliveira, Anselmo Gomes de [UNESP] Tabosa do Egito, Eryvaldo Socrates |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
Univ Fed Rio Grande do Norte Universidade Federal do Rio de Janeiro (UFRJ) Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Liberato Cavalcanti Freire, Marjorie Caroline Alexandrino, Francisco Marcelino, Henrique Rodrigues Souza Picciani, Paulo Henrique de Holanda e Silva, Kattya Gyselle de Genre, Julieta Oliveira, Anselmo Gomes de [UNESP] Tabosa do Egito, Eryvaldo Socrates |
dc.subject.por.fl_str_mv |
Amphotericin B drug release kinetic profile thermodynamics hydrogels films nanofibers |
topic |
Amphotericin B drug release kinetic profile thermodynamics hydrogels films nanofibers |
description |
Understanding the factors that can modify the drug release profile of a drug from a Drug-Delivery-System (DDS) is a mandatory step to determine the effectiveness of new therapies. The aim of this study was to assess the Amphotericin-B (AmB) kinetic release profiles from polymeric systems with different compositions and geometries and to correlate these profiles with the thermodynamic parameters through mathematical modeling. Film casting and electrospinning techniques were used to compare behavior of films and fibers, respectively. Release profiles from the DDSs were performed, and the mathematical modeling of the data was carried out. Activation energy, enthalpy, entropy and Gibbs free energy of the drug release process were determined. AmB release profiles showed that the relationship to overcome the enthalpic barrier was PVA-fiber > PVA-film > PLA-fiber > PLA-film. Drug release kinetics from the fibers and the films were better fitted on the Peppas-Sahlin and Higuchi models, respectively. The thermodynamic parameters corroborate these findings, revealing that the AmB release from the evaluated systems was an endothermic and non-spontaneous process. Thermodynamic parameters can be used to explain the drug kinetic release profiles. Such an approach is of utmost importance for DDS containing insoluble compounds, such as AmB, which is associated with an erratic bioavailability. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-06-01 2018-11-26T17:35:00Z 2018-11-26T17:35:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.3390/ma10060651 Materials. Basel: Mdpi Ag, v. 10, n. 6, 18 p., 2017. 1996-1944 http://hdl.handle.net/11449/162933 10.3390/ma10060651 WOS:000404415000085 WOS000404415000085.pdf |
url |
http://dx.doi.org/10.3390/ma10060651 http://hdl.handle.net/11449/162933 |
identifier_str_mv |
Materials. Basel: Mdpi Ag, v. 10, n. 6, 18 p., 2017. 1996-1944 10.3390/ma10060651 WOS:000404415000085 WOS000404415000085.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Materials 0,732 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
18 application/pdf |
dc.publisher.none.fl_str_mv |
Mdpi Ag |
publisher.none.fl_str_mv |
Mdpi Ag |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808129096386871296 |