Zinc Supplementation Attenuates Cardiac Remodeling after Experimental Myocardial Infarction
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1159/000494011 http://hdl.handle.net/11449/188165 |
Resumo: | Background/Aims: The objective of our study was to evaluate the effects of zinc supplementation on cardiac remodeling following acute myocardial infarction in rats. Methods: Animals were subdivided into 4 groups and observed for 3 months: 1) Sham Control; 2) Sham Zinc: Sham animals receiving zinc supplementation; 3) Infarction Control; 4) Infarction Zinc. After the followup period, we studied hypertrophy and ventricular geometry, functional alterations in vivo and in vitro, changes related to collagen, oxidative stress, and inflammation, assessed by echocardiogram, isolated heart study, western blot, flow cytometer, morphometry, and spectrophotometry. Results: Infarction induced a significant worsening of the functional variables. On the other hand, zinc attenuated both systolic and diastolic cardiac dysfunction induced by infarction. Considering the infarct size, there was no difference between the groups. Catalase and superoxide dismutase decreased in infarcted animals, and zinc increased its activity. We found higher expression of collagens I and III in infarcted animals, but there was no effect of zinc supplementation. Likewise, infarcted animals had higher levels of IL-10, but without zinc interference. Nrf-2 values were not different among the groups. Infarction increased the amount of Treg cells in the spleen as well as the amount of total lymphocytes. Zinc increased the amount of CD4+ in infarcted animals, but we did not observe effects in relation to Treg cells. Conclusion: zinc attenuates cardiac remodeling after infarction in rats; this effect is associated with modulation of antioxidant enzymes, but without the involvement of collagens I and III, Nrf-2, IL-10, and Treg cells. |
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Zinc Supplementation Attenuates Cardiac Remodeling after Experimental Myocardial InfarctionChronic remodelingCoronary occlusionFunctionHypertrophyTreg cellsZincBackground/Aims: The objective of our study was to evaluate the effects of zinc supplementation on cardiac remodeling following acute myocardial infarction in rats. Methods: Animals were subdivided into 4 groups and observed for 3 months: 1) Sham Control; 2) Sham Zinc: Sham animals receiving zinc supplementation; 3) Infarction Control; 4) Infarction Zinc. After the followup period, we studied hypertrophy and ventricular geometry, functional alterations in vivo and in vitro, changes related to collagen, oxidative stress, and inflammation, assessed by echocardiogram, isolated heart study, western blot, flow cytometer, morphometry, and spectrophotometry. Results: Infarction induced a significant worsening of the functional variables. On the other hand, zinc attenuated both systolic and diastolic cardiac dysfunction induced by infarction. Considering the infarct size, there was no difference between the groups. Catalase and superoxide dismutase decreased in infarcted animals, and zinc increased its activity. We found higher expression of collagens I and III in infarcted animals, but there was no effect of zinc supplementation. Likewise, infarcted animals had higher levels of IL-10, but without zinc interference. Nrf-2 values were not different among the groups. Infarction increased the amount of Treg cells in the spleen as well as the amount of total lymphocytes. Zinc increased the amount of CD4+ in infarcted animals, but we did not observe effects in relation to Treg cells. Conclusion: zinc attenuates cardiac remodeling after infarction in rats; this effect is associated with modulation of antioxidant enzymes, but without the involvement of collagens I and III, Nrf-2, IL-10, and Treg cells.São Paulo State University (Unesp) Botucatu Medical School Internal Medicine DepartmentSão Paulo State University (Unesp) Institute of Biosciences of Botucatu Chemistry and Biochemistry DepartmentSão Paulo State University (Unesp) Institute of Biosciences of Botucatu Microbiology and Immunology DepartmentFlow Citometry Laboratory Amaral Carvalho FundationSão Paulo State University (Unesp) Botucatu Medical School Internal Medicine DepartmentSão Paulo State University (Unesp) Institute of Biosciences of Botucatu Chemistry and Biochemistry DepartmentSão Paulo State University (Unesp) Institute of Biosciences of Botucatu Microbiology and Immunology DepartmentUniversidade Estadual Paulista (Unesp)Amaral Carvalho FundationGonçalves, Andrea F. [UNESP]Polegato, Bertha F. [UNESP]Fernandes, Ana Angélica [UNESP]Ishikawa, Larissa Lumi [UNESP]Okoshi, Katashi [UNESP]Bazan, Silméia G. Z. [UNESP]Minicucci, Marcos F. [UNESP]Azevedo, Paula S. [UNESP]Ikoma, Maura R.Penitenti, MarcimaraChiuso-Minicucci, Fernanda [UNESP]R Paiva, Sergio A. [UNESP]Zornoff, Leonardo A. M. [UNESP]2019-10-06T15:59:20Z2019-10-06T15:59:20Z2018-10-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article363-377http://dx.doi.org/10.1159/000494011Cellular Physiology and Biochemistry, v. 50, n. 1, p. 363-377, 2018.1421-97781015-8987http://hdl.handle.net/11449/18816510.1159/0004940112-s2.0-85054488500Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengCellular Physiology and Biochemistryinfo:eu-repo/semantics/openAccess2024-08-14T17:23:20Zoai:repositorio.unesp.br:11449/188165Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-14T17:23:20Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Zinc Supplementation Attenuates Cardiac Remodeling after Experimental Myocardial Infarction |
title |
Zinc Supplementation Attenuates Cardiac Remodeling after Experimental Myocardial Infarction |
spellingShingle |
Zinc Supplementation Attenuates Cardiac Remodeling after Experimental Myocardial Infarction Gonçalves, Andrea F. [UNESP] Chronic remodeling Coronary occlusion Function Hypertrophy Treg cells Zinc |
title_short |
Zinc Supplementation Attenuates Cardiac Remodeling after Experimental Myocardial Infarction |
title_full |
Zinc Supplementation Attenuates Cardiac Remodeling after Experimental Myocardial Infarction |
title_fullStr |
Zinc Supplementation Attenuates Cardiac Remodeling after Experimental Myocardial Infarction |
title_full_unstemmed |
Zinc Supplementation Attenuates Cardiac Remodeling after Experimental Myocardial Infarction |
title_sort |
Zinc Supplementation Attenuates Cardiac Remodeling after Experimental Myocardial Infarction |
author |
Gonçalves, Andrea F. [UNESP] |
author_facet |
Gonçalves, Andrea F. [UNESP] Polegato, Bertha F. [UNESP] Fernandes, Ana Angélica [UNESP] Ishikawa, Larissa Lumi [UNESP] Okoshi, Katashi [UNESP] Bazan, Silméia G. Z. [UNESP] Minicucci, Marcos F. [UNESP] Azevedo, Paula S. [UNESP] Ikoma, Maura R. Penitenti, Marcimara Chiuso-Minicucci, Fernanda [UNESP] R Paiva, Sergio A. [UNESP] Zornoff, Leonardo A. M. [UNESP] |
author_role |
author |
author2 |
Polegato, Bertha F. [UNESP] Fernandes, Ana Angélica [UNESP] Ishikawa, Larissa Lumi [UNESP] Okoshi, Katashi [UNESP] Bazan, Silméia G. Z. [UNESP] Minicucci, Marcos F. [UNESP] Azevedo, Paula S. [UNESP] Ikoma, Maura R. Penitenti, Marcimara Chiuso-Minicucci, Fernanda [UNESP] R Paiva, Sergio A. [UNESP] Zornoff, Leonardo A. M. [UNESP] |
author2_role |
author author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Amaral Carvalho Fundation |
dc.contributor.author.fl_str_mv |
Gonçalves, Andrea F. [UNESP] Polegato, Bertha F. [UNESP] Fernandes, Ana Angélica [UNESP] Ishikawa, Larissa Lumi [UNESP] Okoshi, Katashi [UNESP] Bazan, Silméia G. Z. [UNESP] Minicucci, Marcos F. [UNESP] Azevedo, Paula S. [UNESP] Ikoma, Maura R. Penitenti, Marcimara Chiuso-Minicucci, Fernanda [UNESP] R Paiva, Sergio A. [UNESP] Zornoff, Leonardo A. M. [UNESP] |
dc.subject.por.fl_str_mv |
Chronic remodeling Coronary occlusion Function Hypertrophy Treg cells Zinc |
topic |
Chronic remodeling Coronary occlusion Function Hypertrophy Treg cells Zinc |
description |
Background/Aims: The objective of our study was to evaluate the effects of zinc supplementation on cardiac remodeling following acute myocardial infarction in rats. Methods: Animals were subdivided into 4 groups and observed for 3 months: 1) Sham Control; 2) Sham Zinc: Sham animals receiving zinc supplementation; 3) Infarction Control; 4) Infarction Zinc. After the followup period, we studied hypertrophy and ventricular geometry, functional alterations in vivo and in vitro, changes related to collagen, oxidative stress, and inflammation, assessed by echocardiogram, isolated heart study, western blot, flow cytometer, morphometry, and spectrophotometry. Results: Infarction induced a significant worsening of the functional variables. On the other hand, zinc attenuated both systolic and diastolic cardiac dysfunction induced by infarction. Considering the infarct size, there was no difference between the groups. Catalase and superoxide dismutase decreased in infarcted animals, and zinc increased its activity. We found higher expression of collagens I and III in infarcted animals, but there was no effect of zinc supplementation. Likewise, infarcted animals had higher levels of IL-10, but without zinc interference. Nrf-2 values were not different among the groups. Infarction increased the amount of Treg cells in the spleen as well as the amount of total lymphocytes. Zinc increased the amount of CD4+ in infarcted animals, but we did not observe effects in relation to Treg cells. Conclusion: zinc attenuates cardiac remodeling after infarction in rats; this effect is associated with modulation of antioxidant enzymes, but without the involvement of collagens I and III, Nrf-2, IL-10, and Treg cells. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-10-01 2019-10-06T15:59:20Z 2019-10-06T15:59:20Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1159/000494011 Cellular Physiology and Biochemistry, v. 50, n. 1, p. 363-377, 2018. 1421-9778 1015-8987 http://hdl.handle.net/11449/188165 10.1159/000494011 2-s2.0-85054488500 |
url |
http://dx.doi.org/10.1159/000494011 http://hdl.handle.net/11449/188165 |
identifier_str_mv |
Cellular Physiology and Biochemistry, v. 50, n. 1, p. 363-377, 2018. 1421-9778 1015-8987 10.1159/000494011 2-s2.0-85054488500 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Cellular Physiology and Biochemistry |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
363-377 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808128155321368576 |