Melanoma: Clinical, evolutive and histopathological characteristics of a series of 136 cases

Detalhes bibliográficos
Autor(a) principal: Ocanha-Xavier, Juliana Polizel
Data de Publicação: 2018
Outros Autores: Xavier-Junior, José Cândido Caldeira, Marques, Mariângela Esther Alencar [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1590/abd1806-4841.20186690
http://hdl.handle.net/11449/177152
Resumo: Background: The incidence of melanoma has been increasing in Brazil and all over the world. Despite improvements in diagnosis and treatment, mortality remains unchanged. Objective: To associate clinical and histopathological aspects with the evolution of 136 cases of cutaneous melanoma. Methods: Retrospective cohort study that analyzed all patients diagnosed with melanoma during the period from 2003 to 2011, with at least 4 years follow up. Archived slides were analyzed to study histopathological variables (Breslow, ulceration, mitoses and histological regression). Medical records were used to retrieve clinical variables (age, sex, localization, time of appearance, diameter) and progression (metastases or death). Association measures were assessed by statistical analysis. Results: There was no statistically significant difference between groups according to age. Superficial spreading subtype showed lower Breslow (0.5mm) than acral lentiginous and nodular subtypes (2 and 4.6mm respectively), less ulceration and metastases (9.4% against 50 and 70.6%). Nodular subtype had higher mitoses’ median (5.0/mm2) than superficial spreading and lentigo maligna (0.0/mm2, for both). Regression was more frequent in superficial spreading and lentigo maligna subtypes. There were only deaths by melanoma in the acral group, however, there were deaths for other reasons in groups superficial spreading one, acral lentiginous one and lentigo maligna two. Study limitations: Use of medical records as a source of data to the study. Conclusions: Superficial spreading subtype presents better prognosis indicators. Histological subtype should be considered in follow-up and treatment protocols of patients with cutaneous melanoma.
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spelling Melanoma: Clinical, evolutive and histopathological characteristics of a series of 136 casesMelanomaPathologyPrognosisSurvival rateBackground: The incidence of melanoma has been increasing in Brazil and all over the world. Despite improvements in diagnosis and treatment, mortality remains unchanged. Objective: To associate clinical and histopathological aspects with the evolution of 136 cases of cutaneous melanoma. Methods: Retrospective cohort study that analyzed all patients diagnosed with melanoma during the period from 2003 to 2011, with at least 4 years follow up. Archived slides were analyzed to study histopathological variables (Breslow, ulceration, mitoses and histological regression). Medical records were used to retrieve clinical variables (age, sex, localization, time of appearance, diameter) and progression (metastases or death). Association measures were assessed by statistical analysis. Results: There was no statistically significant difference between groups according to age. Superficial spreading subtype showed lower Breslow (0.5mm) than acral lentiginous and nodular subtypes (2 and 4.6mm respectively), less ulceration and metastases (9.4% against 50 and 70.6%). Nodular subtype had higher mitoses’ median (5.0/mm2) than superficial spreading and lentigo maligna (0.0/mm2, for both). Regression was more frequent in superficial spreading and lentigo maligna subtypes. There were only deaths by melanoma in the acral group, however, there were deaths for other reasons in groups superficial spreading one, acral lentiginous one and lentigo maligna two. Study limitations: Use of medical records as a source of data to the study. Conclusions: Superficial spreading subtype presents better prognosis indicators. Histological subtype should be considered in follow-up and treatment protocols of patients with cutaneous melanoma.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Clínica TiradentesInstituto de Patologia de AraçatubaDepartment of Pathology Universidade Estadual Paulista (UNESP)Department of Pathology Universidade Estadual Paulista (UNESP)FAPESP: 16013-5/2014Clínica TiradentesInstituto de Patologia de AraçatubaUniversidade Estadual Paulista (Unesp)Ocanha-Xavier, Juliana PolizelXavier-Junior, José Cândido CaldeiraMarques, Mariângela Esther Alencar [UNESP]2018-12-11T17:24:14Z2018-12-11T17:24:14Z2018-05-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article373-376application/pdfhttp://dx.doi.org/10.1590/abd1806-4841.20186690Anais Brasileiros de Dermatologia, v. 93, n. 3, p. 373-376, 2018.1806-48410365-0596http://hdl.handle.net/11449/17715210.1590/abd1806-4841.20186690S0365-059620180003003732-s2.0-85048819079S0365-05962018000300373.pdf7528116925519142Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengAnais Brasileiros de Dermatologia0,520info:eu-repo/semantics/openAccess2024-09-19T18:57:27Zoai:repositorio.unesp.br:11449/177152Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestrepositoriounesp@unesp.bropendoar:29462024-09-19T18:57:27Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Melanoma: Clinical, evolutive and histopathological characteristics of a series of 136 cases
title Melanoma: Clinical, evolutive and histopathological characteristics of a series of 136 cases
spellingShingle Melanoma: Clinical, evolutive and histopathological characteristics of a series of 136 cases
Ocanha-Xavier, Juliana Polizel
Melanoma
Pathology
Prognosis
Survival rate
title_short Melanoma: Clinical, evolutive and histopathological characteristics of a series of 136 cases
title_full Melanoma: Clinical, evolutive and histopathological characteristics of a series of 136 cases
title_fullStr Melanoma: Clinical, evolutive and histopathological characteristics of a series of 136 cases
title_full_unstemmed Melanoma: Clinical, evolutive and histopathological characteristics of a series of 136 cases
title_sort Melanoma: Clinical, evolutive and histopathological characteristics of a series of 136 cases
author Ocanha-Xavier, Juliana Polizel
author_facet Ocanha-Xavier, Juliana Polizel
Xavier-Junior, José Cândido Caldeira
Marques, Mariângela Esther Alencar [UNESP]
author_role author
author2 Xavier-Junior, José Cândido Caldeira
Marques, Mariângela Esther Alencar [UNESP]
author2_role author
author
dc.contributor.none.fl_str_mv Clínica Tiradentes
Instituto de Patologia de Araçatuba
Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv Ocanha-Xavier, Juliana Polizel
Xavier-Junior, José Cândido Caldeira
Marques, Mariângela Esther Alencar [UNESP]
dc.subject.por.fl_str_mv Melanoma
Pathology
Prognosis
Survival rate
topic Melanoma
Pathology
Prognosis
Survival rate
description Background: The incidence of melanoma has been increasing in Brazil and all over the world. Despite improvements in diagnosis and treatment, mortality remains unchanged. Objective: To associate clinical and histopathological aspects with the evolution of 136 cases of cutaneous melanoma. Methods: Retrospective cohort study that analyzed all patients diagnosed with melanoma during the period from 2003 to 2011, with at least 4 years follow up. Archived slides were analyzed to study histopathological variables (Breslow, ulceration, mitoses and histological regression). Medical records were used to retrieve clinical variables (age, sex, localization, time of appearance, diameter) and progression (metastases or death). Association measures were assessed by statistical analysis. Results: There was no statistically significant difference between groups according to age. Superficial spreading subtype showed lower Breslow (0.5mm) than acral lentiginous and nodular subtypes (2 and 4.6mm respectively), less ulceration and metastases (9.4% against 50 and 70.6%). Nodular subtype had higher mitoses’ median (5.0/mm2) than superficial spreading and lentigo maligna (0.0/mm2, for both). Regression was more frequent in superficial spreading and lentigo maligna subtypes. There were only deaths by melanoma in the acral group, however, there were deaths for other reasons in groups superficial spreading one, acral lentiginous one and lentigo maligna two. Study limitations: Use of medical records as a source of data to the study. Conclusions: Superficial spreading subtype presents better prognosis indicators. Histological subtype should be considered in follow-up and treatment protocols of patients with cutaneous melanoma.
publishDate 2018
dc.date.none.fl_str_mv 2018-12-11T17:24:14Z
2018-12-11T17:24:14Z
2018-05-01
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/abd1806-4841.20186690
Anais Brasileiros de Dermatologia, v. 93, n. 3, p. 373-376, 2018.
1806-4841
0365-0596
http://hdl.handle.net/11449/177152
10.1590/abd1806-4841.20186690
S0365-05962018000300373
2-s2.0-85048819079
S0365-05962018000300373.pdf
7528116925519142
url http://dx.doi.org/10.1590/abd1806-4841.20186690
http://hdl.handle.net/11449/177152
identifier_str_mv Anais Brasileiros de Dermatologia, v. 93, n. 3, p. 373-376, 2018.
1806-4841
0365-0596
10.1590/abd1806-4841.20186690
S0365-05962018000300373
2-s2.0-85048819079
S0365-05962018000300373.pdf
7528116925519142
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Anais Brasileiros de Dermatologia
0,520
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 373-376
application/pdf
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv repositoriounesp@unesp.br
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