Melanoma: Clinical, evolutive and histopathological characteristics of a series of 136 cases
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1590/abd1806-4841.20186690 http://hdl.handle.net/11449/177152 |
Resumo: | Background: The incidence of melanoma has been increasing in Brazil and all over the world. Despite improvements in diagnosis and treatment, mortality remains unchanged. Objective: To associate clinical and histopathological aspects with the evolution of 136 cases of cutaneous melanoma. Methods: Retrospective cohort study that analyzed all patients diagnosed with melanoma during the period from 2003 to 2011, with at least 4 years follow up. Archived slides were analyzed to study histopathological variables (Breslow, ulceration, mitoses and histological regression). Medical records were used to retrieve clinical variables (age, sex, localization, time of appearance, diameter) and progression (metastases or death). Association measures were assessed by statistical analysis. Results: There was no statistically significant difference between groups according to age. Superficial spreading subtype showed lower Breslow (0.5mm) than acral lentiginous and nodular subtypes (2 and 4.6mm respectively), less ulceration and metastases (9.4% against 50 and 70.6%). Nodular subtype had higher mitoses’ median (5.0/mm2) than superficial spreading and lentigo maligna (0.0/mm2, for both). Regression was more frequent in superficial spreading and lentigo maligna subtypes. There were only deaths by melanoma in the acral group, however, there were deaths for other reasons in groups superficial spreading one, acral lentiginous one and lentigo maligna two. Study limitations: Use of medical records as a source of data to the study. Conclusions: Superficial spreading subtype presents better prognosis indicators. Histological subtype should be considered in follow-up and treatment protocols of patients with cutaneous melanoma. |
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Melanoma: Clinical, evolutive and histopathological characteristics of a series of 136 casesMelanomaPathologyPrognosisSurvival rateBackground: The incidence of melanoma has been increasing in Brazil and all over the world. Despite improvements in diagnosis and treatment, mortality remains unchanged. Objective: To associate clinical and histopathological aspects with the evolution of 136 cases of cutaneous melanoma. Methods: Retrospective cohort study that analyzed all patients diagnosed with melanoma during the period from 2003 to 2011, with at least 4 years follow up. Archived slides were analyzed to study histopathological variables (Breslow, ulceration, mitoses and histological regression). Medical records were used to retrieve clinical variables (age, sex, localization, time of appearance, diameter) and progression (metastases or death). Association measures were assessed by statistical analysis. Results: There was no statistically significant difference between groups according to age. Superficial spreading subtype showed lower Breslow (0.5mm) than acral lentiginous and nodular subtypes (2 and 4.6mm respectively), less ulceration and metastases (9.4% against 50 and 70.6%). Nodular subtype had higher mitoses’ median (5.0/mm2) than superficial spreading and lentigo maligna (0.0/mm2, for both). Regression was more frequent in superficial spreading and lentigo maligna subtypes. There were only deaths by melanoma in the acral group, however, there were deaths for other reasons in groups superficial spreading one, acral lentiginous one and lentigo maligna two. Study limitations: Use of medical records as a source of data to the study. Conclusions: Superficial spreading subtype presents better prognosis indicators. Histological subtype should be considered in follow-up and treatment protocols of patients with cutaneous melanoma.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Clínica TiradentesInstituto de Patologia de AraçatubaDepartment of Pathology Universidade Estadual Paulista (UNESP)Department of Pathology Universidade Estadual Paulista (UNESP)FAPESP: 16013-5/2014Clínica TiradentesInstituto de Patologia de AraçatubaUniversidade Estadual Paulista (Unesp)Ocanha-Xavier, Juliana PolizelXavier-Junior, José Cândido CaldeiraMarques, Mariângela Esther Alencar [UNESP]2018-12-11T17:24:14Z2018-12-11T17:24:14Z2018-05-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article373-376application/pdfhttp://dx.doi.org/10.1590/abd1806-4841.20186690Anais Brasileiros de Dermatologia, v. 93, n. 3, p. 373-376, 2018.1806-48410365-0596http://hdl.handle.net/11449/17715210.1590/abd1806-4841.20186690S0365-059620180003003732-s2.0-85048819079S0365-05962018000300373.pdf7528116925519142Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengAnais Brasileiros de Dermatologia0,520info:eu-repo/semantics/openAccess2024-09-19T18:57:27Zoai:repositorio.unesp.br:11449/177152Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestrepositoriounesp@unesp.bropendoar:29462024-09-19T18:57:27Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Melanoma: Clinical, evolutive and histopathological characteristics of a series of 136 cases |
title |
Melanoma: Clinical, evolutive and histopathological characteristics of a series of 136 cases |
spellingShingle |
Melanoma: Clinical, evolutive and histopathological characteristics of a series of 136 cases Ocanha-Xavier, Juliana Polizel Melanoma Pathology Prognosis Survival rate |
title_short |
Melanoma: Clinical, evolutive and histopathological characteristics of a series of 136 cases |
title_full |
Melanoma: Clinical, evolutive and histopathological characteristics of a series of 136 cases |
title_fullStr |
Melanoma: Clinical, evolutive and histopathological characteristics of a series of 136 cases |
title_full_unstemmed |
Melanoma: Clinical, evolutive and histopathological characteristics of a series of 136 cases |
title_sort |
Melanoma: Clinical, evolutive and histopathological characteristics of a series of 136 cases |
author |
Ocanha-Xavier, Juliana Polizel |
author_facet |
Ocanha-Xavier, Juliana Polizel Xavier-Junior, José Cândido Caldeira Marques, Mariângela Esther Alencar [UNESP] |
author_role |
author |
author2 |
Xavier-Junior, José Cândido Caldeira Marques, Mariângela Esther Alencar [UNESP] |
author2_role |
author author |
dc.contributor.none.fl_str_mv |
Clínica Tiradentes Instituto de Patologia de Araçatuba Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Ocanha-Xavier, Juliana Polizel Xavier-Junior, José Cândido Caldeira Marques, Mariângela Esther Alencar [UNESP] |
dc.subject.por.fl_str_mv |
Melanoma Pathology Prognosis Survival rate |
topic |
Melanoma Pathology Prognosis Survival rate |
description |
Background: The incidence of melanoma has been increasing in Brazil and all over the world. Despite improvements in diagnosis and treatment, mortality remains unchanged. Objective: To associate clinical and histopathological aspects with the evolution of 136 cases of cutaneous melanoma. Methods: Retrospective cohort study that analyzed all patients diagnosed with melanoma during the period from 2003 to 2011, with at least 4 years follow up. Archived slides were analyzed to study histopathological variables (Breslow, ulceration, mitoses and histological regression). Medical records were used to retrieve clinical variables (age, sex, localization, time of appearance, diameter) and progression (metastases or death). Association measures were assessed by statistical analysis. Results: There was no statistically significant difference between groups according to age. Superficial spreading subtype showed lower Breslow (0.5mm) than acral lentiginous and nodular subtypes (2 and 4.6mm respectively), less ulceration and metastases (9.4% against 50 and 70.6%). Nodular subtype had higher mitoses’ median (5.0/mm2) than superficial spreading and lentigo maligna (0.0/mm2, for both). Regression was more frequent in superficial spreading and lentigo maligna subtypes. There were only deaths by melanoma in the acral group, however, there were deaths for other reasons in groups superficial spreading one, acral lentiginous one and lentigo maligna two. Study limitations: Use of medical records as a source of data to the study. Conclusions: Superficial spreading subtype presents better prognosis indicators. Histological subtype should be considered in follow-up and treatment protocols of patients with cutaneous melanoma. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-12-11T17:24:14Z 2018-12-11T17:24:14Z 2018-05-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/abd1806-4841.20186690 Anais Brasileiros de Dermatologia, v. 93, n. 3, p. 373-376, 2018. 1806-4841 0365-0596 http://hdl.handle.net/11449/177152 10.1590/abd1806-4841.20186690 S0365-05962018000300373 2-s2.0-85048819079 S0365-05962018000300373.pdf 7528116925519142 |
url |
http://dx.doi.org/10.1590/abd1806-4841.20186690 http://hdl.handle.net/11449/177152 |
identifier_str_mv |
Anais Brasileiros de Dermatologia, v. 93, n. 3, p. 373-376, 2018. 1806-4841 0365-0596 10.1590/abd1806-4841.20186690 S0365-05962018000300373 2-s2.0-85048819079 S0365-05962018000300373.pdf 7528116925519142 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Anais Brasileiros de Dermatologia 0,520 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
373-376 application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
repositoriounesp@unesp.br |
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1813546449530519552 |