Influência do treinamento físico aeróbio sobre os biomarcadores cardiovasculares e endócrino-inflamatórios em mulheres normotensas e hipertensas no pós-menopausa

• Autor(a) principal: Jarrete, Aline Pincerato [UNESP]
• Data de Publicação: 2015
• Tipo de documento: Dissertação
• Idioma: por
• Título da fonte: Repositório Institucional da UNESP
• Texto Completo: http://hdl.handle.net/11449/132617; http://www.athena.biblioteca.unesp.br/exlibris/bd/cathedra/15-12-2015/000855835.pdf
• topic: Physical education and training; Educação fisica; Exercícios físicos; Menopausa; Sistema cardiovascular

The postmenopausal period is associated with greater cardiovascular risk compared to premenopausal. This fact has been partly attributed to estrogen deficiency. Other studies highlight the relationship between the increase in oxidative stress, inflammatory biomarkers and cardiovascular diseases (CDV) at this stage of life, especially hypertension. However, other studies are needed to understand the mechanisms responsible for this phenomenon. On the other hand, it is known that physical exercise is an important strategy both in prevention and treatment of CVD. So, the aim of this study was to evaluate the baseline concentrations of cardiovascular and endocrine-inflammatory biomarkers in normotensive (NT) and hypertensive (HT) postmenopausal women and the possible differences in patterns of response against aerobic exercise training (AET). Thirty-seven volunteers completed the study, 19 NT and 18 HT. Were evaluated: a) anthropometric parameters - body mass index (BMI), waist circumference (WC) and waist-hip ratio (WHR); b) cardiovascular parameters - systolic blood pressure (SBP), diastolic blood pressure (DBP) and rest heart rate (HR); c) biochemical parameters - lipid profile and glycemia, nitrite/nitrate (NOx-), cyclic guanosine monophosphate (cGMP), asymmetric dimethylarginine (ADMA), superoxide dismutase (SOD) and catalase activity, malondialdehyde (MDA), cortisol, leptin and interleukin-1β (IL-1β). AET consisted of 24 sessions of walking on a treadmill, 3 days/week, 30 to 40 min, in the maximal lactate steady state intensity. Were observed only the HT group decreased BMI (-1.5%) in response to AET. No changes in other anthropometric parameters were observed, as well as lipid profile and glycemia in both groups. On the other hand, AET decreased SBP (- 4.4 mmHg), DBP (- 4.3 mmHg) e HR (-3.9%) only in HT group. This reduction was accompanied by an increase in NOx- (+37.7%) and cGMP (+30.8%) plasmatic concentration. In NT group, ...