Specific protocols of controlled ovarian stimulation for oocyte cryopreservation in breast cancer patients

Detalhes bibliográficos
Autor(a) principal: Cavagna, Felipe
Data de Publicação: 2018
Outros Autores: Pontes, A. [UNESP], Cavagna, M., Dzik, A., Donadio, N. F., Portela, R., Nagai, M. T., Gebrim, L. H.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.3747/co.25.3889
http://hdl.handle.net/11449/228649
Resumo: Background Fertility preservation is an important concern in breast cancer patients. In the present investigation, we set out to create a specific protocol of controlled ovarian stimulation (cos) for oocyte cryopreservation in breast cancer patients. Methods From November 2014 to December 2016, 109 patients were studied. The patients were assigned to a specific random-start ovarian stimulation protocol for oocyte cryopreservation. The endpoints were the numbers of oocytes retrieved and of mature oocytes cryopreserved, the total number of days of ovarian stimulation, the total dose of gonadotropin administered, and the estradiol level on the day of the trigger. Results Mean age in this cohort was 31.27 ± 4.23 years. The average duration of cos was 10.0 ± 1.39 days. The mean number of oocytes collected was 11.62 ± 7.96 and the mean number of vitrified oocytes was 9.60 ± 6.87. The mean estradiol concentration on triggering day was 706.30 ± 450.48 pg/mL, and the mean dose of gonadotropins administered was 2610.00 ± 716.51 IU. When comparing outcomes by phase of the cycle in which cos was commenced, we observed no significant differences in the numbers of oocytes collected and vitrified, the length of ovarian stimulation, and the estradiol level on trigger day. The total dose of follicle-stimulating hormone and human menopausal gonadotropin administered was statistically greater in the group starting cos in the luteal phase than in the group starting in the late follicular phase. Conclusions Our results suggest that using a specific protocol with random-start ovarian stimulation for oocyte cryopreservation in breast cancer patients is effective and could be offered to young women undergoing oncologic treatment.
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spelling Specific protocols of controlled ovarian stimulation for oocyte cryopreservation in breast cancer patientsBreast cancerFertility preservationOocyte cryopreservationOvarian stimulationBackground Fertility preservation is an important concern in breast cancer patients. In the present investigation, we set out to create a specific protocol of controlled ovarian stimulation (cos) for oocyte cryopreservation in breast cancer patients. Methods From November 2014 to December 2016, 109 patients were studied. The patients were assigned to a specific random-start ovarian stimulation protocol for oocyte cryopreservation. The endpoints were the numbers of oocytes retrieved and of mature oocytes cryopreserved, the total number of days of ovarian stimulation, the total dose of gonadotropin administered, and the estradiol level on the day of the trigger. Results Mean age in this cohort was 31.27 ± 4.23 years. The average duration of cos was 10.0 ± 1.39 days. The mean number of oocytes collected was 11.62 ± 7.96 and the mean number of vitrified oocytes was 9.60 ± 6.87. The mean estradiol concentration on triggering day was 706.30 ± 450.48 pg/mL, and the mean dose of gonadotropins administered was 2610.00 ± 716.51 IU. When comparing outcomes by phase of the cycle in which cos was commenced, we observed no significant differences in the numbers of oocytes collected and vitrified, the length of ovarian stimulation, and the estradiol level on trigger day. The total dose of follicle-stimulating hormone and human menopausal gonadotropin administered was statistically greater in the group starting cos in the luteal phase than in the group starting in the late follicular phase. Conclusions Our results suggest that using a specific protocol with random-start ovarian stimulation for oocyte cryopreservation in breast cancer patients is effective and could be offered to young women undergoing oncologic treatment.Women’s Health Reference Center Hospital Perola ByingtonDepartment of Gynecology and Obstetrics Botucatu Medical School University of the State of Sao PauloDepartment of Gynecology and Obstetrics Botucatu Medical School University of the State of Sao PauloHospital Perola ByingtonUniversidade Estadual Paulista (UNESP)Cavagna, FelipePontes, A. [UNESP]Cavagna, M.Dzik, A.Donadio, N. F.Portela, R.Nagai, M. T.Gebrim, L. H.2022-04-29T08:27:54Z2022-04-29T08:27:54Z2018-12-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlee527-e532http://dx.doi.org/10.3747/co.25.3889Current Oncology, v. 25, n. 6, p. e527-e532, 2018.1718-77291198-0052http://hdl.handle.net/11449/22864910.3747/co.25.38892-s2.0-85059500915Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengCurrent Oncologyinfo:eu-repo/semantics/openAccess2024-08-16T14:12:39Zoai:repositorio.unesp.br:11449/228649Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-16T14:12:39Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Specific protocols of controlled ovarian stimulation for oocyte cryopreservation in breast cancer patients
title Specific protocols of controlled ovarian stimulation for oocyte cryopreservation in breast cancer patients
spellingShingle Specific protocols of controlled ovarian stimulation for oocyte cryopreservation in breast cancer patients
Cavagna, Felipe
Breast cancer
Fertility preservation
Oocyte cryopreservation
Ovarian stimulation
title_short Specific protocols of controlled ovarian stimulation for oocyte cryopreservation in breast cancer patients
title_full Specific protocols of controlled ovarian stimulation for oocyte cryopreservation in breast cancer patients
title_fullStr Specific protocols of controlled ovarian stimulation for oocyte cryopreservation in breast cancer patients
title_full_unstemmed Specific protocols of controlled ovarian stimulation for oocyte cryopreservation in breast cancer patients
title_sort Specific protocols of controlled ovarian stimulation for oocyte cryopreservation in breast cancer patients
author Cavagna, Felipe
author_facet Cavagna, Felipe
Pontes, A. [UNESP]
Cavagna, M.
Dzik, A.
Donadio, N. F.
Portela, R.
Nagai, M. T.
Gebrim, L. H.
author_role author
author2 Pontes, A. [UNESP]
Cavagna, M.
Dzik, A.
Donadio, N. F.
Portela, R.
Nagai, M. T.
Gebrim, L. H.
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Hospital Perola Byington
Universidade Estadual Paulista (UNESP)
dc.contributor.author.fl_str_mv Cavagna, Felipe
Pontes, A. [UNESP]
Cavagna, M.
Dzik, A.
Donadio, N. F.
Portela, R.
Nagai, M. T.
Gebrim, L. H.
dc.subject.por.fl_str_mv Breast cancer
Fertility preservation
Oocyte cryopreservation
Ovarian stimulation
topic Breast cancer
Fertility preservation
Oocyte cryopreservation
Ovarian stimulation
description Background Fertility preservation is an important concern in breast cancer patients. In the present investigation, we set out to create a specific protocol of controlled ovarian stimulation (cos) for oocyte cryopreservation in breast cancer patients. Methods From November 2014 to December 2016, 109 patients were studied. The patients were assigned to a specific random-start ovarian stimulation protocol for oocyte cryopreservation. The endpoints were the numbers of oocytes retrieved and of mature oocytes cryopreserved, the total number of days of ovarian stimulation, the total dose of gonadotropin administered, and the estradiol level on the day of the trigger. Results Mean age in this cohort was 31.27 ± 4.23 years. The average duration of cos was 10.0 ± 1.39 days. The mean number of oocytes collected was 11.62 ± 7.96 and the mean number of vitrified oocytes was 9.60 ± 6.87. The mean estradiol concentration on triggering day was 706.30 ± 450.48 pg/mL, and the mean dose of gonadotropins administered was 2610.00 ± 716.51 IU. When comparing outcomes by phase of the cycle in which cos was commenced, we observed no significant differences in the numbers of oocytes collected and vitrified, the length of ovarian stimulation, and the estradiol level on trigger day. The total dose of follicle-stimulating hormone and human menopausal gonadotropin administered was statistically greater in the group starting cos in the luteal phase than in the group starting in the late follicular phase. Conclusions Our results suggest that using a specific protocol with random-start ovarian stimulation for oocyte cryopreservation in breast cancer patients is effective and could be offered to young women undergoing oncologic treatment.
publishDate 2018
dc.date.none.fl_str_mv 2018-12-01
2022-04-29T08:27:54Z
2022-04-29T08:27:54Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.3747/co.25.3889
Current Oncology, v. 25, n. 6, p. e527-e532, 2018.
1718-7729
1198-0052
http://hdl.handle.net/11449/228649
10.3747/co.25.3889
2-s2.0-85059500915
url http://dx.doi.org/10.3747/co.25.3889
http://hdl.handle.net/11449/228649
identifier_str_mv Current Oncology, v. 25, n. 6, p. e527-e532, 2018.
1718-7729
1198-0052
10.3747/co.25.3889
2-s2.0-85059500915
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Current Oncology
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv e527-e532
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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