PLATELET-RICH PLASMA (PRP) AND TRANEXAMIC ACID (TXA) APPLIED IN TOTAL KNEE ARTHROPLASTY

Detalhes bibliográficos
Autor(a) principal: Fernandes Guerreiro, Joao Paulo [UNESP]
Data de Publicação: 2019
Outros Autores: Lima, Diogenes Rodrigues, Bordignon, Glaucia, Danieli, Marcus Vinicius [UNESP], Queiroz, Alexandre Oliveira, Cataneo, Daniele Cristina [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1590/1413-785220192705214417
http://hdl.handle.net/11449/194886
Resumo: Objective: To evaluate the efficacy of platelet-rich plasma (PRP) and tranexamic acid (TXA) applied in total knee arthroplasty. Methods: We selected and randomized 84 patients. TXA was applied in 23 patients, PRP in 20, and PRP in combination with TXA in 20. Hemoglobin was measured preoperatively and 24 and 48 hours postoperatively. The function questionnaire, pain scale and gain of knee flexion were monitored until the second postoperative year. Results: There was a difference (p <0.01) in the decrease in hemoglobin 48 hours after surgery between the TXA group and the control and PRP groups. In terms of pain, the TXA group at 24 and 48 hours after surgery and the PRP group at 48 hours after surgery showed advantages (p <0.01). Knee flexion gain in the first 24 hours postoperatively was better in the TXA group (p <0.05). Conclusion: TXA was effective in lowering the drop in hemoglobin level, reducing pain and improving movement gain 48 hours after the procedure. PRP was not effective in reducing bleeding or improving knee function after arthroplasty, but provided better control of postoperative pain.
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spelling PLATELET-RICH PLASMA (PRP) AND TRANEXAMIC ACID (TXA) APPLIED IN TOTAL KNEE ARTHROPLASTYArthroplasty, Replacement, KneeTranexamic AcidPlatelet-Rich PlasmaHemorrhagePainObjective: To evaluate the efficacy of platelet-rich plasma (PRP) and tranexamic acid (TXA) applied in total knee arthroplasty. Methods: We selected and randomized 84 patients. TXA was applied in 23 patients, PRP in 20, and PRP in combination with TXA in 20. Hemoglobin was measured preoperatively and 24 and 48 hours postoperatively. The function questionnaire, pain scale and gain of knee flexion were monitored until the second postoperative year. Results: There was a difference (p <0.01) in the decrease in hemoglobin 48 hours after surgery between the TXA group and the control and PRP groups. In terms of pain, the TXA group at 24 and 48 hours after surgery and the PRP group at 48 hours after surgery showed advantages (p <0.01). Knee flexion gain in the first 24 hours postoperatively was better in the TXA group (p <0.05). Conclusion: TXA was effective in lowering the drop in hemoglobin level, reducing pain and improving movement gain 48 hours after the procedure. PRP was not effective in reducing bleeding or improving knee function after arthroplasty, but provided better control of postoperative pain.Hosp Ortoped Uniorte, Londrina, PR, BrazilHosp Evangel Londrina, Londrina, PR, BrazilUniv Estadual Paulista Julio de Mesquite Filho, Botucatu, SP, BrazilUniv Estadual Paulista Julio de Mesquite Filho, Botucatu, SP, BrazilAtha Comunicacao & EditoraHosp Ortoped UniorteHosp Evangel LondrinaUniversidade Estadual Paulista (Unesp)Fernandes Guerreiro, Joao Paulo [UNESP]Lima, Diogenes RodriguesBordignon, GlauciaDanieli, Marcus Vinicius [UNESP]Queiroz, Alexandre OliveiraCataneo, Daniele Cristina [UNESP]2020-12-10T16:57:38Z2020-12-10T16:57:38Z2019-09-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article248-251application/pdfhttp://dx.doi.org/10.1590/1413-785220192705214417Acta Ortopedica Brasileira. Sao Paulo Sp: Atha Comunicacao & Editora, v. 27, n. 5, p. 248-251, 2019.1413-7852http://hdl.handle.net/11449/19488610.1590/1413-785220192705214417S1413-78522019000500248WOS:000489135700002S1413-78522019000500248.pdfWeb of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengActa Ortopedica Brasileirainfo:eu-repo/semantics/openAccess2024-01-16T06:30:36Zoai:repositorio.unesp.br:11449/194886Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T23:09:30.875500Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv PLATELET-RICH PLASMA (PRP) AND TRANEXAMIC ACID (TXA) APPLIED IN TOTAL KNEE ARTHROPLASTY
title PLATELET-RICH PLASMA (PRP) AND TRANEXAMIC ACID (TXA) APPLIED IN TOTAL KNEE ARTHROPLASTY
spellingShingle PLATELET-RICH PLASMA (PRP) AND TRANEXAMIC ACID (TXA) APPLIED IN TOTAL KNEE ARTHROPLASTY
Fernandes Guerreiro, Joao Paulo [UNESP]
Arthroplasty, Replacement, Knee
Tranexamic Acid
Platelet-Rich Plasma
Hemorrhage
Pain
title_short PLATELET-RICH PLASMA (PRP) AND TRANEXAMIC ACID (TXA) APPLIED IN TOTAL KNEE ARTHROPLASTY
title_full PLATELET-RICH PLASMA (PRP) AND TRANEXAMIC ACID (TXA) APPLIED IN TOTAL KNEE ARTHROPLASTY
title_fullStr PLATELET-RICH PLASMA (PRP) AND TRANEXAMIC ACID (TXA) APPLIED IN TOTAL KNEE ARTHROPLASTY
title_full_unstemmed PLATELET-RICH PLASMA (PRP) AND TRANEXAMIC ACID (TXA) APPLIED IN TOTAL KNEE ARTHROPLASTY
title_sort PLATELET-RICH PLASMA (PRP) AND TRANEXAMIC ACID (TXA) APPLIED IN TOTAL KNEE ARTHROPLASTY
author Fernandes Guerreiro, Joao Paulo [UNESP]
author_facet Fernandes Guerreiro, Joao Paulo [UNESP]
Lima, Diogenes Rodrigues
Bordignon, Glaucia
Danieli, Marcus Vinicius [UNESP]
Queiroz, Alexandre Oliveira
Cataneo, Daniele Cristina [UNESP]
author_role author
author2 Lima, Diogenes Rodrigues
Bordignon, Glaucia
Danieli, Marcus Vinicius [UNESP]
Queiroz, Alexandre Oliveira
Cataneo, Daniele Cristina [UNESP]
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Hosp Ortoped Uniorte
Hosp Evangel Londrina
Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv Fernandes Guerreiro, Joao Paulo [UNESP]
Lima, Diogenes Rodrigues
Bordignon, Glaucia
Danieli, Marcus Vinicius [UNESP]
Queiroz, Alexandre Oliveira
Cataneo, Daniele Cristina [UNESP]
dc.subject.por.fl_str_mv Arthroplasty, Replacement, Knee
Tranexamic Acid
Platelet-Rich Plasma
Hemorrhage
Pain
topic Arthroplasty, Replacement, Knee
Tranexamic Acid
Platelet-Rich Plasma
Hemorrhage
Pain
description Objective: To evaluate the efficacy of platelet-rich plasma (PRP) and tranexamic acid (TXA) applied in total knee arthroplasty. Methods: We selected and randomized 84 patients. TXA was applied in 23 patients, PRP in 20, and PRP in combination with TXA in 20. Hemoglobin was measured preoperatively and 24 and 48 hours postoperatively. The function questionnaire, pain scale and gain of knee flexion were monitored until the second postoperative year. Results: There was a difference (p <0.01) in the decrease in hemoglobin 48 hours after surgery between the TXA group and the control and PRP groups. In terms of pain, the TXA group at 24 and 48 hours after surgery and the PRP group at 48 hours after surgery showed advantages (p <0.01). Knee flexion gain in the first 24 hours postoperatively was better in the TXA group (p <0.05). Conclusion: TXA was effective in lowering the drop in hemoglobin level, reducing pain and improving movement gain 48 hours after the procedure. PRP was not effective in reducing bleeding or improving knee function after arthroplasty, but provided better control of postoperative pain.
publishDate 2019
dc.date.none.fl_str_mv 2019-09-01
2020-12-10T16:57:38Z
2020-12-10T16:57:38Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/1413-785220192705214417
Acta Ortopedica Brasileira. Sao Paulo Sp: Atha Comunicacao & Editora, v. 27, n. 5, p. 248-251, 2019.
1413-7852
http://hdl.handle.net/11449/194886
10.1590/1413-785220192705214417
S1413-78522019000500248
WOS:000489135700002
S1413-78522019000500248.pdf
url http://dx.doi.org/10.1590/1413-785220192705214417
http://hdl.handle.net/11449/194886
identifier_str_mv Acta Ortopedica Brasileira. Sao Paulo Sp: Atha Comunicacao & Editora, v. 27, n. 5, p. 248-251, 2019.
1413-7852
10.1590/1413-785220192705214417
S1413-78522019000500248
WOS:000489135700002
S1413-78522019000500248.pdf
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Acta Ortopedica Brasileira
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 248-251
application/pdf
dc.publisher.none.fl_str_mv Atha Comunicacao & Editora
publisher.none.fl_str_mv Atha Comunicacao & Editora
dc.source.none.fl_str_mv Web of Science
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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