Use of cardiac troponin I (cTnI) levels to diagnose severe hypoxia and myocardial injury induced by perinatal asphyxia in neonatal dogs

Detalhes bibliográficos
Autor(a) principal: Nobre Pacífico Pereira, Keylla Helena [UNESP]
Data de Publicação: 2022
Outros Autores: Hibaru, Viviane Yukari [UNESP], Fuchs, Kárita da Mata [UNESP], Cruz dos Santos Correia, Luiz Eduardo [UNESP], Lopes, Maria Denise [UNESP], Ferreira, João Carlos Pinheiro [UNESP], Ferreira de Souza, Fabiana [UNESP], Machado, Luiz Henrique de Araújo [UNESP], Chiacchio, Simone Biagio [UNESP], Gomes Lourenço, Maria Lucia [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1016/j.theriogenology.2021.12.027
http://hdl.handle.net/11449/230129
Resumo: Prolonged perinatal asphyxia and subsequent severe hypoxia are the main causes of mortality in neonatal dogs in the first days of life. In medicine, specific cardiac biochemical markers, such as troponin I, are used to diagnose ischemic and nonischemic myocardial injury in asphyxiated newborns after birth. Thus, the objectives of this study were to compare the levels of cardiac troponin I (cTnI) between asphyxiated and nonasphyxiated newborn dogs and evaluate the correlations of cTnI levels with the modified Apgar score, the levels of oxygen saturation, blood glucose, and lactatemia, and blood gas parameters. This study aimed to determine the possible use of cTnI as a marker of severe hypoxia and myocardial ischemic injury in neonatal dogs. Fifteen animals in a eutocic vaginal delivery group (VG), 15 animals in a cesarean section group (CG), and 13 animals in a hypoxia (asphyxiated) group (HG) were evaluated. The animals in the asphyxiated group were from dystocic deliveries and born by vaginal delivery or cesarean section. All groups were evaluated at birth and after 60 min. The newborns in the VG and CG exhibited mixed acidosis (respiratory acidosis due to increased partial pressure of CO2 (pCO2) and metabolic acidosis due to reduced pH and bicarbonate (HCO3) levels, base excess/deficit in the extracellular fluid compartment (BEecf), and increased lactate levels) due to transient physiological hypoxemia at birth. The cTnI levels in the VG and CG were within the reference standards for healthy dogs. No correlations between cTnI level and the other parameters were observed in the VG and CG. Newborns in the HG exhibited prominent mixed acidosis (p < 0.05) due to severe hypoxemia. The Apgar score and blood gas parameters showed that these dogs were born asphyxiated, and they presented low vitality and the need for resuscitation maneuvers. The cTnI levels in the HG were significantly higher than those in the VG and CG (p < 0.05) and above the reference standards for healthy dogs, which indicated ischemic myocardial injury. The cTnI level was negatively correlated (p < 0.05) with the parameters Apgar score, heart rate, peripheral oxygen saturation (sO2) level, reflex score, and total carbon dioxide (TCO2) level and positively correlated (p < 0.01) with lactate level. This study showed that asphyxiated newborn dogs have higher serum cTnI levels than nonasphyxiated newborn dogs; thus, the cTnI can be used as a marker of severe hypoxia and ischemic myocardial damage in newborn dogs.
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spelling Use of cardiac troponin I (cTnI) levels to diagnose severe hypoxia and myocardial injury induced by perinatal asphyxia in neonatal dogsApgar scoreCesarean sectionHypoxemiaMyocardiumPuppiesProlonged perinatal asphyxia and subsequent severe hypoxia are the main causes of mortality in neonatal dogs in the first days of life. In medicine, specific cardiac biochemical markers, such as troponin I, are used to diagnose ischemic and nonischemic myocardial injury in asphyxiated newborns after birth. Thus, the objectives of this study were to compare the levels of cardiac troponin I (cTnI) between asphyxiated and nonasphyxiated newborn dogs and evaluate the correlations of cTnI levels with the modified Apgar score, the levels of oxygen saturation, blood glucose, and lactatemia, and blood gas parameters. This study aimed to determine the possible use of cTnI as a marker of severe hypoxia and myocardial ischemic injury in neonatal dogs. Fifteen animals in a eutocic vaginal delivery group (VG), 15 animals in a cesarean section group (CG), and 13 animals in a hypoxia (asphyxiated) group (HG) were evaluated. The animals in the asphyxiated group were from dystocic deliveries and born by vaginal delivery or cesarean section. All groups were evaluated at birth and after 60 min. The newborns in the VG and CG exhibited mixed acidosis (respiratory acidosis due to increased partial pressure of CO2 (pCO2) and metabolic acidosis due to reduced pH and bicarbonate (HCO3) levels, base excess/deficit in the extracellular fluid compartment (BEecf), and increased lactate levels) due to transient physiological hypoxemia at birth. The cTnI levels in the VG and CG were within the reference standards for healthy dogs. No correlations between cTnI level and the other parameters were observed in the VG and CG. Newborns in the HG exhibited prominent mixed acidosis (p < 0.05) due to severe hypoxemia. The Apgar score and blood gas parameters showed that these dogs were born asphyxiated, and they presented low vitality and the need for resuscitation maneuvers. The cTnI levels in the HG were significantly higher than those in the VG and CG (p < 0.05) and above the reference standards for healthy dogs, which indicated ischemic myocardial injury. The cTnI level was negatively correlated (p < 0.05) with the parameters Apgar score, heart rate, peripheral oxygen saturation (sO2) level, reflex score, and total carbon dioxide (TCO2) level and positively correlated (p < 0.01) with lactate level. This study showed that asphyxiated newborn dogs have higher serum cTnI levels than nonasphyxiated newborn dogs; thus, the cTnI can be used as a marker of severe hypoxia and ischemic myocardial damage in newborn dogs.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Veterinary Neonatology Research Group São Paulo State University (UNESP) School of Veterinary Medicine and Animal Science Department of Veterinary ClinicsSão Paulo State University (UNESP) School of Veterinary Medicine and Animal Science Department of Animal Improvement and NutritionSão Paulo State University (UNESP) School of Veterinary Medicine and Animal Science Department of Veterinary Surgery and Animal ReproductionVeterinary Neonatology Research Group São Paulo State University (UNESP) School of Veterinary Medicine and Animal Science Department of Veterinary ClinicsSão Paulo State University (UNESP) School of Veterinary Medicine and Animal Science Department of Animal Improvement and NutritionSão Paulo State University (UNESP) School of Veterinary Medicine and Animal Science Department of Veterinary Surgery and Animal ReproductionFAPESP: 2019/21366-0Universidade Estadual Paulista (UNESP)Nobre Pacífico Pereira, Keylla Helena [UNESP]Hibaru, Viviane Yukari [UNESP]Fuchs, Kárita da Mata [UNESP]Cruz dos Santos Correia, Luiz Eduardo [UNESP]Lopes, Maria Denise [UNESP]Ferreira, João Carlos Pinheiro [UNESP]Ferreira de Souza, Fabiana [UNESP]Machado, Luiz Henrique de Araújo [UNESP]Chiacchio, Simone Biagio [UNESP]Gomes Lourenço, Maria Lucia [UNESP]2022-04-29T08:38:04Z2022-04-29T08:38:04Z2022-03-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article146-153http://dx.doi.org/10.1016/j.theriogenology.2021.12.027Theriogenology, v. 180, p. 146-153.0093-691Xhttp://hdl.handle.net/11449/23012910.1016/j.theriogenology.2021.12.0272-s2.0-85121917960Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengTheriogenologyinfo:eu-repo/semantics/openAccess2024-09-09T14:06:06Zoai:repositorio.unesp.br:11449/230129Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestrepositoriounesp@unesp.bropendoar:29462024-09-09T14:06:06Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Use of cardiac troponin I (cTnI) levels to diagnose severe hypoxia and myocardial injury induced by perinatal asphyxia in neonatal dogs
title Use of cardiac troponin I (cTnI) levels to diagnose severe hypoxia and myocardial injury induced by perinatal asphyxia in neonatal dogs
spellingShingle Use of cardiac troponin I (cTnI) levels to diagnose severe hypoxia and myocardial injury induced by perinatal asphyxia in neonatal dogs
Nobre Pacífico Pereira, Keylla Helena [UNESP]
Apgar score
Cesarean section
Hypoxemia
Myocardium
Puppies
title_short Use of cardiac troponin I (cTnI) levels to diagnose severe hypoxia and myocardial injury induced by perinatal asphyxia in neonatal dogs
title_full Use of cardiac troponin I (cTnI) levels to diagnose severe hypoxia and myocardial injury induced by perinatal asphyxia in neonatal dogs
title_fullStr Use of cardiac troponin I (cTnI) levels to diagnose severe hypoxia and myocardial injury induced by perinatal asphyxia in neonatal dogs
title_full_unstemmed Use of cardiac troponin I (cTnI) levels to diagnose severe hypoxia and myocardial injury induced by perinatal asphyxia in neonatal dogs
title_sort Use of cardiac troponin I (cTnI) levels to diagnose severe hypoxia and myocardial injury induced by perinatal asphyxia in neonatal dogs
author Nobre Pacífico Pereira, Keylla Helena [UNESP]
author_facet Nobre Pacífico Pereira, Keylla Helena [UNESP]
Hibaru, Viviane Yukari [UNESP]
Fuchs, Kárita da Mata [UNESP]
Cruz dos Santos Correia, Luiz Eduardo [UNESP]
Lopes, Maria Denise [UNESP]
Ferreira, João Carlos Pinheiro [UNESP]
Ferreira de Souza, Fabiana [UNESP]
Machado, Luiz Henrique de Araújo [UNESP]
Chiacchio, Simone Biagio [UNESP]
Gomes Lourenço, Maria Lucia [UNESP]
author_role author
author2 Hibaru, Viviane Yukari [UNESP]
Fuchs, Kárita da Mata [UNESP]
Cruz dos Santos Correia, Luiz Eduardo [UNESP]
Lopes, Maria Denise [UNESP]
Ferreira, João Carlos Pinheiro [UNESP]
Ferreira de Souza, Fabiana [UNESP]
Machado, Luiz Henrique de Araújo [UNESP]
Chiacchio, Simone Biagio [UNESP]
Gomes Lourenço, Maria Lucia [UNESP]
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (UNESP)
dc.contributor.author.fl_str_mv Nobre Pacífico Pereira, Keylla Helena [UNESP]
Hibaru, Viviane Yukari [UNESP]
Fuchs, Kárita da Mata [UNESP]
Cruz dos Santos Correia, Luiz Eduardo [UNESP]
Lopes, Maria Denise [UNESP]
Ferreira, João Carlos Pinheiro [UNESP]
Ferreira de Souza, Fabiana [UNESP]
Machado, Luiz Henrique de Araújo [UNESP]
Chiacchio, Simone Biagio [UNESP]
Gomes Lourenço, Maria Lucia [UNESP]
dc.subject.por.fl_str_mv Apgar score
Cesarean section
Hypoxemia
Myocardium
Puppies
topic Apgar score
Cesarean section
Hypoxemia
Myocardium
Puppies
description Prolonged perinatal asphyxia and subsequent severe hypoxia are the main causes of mortality in neonatal dogs in the first days of life. In medicine, specific cardiac biochemical markers, such as troponin I, are used to diagnose ischemic and nonischemic myocardial injury in asphyxiated newborns after birth. Thus, the objectives of this study were to compare the levels of cardiac troponin I (cTnI) between asphyxiated and nonasphyxiated newborn dogs and evaluate the correlations of cTnI levels with the modified Apgar score, the levels of oxygen saturation, blood glucose, and lactatemia, and blood gas parameters. This study aimed to determine the possible use of cTnI as a marker of severe hypoxia and myocardial ischemic injury in neonatal dogs. Fifteen animals in a eutocic vaginal delivery group (VG), 15 animals in a cesarean section group (CG), and 13 animals in a hypoxia (asphyxiated) group (HG) were evaluated. The animals in the asphyxiated group were from dystocic deliveries and born by vaginal delivery or cesarean section. All groups were evaluated at birth and after 60 min. The newborns in the VG and CG exhibited mixed acidosis (respiratory acidosis due to increased partial pressure of CO2 (pCO2) and metabolic acidosis due to reduced pH and bicarbonate (HCO3) levels, base excess/deficit in the extracellular fluid compartment (BEecf), and increased lactate levels) due to transient physiological hypoxemia at birth. The cTnI levels in the VG and CG were within the reference standards for healthy dogs. No correlations between cTnI level and the other parameters were observed in the VG and CG. Newborns in the HG exhibited prominent mixed acidosis (p < 0.05) due to severe hypoxemia. The Apgar score and blood gas parameters showed that these dogs were born asphyxiated, and they presented low vitality and the need for resuscitation maneuvers. The cTnI levels in the HG were significantly higher than those in the VG and CG (p < 0.05) and above the reference standards for healthy dogs, which indicated ischemic myocardial injury. The cTnI level was negatively correlated (p < 0.05) with the parameters Apgar score, heart rate, peripheral oxygen saturation (sO2) level, reflex score, and total carbon dioxide (TCO2) level and positively correlated (p < 0.01) with lactate level. This study showed that asphyxiated newborn dogs have higher serum cTnI levels than nonasphyxiated newborn dogs; thus, the cTnI can be used as a marker of severe hypoxia and ischemic myocardial damage in newborn dogs.
publishDate 2022
dc.date.none.fl_str_mv 2022-04-29T08:38:04Z
2022-04-29T08:38:04Z
2022-03-01
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1016/j.theriogenology.2021.12.027
Theriogenology, v. 180, p. 146-153.
0093-691X
http://hdl.handle.net/11449/230129
10.1016/j.theriogenology.2021.12.027
2-s2.0-85121917960
url http://dx.doi.org/10.1016/j.theriogenology.2021.12.027
http://hdl.handle.net/11449/230129
identifier_str_mv Theriogenology, v. 180, p. 146-153.
0093-691X
10.1016/j.theriogenology.2021.12.027
2-s2.0-85121917960
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Theriogenology
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 146-153
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv repositoriounesp@unesp.br
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