Rhodococcus equi pVAPN type causing pneumonia in a dog coinfected with canine morbillivirus (distemper virus) and Toxoplasma gondii
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.micpath.2019.01.048 http://hdl.handle.net/11449/188717 |
Resumo: | Canine morbillivirus (previously, canine distemper virus, CDV) is a highly contagious infectious disease-causing agent that produces immunosuppressive infections and multiple clinical signs. Canine toxoplasmosis is an opportunistic disease characterized by enteric, pulmonary, and neuromuscular signs that might be confused with CDV-induced infections. Rhodococcus equi is a Gram-positive intracellular facultative bacterium that is also opportunistic in nature, and causes pyogranulomatous infections in humans and multiple host animals, although canine rhodococcosis is rare or unrecognized. The pathogenicity of R. equi is intimately related to the presence of plasmid-encoded virulence-associated proteins (Vap). Three host-adapted virulence plasmid types of R. equi have been recognized: the circular pVAPA and pVAPB are associated with equine and porcine strains, respectively, and the recently detected linear pVAPN virulence plasmid is related to bovine isolates. Nevertheless, data regarding the detection of host-adapted virulence plasmid types of R. equi isolated from companion animals are scarce. This report describes a case of an uncommon coinfection due to R. equi, T. gondii and CDV, which was diagnosed in a pet dog with respiratory distress. In this case, CDV most likely induced immunosuppression, which facilitated opportunistic infections by R. equi and T. gondii. The analysis of the virulence profile of R. equi revealed the novel pVAPN plasmid type, initially related to bovine strains. This is the second report of the bovine-associated pVAPN type in a pet dog, with an unusual coinfection with T. gondii and CDV. These findings represent a public health concern due to the close contact between pet animals and their owners, particularly because the pVAPN plasmid type was recently detected in people with HIV/AIDS from the same geographical region. |
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Rhodococcus equi pVAPN type causing pneumonia in a dog coinfected with canine morbillivirus (distemper virus) and Toxoplasma gondiiBovine-associated plasmid typeCanine rhodococcosisEmerging infectious diseasesImmunocompromised patientspVAPNCanine morbillivirus (previously, canine distemper virus, CDV) is a highly contagious infectious disease-causing agent that produces immunosuppressive infections and multiple clinical signs. Canine toxoplasmosis is an opportunistic disease characterized by enteric, pulmonary, and neuromuscular signs that might be confused with CDV-induced infections. Rhodococcus equi is a Gram-positive intracellular facultative bacterium that is also opportunistic in nature, and causes pyogranulomatous infections in humans and multiple host animals, although canine rhodococcosis is rare or unrecognized. The pathogenicity of R. equi is intimately related to the presence of plasmid-encoded virulence-associated proteins (Vap). Three host-adapted virulence plasmid types of R. equi have been recognized: the circular pVAPA and pVAPB are associated with equine and porcine strains, respectively, and the recently detected linear pVAPN virulence plasmid is related to bovine isolates. Nevertheless, data regarding the detection of host-adapted virulence plasmid types of R. equi isolated from companion animals are scarce. This report describes a case of an uncommon coinfection due to R. equi, T. gondii and CDV, which was diagnosed in a pet dog with respiratory distress. In this case, CDV most likely induced immunosuppression, which facilitated opportunistic infections by R. equi and T. gondii. The analysis of the virulence profile of R. equi revealed the novel pVAPN plasmid type, initially related to bovine strains. This is the second report of the bovine-associated pVAPN type in a pet dog, with an unusual coinfection with T. gondii and CDV. These findings represent a public health concern due to the close contact between pet animals and their owners, particularly because the pVAPN plasmid type was recently detected in people with HIV/AIDS from the same geographical region.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)UNESP-São Paulo State University Department of Veterinary Hygiene and Public Health School of Veterinary Medicine and Animal SciencesUNESP Department of Veterinary Clinical SciencesVetMol LaboratoryUEL-Londrina State University Department of Preventive Veterinary MedicineKitasato University Department of Animal HygieneUNESP-São Paulo State University Department of Veterinary Hygiene and Public Health School of Veterinary Medicine and Animal SciencesUNESP Department of Veterinary Clinical SciencesFAPESP: 2015/20585-9CNPq: 306116/2016-2Universidade Estadual Paulista (Unesp)VetMol LaboratoryUniversidade Estadual de Londrina (UEL)Kitasato UniversityPortilho, Fábio V.R. [UNESP]Paes, Antonio C. [UNESP]Megid, Jane [UNESP]Hataka, Alessandre [UNESP]Neto, Rafael TorresHeadley, Selwyn A.Oliveira, Thalita E.S.Colhado, Bruna S. [UNESP]de Paula, Carolina L. [UNESP]Guerra, Simony T. [UNESP]Mota, André R. [UNESP]Listoni, Fernando J.P. [UNESP]Takai, ShinjiRibeiro, Márcio G. [UNESP]2019-10-06T16:16:57Z2019-10-06T16:16:57Z2019-04-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article112-117http://dx.doi.org/10.1016/j.micpath.2019.01.048Microbial Pathogenesis, v. 129, p. 112-117.1096-12080882-4010http://hdl.handle.net/11449/18871710.1016/j.micpath.2019.01.0482-s2.0-85061352000Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengMicrobial Pathogenesisinfo:eu-repo/semantics/openAccess2021-10-23T02:05:36Zoai:repositorio.unesp.br:11449/188717Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462021-10-23T02:05:36Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Rhodococcus equi pVAPN type causing pneumonia in a dog coinfected with canine morbillivirus (distemper virus) and Toxoplasma gondii |
title |
Rhodococcus equi pVAPN type causing pneumonia in a dog coinfected with canine morbillivirus (distemper virus) and Toxoplasma gondii |
spellingShingle |
Rhodococcus equi pVAPN type causing pneumonia in a dog coinfected with canine morbillivirus (distemper virus) and Toxoplasma gondii Portilho, Fábio V.R. [UNESP] Bovine-associated plasmid type Canine rhodococcosis Emerging infectious diseases Immunocompromised patients pVAPN |
title_short |
Rhodococcus equi pVAPN type causing pneumonia in a dog coinfected with canine morbillivirus (distemper virus) and Toxoplasma gondii |
title_full |
Rhodococcus equi pVAPN type causing pneumonia in a dog coinfected with canine morbillivirus (distemper virus) and Toxoplasma gondii |
title_fullStr |
Rhodococcus equi pVAPN type causing pneumonia in a dog coinfected with canine morbillivirus (distemper virus) and Toxoplasma gondii |
title_full_unstemmed |
Rhodococcus equi pVAPN type causing pneumonia in a dog coinfected with canine morbillivirus (distemper virus) and Toxoplasma gondii |
title_sort |
Rhodococcus equi pVAPN type causing pneumonia in a dog coinfected with canine morbillivirus (distemper virus) and Toxoplasma gondii |
author |
Portilho, Fábio V.R. [UNESP] |
author_facet |
Portilho, Fábio V.R. [UNESP] Paes, Antonio C. [UNESP] Megid, Jane [UNESP] Hataka, Alessandre [UNESP] Neto, Rafael Torres Headley, Selwyn A. Oliveira, Thalita E.S. Colhado, Bruna S. [UNESP] de Paula, Carolina L. [UNESP] Guerra, Simony T. [UNESP] Mota, André R. [UNESP] Listoni, Fernando J.P. [UNESP] Takai, Shinji Ribeiro, Márcio G. [UNESP] |
author_role |
author |
author2 |
Paes, Antonio C. [UNESP] Megid, Jane [UNESP] Hataka, Alessandre [UNESP] Neto, Rafael Torres Headley, Selwyn A. Oliveira, Thalita E.S. Colhado, Bruna S. [UNESP] de Paula, Carolina L. [UNESP] Guerra, Simony T. [UNESP] Mota, André R. [UNESP] Listoni, Fernando J.P. [UNESP] Takai, Shinji Ribeiro, Márcio G. [UNESP] |
author2_role |
author author author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) VetMol Laboratory Universidade Estadual de Londrina (UEL) Kitasato University |
dc.contributor.author.fl_str_mv |
Portilho, Fábio V.R. [UNESP] Paes, Antonio C. [UNESP] Megid, Jane [UNESP] Hataka, Alessandre [UNESP] Neto, Rafael Torres Headley, Selwyn A. Oliveira, Thalita E.S. Colhado, Bruna S. [UNESP] de Paula, Carolina L. [UNESP] Guerra, Simony T. [UNESP] Mota, André R. [UNESP] Listoni, Fernando J.P. [UNESP] Takai, Shinji Ribeiro, Márcio G. [UNESP] |
dc.subject.por.fl_str_mv |
Bovine-associated plasmid type Canine rhodococcosis Emerging infectious diseases Immunocompromised patients pVAPN |
topic |
Bovine-associated plasmid type Canine rhodococcosis Emerging infectious diseases Immunocompromised patients pVAPN |
description |
Canine morbillivirus (previously, canine distemper virus, CDV) is a highly contagious infectious disease-causing agent that produces immunosuppressive infections and multiple clinical signs. Canine toxoplasmosis is an opportunistic disease characterized by enteric, pulmonary, and neuromuscular signs that might be confused with CDV-induced infections. Rhodococcus equi is a Gram-positive intracellular facultative bacterium that is also opportunistic in nature, and causes pyogranulomatous infections in humans and multiple host animals, although canine rhodococcosis is rare or unrecognized. The pathogenicity of R. equi is intimately related to the presence of plasmid-encoded virulence-associated proteins (Vap). Three host-adapted virulence plasmid types of R. equi have been recognized: the circular pVAPA and pVAPB are associated with equine and porcine strains, respectively, and the recently detected linear pVAPN virulence plasmid is related to bovine isolates. Nevertheless, data regarding the detection of host-adapted virulence plasmid types of R. equi isolated from companion animals are scarce. This report describes a case of an uncommon coinfection due to R. equi, T. gondii and CDV, which was diagnosed in a pet dog with respiratory distress. In this case, CDV most likely induced immunosuppression, which facilitated opportunistic infections by R. equi and T. gondii. The analysis of the virulence profile of R. equi revealed the novel pVAPN plasmid type, initially related to bovine strains. This is the second report of the bovine-associated pVAPN type in a pet dog, with an unusual coinfection with T. gondii and CDV. These findings represent a public health concern due to the close contact between pet animals and their owners, particularly because the pVAPN plasmid type was recently detected in people with HIV/AIDS from the same geographical region. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-10-06T16:16:57Z 2019-10-06T16:16:57Z 2019-04-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.micpath.2019.01.048 Microbial Pathogenesis, v. 129, p. 112-117. 1096-1208 0882-4010 http://hdl.handle.net/11449/188717 10.1016/j.micpath.2019.01.048 2-s2.0-85061352000 |
url |
http://dx.doi.org/10.1016/j.micpath.2019.01.048 http://hdl.handle.net/11449/188717 |
identifier_str_mv |
Microbial Pathogenesis, v. 129, p. 112-117. 1096-1208 0882-4010 10.1016/j.micpath.2019.01.048 2-s2.0-85061352000 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Microbial Pathogenesis |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
112-117 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1799965184724303872 |