Ilex paraguariensis supplementation may be an effective nutritional approach to modulate oxidative stress during perimenopause
Autor(a) principal: | |
---|---|
Data de Publicação: | 2017 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.exger.2017.01.011 http://hdl.handle.net/11449/174163 |
Resumo: | Perimenopause is a period in a woman's life that precedes menopause and is characterized by hormonal changes that result in increased oxidative stress. Since oxidative stress is associated with age-related diseases and perimenopausal symptoms including somato-vegetative manifestations, nutritional antioxidant supplementation may be an effective approach to minimizing this stress. Mate tea (MT) (Ilex paraguariensis), a typical and inexpensive beverage consumed in the Brazilian south-east, Argentina and Uruguay, increases antioxidant defense. We hypothesized that MT could minimize oxidative stress during perimenopause by modulating enzymatic antioxidant defense. To test this, we analyzed the lipid oxidative damage and antioxidant defense in erythrocytes and liver of rats, after MT treatment. Female Wistar rats (aged 16 months) in proven perimenopause period received 20 mg/kg BW/day of mate tea, by gavage (PM + MT group) or water (PM group). Female rats aged 4 months (AD group) received water. Erythrocytes and liver were used to determine lipid oxidative damage, determined by malondialdehyde (MDA); superoxide dismutase (SOD), glutathione peroxidase (GPx) and catalase (CAT) activities. Total plasma antioxidant capacity was examined by ferric reducing antioxidant power assay (FRAP) and estrogen by radioimmunoassay. MT increased FRAP and did not change estrogen levels. Increased SOD and GPx, and reduced MDA were observed in both tissues studied. Increased CAT activity was observed only in the liver. We confirmed the hypothesis that MT was capable of minimizing oxidative stress in this period of life by modulating antioxidant defense. |
id |
UNSP_134bc971afb6c767d6f4595174a5bd40 |
---|---|
oai_identifier_str |
oai:repositorio.unesp.br:11449/174163 |
network_acronym_str |
UNSP |
network_name_str |
Repositório Institucional da UNESP |
repository_id_str |
2946 |
spelling |
Ilex paraguariensis supplementation may be an effective nutritional approach to modulate oxidative stress during perimenopauseAntioxidant capacityMateOxidative damageOxidative stressPerimenopausePerimenopause is a period in a woman's life that precedes menopause and is characterized by hormonal changes that result in increased oxidative stress. Since oxidative stress is associated with age-related diseases and perimenopausal symptoms including somato-vegetative manifestations, nutritional antioxidant supplementation may be an effective approach to minimizing this stress. Mate tea (MT) (Ilex paraguariensis), a typical and inexpensive beverage consumed in the Brazilian south-east, Argentina and Uruguay, increases antioxidant defense. We hypothesized that MT could minimize oxidative stress during perimenopause by modulating enzymatic antioxidant defense. To test this, we analyzed the lipid oxidative damage and antioxidant defense in erythrocytes and liver of rats, after MT treatment. Female Wistar rats (aged 16 months) in proven perimenopause period received 20 mg/kg BW/day of mate tea, by gavage (PM + MT group) or water (PM group). Female rats aged 4 months (AD group) received water. Erythrocytes and liver were used to determine lipid oxidative damage, determined by malondialdehyde (MDA); superoxide dismutase (SOD), glutathione peroxidase (GPx) and catalase (CAT) activities. Total plasma antioxidant capacity was examined by ferric reducing antioxidant power assay (FRAP) and estrogen by radioimmunoassay. MT increased FRAP and did not change estrogen levels. Increased SOD and GPx, and reduced MDA were observed in both tissues studied. Increased CAT activity was observed only in the liver. We confirmed the hypothesis that MT was capable of minimizing oxidative stress in this period of life by modulating antioxidant defense.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Programa Multic�ntrico de P�s-Gradua��o em Ci�ncias Fisiol�gicas SBFis/UNESP Univ Estadual PaulistaLaboratory of Biochemistry Department of Basic Sciences Ara�atuba Dental School UNESP – Univ Estadual PaulistaDepartment of Organic Chemistry Chemistry Institute UNESP – Univ Estadual PaulistaDepartment of Physiology Institute of Basic Health Sciences Federal University of Rio Grande do SulDepartment of Analytical Chemistry and Physical Chemistry School of Pharmacy and Biochemistry University of Buenos AiresPrograma Multic�ntrico de P�s-Gradua��o em Ci�ncias Fisiol�gicas SBFis/UNESP Univ Estadual PaulistaLaboratory of Biochemistry Department of Basic Sciences Ara�atuba Dental School UNESP – Univ Estadual PaulistaDepartment of Organic Chemistry Chemistry Institute UNESP – Univ Estadual PaulistaUniversidade Estadual Paulista (Unesp)Federal University of Rio Grande do SulUniversity of Buenos AiresPereira, Ariana Aparecida Ferreira [UNESP]Tirapeli, Keny Gon�alves [UNESP]Chaves-Neto, Antonio Hernandes [UNESP]da Silva Brasilino, Matheus [UNESP]da Rocha, Cl�udia Quintino [UNESP]Bell�-Klein, AdrianeLlesuy, Suzana FranciscaDornelles, Rita C�ssia Menegati [UNESP]Nakamune, Ana Cl�udia de Melo Stevanato [UNESP]2018-12-11T17:09:39Z2018-12-11T17:09:39Z2017-04-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article14-18application/pdfhttp://dx.doi.org/10.1016/j.exger.2017.01.011Experimental Gerontology, v. 90, p. 14-18.1873-68150531-5565http://hdl.handle.net/11449/17416310.1016/j.exger.2017.01.0112-s2.0-850113569062-s2.0-85011356906.pdfScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengExperimental Gerontology1,450info:eu-repo/semantics/openAccess2024-01-22T06:24:19Zoai:repositorio.unesp.br:11449/174163Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T23:40:42.561307Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Ilex paraguariensis supplementation may be an effective nutritional approach to modulate oxidative stress during perimenopause |
title |
Ilex paraguariensis supplementation may be an effective nutritional approach to modulate oxidative stress during perimenopause |
spellingShingle |
Ilex paraguariensis supplementation may be an effective nutritional approach to modulate oxidative stress during perimenopause Pereira, Ariana Aparecida Ferreira [UNESP] Antioxidant capacity Mate Oxidative damage Oxidative stress Perimenopause |
title_short |
Ilex paraguariensis supplementation may be an effective nutritional approach to modulate oxidative stress during perimenopause |
title_full |
Ilex paraguariensis supplementation may be an effective nutritional approach to modulate oxidative stress during perimenopause |
title_fullStr |
Ilex paraguariensis supplementation may be an effective nutritional approach to modulate oxidative stress during perimenopause |
title_full_unstemmed |
Ilex paraguariensis supplementation may be an effective nutritional approach to modulate oxidative stress during perimenopause |
title_sort |
Ilex paraguariensis supplementation may be an effective nutritional approach to modulate oxidative stress during perimenopause |
author |
Pereira, Ariana Aparecida Ferreira [UNESP] |
author_facet |
Pereira, Ariana Aparecida Ferreira [UNESP] Tirapeli, Keny Gon�alves [UNESP] Chaves-Neto, Antonio Hernandes [UNESP] da Silva Brasilino, Matheus [UNESP] da Rocha, Cl�udia Quintino [UNESP] Bell�-Klein, Adriane Llesuy, Suzana Francisca Dornelles, Rita C�ssia Menegati [UNESP] Nakamune, Ana Cl�udia de Melo Stevanato [UNESP] |
author_role |
author |
author2 |
Tirapeli, Keny Gon�alves [UNESP] Chaves-Neto, Antonio Hernandes [UNESP] da Silva Brasilino, Matheus [UNESP] da Rocha, Cl�udia Quintino [UNESP] Bell�-Klein, Adriane Llesuy, Suzana Francisca Dornelles, Rita C�ssia Menegati [UNESP] Nakamune, Ana Cl�udia de Melo Stevanato [UNESP] |
author2_role |
author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Federal University of Rio Grande do Sul University of Buenos Aires |
dc.contributor.author.fl_str_mv |
Pereira, Ariana Aparecida Ferreira [UNESP] Tirapeli, Keny Gon�alves [UNESP] Chaves-Neto, Antonio Hernandes [UNESP] da Silva Brasilino, Matheus [UNESP] da Rocha, Cl�udia Quintino [UNESP] Bell�-Klein, Adriane Llesuy, Suzana Francisca Dornelles, Rita C�ssia Menegati [UNESP] Nakamune, Ana Cl�udia de Melo Stevanato [UNESP] |
dc.subject.por.fl_str_mv |
Antioxidant capacity Mate Oxidative damage Oxidative stress Perimenopause |
topic |
Antioxidant capacity Mate Oxidative damage Oxidative stress Perimenopause |
description |
Perimenopause is a period in a woman's life that precedes menopause and is characterized by hormonal changes that result in increased oxidative stress. Since oxidative stress is associated with age-related diseases and perimenopausal symptoms including somato-vegetative manifestations, nutritional antioxidant supplementation may be an effective approach to minimizing this stress. Mate tea (MT) (Ilex paraguariensis), a typical and inexpensive beverage consumed in the Brazilian south-east, Argentina and Uruguay, increases antioxidant defense. We hypothesized that MT could minimize oxidative stress during perimenopause by modulating enzymatic antioxidant defense. To test this, we analyzed the lipid oxidative damage and antioxidant defense in erythrocytes and liver of rats, after MT treatment. Female Wistar rats (aged 16 months) in proven perimenopause period received 20 mg/kg BW/day of mate tea, by gavage (PM + MT group) or water (PM group). Female rats aged 4 months (AD group) received water. Erythrocytes and liver were used to determine lipid oxidative damage, determined by malondialdehyde (MDA); superoxide dismutase (SOD), glutathione peroxidase (GPx) and catalase (CAT) activities. Total plasma antioxidant capacity was examined by ferric reducing antioxidant power assay (FRAP) and estrogen by radioimmunoassay. MT increased FRAP and did not change estrogen levels. Increased SOD and GPx, and reduced MDA were observed in both tissues studied. Increased CAT activity was observed only in the liver. We confirmed the hypothesis that MT was capable of minimizing oxidative stress in this period of life by modulating antioxidant defense. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-04-01 2018-12-11T17:09:39Z 2018-12-11T17:09:39Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.exger.2017.01.011 Experimental Gerontology, v. 90, p. 14-18. 1873-6815 0531-5565 http://hdl.handle.net/11449/174163 10.1016/j.exger.2017.01.011 2-s2.0-85011356906 2-s2.0-85011356906.pdf |
url |
http://dx.doi.org/10.1016/j.exger.2017.01.011 http://hdl.handle.net/11449/174163 |
identifier_str_mv |
Experimental Gerontology, v. 90, p. 14-18. 1873-6815 0531-5565 10.1016/j.exger.2017.01.011 2-s2.0-85011356906 2-s2.0-85011356906.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Experimental Gerontology 1,450 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
14-18 application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808129542375604224 |