Cellulose nanofibers improve the performance of retrograded starch/pectin microparticles for colon-specific delivery of 5-ASA
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.3390/pharmaceutics13091515 http://hdl.handle.net/11449/229565 |
Resumo: | Cellulose nanofibers (CNF) were employed as the nanoreinforcement of a retrograded starch/pectin (RS/P) excipient to optimize its colon-specific properties. Although starch retrogra-dation ranged from 32 to 73%, CNF addition discretely disfavored the RS yield. This result agrees with the finding that in situ CNF reduces the presence of the RS crystallinity pattern. A thermal analysis revealed that the contribution of pectin improves the thermal stability of the RS/CNF mixture. Through a complete factorial design, it was possible to optimize the spray-drying conditions to obtain powders with high yield (57%) and low moisture content (1.2%). The powders observed by Field Emission Gum Scanning Electron Microscopy (FEG-SEM) had 1–10 µm and a circular shape. The developed methodology allowed us to obtain 5-aminosalicilic acid-loaded microparticles with high encapsulation efficiency (16–98%) and drug loading (1.97–26.63%). The presence of CNF in RS/P samples was responsible for decreasing the burst effect of release in simulated gastric and duodenal media, allowing the greatest mass of drug to be targeted to the colon. Considering that spray-drying is a scalable process, widely used by the pharmaceutical industry, the results obtained indicate the potential of these microparticles as raw material for obtaining other dosage forms to deliver 5-ASA to the distal parts of gastrointestinal tract, affected by inflammatory bowel disease. |
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Cellulose nanofibers improve the performance of retrograded starch/pectin microparticles for colon-specific delivery of 5-ASA5-ASACellulose nanofibersColon-specific deliveryMicroparticlesRetrograded starchSpray dryerCellulose nanofibers (CNF) were employed as the nanoreinforcement of a retrograded starch/pectin (RS/P) excipient to optimize its colon-specific properties. Although starch retrogra-dation ranged from 32 to 73%, CNF addition discretely disfavored the RS yield. This result agrees with the finding that in situ CNF reduces the presence of the RS crystallinity pattern. A thermal analysis revealed that the contribution of pectin improves the thermal stability of the RS/CNF mixture. Through a complete factorial design, it was possible to optimize the spray-drying conditions to obtain powders with high yield (57%) and low moisture content (1.2%). The powders observed by Field Emission Gum Scanning Electron Microscopy (FEG-SEM) had 1–10 µm and a circular shape. The developed methodology allowed us to obtain 5-aminosalicilic acid-loaded microparticles with high encapsulation efficiency (16–98%) and drug loading (1.97–26.63%). The presence of CNF in RS/P samples was responsible for decreasing the burst effect of release in simulated gastric and duodenal media, allowing the greatest mass of drug to be targeted to the colon. Considering that spray-drying is a scalable process, widely used by the pharmaceutical industry, the results obtained indicate the potential of these microparticles as raw material for obtaining other dosage forms to deliver 5-ASA to the distal parts of gastrointestinal tract, affected by inflammatory bowel disease.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Department of Drugs and Medicines School of Pharmaceutical Sciences São Paulo State University (UNESP)Department of Drugs and Medicines School of Pharmaceutical Sciences São Paulo State University (UNESP)FAPESP: 2014/50928-2FAPESP: 2019/19817-3CNPq: 465687/2014-8Universidade Estadual Paulista (UNESP)Meneguin, Andréia Bagliotti [UNESP]Sábio, Rafael Miguel [UNESP]de Souza, Maurício Palmeira Chaves [UNESP]Fernandes, Richard Perosa [UNESP]de Oliveira, Anselmo Gomes [UNESP]Chorilli, Marlus [UNESP]2022-04-29T08:33:14Z2022-04-29T08:33:14Z2021-09-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.3390/pharmaceutics13091515Pharmaceutics, v. 13, n. 9, 2021.1999-4923http://hdl.handle.net/11449/22956510.3390/pharmaceutics130915152-s2.0-85115368466Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengPharmaceuticsinfo:eu-repo/semantics/openAccess2024-06-24T13:45:18Zoai:repositorio.unesp.br:11449/229565Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T15:37:54.438676Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Cellulose nanofibers improve the performance of retrograded starch/pectin microparticles for colon-specific delivery of 5-ASA |
title |
Cellulose nanofibers improve the performance of retrograded starch/pectin microparticles for colon-specific delivery of 5-ASA |
spellingShingle |
Cellulose nanofibers improve the performance of retrograded starch/pectin microparticles for colon-specific delivery of 5-ASA Meneguin, Andréia Bagliotti [UNESP] 5-ASA Cellulose nanofibers Colon-specific delivery Microparticles Retrograded starch Spray dryer |
title_short |
Cellulose nanofibers improve the performance of retrograded starch/pectin microparticles for colon-specific delivery of 5-ASA |
title_full |
Cellulose nanofibers improve the performance of retrograded starch/pectin microparticles for colon-specific delivery of 5-ASA |
title_fullStr |
Cellulose nanofibers improve the performance of retrograded starch/pectin microparticles for colon-specific delivery of 5-ASA |
title_full_unstemmed |
Cellulose nanofibers improve the performance of retrograded starch/pectin microparticles for colon-specific delivery of 5-ASA |
title_sort |
Cellulose nanofibers improve the performance of retrograded starch/pectin microparticles for colon-specific delivery of 5-ASA |
author |
Meneguin, Andréia Bagliotti [UNESP] |
author_facet |
Meneguin, Andréia Bagliotti [UNESP] Sábio, Rafael Miguel [UNESP] de Souza, Maurício Palmeira Chaves [UNESP] Fernandes, Richard Perosa [UNESP] de Oliveira, Anselmo Gomes [UNESP] Chorilli, Marlus [UNESP] |
author_role |
author |
author2 |
Sábio, Rafael Miguel [UNESP] de Souza, Maurício Palmeira Chaves [UNESP] Fernandes, Richard Perosa [UNESP] de Oliveira, Anselmo Gomes [UNESP] Chorilli, Marlus [UNESP] |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (UNESP) |
dc.contributor.author.fl_str_mv |
Meneguin, Andréia Bagliotti [UNESP] Sábio, Rafael Miguel [UNESP] de Souza, Maurício Palmeira Chaves [UNESP] Fernandes, Richard Perosa [UNESP] de Oliveira, Anselmo Gomes [UNESP] Chorilli, Marlus [UNESP] |
dc.subject.por.fl_str_mv |
5-ASA Cellulose nanofibers Colon-specific delivery Microparticles Retrograded starch Spray dryer |
topic |
5-ASA Cellulose nanofibers Colon-specific delivery Microparticles Retrograded starch Spray dryer |
description |
Cellulose nanofibers (CNF) were employed as the nanoreinforcement of a retrograded starch/pectin (RS/P) excipient to optimize its colon-specific properties. Although starch retrogra-dation ranged from 32 to 73%, CNF addition discretely disfavored the RS yield. This result agrees with the finding that in situ CNF reduces the presence of the RS crystallinity pattern. A thermal analysis revealed that the contribution of pectin improves the thermal stability of the RS/CNF mixture. Through a complete factorial design, it was possible to optimize the spray-drying conditions to obtain powders with high yield (57%) and low moisture content (1.2%). The powders observed by Field Emission Gum Scanning Electron Microscopy (FEG-SEM) had 1–10 µm and a circular shape. The developed methodology allowed us to obtain 5-aminosalicilic acid-loaded microparticles with high encapsulation efficiency (16–98%) and drug loading (1.97–26.63%). The presence of CNF in RS/P samples was responsible for decreasing the burst effect of release in simulated gastric and duodenal media, allowing the greatest mass of drug to be targeted to the colon. Considering that spray-drying is a scalable process, widely used by the pharmaceutical industry, the results obtained indicate the potential of these microparticles as raw material for obtaining other dosage forms to deliver 5-ASA to the distal parts of gastrointestinal tract, affected by inflammatory bowel disease. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-09-01 2022-04-29T08:33:14Z 2022-04-29T08:33:14Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.3390/pharmaceutics13091515 Pharmaceutics, v. 13, n. 9, 2021. 1999-4923 http://hdl.handle.net/11449/229565 10.3390/pharmaceutics13091515 2-s2.0-85115368466 |
url |
http://dx.doi.org/10.3390/pharmaceutics13091515 http://hdl.handle.net/11449/229565 |
identifier_str_mv |
Pharmaceutics, v. 13, n. 9, 2021. 1999-4923 10.3390/pharmaceutics13091515 2-s2.0-85115368466 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Pharmaceutics |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808128542028857344 |