Cellulose nanofibers improve the performance of retrograded starch/pectin microparticles for colon-specific delivery of 5-ASA

Detalhes bibliográficos
Autor(a) principal: Meneguin, Andréia Bagliotti [UNESP]
Data de Publicação: 2021
Outros Autores: Sábio, Rafael Miguel [UNESP], de Souza, Maurício Palmeira Chaves [UNESP], Fernandes, Richard Perosa [UNESP], de Oliveira, Anselmo Gomes [UNESP], Chorilli, Marlus [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.3390/pharmaceutics13091515
http://hdl.handle.net/11449/229565
Resumo: Cellulose nanofibers (CNF) were employed as the nanoreinforcement of a retrograded starch/pectin (RS/P) excipient to optimize its colon-specific properties. Although starch retrogra-dation ranged from 32 to 73%, CNF addition discretely disfavored the RS yield. This result agrees with the finding that in situ CNF reduces the presence of the RS crystallinity pattern. A thermal analysis revealed that the contribution of pectin improves the thermal stability of the RS/CNF mixture. Through a complete factorial design, it was possible to optimize the spray-drying conditions to obtain powders with high yield (57%) and low moisture content (1.2%). The powders observed by Field Emission Gum Scanning Electron Microscopy (FEG-SEM) had 1–10 µm and a circular shape. The developed methodology allowed us to obtain 5-aminosalicilic acid-loaded microparticles with high encapsulation efficiency (16–98%) and drug loading (1.97–26.63%). The presence of CNF in RS/P samples was responsible for decreasing the burst effect of release in simulated gastric and duodenal media, allowing the greatest mass of drug to be targeted to the colon. Considering that spray-drying is a scalable process, widely used by the pharmaceutical industry, the results obtained indicate the potential of these microparticles as raw material for obtaining other dosage forms to deliver 5-ASA to the distal parts of gastrointestinal tract, affected by inflammatory bowel disease.
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spelling Cellulose nanofibers improve the performance of retrograded starch/pectin microparticles for colon-specific delivery of 5-ASA5-ASACellulose nanofibersColon-specific deliveryMicroparticlesRetrograded starchSpray dryerCellulose nanofibers (CNF) were employed as the nanoreinforcement of a retrograded starch/pectin (RS/P) excipient to optimize its colon-specific properties. Although starch retrogra-dation ranged from 32 to 73%, CNF addition discretely disfavored the RS yield. This result agrees with the finding that in situ CNF reduces the presence of the RS crystallinity pattern. A thermal analysis revealed that the contribution of pectin improves the thermal stability of the RS/CNF mixture. Through a complete factorial design, it was possible to optimize the spray-drying conditions to obtain powders with high yield (57%) and low moisture content (1.2%). The powders observed by Field Emission Gum Scanning Electron Microscopy (FEG-SEM) had 1–10 µm and a circular shape. The developed methodology allowed us to obtain 5-aminosalicilic acid-loaded microparticles with high encapsulation efficiency (16–98%) and drug loading (1.97–26.63%). The presence of CNF in RS/P samples was responsible for decreasing the burst effect of release in simulated gastric and duodenal media, allowing the greatest mass of drug to be targeted to the colon. Considering that spray-drying is a scalable process, widely used by the pharmaceutical industry, the results obtained indicate the potential of these microparticles as raw material for obtaining other dosage forms to deliver 5-ASA to the distal parts of gastrointestinal tract, affected by inflammatory bowel disease.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Department of Drugs and Medicines School of Pharmaceutical Sciences São Paulo State University (UNESP)Department of Drugs and Medicines School of Pharmaceutical Sciences São Paulo State University (UNESP)FAPESP: 2014/50928-2FAPESP: 2019/19817-3CNPq: 465687/2014-8Universidade Estadual Paulista (UNESP)Meneguin, Andréia Bagliotti [UNESP]Sábio, Rafael Miguel [UNESP]de Souza, Maurício Palmeira Chaves [UNESP]Fernandes, Richard Perosa [UNESP]de Oliveira, Anselmo Gomes [UNESP]Chorilli, Marlus [UNESP]2022-04-29T08:33:14Z2022-04-29T08:33:14Z2021-09-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.3390/pharmaceutics13091515Pharmaceutics, v. 13, n. 9, 2021.1999-4923http://hdl.handle.net/11449/22956510.3390/pharmaceutics130915152-s2.0-85115368466Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengPharmaceuticsinfo:eu-repo/semantics/openAccess2024-06-24T13:45:18Zoai:repositorio.unesp.br:11449/229565Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T15:37:54.438676Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Cellulose nanofibers improve the performance of retrograded starch/pectin microparticles for colon-specific delivery of 5-ASA
title Cellulose nanofibers improve the performance of retrograded starch/pectin microparticles for colon-specific delivery of 5-ASA
spellingShingle Cellulose nanofibers improve the performance of retrograded starch/pectin microparticles for colon-specific delivery of 5-ASA
Meneguin, Andréia Bagliotti [UNESP]
5-ASA
Cellulose nanofibers
Colon-specific delivery
Microparticles
Retrograded starch
Spray dryer
title_short Cellulose nanofibers improve the performance of retrograded starch/pectin microparticles for colon-specific delivery of 5-ASA
title_full Cellulose nanofibers improve the performance of retrograded starch/pectin microparticles for colon-specific delivery of 5-ASA
title_fullStr Cellulose nanofibers improve the performance of retrograded starch/pectin microparticles for colon-specific delivery of 5-ASA
title_full_unstemmed Cellulose nanofibers improve the performance of retrograded starch/pectin microparticles for colon-specific delivery of 5-ASA
title_sort Cellulose nanofibers improve the performance of retrograded starch/pectin microparticles for colon-specific delivery of 5-ASA
author Meneguin, Andréia Bagliotti [UNESP]
author_facet Meneguin, Andréia Bagliotti [UNESP]
Sábio, Rafael Miguel [UNESP]
de Souza, Maurício Palmeira Chaves [UNESP]
Fernandes, Richard Perosa [UNESP]
de Oliveira, Anselmo Gomes [UNESP]
Chorilli, Marlus [UNESP]
author_role author
author2 Sábio, Rafael Miguel [UNESP]
de Souza, Maurício Palmeira Chaves [UNESP]
Fernandes, Richard Perosa [UNESP]
de Oliveira, Anselmo Gomes [UNESP]
Chorilli, Marlus [UNESP]
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (UNESP)
dc.contributor.author.fl_str_mv Meneguin, Andréia Bagliotti [UNESP]
Sábio, Rafael Miguel [UNESP]
de Souza, Maurício Palmeira Chaves [UNESP]
Fernandes, Richard Perosa [UNESP]
de Oliveira, Anselmo Gomes [UNESP]
Chorilli, Marlus [UNESP]
dc.subject.por.fl_str_mv 5-ASA
Cellulose nanofibers
Colon-specific delivery
Microparticles
Retrograded starch
Spray dryer
topic 5-ASA
Cellulose nanofibers
Colon-specific delivery
Microparticles
Retrograded starch
Spray dryer
description Cellulose nanofibers (CNF) were employed as the nanoreinforcement of a retrograded starch/pectin (RS/P) excipient to optimize its colon-specific properties. Although starch retrogra-dation ranged from 32 to 73%, CNF addition discretely disfavored the RS yield. This result agrees with the finding that in situ CNF reduces the presence of the RS crystallinity pattern. A thermal analysis revealed that the contribution of pectin improves the thermal stability of the RS/CNF mixture. Through a complete factorial design, it was possible to optimize the spray-drying conditions to obtain powders with high yield (57%) and low moisture content (1.2%). The powders observed by Field Emission Gum Scanning Electron Microscopy (FEG-SEM) had 1–10 µm and a circular shape. The developed methodology allowed us to obtain 5-aminosalicilic acid-loaded microparticles with high encapsulation efficiency (16–98%) and drug loading (1.97–26.63%). The presence of CNF in RS/P samples was responsible for decreasing the burst effect of release in simulated gastric and duodenal media, allowing the greatest mass of drug to be targeted to the colon. Considering that spray-drying is a scalable process, widely used by the pharmaceutical industry, the results obtained indicate the potential of these microparticles as raw material for obtaining other dosage forms to deliver 5-ASA to the distal parts of gastrointestinal tract, affected by inflammatory bowel disease.
publishDate 2021
dc.date.none.fl_str_mv 2021-09-01
2022-04-29T08:33:14Z
2022-04-29T08:33:14Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.3390/pharmaceutics13091515
Pharmaceutics, v. 13, n. 9, 2021.
1999-4923
http://hdl.handle.net/11449/229565
10.3390/pharmaceutics13091515
2-s2.0-85115368466
url http://dx.doi.org/10.3390/pharmaceutics13091515
http://hdl.handle.net/11449/229565
identifier_str_mv Pharmaceutics, v. 13, n. 9, 2021.
1999-4923
10.3390/pharmaceutics13091515
2-s2.0-85115368466
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Pharmaceutics
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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