Efficacy and safety of morphine and methadone as analgesics in a balanced anaesthetic protocol in rabbits
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | spa |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.15381/rivep.v33i4.23358 http://hdl.handle.net/11449/247801 |
Resumo: | The efficacy of preventive analgesia and the cardiopulmonary effects of morphine or methadone in rabbits undergoing experimental skin surgery were evaluated and compared. Thirty-six rabbits were randomly assigned to three experimental groups: Control, Morphine, and Methadone. The rabbits received midazolam 1 mg/kg IM associated with: placebo (NaCl 0.9%) 0.05 ml/kg, methadone 0.5 mg/kg or morphine 0.5 mg/kg, depending on the experimental group. Anaesthesia was induced and maintained with isoflurane. Heart (HR) and respiratory (fR) rates, peripheral oxygen saturation (SpO2), mean arterial pressure (MAP), and body temperature were assessed every 10 minutes. Electrocardiographic examination was performed after sedation, in the trans and immediate postoperative period. After procedure, the control group received tramadol 5 mg/kg IV. Postoperative analgesia was assessed using the visual analogue scale (VAS) and Von-Frey filament stimulation responses. All variables were compared between groups by ANOVA or Friedman. Methadone and morphine caused an increase in MAP (p=0.0112) and a decrease in HR (p=0.0001). fR and SpO2 were reduced in the methadone group (p=0.0100). The response to Von-Frey filaments (p=0.6824) and VAS (p=0.7661) were similar between treatments, however, the control group presented a higher proportion of analgesic rescue (33%) compared to morphine (19%) and methadone (12%). Electrocardiographic variables were similar between treatments (p>0.05). In conclusion, preventive treatment with morphine or methadone was effective in controlling trans and postoperative pain in rabbits, and its cardiovascular effects were limited; however, methadone caused marked respiratory depression. |
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Efficacy and safety of morphine and methadone as analgesics in a balanced anaesthetic protocol in rabbitsEficacia y seguridad de morfina y metadona como analgésicos en un protocolo anestésico balanceado en conejosanalgesiaanalgesic rescuemethadonemorphinerespiratory depressionThe efficacy of preventive analgesia and the cardiopulmonary effects of morphine or methadone in rabbits undergoing experimental skin surgery were evaluated and compared. Thirty-six rabbits were randomly assigned to three experimental groups: Control, Morphine, and Methadone. The rabbits received midazolam 1 mg/kg IM associated with: placebo (NaCl 0.9%) 0.05 ml/kg, methadone 0.5 mg/kg or morphine 0.5 mg/kg, depending on the experimental group. Anaesthesia was induced and maintained with isoflurane. Heart (HR) and respiratory (fR) rates, peripheral oxygen saturation (SpO2), mean arterial pressure (MAP), and body temperature were assessed every 10 minutes. Electrocardiographic examination was performed after sedation, in the trans and immediate postoperative period. After procedure, the control group received tramadol 5 mg/kg IV. Postoperative analgesia was assessed using the visual analogue scale (VAS) and Von-Frey filament stimulation responses. All variables were compared between groups by ANOVA or Friedman. Methadone and morphine caused an increase in MAP (p=0.0112) and a decrease in HR (p=0.0001). fR and SpO2 were reduced in the methadone group (p=0.0100). The response to Von-Frey filaments (p=0.6824) and VAS (p=0.7661) were similar between treatments, however, the control group presented a higher proportion of analgesic rescue (33%) compared to morphine (19%) and methadone (12%). Electrocardiographic variables were similar between treatments (p>0.05). In conclusion, preventive treatment with morphine or methadone was effective in controlling trans and postoperative pain in rabbits, and its cardiovascular effects were limited; however, methadone caused marked respiratory depression.Instituto de Ciências Agrarias Universidade Federal dos Vales do Jequitinhonha e Mucuri (UFVJM), Unaí, Minas GeraisGrupo de Investigación INCA-CES Facultad de Medicina Veterinaria y Zootecnia Universidad CESCentro de Investigación el Nus Corporación Colombiana de Investigación Agropecuaria (AGROSAVIA) Corregimiento San José del Nus, AntioquiaDepartamento de Patobiologia Veterinária e Teriogenologia Faculdade de Ciências Agrárias e Veterinárias Universidade Estadual Paulista «Júlio de Mesquita Filho» (UNESP), JaboticabalDepartamento de Medicina Veterinária União das Faculdades dos Grandes LagosDepartamento de Patobiologia Veterinária e Teriogenologia Faculdade de Ciências Agrárias e Veterinárias Universidade Estadual Paulista «Júlio de Mesquita Filho» (UNESP), JaboticabalUniversidade Federal de Viçosa (UFV)Universidad CESCorregimiento San José del NusUniversidade Estadual Paulista (UNESP)União das Faculdades dos Grandes LagosNobre, Camila VieiraUscategui, Ricardo A.R.Noriega, JorgeGasser, Beatriz [UNESP]Pazzini, Josiane Moraisde Almeida, Vívian Tavares [UNESP]de Nardi, Andrigo Barboza [UNESP]de Andrade, James Newton2023-07-29T13:26:14Z2023-07-29T13:26:14Z2022-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.15381/rivep.v33i4.23358Revista de Investigaciones Veterinarias del Peru, v. 33, n. 4, 2022.1609-91171682-3419http://hdl.handle.net/11449/24780110.15381/rivep.v33i4.233582-s2.0-85140711575Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPspaRevista de Investigaciones Veterinarias del Peruinfo:eu-repo/semantics/openAccess2023-07-29T13:26:14Zoai:repositorio.unesp.br:11449/247801Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462023-07-29T13:26:14Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Efficacy and safety of morphine and methadone as analgesics in a balanced anaesthetic protocol in rabbits Eficacia y seguridad de morfina y metadona como analgésicos en un protocolo anestésico balanceado en conejos |
title |
Efficacy and safety of morphine and methadone as analgesics in a balanced anaesthetic protocol in rabbits |
spellingShingle |
Efficacy and safety of morphine and methadone as analgesics in a balanced anaesthetic protocol in rabbits Nobre, Camila Vieira analgesia analgesic rescue methadone morphine respiratory depression |
title_short |
Efficacy and safety of morphine and methadone as analgesics in a balanced anaesthetic protocol in rabbits |
title_full |
Efficacy and safety of morphine and methadone as analgesics in a balanced anaesthetic protocol in rabbits |
title_fullStr |
Efficacy and safety of morphine and methadone as analgesics in a balanced anaesthetic protocol in rabbits |
title_full_unstemmed |
Efficacy and safety of morphine and methadone as analgesics in a balanced anaesthetic protocol in rabbits |
title_sort |
Efficacy and safety of morphine and methadone as analgesics in a balanced anaesthetic protocol in rabbits |
author |
Nobre, Camila Vieira |
author_facet |
Nobre, Camila Vieira Uscategui, Ricardo A.R. Noriega, Jorge Gasser, Beatriz [UNESP] Pazzini, Josiane Morais de Almeida, Vívian Tavares [UNESP] de Nardi, Andrigo Barboza [UNESP] de Andrade, James Newton |
author_role |
author |
author2 |
Uscategui, Ricardo A.R. Noriega, Jorge Gasser, Beatriz [UNESP] Pazzini, Josiane Morais de Almeida, Vívian Tavares [UNESP] de Nardi, Andrigo Barboza [UNESP] de Andrade, James Newton |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Federal de Viçosa (UFV) Universidad CES Corregimiento San José del Nus Universidade Estadual Paulista (UNESP) União das Faculdades dos Grandes Lagos |
dc.contributor.author.fl_str_mv |
Nobre, Camila Vieira Uscategui, Ricardo A.R. Noriega, Jorge Gasser, Beatriz [UNESP] Pazzini, Josiane Morais de Almeida, Vívian Tavares [UNESP] de Nardi, Andrigo Barboza [UNESP] de Andrade, James Newton |
dc.subject.por.fl_str_mv |
analgesia analgesic rescue methadone morphine respiratory depression |
topic |
analgesia analgesic rescue methadone morphine respiratory depression |
description |
The efficacy of preventive analgesia and the cardiopulmonary effects of morphine or methadone in rabbits undergoing experimental skin surgery were evaluated and compared. Thirty-six rabbits were randomly assigned to three experimental groups: Control, Morphine, and Methadone. The rabbits received midazolam 1 mg/kg IM associated with: placebo (NaCl 0.9%) 0.05 ml/kg, methadone 0.5 mg/kg or morphine 0.5 mg/kg, depending on the experimental group. Anaesthesia was induced and maintained with isoflurane. Heart (HR) and respiratory (fR) rates, peripheral oxygen saturation (SpO2), mean arterial pressure (MAP), and body temperature were assessed every 10 minutes. Electrocardiographic examination was performed after sedation, in the trans and immediate postoperative period. After procedure, the control group received tramadol 5 mg/kg IV. Postoperative analgesia was assessed using the visual analogue scale (VAS) and Von-Frey filament stimulation responses. All variables were compared between groups by ANOVA or Friedman. Methadone and morphine caused an increase in MAP (p=0.0112) and a decrease in HR (p=0.0001). fR and SpO2 were reduced in the methadone group (p=0.0100). The response to Von-Frey filaments (p=0.6824) and VAS (p=0.7661) were similar between treatments, however, the control group presented a higher proportion of analgesic rescue (33%) compared to morphine (19%) and methadone (12%). Electrocardiographic variables were similar between treatments (p>0.05). In conclusion, preventive treatment with morphine or methadone was effective in controlling trans and postoperative pain in rabbits, and its cardiovascular effects were limited; however, methadone caused marked respiratory depression. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-01-01 2023-07-29T13:26:14Z 2023-07-29T13:26:14Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.15381/rivep.v33i4.23358 Revista de Investigaciones Veterinarias del Peru, v. 33, n. 4, 2022. 1609-9117 1682-3419 http://hdl.handle.net/11449/247801 10.15381/rivep.v33i4.23358 2-s2.0-85140711575 |
url |
http://dx.doi.org/10.15381/rivep.v33i4.23358 http://hdl.handle.net/11449/247801 |
identifier_str_mv |
Revista de Investigaciones Veterinarias del Peru, v. 33, n. 4, 2022. 1609-9117 1682-3419 10.15381/rivep.v33i4.23358 2-s2.0-85140711575 |
dc.language.iso.fl_str_mv |
spa |
language |
spa |
dc.relation.none.fl_str_mv |
Revista de Investigaciones Veterinarias del Peru |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
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1799964759917854720 |