Long-Term Clearance and Biodistribution of Magnetic Nanoparticles Assessed by AC Biosusceptometry
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.3390/ma15062121 http://hdl.handle.net/11449/223688 |
Resumo: | Once administered in an organism, the physiological parameters of magnetic nanoparticles (MNPs) must be addressed, as well as their possible interactions and retention and elimination profiles. Alternating current biosusceptometry (ACB) is a biomagnetic detection system used to detect and quantify MNPs. The aims of this study were to evaluate the biodistribution and clearance of MNPs profiles through long-time in vivo analysis and determine the elimination time carried out by the association between the ACB system and MnFe2O4 nanoparticles. The liver, lung, spleen, kidneys, and heart and a blood sample were collected for biodistribution analysis and, for elimination analysis, and over 60 days. During the period analyzed, the animal’s feces were also collectedd. It was possible to notice a higher uptake by the liver and the spleen due to their characteristics of retention and uptake. In 60 days, we observed an absence of MNPs in the spleen and a significant decay in the liver. We also determined the MNPs’ half-life through the liver and the spleen elimination. The data indicated a concentration decay profile over the 60 days, which suggests that, in addition to elimination via feces, there is an endogenous mechanism of metabolization or possible agglomeration of MNPs, resulting in loss of ACB signal intensity. |
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Long-Term Clearance and Biodistribution of Magnetic Nanoparticles Assessed by AC BiosusceptometryAlternate current biosusceptometryBiodistributionClearanceLong-time analysisMagnetic nanoparticlesOnce administered in an organism, the physiological parameters of magnetic nanoparticles (MNPs) must be addressed, as well as their possible interactions and retention and elimination profiles. Alternating current biosusceptometry (ACB) is a biomagnetic detection system used to detect and quantify MNPs. The aims of this study were to evaluate the biodistribution and clearance of MNPs profiles through long-time in vivo analysis and determine the elimination time carried out by the association between the ACB system and MnFe2O4 nanoparticles. The liver, lung, spleen, kidneys, and heart and a blood sample were collected for biodistribution analysis and, for elimination analysis, and over 60 days. During the period analyzed, the animal’s feces were also collectedd. It was possible to notice a higher uptake by the liver and the spleen due to their characteristics of retention and uptake. In 60 days, we observed an absence of MNPs in the spleen and a significant decay in the liver. We also determined the MNPs’ half-life through the liver and the spleen elimination. The data indicated a concentration decay profile over the 60 days, which suggests that, in addition to elimination via feces, there is an endogenous mechanism of metabolization or possible agglomeration of MNPs, resulting in loss of ACB signal intensity.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Department of Biophysics and Pharmacology Institute of Biosciences São Paulo State University—UNESP, SPInstitute of Physics Federal University of Goiás, GOFaculty of Philosophy Sciences and Letters at Ribeirão Preto University of São Paulo, SPDepartment of Biophysics and Pharmacology Institute of Biosciences São Paulo State University—UNESP, SPFAPESP: 2013/03258-9FAPESP: 2015/1492.3-9CNPq: 304107/2019-0CNPq: 312074/2018-9CAPES: 88882.432964/2019-01Universidade Estadual Paulista (UNESP)Universidade Federal de Goiás (UFG)Universidade de São Paulo (USP)Soares, Guilherme A. [UNESP]Faria, João V. C. [UNESP]Pinto, Leonardo A. [UNESP]Prospero, Andre G. [UNESP]Pereira, Gabriele M. [UNESP]Stoppa, Erick G. [UNESP]Buranello, Lais P. [UNESP]Bakuzis, Andris F.Baffa, OswaldoMiranda, José R. A. [UNESP]2022-04-28T19:52:23Z2022-04-28T19:52:23Z2022-03-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.3390/ma15062121Materials, v. 15, n. 6, 2022.1996-1944http://hdl.handle.net/11449/22368810.3390/ma150621212-s2.0-85126753592Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengMaterialsinfo:eu-repo/semantics/openAccess2022-04-28T19:52:23Zoai:repositorio.unesp.br:11449/223688Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T22:29:43.349813Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Long-Term Clearance and Biodistribution of Magnetic Nanoparticles Assessed by AC Biosusceptometry |
title |
Long-Term Clearance and Biodistribution of Magnetic Nanoparticles Assessed by AC Biosusceptometry |
spellingShingle |
Long-Term Clearance and Biodistribution of Magnetic Nanoparticles Assessed by AC Biosusceptometry Soares, Guilherme A. [UNESP] Alternate current biosusceptometry Biodistribution Clearance Long-time analysis Magnetic nanoparticles |
title_short |
Long-Term Clearance and Biodistribution of Magnetic Nanoparticles Assessed by AC Biosusceptometry |
title_full |
Long-Term Clearance and Biodistribution of Magnetic Nanoparticles Assessed by AC Biosusceptometry |
title_fullStr |
Long-Term Clearance and Biodistribution of Magnetic Nanoparticles Assessed by AC Biosusceptometry |
title_full_unstemmed |
Long-Term Clearance and Biodistribution of Magnetic Nanoparticles Assessed by AC Biosusceptometry |
title_sort |
Long-Term Clearance and Biodistribution of Magnetic Nanoparticles Assessed by AC Biosusceptometry |
author |
Soares, Guilherme A. [UNESP] |
author_facet |
Soares, Guilherme A. [UNESP] Faria, João V. C. [UNESP] Pinto, Leonardo A. [UNESP] Prospero, Andre G. [UNESP] Pereira, Gabriele M. [UNESP] Stoppa, Erick G. [UNESP] Buranello, Lais P. [UNESP] Bakuzis, Andris F. Baffa, Oswaldo Miranda, José R. A. [UNESP] |
author_role |
author |
author2 |
Faria, João V. C. [UNESP] Pinto, Leonardo A. [UNESP] Prospero, Andre G. [UNESP] Pereira, Gabriele M. [UNESP] Stoppa, Erick G. [UNESP] Buranello, Lais P. [UNESP] Bakuzis, Andris F. Baffa, Oswaldo Miranda, José R. A. [UNESP] |
author2_role |
author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (UNESP) Universidade Federal de Goiás (UFG) Universidade de São Paulo (USP) |
dc.contributor.author.fl_str_mv |
Soares, Guilherme A. [UNESP] Faria, João V. C. [UNESP] Pinto, Leonardo A. [UNESP] Prospero, Andre G. [UNESP] Pereira, Gabriele M. [UNESP] Stoppa, Erick G. [UNESP] Buranello, Lais P. [UNESP] Bakuzis, Andris F. Baffa, Oswaldo Miranda, José R. A. [UNESP] |
dc.subject.por.fl_str_mv |
Alternate current biosusceptometry Biodistribution Clearance Long-time analysis Magnetic nanoparticles |
topic |
Alternate current biosusceptometry Biodistribution Clearance Long-time analysis Magnetic nanoparticles |
description |
Once administered in an organism, the physiological parameters of magnetic nanoparticles (MNPs) must be addressed, as well as their possible interactions and retention and elimination profiles. Alternating current biosusceptometry (ACB) is a biomagnetic detection system used to detect and quantify MNPs. The aims of this study were to evaluate the biodistribution and clearance of MNPs profiles through long-time in vivo analysis and determine the elimination time carried out by the association between the ACB system and MnFe2O4 nanoparticles. The liver, lung, spleen, kidneys, and heart and a blood sample were collected for biodistribution analysis and, for elimination analysis, and over 60 days. During the period analyzed, the animal’s feces were also collectedd. It was possible to notice a higher uptake by the liver and the spleen due to their characteristics of retention and uptake. In 60 days, we observed an absence of MNPs in the spleen and a significant decay in the liver. We also determined the MNPs’ half-life through the liver and the spleen elimination. The data indicated a concentration decay profile over the 60 days, which suggests that, in addition to elimination via feces, there is an endogenous mechanism of metabolization or possible agglomeration of MNPs, resulting in loss of ACB signal intensity. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-04-28T19:52:23Z 2022-04-28T19:52:23Z 2022-03-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.3390/ma15062121 Materials, v. 15, n. 6, 2022. 1996-1944 http://hdl.handle.net/11449/223688 10.3390/ma15062121 2-s2.0-85126753592 |
url |
http://dx.doi.org/10.3390/ma15062121 http://hdl.handle.net/11449/223688 |
identifier_str_mv |
Materials, v. 15, n. 6, 2022. 1996-1944 10.3390/ma15062121 2-s2.0-85126753592 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Materials |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808129431052484608 |