Real-time liver uptake and biodistribution of magnetic nanoparticles determined by AC biosusceptometry
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.nano.2017.02.005 http://hdl.handle.net/11449/162855 |
Resumo: | We describe the development of a joint in vivo/ex vivo protocol to monitor magnetic nanoparticles in animal models. Alternating current biosusceptometry (ACB) enables the assessment of magnetic nanoparticle accumulation, followed by quantitative analysis of concentrations in organs of interest. We present a study of real-time liver accumulation, followed by the assessment of sequential biodistribution using the same technique. For quantification, we validated our results by comparing all of the data with electron spin resonance (ESR). The ACB had viable temporal resolution and accuracy to differentiate temporal parameters of liver accumulation, caused by vasculature extravasation and macrophages action. The biodistribution experiment showed different uptake profiles for different doses and injection protocols. Comparisons with the ESR system indicated a correlation index of 0.993. We present the ACB system as an accessible and versatile tool to monitor magnetic nanoparticles, allowing in vivo and real-time evaluations of distribution and quantitative assessments of particle concentrations. (C) 2017 Elsevier Inc. All rights reserved. |
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Real-time liver uptake and biodistribution of magnetic nanoparticles determined by AC biosusceptometryAC biosusceptometryMagnetic nanoparticlesBiomedical instrumentsReal time monitoringQuantification methodsNanoparticle uptakeWe describe the development of a joint in vivo/ex vivo protocol to monitor magnetic nanoparticles in animal models. Alternating current biosusceptometry (ACB) enables the assessment of magnetic nanoparticle accumulation, followed by quantitative analysis of concentrations in organs of interest. We present a study of real-time liver accumulation, followed by the assessment of sequential biodistribution using the same technique. For quantification, we validated our results by comparing all of the data with electron spin resonance (ESR). The ACB had viable temporal resolution and accuracy to differentiate temporal parameters of liver accumulation, caused by vasculature extravasation and macrophages action. The biodistribution experiment showed different uptake profiles for different doses and injection protocols. Comparisons with the ESR system indicated a correlation index of 0.993. We present the ACB system as an accessible and versatile tool to monitor magnetic nanoparticles, allowing in vivo and real-time evaluations of distribution and quantitative assessments of particle concentrations. (C) 2017 Elsevier Inc. All rights reserved.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Univ Estadual Paulista, Dept Fis & Biofis, Lab Biomagnetismo, IBB, Botucatu, SP, BrazilUniv Fed Goias, Inst Fis, Goiania, Go, BrazilUniv Texas MD Anderson Canc Ctr, Dept Expt Radiat Oncol, Houston, TX 77030 USAUniv Estadual Paulista, Fac Med Botucatu, Dept Doencas Trop & Diagnost Imagem, Botucatu, SP, BrazilUniv Sao Paulo, Fac Med Ribeirao Preto, Ribeirao Preto, SP, BrazilUniv Sao Paulo, Fac Filosofia Ciencias & Letras Ribeirao Preto, Dept Fis, Ribeirao Preto, SP, BrazilUniv Estadual Paulista, Dept Fis & Biofis, Lab Biomagnetismo, IBB, Botucatu, SP, BrazilUniv Estadual Paulista, Fac Med Botucatu, Dept Doencas Trop & Diagnost Imagem, Botucatu, SP, BrazilFAPESP: 2010/07639-9FAPESP: 2011/18696-6FAPESP: 2013/20842-6FAPESP: 2015/14914-0Elsevier B.V.Universidade Estadual Paulista (Unesp)Universidade Federal de Goiás (UFG)Univ Texas MD Anderson Canc CtrUniversidade de São Paulo (USP)Quini, Caio C. [UNESP]Prospero, Andre G. [UNESP]Calabresi, Marcos F. F. [UNESP]Moretto, Gustavo M. [UNESP]Zufelato, NicholasKrishnan, SunilPina, Diana R. [UNESP]Oliveira, Ricardo B.Baffa, OswaldoBakuzis, Andris F.Miranda, Jose R. A. [UNESP]2018-11-26T17:34:41Z2018-11-26T17:34:41Z2017-05-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1519-1529application/pdfhttp://dx.doi.org/10.1016/j.nano.2017.02.005Nanomedicine-nanotechnology Biology And Medicine. Amsterdam: Elsevier Science Bv, v. 13, n. 4, p. 1519-1529, 2017.1549-9634http://hdl.handle.net/11449/16285510.1016/j.nano.2017.02.005WOS:000402678800019WOS000402678800019.pdfWeb of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengNanomedicine-nanotechnology Biology And Medicine1,743info:eu-repo/semantics/openAccess2024-08-15T15:22:34Zoai:repositorio.unesp.br:11449/162855Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-15T15:22:34Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Real-time liver uptake and biodistribution of magnetic nanoparticles determined by AC biosusceptometry |
title |
Real-time liver uptake and biodistribution of magnetic nanoparticles determined by AC biosusceptometry |
spellingShingle |
Real-time liver uptake and biodistribution of magnetic nanoparticles determined by AC biosusceptometry Quini, Caio C. [UNESP] AC biosusceptometry Magnetic nanoparticles Biomedical instruments Real time monitoring Quantification methods Nanoparticle uptake |
title_short |
Real-time liver uptake and biodistribution of magnetic nanoparticles determined by AC biosusceptometry |
title_full |
Real-time liver uptake and biodistribution of magnetic nanoparticles determined by AC biosusceptometry |
title_fullStr |
Real-time liver uptake and biodistribution of magnetic nanoparticles determined by AC biosusceptometry |
title_full_unstemmed |
Real-time liver uptake and biodistribution of magnetic nanoparticles determined by AC biosusceptometry |
title_sort |
Real-time liver uptake and biodistribution of magnetic nanoparticles determined by AC biosusceptometry |
author |
Quini, Caio C. [UNESP] |
author_facet |
Quini, Caio C. [UNESP] Prospero, Andre G. [UNESP] Calabresi, Marcos F. F. [UNESP] Moretto, Gustavo M. [UNESP] Zufelato, Nicholas Krishnan, Sunil Pina, Diana R. [UNESP] Oliveira, Ricardo B. Baffa, Oswaldo Bakuzis, Andris F. Miranda, Jose R. A. [UNESP] |
author_role |
author |
author2 |
Prospero, Andre G. [UNESP] Calabresi, Marcos F. F. [UNESP] Moretto, Gustavo M. [UNESP] Zufelato, Nicholas Krishnan, Sunil Pina, Diana R. [UNESP] Oliveira, Ricardo B. Baffa, Oswaldo Bakuzis, Andris F. Miranda, Jose R. A. [UNESP] |
author2_role |
author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Universidade Federal de Goiás (UFG) Univ Texas MD Anderson Canc Ctr Universidade de São Paulo (USP) |
dc.contributor.author.fl_str_mv |
Quini, Caio C. [UNESP] Prospero, Andre G. [UNESP] Calabresi, Marcos F. F. [UNESP] Moretto, Gustavo M. [UNESP] Zufelato, Nicholas Krishnan, Sunil Pina, Diana R. [UNESP] Oliveira, Ricardo B. Baffa, Oswaldo Bakuzis, Andris F. Miranda, Jose R. A. [UNESP] |
dc.subject.por.fl_str_mv |
AC biosusceptometry Magnetic nanoparticles Biomedical instruments Real time monitoring Quantification methods Nanoparticle uptake |
topic |
AC biosusceptometry Magnetic nanoparticles Biomedical instruments Real time monitoring Quantification methods Nanoparticle uptake |
description |
We describe the development of a joint in vivo/ex vivo protocol to monitor magnetic nanoparticles in animal models. Alternating current biosusceptometry (ACB) enables the assessment of magnetic nanoparticle accumulation, followed by quantitative analysis of concentrations in organs of interest. We present a study of real-time liver accumulation, followed by the assessment of sequential biodistribution using the same technique. For quantification, we validated our results by comparing all of the data with electron spin resonance (ESR). The ACB had viable temporal resolution and accuracy to differentiate temporal parameters of liver accumulation, caused by vasculature extravasation and macrophages action. The biodistribution experiment showed different uptake profiles for different doses and injection protocols. Comparisons with the ESR system indicated a correlation index of 0.993. We present the ACB system as an accessible and versatile tool to monitor magnetic nanoparticles, allowing in vivo and real-time evaluations of distribution and quantitative assessments of particle concentrations. (C) 2017 Elsevier Inc. All rights reserved. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-05-01 2018-11-26T17:34:41Z 2018-11-26T17:34:41Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.nano.2017.02.005 Nanomedicine-nanotechnology Biology And Medicine. Amsterdam: Elsevier Science Bv, v. 13, n. 4, p. 1519-1529, 2017. 1549-9634 http://hdl.handle.net/11449/162855 10.1016/j.nano.2017.02.005 WOS:000402678800019 WOS000402678800019.pdf |
url |
http://dx.doi.org/10.1016/j.nano.2017.02.005 http://hdl.handle.net/11449/162855 |
identifier_str_mv |
Nanomedicine-nanotechnology Biology And Medicine. Amsterdam: Elsevier Science Bv, v. 13, n. 4, p. 1519-1529, 2017. 1549-9634 10.1016/j.nano.2017.02.005 WOS:000402678800019 WOS000402678800019.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Nanomedicine-nanotechnology Biology And Medicine 1,743 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
1519-1529 application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier B.V. |
publisher.none.fl_str_mv |
Elsevier B.V. |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808128127089508352 |