Porencephaly and cortical dysplasia as cause of seizures in a dog

Detalhes bibliográficos
Autor(a) principal: Machado, Gisele Fabrino [UNESP]
Data de Publicação: 2012
Outros Autores: Laranjeira, Maria Gisela [UNESP], Schweigert, Augusto [UNESP], de Melo, Guilherme Dias [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1186/1746-6148-8-246
http://hdl.handle.net/11449/14842
Resumo: Background: Seizures are a common problem in small animal neurology and it may be related to underlying diseases. Porencephaly is an extremely rare disorder, and in Veterinary Medicine it affects more often ruminants, with only few reports in dogs.Case presentation: A one-year-old intact male Shih-Tzu dog was referred to Veterinary University Hospital with history of abnormal gait and generalized tonic-clonic seizures. Signs included hypermetria, abnormal nystagmus and increased myotatic reflexes. At necropsy, during the brain analysis, a cleft was observed in the left parietal and occipital lobes, creating a communication between the subarachnoid space and the left lateral ventricle, consistent with porencephaly; and also a focal atrophy of the caudal paravermal and vermal portions of the cerebellum. Furthermore, the histological examination showed cortical and cerebellar neuronal dysplasia.Conclusions: Reports of seizures due to porencephaly are rare in dogs. In this case, the dog presented a group of brain abnormalities which per se or in assemblage could result in seizure manifestation.
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spelling Porencephaly and cortical dysplasia as cause of seizures in a dogBrainCanineCentral nervous system diseasesCerebellumHippocampusNeuropathologyBackground: Seizures are a common problem in small animal neurology and it may be related to underlying diseases. Porencephaly is an extremely rare disorder, and in Veterinary Medicine it affects more often ruminants, with only few reports in dogs.Case presentation: A one-year-old intact male Shih-Tzu dog was referred to Veterinary University Hospital with history of abnormal gait and generalized tonic-clonic seizures. Signs included hypermetria, abnormal nystagmus and increased myotatic reflexes. At necropsy, during the brain analysis, a cleft was observed in the left parietal and occipital lobes, creating a communication between the subarachnoid space and the left lateral ventricle, consistent with porencephaly; and also a focal atrophy of the caudal paravermal and vermal portions of the cerebellum. Furthermore, the histological examination showed cortical and cerebellar neuronal dysplasia.Conclusions: Reports of seizures due to porencephaly are rare in dogs. In this case, the dog presented a group of brain abnormalities which per se or in assemblage could result in seizure manifestation.UNESP Univ Estadual Paulista, Coll Vet Med, Dept Anim Clin Surg & Reprod, BR-16050680 Aracatuba, SP, BrazilUNESP Univ Estadual Paulista, Coll Vet Med, Dept Anim Clin Surg & Reprod, BR-16050680 Aracatuba, SP, BrazilBiomed Central Ltd.Universidade Estadual Paulista (Unesp)Machado, Gisele Fabrino [UNESP]Laranjeira, Maria Gisela [UNESP]Schweigert, Augusto [UNESP]de Melo, Guilherme Dias [UNESP]2013-09-30T18:29:49Z2014-05-20T13:42:40Z2013-09-30T18:29:49Z2014-05-20T13:42:40Z2012-12-27info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article5application/pdfhttp://dx.doi.org/10.1186/1746-6148-8-246Bmc Veterinary Research. London: Biomed Central Ltd., v. 8, p. 5, 2012.1746-6148http://hdl.handle.net/11449/1484210.1186/1746-6148-8-246WOS:000313121200001WOS000313121200001.pdf03104055581256349599462823853911Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengBMC Veterinary Research1.9580,934info:eu-repo/semantics/openAccess2024-09-04T18:03:43Zoai:repositorio.unesp.br:11449/14842Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestrepositoriounesp@unesp.bropendoar:29462024-09-04T18:03:43Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Porencephaly and cortical dysplasia as cause of seizures in a dog
title Porencephaly and cortical dysplasia as cause of seizures in a dog
spellingShingle Porencephaly and cortical dysplasia as cause of seizures in a dog
Machado, Gisele Fabrino [UNESP]
Brain
Canine
Central nervous system diseases
Cerebellum
Hippocampus
Neuropathology
title_short Porencephaly and cortical dysplasia as cause of seizures in a dog
title_full Porencephaly and cortical dysplasia as cause of seizures in a dog
title_fullStr Porencephaly and cortical dysplasia as cause of seizures in a dog
title_full_unstemmed Porencephaly and cortical dysplasia as cause of seizures in a dog
title_sort Porencephaly and cortical dysplasia as cause of seizures in a dog
author Machado, Gisele Fabrino [UNESP]
author_facet Machado, Gisele Fabrino [UNESP]
Laranjeira, Maria Gisela [UNESP]
Schweigert, Augusto [UNESP]
de Melo, Guilherme Dias [UNESP]
author_role author
author2 Laranjeira, Maria Gisela [UNESP]
Schweigert, Augusto [UNESP]
de Melo, Guilherme Dias [UNESP]
author2_role author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv Machado, Gisele Fabrino [UNESP]
Laranjeira, Maria Gisela [UNESP]
Schweigert, Augusto [UNESP]
de Melo, Guilherme Dias [UNESP]
dc.subject.por.fl_str_mv Brain
Canine
Central nervous system diseases
Cerebellum
Hippocampus
Neuropathology
topic Brain
Canine
Central nervous system diseases
Cerebellum
Hippocampus
Neuropathology
description Background: Seizures are a common problem in small animal neurology and it may be related to underlying diseases. Porencephaly is an extremely rare disorder, and in Veterinary Medicine it affects more often ruminants, with only few reports in dogs.Case presentation: A one-year-old intact male Shih-Tzu dog was referred to Veterinary University Hospital with history of abnormal gait and generalized tonic-clonic seizures. Signs included hypermetria, abnormal nystagmus and increased myotatic reflexes. At necropsy, during the brain analysis, a cleft was observed in the left parietal and occipital lobes, creating a communication between the subarachnoid space and the left lateral ventricle, consistent with porencephaly; and also a focal atrophy of the caudal paravermal and vermal portions of the cerebellum. Furthermore, the histological examination showed cortical and cerebellar neuronal dysplasia.Conclusions: Reports of seizures due to porencephaly are rare in dogs. In this case, the dog presented a group of brain abnormalities which per se or in assemblage could result in seizure manifestation.
publishDate 2012
dc.date.none.fl_str_mv 2012-12-27
2013-09-30T18:29:49Z
2013-09-30T18:29:49Z
2014-05-20T13:42:40Z
2014-05-20T13:42:40Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1186/1746-6148-8-246
Bmc Veterinary Research. London: Biomed Central Ltd., v. 8, p. 5, 2012.
1746-6148
http://hdl.handle.net/11449/14842
10.1186/1746-6148-8-246
WOS:000313121200001
WOS000313121200001.pdf
0310405558125634
9599462823853911
url http://dx.doi.org/10.1186/1746-6148-8-246
http://hdl.handle.net/11449/14842
identifier_str_mv Bmc Veterinary Research. London: Biomed Central Ltd., v. 8, p. 5, 2012.
1746-6148
10.1186/1746-6148-8-246
WOS:000313121200001
WOS000313121200001.pdf
0310405558125634
9599462823853911
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv BMC Veterinary Research
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eu_rights_str_mv openAccess
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application/pdf
dc.publisher.none.fl_str_mv Biomed Central Ltd.
publisher.none.fl_str_mv Biomed Central Ltd.
dc.source.none.fl_str_mv Web of Science
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv repositoriounesp@unesp.br
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