Biocompatibility of Intracanal Medications Based on Calcium Hydroxide

• Autor(a) principal: Andolfatto, Carolina [UNESP]
• Data de Publicação: 2012
• Outros Autores: Silva, Guilherme Ferreira da [UNESP], Cornélio, Ana Livia Gomes [UNESP], Tanomaru, Juliane Maria Guerreiro [UNESP], Tanomaru Filho, Mario [UNESP], Faria, Gisele [UNESP], Bonetti Filho, Idomeo [UNESP], Cerri, Paulo Sérgio [UNESP]
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UNESP
• Texto Completo: http://www.hindawi.com/journals/isrn/2012/904963/; http://hdl.handle.net/11449/125976
• topic: Biocompatibilidade; Hidróxido de cálcio; Medicação intracanal

The aim of this study was to evaluate the rat subcutaneous tissue reaction to calcium hydroxide-based intracanal medicaments, UltraCal XS (calcium hydroxide, barium sulphate, aqueous matrix), Hydropast (calcium hydroxide, barium sulphate, and propyleneglycol), and Calen (Calcium hydroxide, zinc oxide, colophony, and polyethyleneglycol), used as a control. Methods. Forty-eight rats (Rattus Norvegicus Holtzman) were distributed in three groups: Calen, UltraCal XS, and Hydropast. Polyethylene tubes filled with one of the medicaments were implanted in the dorsal subcutaneous. After 7 and 30 days, the implants were removed and the specimens were fixed and embedded in paraffin. Morphological and quantitative analyses were carried out in the HE-stained sections. The numerical density of inflammatory cells in the capsule was evaluated and statistical analyses were performed (P>/0.05). Results. At 7 days, all materials induced an inflammatory reaction in the subcutaneous tissue adjacent to the implants. In all groups, a significant reduction in the number of inflammatory cells and giant cells was verified in the period of 30 days. Conclusion. These results indicate that the calcium hydroxide-based medicaments evaluated present biocompatibility similar to Calen.