Antiglycation and antitumoral activity of Tribulus terrestris dry extract
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://hdl.handle.net/11449/209328 |
Resumo: | Objective: Investigation of the antiglycation and antitumoral potential of standardized and saponins-enriched extracts of Tribulus terrestris herbal medicine. Materials and Methods: The procedures for the evaluation of the antiglycation activity of the standardized (TtSE) and saponins-enriched (TtEE) extracts of T. terrestris were: determination of relative mobility in electrophoresis (RME), free amino groups using OPA method and advanced glycation end-products (AGEs) fluorescence. Antioxidant activity was determined by DPPH radical scavenging test. In vitro antitumor activity of TtSE and TtEE was evaluated in human tumor cell lines. Results: The results were obtained by antiglycation tests (RME, OPA method and AGEs fluorescence determination), using BSA as protein and ribose as glycation agent, and antioxidant assay (DPPH test); it was verified that both extracts of T. terrestris have antiglycation and antioxidant activity. In addition, the extracts were able to induce death of more than 50% of human tumor cell lines. Conclusion: The present study showed that standardized and saponins-enriched extracts of T. terrestris herbal medicine present antiglycation and antioxidant and antiproliferative action in human tumor cells lines. The saponins-enriched extract proved a greater antiglycation and antioxidant activity in comparison to the standardized type. |
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Antiglycation and antitumoral activity of Tribulus terrestris dry extractTribulus terrestrisAntiproliferativeProtein glycationSteroidal saponinsObjective: Investigation of the antiglycation and antitumoral potential of standardized and saponins-enriched extracts of Tribulus terrestris herbal medicine. Materials and Methods: The procedures for the evaluation of the antiglycation activity of the standardized (TtSE) and saponins-enriched (TtEE) extracts of T. terrestris were: determination of relative mobility in electrophoresis (RME), free amino groups using OPA method and advanced glycation end-products (AGEs) fluorescence. Antioxidant activity was determined by DPPH radical scavenging test. In vitro antitumor activity of TtSE and TtEE was evaluated in human tumor cell lines. Results: The results were obtained by antiglycation tests (RME, OPA method and AGEs fluorescence determination), using BSA as protein and ribose as glycation agent, and antioxidant assay (DPPH test); it was verified that both extracts of T. terrestris have antiglycation and antioxidant activity. In addition, the extracts were able to induce death of more than 50% of human tumor cell lines. Conclusion: The present study showed that standardized and saponins-enriched extracts of T. terrestris herbal medicine present antiglycation and antioxidant and antiproliferative action in human tumor cells lines. The saponins-enriched extract proved a greater antiglycation and antioxidant activity in comparison to the standardized type.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Sao Paulo State Univ UNESP, Inst Chem, Araraquara, SP, BrazilFundacao Educ Municlpio Assis FEMA, Assis, SP, BrazilUniv Estadual Campinas, Fac Pharmaceut Sci, UNICAMP, Campinas, SP, BrazilSao Paulo State Univ UNESP, Sch Sci Humanities & Languages, Dept Biotechnol, Lab Herbal Med & Nat Prod, Assis, SP, BrazilSao Paulo State Univ UNESP, Inst Chem, Araraquara, SP, BrazilSao Paulo State Univ UNESP, Sch Sci Humanities & Languages, Dept Biotechnol, Lab Herbal Med & Nat Prod, Assis, SP, BrazilFAPESP: 2015/17893-3Mashhad Univ Med SciencesUniversidade Estadual Paulista (Unesp)Fundacao Educ Municlpio Assis FEMAUniversidade Estadual de Campinas (UNICAMP)Malaguti Figueiredo, Celia Cristina [UNESP]Gomes, Amanda Costa [UNESP]Granero, Filipe Oliveira [UNESP]Bronzel Junior, Joao Luiz [UNESP]Silva, Luciana PereiraTasca Gois Ruiz, Ana LuciaGoncalves da Silva, Regildo Marcio [UNESP]2021-06-25T11:56:27Z2021-06-25T11:56:27Z2021-05-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article224-237Avicenna Journal Of Phytomedicine. Mashhad: Mashhad Univ Med Sciences, v. 11, n. 3, p. 224-237, 2021.2228-7930http://hdl.handle.net/11449/209328WOS:000640070600003Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengAvicenna Journal Of Phytomedicineinfo:eu-repo/semantics/openAccess2021-10-23T19:28:03Zoai:repositorio.unesp.br:11449/209328Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T14:57:11.657219Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Antiglycation and antitumoral activity of Tribulus terrestris dry extract |
title |
Antiglycation and antitumoral activity of Tribulus terrestris dry extract |
spellingShingle |
Antiglycation and antitumoral activity of Tribulus terrestris dry extract Malaguti Figueiredo, Celia Cristina [UNESP] Tribulus terrestris Antiproliferative Protein glycation Steroidal saponins |
title_short |
Antiglycation and antitumoral activity of Tribulus terrestris dry extract |
title_full |
Antiglycation and antitumoral activity of Tribulus terrestris dry extract |
title_fullStr |
Antiglycation and antitumoral activity of Tribulus terrestris dry extract |
title_full_unstemmed |
Antiglycation and antitumoral activity of Tribulus terrestris dry extract |
title_sort |
Antiglycation and antitumoral activity of Tribulus terrestris dry extract |
author |
Malaguti Figueiredo, Celia Cristina [UNESP] |
author_facet |
Malaguti Figueiredo, Celia Cristina [UNESP] Gomes, Amanda Costa [UNESP] Granero, Filipe Oliveira [UNESP] Bronzel Junior, Joao Luiz [UNESP] Silva, Luciana Pereira Tasca Gois Ruiz, Ana Lucia Goncalves da Silva, Regildo Marcio [UNESP] |
author_role |
author |
author2 |
Gomes, Amanda Costa [UNESP] Granero, Filipe Oliveira [UNESP] Bronzel Junior, Joao Luiz [UNESP] Silva, Luciana Pereira Tasca Gois Ruiz, Ana Lucia Goncalves da Silva, Regildo Marcio [UNESP] |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Fundacao Educ Municlpio Assis FEMA Universidade Estadual de Campinas (UNICAMP) |
dc.contributor.author.fl_str_mv |
Malaguti Figueiredo, Celia Cristina [UNESP] Gomes, Amanda Costa [UNESP] Granero, Filipe Oliveira [UNESP] Bronzel Junior, Joao Luiz [UNESP] Silva, Luciana Pereira Tasca Gois Ruiz, Ana Lucia Goncalves da Silva, Regildo Marcio [UNESP] |
dc.subject.por.fl_str_mv |
Tribulus terrestris Antiproliferative Protein glycation Steroidal saponins |
topic |
Tribulus terrestris Antiproliferative Protein glycation Steroidal saponins |
description |
Objective: Investigation of the antiglycation and antitumoral potential of standardized and saponins-enriched extracts of Tribulus terrestris herbal medicine. Materials and Methods: The procedures for the evaluation of the antiglycation activity of the standardized (TtSE) and saponins-enriched (TtEE) extracts of T. terrestris were: determination of relative mobility in electrophoresis (RME), free amino groups using OPA method and advanced glycation end-products (AGEs) fluorescence. Antioxidant activity was determined by DPPH radical scavenging test. In vitro antitumor activity of TtSE and TtEE was evaluated in human tumor cell lines. Results: The results were obtained by antiglycation tests (RME, OPA method and AGEs fluorescence determination), using BSA as protein and ribose as glycation agent, and antioxidant assay (DPPH test); it was verified that both extracts of T. terrestris have antiglycation and antioxidant activity. In addition, the extracts were able to induce death of more than 50% of human tumor cell lines. Conclusion: The present study showed that standardized and saponins-enriched extracts of T. terrestris herbal medicine present antiglycation and antioxidant and antiproliferative action in human tumor cells lines. The saponins-enriched extract proved a greater antiglycation and antioxidant activity in comparison to the standardized type. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-06-25T11:56:27Z 2021-06-25T11:56:27Z 2021-05-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
Avicenna Journal Of Phytomedicine. Mashhad: Mashhad Univ Med Sciences, v. 11, n. 3, p. 224-237, 2021. 2228-7930 http://hdl.handle.net/11449/209328 WOS:000640070600003 |
identifier_str_mv |
Avicenna Journal Of Phytomedicine. Mashhad: Mashhad Univ Med Sciences, v. 11, n. 3, p. 224-237, 2021. 2228-7930 WOS:000640070600003 |
url |
http://hdl.handle.net/11449/209328 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Avicenna Journal Of Phytomedicine |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
224-237 |
dc.publisher.none.fl_str_mv |
Mashhad Univ Med Sciences |
publisher.none.fl_str_mv |
Mashhad Univ Med Sciences |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808128440572837888 |