Atividade in vitro do danofloxacin e de sete drogas antimicrobianas frente a linhagens de Staphylococcus aureus isoladas de mastite bovina
Autor(a) principal: | |
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Data de Publicação: | 1998 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://hdl.handle.net/11449/224337 |
Resumo: | The antimicrobial activity of danofloxacin, a new 4-fluoroquinolone for exclusive use in Veterinary Medicine, was compared in vitro with other seven drugs against 200 strains of Staphylococcus aureus isolated from bovine mastitis. By using the antimicrobial disk diffusion method (Bauer-Kirby), the results showed that the imipenem (100%), trimethoprim/sulfamethoxazole (98.9%), cefuroxime (97.3%) were the most effective drugs taking into consideration the percentuals of sensitiveness. However, considering the percentuals of the moderately sensitive strains, danofloxacin emerged as the third most active drug. The antimicrobial dilution susceptibility test used to study the minimal inhibitory concentration (MIC) and the minimal bactericidal concentration (MBC) of danofloxacin, characterized its significative antimicrobial activity by showing a close relationship between both concentrations (MIC90% = 0.18μg/ml - MBC90% = 0.23μg/ml), as well as a MIC/MBC ratio of 1:1 and 1:2 for most of tested strains. |
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Atividade in vitro do danofloxacin e de sete drogas antimicrobianas frente a linhagens de Staphylococcus aureus isoladas de mastite bovinaAntimicrobial activity of danofloxacin and seven other drugs against Staphylococcus aureus from bovine mastitisBovineDanofloxacinMastitisStaphylococcus aureusThe antimicrobial activity of danofloxacin, a new 4-fluoroquinolone for exclusive use in Veterinary Medicine, was compared in vitro with other seven drugs against 200 strains of Staphylococcus aureus isolated from bovine mastitis. By using the antimicrobial disk diffusion method (Bauer-Kirby), the results showed that the imipenem (100%), trimethoprim/sulfamethoxazole (98.9%), cefuroxime (97.3%) were the most effective drugs taking into consideration the percentuals of sensitiveness. However, considering the percentuals of the moderately sensitive strains, danofloxacin emerged as the third most active drug. The antimicrobial dilution susceptibility test used to study the minimal inhibitory concentration (MIC) and the minimal bactericidal concentration (MBC) of danofloxacin, characterized its significative antimicrobial activity by showing a close relationship between both concentrations (MIC90% = 0.18μg/ml - MBC90% = 0.23μg/ml), as well as a MIC/MBC ratio of 1:1 and 1:2 for most of tested strains.Depto. de Higiene Vet. e Saude Pub. Faculdade de Med. Vet. Zootecnia UNESP, Caixa Postal, 510, CEP 18618-000 - Botucatu, SPDepto. de Higiene Vet. e Saude Pub. Faculdade de Med. Vet. Zootecnia UNESP, Caixa Postal, 510, CEP 18618-000 - Botucatu, SPUniversidade Estadual Paulista (UNESP)Cruz, A. D.Batista, G. C.M.Modolo, J. R. [UNESP]Gottschalk, A. F. [UNESP]Lopes, C. A.M.2022-04-28T19:55:59Z2022-04-28T19:55:59Z1998-08-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article369-373Arquivo Brasileiro de Medicina Veterinaria e Zootecnia, v. 50, n. 4, p. 369-373, 1998.0102-0935http://hdl.handle.net/11449/2243372-s2.0-0041171319Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPporArquivo Brasileiro de Medicina Veterinaria e Zootecniainfo:eu-repo/semantics/openAccess2022-04-28T19:55:59Zoai:repositorio.unesp.br:11449/224337Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462022-04-28T19:55:59Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Atividade in vitro do danofloxacin e de sete drogas antimicrobianas frente a linhagens de Staphylococcus aureus isoladas de mastite bovina Antimicrobial activity of danofloxacin and seven other drugs against Staphylococcus aureus from bovine mastitis |
title |
Atividade in vitro do danofloxacin e de sete drogas antimicrobianas frente a linhagens de Staphylococcus aureus isoladas de mastite bovina |
spellingShingle |
Atividade in vitro do danofloxacin e de sete drogas antimicrobianas frente a linhagens de Staphylococcus aureus isoladas de mastite bovina Cruz, A. D. Bovine Danofloxacin Mastitis Staphylococcus aureus |
title_short |
Atividade in vitro do danofloxacin e de sete drogas antimicrobianas frente a linhagens de Staphylococcus aureus isoladas de mastite bovina |
title_full |
Atividade in vitro do danofloxacin e de sete drogas antimicrobianas frente a linhagens de Staphylococcus aureus isoladas de mastite bovina |
title_fullStr |
Atividade in vitro do danofloxacin e de sete drogas antimicrobianas frente a linhagens de Staphylococcus aureus isoladas de mastite bovina |
title_full_unstemmed |
Atividade in vitro do danofloxacin e de sete drogas antimicrobianas frente a linhagens de Staphylococcus aureus isoladas de mastite bovina |
title_sort |
Atividade in vitro do danofloxacin e de sete drogas antimicrobianas frente a linhagens de Staphylococcus aureus isoladas de mastite bovina |
author |
Cruz, A. D. |
author_facet |
Cruz, A. D. Batista, G. C.M. Modolo, J. R. [UNESP] Gottschalk, A. F. [UNESP] Lopes, C. A.M. |
author_role |
author |
author2 |
Batista, G. C.M. Modolo, J. R. [UNESP] Gottschalk, A. F. [UNESP] Lopes, C. A.M. |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (UNESP) |
dc.contributor.author.fl_str_mv |
Cruz, A. D. Batista, G. C.M. Modolo, J. R. [UNESP] Gottschalk, A. F. [UNESP] Lopes, C. A.M. |
dc.subject.por.fl_str_mv |
Bovine Danofloxacin Mastitis Staphylococcus aureus |
topic |
Bovine Danofloxacin Mastitis Staphylococcus aureus |
description |
The antimicrobial activity of danofloxacin, a new 4-fluoroquinolone for exclusive use in Veterinary Medicine, was compared in vitro with other seven drugs against 200 strains of Staphylococcus aureus isolated from bovine mastitis. By using the antimicrobial disk diffusion method (Bauer-Kirby), the results showed that the imipenem (100%), trimethoprim/sulfamethoxazole (98.9%), cefuroxime (97.3%) were the most effective drugs taking into consideration the percentuals of sensitiveness. However, considering the percentuals of the moderately sensitive strains, danofloxacin emerged as the third most active drug. The antimicrobial dilution susceptibility test used to study the minimal inhibitory concentration (MIC) and the minimal bactericidal concentration (MBC) of danofloxacin, characterized its significative antimicrobial activity by showing a close relationship between both concentrations (MIC90% = 0.18μg/ml - MBC90% = 0.23μg/ml), as well as a MIC/MBC ratio of 1:1 and 1:2 for most of tested strains. |
publishDate |
1998 |
dc.date.none.fl_str_mv |
1998-08-01 2022-04-28T19:55:59Z 2022-04-28T19:55:59Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
Arquivo Brasileiro de Medicina Veterinaria e Zootecnia, v. 50, n. 4, p. 369-373, 1998. 0102-0935 http://hdl.handle.net/11449/224337 2-s2.0-0041171319 |
identifier_str_mv |
Arquivo Brasileiro de Medicina Veterinaria e Zootecnia, v. 50, n. 4, p. 369-373, 1998. 0102-0935 2-s2.0-0041171319 |
url |
http://hdl.handle.net/11449/224337 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
Arquivo Brasileiro de Medicina Veterinaria e Zootecnia |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
369-373 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1799965557220442112 |