Papel da proteína Mx1 na resposta a interferons e no processo neoplásico

Detalhes bibliográficos
Autor(a) principal: Brantis-de-Carvalho, C. E. [UNESP]
Data de Publicação: 2011
Outros Autores: Boldrin, P. E. G. [UNESP], Silva, W. A., Rahal, Paula [UNESP], Tajara, E. H., Carraro, D. M., Camargo, A. A., Zanelli, C. F. [UNESP], Valentini, S. R. [UNESP]
Tipo de documento: Artigo
Idioma: eng
por
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://serv-bib.fcfar.unesp.br/seer/index.php/Cien_Farm/article/view/2048
http://hdl.handle.net/11449/72959
Resumo: The Mx1 protein is encoded by an interferon- induced gene and shares domain organization, homooligomerization capacity and membrane association with the large dynamin-like GTPases. The Mx1 protein is involved in the response to a large number of RNA viruses, such as the bunyavirus family and the influenza virus. Interestingly, it has also been found as a methylation-silenced gene in several types of neoplasm, including head and neck squamous cell carcinoma. In this scenario, MX1 gene silencing is associated with immortalization in several neoplastic cell lines. Thus, Mx1 stands out as one of the key proteins involved in interferon-induced immune response and also plays an important role in cell cycle control. Here we discuss some of the functions of the Mx1 protein, including its antiviral activity, protein folding and involvement in neoplasia, as well as those revealed by investigating its cellular partners.
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spelling Papel da proteína Mx1 na resposta a interferons e no processo neoplásicoRole of Mx1 protein in the response to interferons and neoplastic processInterferonsJAK/STATMX1NeoplasiaPML-NBsSUMOylationVirusinterferonmx1 proteinprotein derivativeunclassified drugantiviral activityBunyaviruscancer cell culturecell immortalizationgene silencinghead and neck squamous cell carcinomaimmune responseInfluenza virusmethylationoncogenesis and malignant transformationprotein foldingprotein functionRNA virusThe Mx1 protein is encoded by an interferon- induced gene and shares domain organization, homooligomerization capacity and membrane association with the large dynamin-like GTPases. The Mx1 protein is involved in the response to a large number of RNA viruses, such as the bunyavirus family and the influenza virus. Interestingly, it has also been found as a methylation-silenced gene in several types of neoplasm, including head and neck squamous cell carcinoma. In this scenario, MX1 gene silencing is associated with immortalization in several neoplastic cell lines. Thus, Mx1 stands out as one of the key proteins involved in interferon-induced immune response and also plays an important role in cell cycle control. Here we discuss some of the functions of the Mx1 protein, including its antiviral activity, protein folding and involvement in neoplasia, as well as those revealed by investigating its cellular partners.A proteína Mx1 é codificada por um gene induzido por interferon e compartilha a organização de seus domínios, a capacidade de homo-oligomerização e associação com membranas com as grandes dinaminas GTPases. A proteína Mx1 está envolvida na resposta contra um grande número de vírus de RNA, como aqueles pertencentes à família Buniavírus e o vírus influenza. Curiosamente, o gene MX1 foi encontrado como silenciado por metilação em diversos processos neoplásicos, incluindo carcinomas de cabeça e pescoço de células escamosas. Neste cenário, o silenciamento gênico de MX1 está associado à imortalização de uma série de linhagens celulares neoplásicas. Assim, Mx1 se destaca como uma das principais proteínas envolvidas nas respostas imunes induzidas por interferon e também desempenha um importante papel no controle do ciclo celular. Aqui discutimos os aspectos funcionais da proteína Mx1 abordando sua atividade antiviral, organização estrutural, envolvimento com neoplasias e, principalmente, os aspectos funcionais obtidos pela determinação de seus parceiros celulares. Palavras-Chave: Interferons. MX1. JAK/STAT. Vírus. Neoplasia. PML-NBs. SUMOilação.Faculdade de Ciências Farmacêuticas de Araraquara UNESP, Araraquara, SPFaculdade de Medicina USP, Ribeirão Preto, SPIBILCE UNESP, São José do Rio Preto, SPFaculdade de Medicina FAMERP, São José do Rio Preto, SPInstituto de Biociências USP, São Paulo, SPHospital do câncer A.C. Camargo Centro Médico e de pesquisa, São Paulo, SPInstituto Ludwig Pesquisa para o Câncer no Hospital Oswaldo Cruz, São Paulo, SPFaculdade de Ciências Farmacêuticas de Araraquara UNESP, Araraquara, SPIBILCE UNESP, São José do Rio Preto, SPUniversidade Estadual Paulista (Unesp)Universidade de São Paulo (USP)Faculdade de Medicina de São José do Rio Preto (FAMERP)Hospital do Câncer A. C. CamargoInstituto Ludwig de pesquisa para o Câncer no Hospital Oswaldo CruzBrantis-de-Carvalho, C. E. [UNESP]Boldrin, P. E. G. [UNESP]Silva, W. A.Rahal, Paula [UNESP]Tajara, E. H.Carraro, D. M.Camargo, A. A.Zanelli, C. F. [UNESP]Valentini, S. R. [UNESP]2014-05-27T11:26:17Z2014-05-27T11:26:17Z2011-12-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article287-295application/pdfhttp://serv-bib.fcfar.unesp.br/seer/index.php/Cien_Farm/article/view/2048Revista de Ciencias Farmaceuticas Basica e Aplicada, v. 32, n. 3, p. 287-295, 2011.1808-4532http://hdl.handle.net/11449/729592-s2.0-848608644602-s2.0-84860864460.pdf799108236267121215256654089001950000-0001-5693-61480000-0001-7831-1149Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengporRevista de Ciências Farmacêuticas Básica e Aplicada0,131info:eu-repo/semantics/openAccess2024-01-01T06:22:31Zoai:repositorio.unesp.br:11449/72959Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-01-01T06:22:31Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Papel da proteína Mx1 na resposta a interferons e no processo neoplásico
Role of Mx1 protein in the response to interferons and neoplastic process
title Papel da proteína Mx1 na resposta a interferons e no processo neoplásico
spellingShingle Papel da proteína Mx1 na resposta a interferons e no processo neoplásico
Brantis-de-Carvalho, C. E. [UNESP]
Interferons
JAK/STAT
MX1
Neoplasia
PML-NBs
SUMOylation
Virus
interferon
mx1 protein
protein derivative
unclassified drug
antiviral activity
Bunyavirus
cancer cell culture
cell immortalization
gene silencing
head and neck squamous cell carcinoma
immune response
Influenza virus
methylation
oncogenesis and malignant transformation
protein folding
protein function
RNA virus
title_short Papel da proteína Mx1 na resposta a interferons e no processo neoplásico
title_full Papel da proteína Mx1 na resposta a interferons e no processo neoplásico
title_fullStr Papel da proteína Mx1 na resposta a interferons e no processo neoplásico
title_full_unstemmed Papel da proteína Mx1 na resposta a interferons e no processo neoplásico
title_sort Papel da proteína Mx1 na resposta a interferons e no processo neoplásico
author Brantis-de-Carvalho, C. E. [UNESP]
author_facet Brantis-de-Carvalho, C. E. [UNESP]
Boldrin, P. E. G. [UNESP]
Silva, W. A.
Rahal, Paula [UNESP]
Tajara, E. H.
Carraro, D. M.
Camargo, A. A.
Zanelli, C. F. [UNESP]
Valentini, S. R. [UNESP]
author_role author
author2 Boldrin, P. E. G. [UNESP]
Silva, W. A.
Rahal, Paula [UNESP]
Tajara, E. H.
Carraro, D. M.
Camargo, A. A.
Zanelli, C. F. [UNESP]
Valentini, S. R. [UNESP]
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
Universidade de São Paulo (USP)
Faculdade de Medicina de São José do Rio Preto (FAMERP)
Hospital do Câncer A. C. Camargo
Instituto Ludwig de pesquisa para o Câncer no Hospital Oswaldo Cruz
dc.contributor.author.fl_str_mv Brantis-de-Carvalho, C. E. [UNESP]
Boldrin, P. E. G. [UNESP]
Silva, W. A.
Rahal, Paula [UNESP]
Tajara, E. H.
Carraro, D. M.
Camargo, A. A.
Zanelli, C. F. [UNESP]
Valentini, S. R. [UNESP]
dc.subject.por.fl_str_mv Interferons
JAK/STAT
MX1
Neoplasia
PML-NBs
SUMOylation
Virus
interferon
mx1 protein
protein derivative
unclassified drug
antiviral activity
Bunyavirus
cancer cell culture
cell immortalization
gene silencing
head and neck squamous cell carcinoma
immune response
Influenza virus
methylation
oncogenesis and malignant transformation
protein folding
protein function
RNA virus
topic Interferons
JAK/STAT
MX1
Neoplasia
PML-NBs
SUMOylation
Virus
interferon
mx1 protein
protein derivative
unclassified drug
antiviral activity
Bunyavirus
cancer cell culture
cell immortalization
gene silencing
head and neck squamous cell carcinoma
immune response
Influenza virus
methylation
oncogenesis and malignant transformation
protein folding
protein function
RNA virus
description The Mx1 protein is encoded by an interferon- induced gene and shares domain organization, homooligomerization capacity and membrane association with the large dynamin-like GTPases. The Mx1 protein is involved in the response to a large number of RNA viruses, such as the bunyavirus family and the influenza virus. Interestingly, it has also been found as a methylation-silenced gene in several types of neoplasm, including head and neck squamous cell carcinoma. In this scenario, MX1 gene silencing is associated with immortalization in several neoplastic cell lines. Thus, Mx1 stands out as one of the key proteins involved in interferon-induced immune response and also plays an important role in cell cycle control. Here we discuss some of the functions of the Mx1 protein, including its antiviral activity, protein folding and involvement in neoplasia, as well as those revealed by investigating its cellular partners.
publishDate 2011
dc.date.none.fl_str_mv 2011-12-01
2014-05-27T11:26:17Z
2014-05-27T11:26:17Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://serv-bib.fcfar.unesp.br/seer/index.php/Cien_Farm/article/view/2048
Revista de Ciencias Farmaceuticas Basica e Aplicada, v. 32, n. 3, p. 287-295, 2011.
1808-4532
http://hdl.handle.net/11449/72959
2-s2.0-84860864460
2-s2.0-84860864460.pdf
7991082362671212
1525665408900195
0000-0001-5693-6148
0000-0001-7831-1149
url http://serv-bib.fcfar.unesp.br/seer/index.php/Cien_Farm/article/view/2048
http://hdl.handle.net/11449/72959
identifier_str_mv Revista de Ciencias Farmaceuticas Basica e Aplicada, v. 32, n. 3, p. 287-295, 2011.
1808-4532
2-s2.0-84860864460
2-s2.0-84860864460.pdf
7991082362671212
1525665408900195
0000-0001-5693-6148
0000-0001-7831-1149
dc.language.iso.fl_str_mv eng
por
language eng
por
dc.relation.none.fl_str_mv Revista de Ciências Farmacêuticas Básica e Aplicada
0,131
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 287-295
application/pdf
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
_version_ 1797790174607835136

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