Beta-adrenergic pathway activation enhances aggressiveness and inhibits stemness in head and neck cancer

Detalhes bibliográficos
Autor(a) principal: Lopes-Santos, Gabriela [UNESP]
Data de Publicação: 2021
Outros Autores: Bernabé, Daniel Galera [UNESP], Miyahara, Glauco Issamu [UNESP], Tjioe, Kellen Cristine [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1016/j.tranon.2021.101117
http://hdl.handle.net/11449/229165
Resumo: Chronic stress leads to the activation of the beta-adrenergic pathway. Its activation has been implicated in the progression of different types of cancer but its role on head and neck squamous cell carcinomas (HNSCCs) remains undefined. The aim of this study was to investigate the influence of the beta-adrenergic pathway activation in the progression of HNSCCs and offer a panel of potential treatments for patients with the active beta-adrenergic pathway. Five hundred and twenty TCGA patients with primary HNSCCs were divided in two groups: ADRB2low / SLC6A2low and ADRB2high / SLC6A2high. Differentially expressed genes (DEGs) were identified through differential expression analysis. The association of clinicopathological and genomic features between the groups was analyzed using a bioinformatic approach. Potential drugs for treatment of HNSCC were identified based on the DEGs. There was association between ADRB2 and SLC6A2 expressions with age, race, tumor site, histologic grade, perineural invasion, and HPV p16 status. It was identified 898 DEGs between the groups. High ADRB2/SLC6A2 expression stimulated HNSCC proliferation, adhesion, invasion, and angiogenesis. On the other hand, genes related to cell stemness were downregulated in patients with activation of the beta- adrenergic pathway. Finally, 56 FDA-approved antineoplastic and immunotherapeutic drugs were identified as potential targets for the personalized treatment.
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spelling Beta-adrenergic pathway activation enhances aggressiveness and inhibits stemness in head and neck cancerBeta-adrenergic receptorsHead and Neck Squamous Cell CarcinomaNorepinephrine Transport ProteinPsychological stressChronic stress leads to the activation of the beta-adrenergic pathway. Its activation has been implicated in the progression of different types of cancer but its role on head and neck squamous cell carcinomas (HNSCCs) remains undefined. The aim of this study was to investigate the influence of the beta-adrenergic pathway activation in the progression of HNSCCs and offer a panel of potential treatments for patients with the active beta-adrenergic pathway. Five hundred and twenty TCGA patients with primary HNSCCs were divided in two groups: ADRB2low / SLC6A2low and ADRB2high / SLC6A2high. Differentially expressed genes (DEGs) were identified through differential expression analysis. The association of clinicopathological and genomic features between the groups was analyzed using a bioinformatic approach. Potential drugs for treatment of HNSCC were identified based on the DEGs. There was association between ADRB2 and SLC6A2 expressions with age, race, tumor site, histologic grade, perineural invasion, and HPV p16 status. It was identified 898 DEGs between the groups. High ADRB2/SLC6A2 expression stimulated HNSCC proliferation, adhesion, invasion, and angiogenesis. On the other hand, genes related to cell stemness were downregulated in patients with activation of the beta- adrenergic pathway. Finally, 56 FDA-approved antineoplastic and immunotherapeutic drugs were identified as potential targets for the personalized treatment.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Oral Oncology Center São Paulo State University (Unesp), School of Dentistry, 1193 José Bonifácio St.Psychoneuroimmunology Laboratory Psychosomatic Research Center Oral Oncology Center São Paulo State University (Unesp), School of Dentistry, 1193 José Bonifácio StOral Oncology Center São Paulo State University (Unesp), School of Dentistry, 1193 José Bonifácio St.Psychoneuroimmunology Laboratory Psychosomatic Research Center Oral Oncology Center São Paulo State University (Unesp), School of Dentistry, 1193 José Bonifácio StFAPESP: 2016/00051–2Universidade Estadual Paulista (UNESP)Lopes-Santos, Gabriela [UNESP]Bernabé, Daniel Galera [UNESP]Miyahara, Glauco Issamu [UNESP]Tjioe, Kellen Cristine [UNESP]2022-04-29T08:30:47Z2022-04-29T08:30:47Z2021-08-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1016/j.tranon.2021.101117Translational Oncology, v. 14, n. 8, 2021.1936-5233http://hdl.handle.net/11449/22916510.1016/j.tranon.2021.1011172-s2.0-85110549142Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengTranslational Oncologyinfo:eu-repo/semantics/openAccess2024-04-11T20:16:33Zoai:repositorio.unesp.br:11449/229165Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T23:52:35.171244Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Beta-adrenergic pathway activation enhances aggressiveness and inhibits stemness in head and neck cancer
title Beta-adrenergic pathway activation enhances aggressiveness and inhibits stemness in head and neck cancer
spellingShingle Beta-adrenergic pathway activation enhances aggressiveness and inhibits stemness in head and neck cancer
Lopes-Santos, Gabriela [UNESP]
Beta-adrenergic receptors
Head and Neck Squamous Cell Carcinoma
Norepinephrine Transport Protein
Psychological stress
title_short Beta-adrenergic pathway activation enhances aggressiveness and inhibits stemness in head and neck cancer
title_full Beta-adrenergic pathway activation enhances aggressiveness and inhibits stemness in head and neck cancer
title_fullStr Beta-adrenergic pathway activation enhances aggressiveness and inhibits stemness in head and neck cancer
title_full_unstemmed Beta-adrenergic pathway activation enhances aggressiveness and inhibits stemness in head and neck cancer
title_sort Beta-adrenergic pathway activation enhances aggressiveness and inhibits stemness in head and neck cancer
author Lopes-Santos, Gabriela [UNESP]
author_facet Lopes-Santos, Gabriela [UNESP]
Bernabé, Daniel Galera [UNESP]
Miyahara, Glauco Issamu [UNESP]
Tjioe, Kellen Cristine [UNESP]
author_role author
author2 Bernabé, Daniel Galera [UNESP]
Miyahara, Glauco Issamu [UNESP]
Tjioe, Kellen Cristine [UNESP]
author2_role author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (UNESP)
dc.contributor.author.fl_str_mv Lopes-Santos, Gabriela [UNESP]
Bernabé, Daniel Galera [UNESP]
Miyahara, Glauco Issamu [UNESP]
Tjioe, Kellen Cristine [UNESP]
dc.subject.por.fl_str_mv Beta-adrenergic receptors
Head and Neck Squamous Cell Carcinoma
Norepinephrine Transport Protein
Psychological stress
topic Beta-adrenergic receptors
Head and Neck Squamous Cell Carcinoma
Norepinephrine Transport Protein
Psychological stress
description Chronic stress leads to the activation of the beta-adrenergic pathway. Its activation has been implicated in the progression of different types of cancer but its role on head and neck squamous cell carcinomas (HNSCCs) remains undefined. The aim of this study was to investigate the influence of the beta-adrenergic pathway activation in the progression of HNSCCs and offer a panel of potential treatments for patients with the active beta-adrenergic pathway. Five hundred and twenty TCGA patients with primary HNSCCs were divided in two groups: ADRB2low / SLC6A2low and ADRB2high / SLC6A2high. Differentially expressed genes (DEGs) were identified through differential expression analysis. The association of clinicopathological and genomic features between the groups was analyzed using a bioinformatic approach. Potential drugs for treatment of HNSCC were identified based on the DEGs. There was association between ADRB2 and SLC6A2 expressions with age, race, tumor site, histologic grade, perineural invasion, and HPV p16 status. It was identified 898 DEGs between the groups. High ADRB2/SLC6A2 expression stimulated HNSCC proliferation, adhesion, invasion, and angiogenesis. On the other hand, genes related to cell stemness were downregulated in patients with activation of the beta- adrenergic pathway. Finally, 56 FDA-approved antineoplastic and immunotherapeutic drugs were identified as potential targets for the personalized treatment.
publishDate 2021
dc.date.none.fl_str_mv 2021-08-01
2022-04-29T08:30:47Z
2022-04-29T08:30:47Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1016/j.tranon.2021.101117
Translational Oncology, v. 14, n. 8, 2021.
1936-5233
http://hdl.handle.net/11449/229165
10.1016/j.tranon.2021.101117
2-s2.0-85110549142
url http://dx.doi.org/10.1016/j.tranon.2021.101117
http://hdl.handle.net/11449/229165
identifier_str_mv Translational Oncology, v. 14, n. 8, 2021.
1936-5233
10.1016/j.tranon.2021.101117
2-s2.0-85110549142
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Translational Oncology
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
_version_ 1808129560873533440

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