Assessment of AMR-ACB System Using Maghemite Nanoparticles in Theranostic Concentration
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo de conferência |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1007/978-3-030-30648-9_81 http://hdl.handle.net/11449/198205 |
Resumo: | Alternating current biosusceptometry assembled with anisotropic magnetoresistive sensor (AMR-ACB) is a radiation-free technique that can enable the real-time monitoring of magnetic nanoparticles in biomedical applications. The aim of this study is to assess the capability of a multi-channel AMR-ACB system in detecting maghemite nanoparticles (MN) in concentrations used in therapeutic and diagnostic (theranostic) applications, such as oncology, multimodal anticancer therapy, or magnetic resonance imaging. The axial sensibility of the AMR-ACB system was successfully characterized in a bench-top study using MN in different concentrations and distances. The MN sample was aligned with the detection axis of the AMR-ACB system, and then it was moved at fixed distances from 0 to 16 mm. The test was repeated with different MN concentrations. The results show that the AMR-ACB system is capable of detecting samples of MN with a concentration of 0.3 mg/mL, and the output signal is directly proportional to the MN concentration. The output signal exhibits exponential decaying with distance, where the signal amplitude at 8.5 mm is approximately 10% of the signal at 0 mm. This work shows that the AMR-ACB system has adequate sensibility to be employed in in vivo studies to detect MN in theranostic concentrations as well as demonstrates the potential of this magnetic method as a possible tool for future diagnosis. |
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Assessment of AMR-ACB System Using Maghemite Nanoparticles in Theranostic ConcentrationAC BiosusceptometryMaghemite nanoparticleMagnetoresistive sensorAlternating current biosusceptometry assembled with anisotropic magnetoresistive sensor (AMR-ACB) is a radiation-free technique that can enable the real-time monitoring of magnetic nanoparticles in biomedical applications. The aim of this study is to assess the capability of a multi-channel AMR-ACB system in detecting maghemite nanoparticles (MN) in concentrations used in therapeutic and diagnostic (theranostic) applications, such as oncology, multimodal anticancer therapy, or magnetic resonance imaging. The axial sensibility of the AMR-ACB system was successfully characterized in a bench-top study using MN in different concentrations and distances. The MN sample was aligned with the detection axis of the AMR-ACB system, and then it was moved at fixed distances from 0 to 16 mm. The test was repeated with different MN concentrations. The results show that the AMR-ACB system is capable of detecting samples of MN with a concentration of 0.3 mg/mL, and the output signal is directly proportional to the MN concentration. The output signal exhibits exponential decaying with distance, where the signal amplitude at 8.5 mm is approximately 10% of the signal at 0 mm. This work shows that the AMR-ACB system has adequate sensibility to be employed in in vivo studies to detect MN in theranostic concentrations as well as demonstrates the potential of this magnetic method as a possible tool for future diagnosis.Institute of Science and Technology UNIFESPInstitute of Chemistry UNESPInstitute of Chemistry UNESPUniversidade Federal de São Paulo (UNIFESP)Universidade Estadual Paulista (Unesp)de Jesus Prates, LeopoldoPaixão, Fabiano Carlosde Moraes, Marli LeiteCoelho, Regina Céliada Silva, Robson Rosa [UNESP]de Godoy, Carlos Marcelo Gurjão2020-12-12T01:06:29Z2020-12-12T01:06:29Z2020-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObject611-615http://dx.doi.org/10.1007/978-3-030-30648-9_81IFMBE Proceedings, v. 75, p. 611-615.1433-92771680-0737http://hdl.handle.net/11449/19820510.1007/978-3-030-30648-9_812-s2.0-85075684187Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengIFMBE Proceedingsinfo:eu-repo/semantics/openAccess2021-10-23T09:55:36Zoai:repositorio.unesp.br:11449/198205Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462021-10-23T09:55:36Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Assessment of AMR-ACB System Using Maghemite Nanoparticles in Theranostic Concentration |
title |
Assessment of AMR-ACB System Using Maghemite Nanoparticles in Theranostic Concentration |
spellingShingle |
Assessment of AMR-ACB System Using Maghemite Nanoparticles in Theranostic Concentration de Jesus Prates, Leopoldo AC Biosusceptometry Maghemite nanoparticle Magnetoresistive sensor |
title_short |
Assessment of AMR-ACB System Using Maghemite Nanoparticles in Theranostic Concentration |
title_full |
Assessment of AMR-ACB System Using Maghemite Nanoparticles in Theranostic Concentration |
title_fullStr |
Assessment of AMR-ACB System Using Maghemite Nanoparticles in Theranostic Concentration |
title_full_unstemmed |
Assessment of AMR-ACB System Using Maghemite Nanoparticles in Theranostic Concentration |
title_sort |
Assessment of AMR-ACB System Using Maghemite Nanoparticles in Theranostic Concentration |
author |
de Jesus Prates, Leopoldo |
author_facet |
de Jesus Prates, Leopoldo Paixão, Fabiano Carlos de Moraes, Marli Leite Coelho, Regina Célia da Silva, Robson Rosa [UNESP] de Godoy, Carlos Marcelo Gurjão |
author_role |
author |
author2 |
Paixão, Fabiano Carlos de Moraes, Marli Leite Coelho, Regina Célia da Silva, Robson Rosa [UNESP] de Godoy, Carlos Marcelo Gurjão |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Federal de São Paulo (UNIFESP) Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
de Jesus Prates, Leopoldo Paixão, Fabiano Carlos de Moraes, Marli Leite Coelho, Regina Célia da Silva, Robson Rosa [UNESP] de Godoy, Carlos Marcelo Gurjão |
dc.subject.por.fl_str_mv |
AC Biosusceptometry Maghemite nanoparticle Magnetoresistive sensor |
topic |
AC Biosusceptometry Maghemite nanoparticle Magnetoresistive sensor |
description |
Alternating current biosusceptometry assembled with anisotropic magnetoresistive sensor (AMR-ACB) is a radiation-free technique that can enable the real-time monitoring of magnetic nanoparticles in biomedical applications. The aim of this study is to assess the capability of a multi-channel AMR-ACB system in detecting maghemite nanoparticles (MN) in concentrations used in therapeutic and diagnostic (theranostic) applications, such as oncology, multimodal anticancer therapy, or magnetic resonance imaging. The axial sensibility of the AMR-ACB system was successfully characterized in a bench-top study using MN in different concentrations and distances. The MN sample was aligned with the detection axis of the AMR-ACB system, and then it was moved at fixed distances from 0 to 16 mm. The test was repeated with different MN concentrations. The results show that the AMR-ACB system is capable of detecting samples of MN with a concentration of 0.3 mg/mL, and the output signal is directly proportional to the MN concentration. The output signal exhibits exponential decaying with distance, where the signal amplitude at 8.5 mm is approximately 10% of the signal at 0 mm. This work shows that the AMR-ACB system has adequate sensibility to be employed in in vivo studies to detect MN in theranostic concentrations as well as demonstrates the potential of this magnetic method as a possible tool for future diagnosis. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-12-12T01:06:29Z 2020-12-12T01:06:29Z 2020-01-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/conferenceObject |
format |
conferenceObject |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1007/978-3-030-30648-9_81 IFMBE Proceedings, v. 75, p. 611-615. 1433-9277 1680-0737 http://hdl.handle.net/11449/198205 10.1007/978-3-030-30648-9_81 2-s2.0-85075684187 |
url |
http://dx.doi.org/10.1007/978-3-030-30648-9_81 http://hdl.handle.net/11449/198205 |
identifier_str_mv |
IFMBE Proceedings, v. 75, p. 611-615. 1433-9277 1680-0737 10.1007/978-3-030-30648-9_81 2-s2.0-85075684187 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
IFMBE Proceedings |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
611-615 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1799965016938512384 |